GREMLIN Database
YRRI - UPF0118 membrane protein YrrI
UniProt: O34472 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 353 (325)
Sequences: 10950 (8503)
Seq/√Len: 471.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
231_G246_G5.2311.00
233_S285_T4.8741.00
62_W66_K4.4391.00
316_A336_T3.1431.00
64_H70_R3.0701.00
54_Y209_D3.0081.00
227_G250_G2.8361.00
280_L284_I2.7821.00
277_K281_V2.5911.00
231_G235_W2.5281.00
227_G246_G2.5251.00
69_P72_L2.5181.00
62_W65_G2.4801.00
52_I175_V2.4371.00
68_L76_V2.2091.00
340_K344_I2.1821.00
268_L283_V2.1651.00
234_F239_L2.1361.00
49_S175_V2.0561.00
106_N109_M2.0561.00
220_L254_V1.9501.00
218_G301_I1.9451.00
176_F180_K1.9181.00
203_A345_H1.8781.00
268_L279_V1.8601.00
281_V284_I1.8551.00
193_T201_G1.8411.00
115_N119_L1.8291.00
71_T75_L1.8281.00
207_D345_H1.8091.00
284_I288_I1.8001.00
57_L70_R1.7921.00
230_A249_S1.7581.00
57_L61_E1.7541.00
232_I235_W1.7431.00
248_I252_T1.7301.00
60_T77_I1.7271.00
171_I175_V1.7231.00
181_D309_H1.7201.00
74_I176_F1.7131.00
300_F304_R1.7061.00
208_V338_V1.6961.00
174_L311_V1.6791.00
231_G242_P1.6651.00
60_T74_I1.6591.00
190_W202_S1.6431.00
125_T128_W1.6401.00
242_P246_G1.6331.00
276_V279_V1.6291.00
74_I78_Y1.6191.00
37_L40_K1.6131.00
235_W242_P1.6031.00
226_L253_N1.5981.00
59_V77_I1.5911.00
240_P274_I1.5901.00
71_T180_K1.5881.00
229_I289_L1.5871.00
174_L178_M1.5841.00
278_A281_V1.5821.00
60_T70_R1.5771.00
271_A282_V1.5751.00
23_Y27_M1.5741.00
321_G329_M1.5561.00
131_G134_H1.5551.00
46_L315_L1.5451.00
117_L120_H1.5381.00
86_G90_Y1.5331.00
134_H138_K1.5301.00
276_V280_L1.4951.00
230_A289_L1.4931.00
252_T263_G1.4821.00
63_L80_L1.4721.00
187_K191_Y1.4711.00
297_L301_I1.4591.00
138_K141_R1.4351.00
101_T105_E1.4251.00
116_G120_H1.4011.00
277_K280_L1.4001.00
120_H124_H1.3901.00
264_A268_L1.3851.00
30_M34_P1.3831.00
119_L122_H1.3571.00
68_L72_L1.3511.00
271_A279_V1.3461.00
130_D134_H1.3421.00
113_T116_G1.3401.00
222_V293_E1.3351.00
56_L179_V1.3261.00
292_M297_L1.3071.00
194_P198_R1.2981.00
245_L267_A1.2971.00
283_V287_F1.2961.00
267_A282_V1.2851.00
93_V97_I1.2741.00
49_S171_I1.2741.00
290_Q294_G1.2661.00
317_L329_M1.2521.00
233_S237_F1.2471.00
117_L121_V1.2471.00
211_S337_A1.2421.00
71_T176_F1.2411.00
82_F86_G1.2391.00
60_T179_V1.2381.00
56_L81_F1.2351.00
133_H137_D1.2331.00
109_M112_E1.2311.00
312_V336_T1.2301.00
223_C253_N1.2161.00
287_F291_F1.2161.00
136_I139_M1.2151.00
132_M135_R1.2141.00
186_K190_W1.2091.00
75_L79_V1.2071.00
57_L182_I1.2001.00
45_P49_S1.1991.00
316_A320_G1.1941.00
112_E115_N1.1911.00
108_P112_E1.1901.00
226_L289_L1.1871.00
131_G135_R1.1871.00
60_T73_S1.1801.00
246_G250_G1.1721.00
281_V285_T1.1711.00
320_G324_A1.1611.00
181_D184_L1.1611.00
68_L73_S1.1571.00
73_S77_I1.1561.00
29_D33_S1.1551.00
129_P133_H1.1531.00
142_Q145_A1.1521.00
104_S108_P1.1511.00
59_V62_W1.1511.00
239_L271_A1.1481.00
188_T191_Y1.1471.00
232_I236_V1.1451.00
52_I171_I1.1441.00
26_F30_M1.1421.00
109_M113_T1.1371.00
237_F282_V1.1321.00
70_R183_E1.1291.00
134_H137_D1.1291.00
118_L122_H1.1281.00
294_G298_S1.1251.00
207_D344_I1.1131.00
204_F342_M1.1121.00
217_R221_L1.1111.00
46_L174_L1.1101.00
60_T64_H1.1091.00
222_V226_L1.1071.00
234_F249_S1.1021.00
53_S178_M1.0671.00
226_L230_A1.0651.00
130_D133_H1.0611.00
327_V331_L1.0611.00
320_G336_T1.0611.00
64_H73_S1.0591.00
33_S37_L1.0521.00
48_I171_I1.0521.00
285_T289_L1.0491.00
135_R138_K1.0491.00
231_G243_L1.0431.00
214_D218_G1.0421.00
227_G231_G1.0391.00
339_L343_M1.0381.00
50_I178_M1.0371.00
296_I300_F1.0371.00
220_L224_L1.0341.00
24_V28_L1.0321.00
222_V297_L1.0311.00
219_Q298_S1.0291.00
164_Y168_A1.0211.00
170_T174_L1.0191.00
174_L315_L1.0171.00
233_S289_L1.0151.00
190_W198_R1.0121.00
138_K142_Q1.0091.00
72_L75_L1.0051.00
49_S53_S1.0041.00
226_L260_P1.0031.00
117_L122_H1.0021.00
272_M279_V1.0021.00
63_L77_I1.0021.00
34_P38_V0.9901.00
78_Y175_V0.9901.00
154_A158_I0.9881.00
139_M142_Q0.9801.00
224_L250_G0.9731.00
312_V340_K0.9671.00
228_V232_I0.9671.00
214_D305_S0.9631.00
250_G254_V0.9591.00
137_D141_R0.9591.00
146_F150_T0.9561.00
141_R145_A0.9551.00
293_E298_S0.9541.00
237_F278_A0.9521.00
316_A332_A0.9501.00
157_G161_V0.9471.00
270_I274_I0.9451.00
203_A207_D0.9431.00
35_F39_I0.9421.00
116_G119_L0.9421.00
221_L225_I0.9391.00
97_I100_L0.9371.00
222_V298_S0.9371.00
237_F285_T0.9351.00
143_T146_F0.9331.00
42_I319_A0.9301.00
145_A148_A0.9301.00
147_F151_I0.9181.00
225_I229_I0.9151.00
234_F282_V0.9131.00
288_I292_M0.9111.00
234_F245_L0.9101.00
49_S174_L0.9081.00
332_A336_T0.9051.00
182_I186_K0.9011.00
248_I263_G0.9011.00
90_Y94_P0.9001.00
61_E64_H0.8991.00
246_G249_S0.8991.00
253_N260_P0.8991.00
275_S278_A0.8971.00
124_H127_D0.8971.00
101_T104_S0.8951.00
118_L124_H0.8941.00
290_Q293_E0.8941.00
292_M296_I0.8901.00
262_I266_P0.8861.00
241_Y244_I0.8861.00
222_V253_N0.8821.00
102_D105_E0.8751.00
228_V231_G0.8681.00
56_L77_I0.8681.00
98_V102_D0.8661.00
150_T153_G0.8631.00
61_E65_G0.8561.00
113_T117_L0.8521.00
147_F150_T0.8471.00
32_W35_F0.8431.00
342_M346_F0.8411.00
279_V283_V0.8391.00
107_I111_A0.8341.00
291_F295_N0.8321.00
282_V286_V0.8311.00
204_F345_H0.8271.00
302_V313_I0.8261.00
233_S281_V0.8261.00
315_L319_A0.8181.00
230_A234_F0.8171.00
122_H125_T0.8171.00
245_L270_I0.8161.00
188_T192_L0.8151.00
89_L93_V0.8141.00
106_N110_F0.8141.00
121_V124_H0.8101.00
112_E116_G0.8081.00
61_E183_E0.8071.00
210_D214_D0.8061.00
308_M336_T0.8051.00
235_W238_G0.8041.00
141_R144_E0.8031.00
84_G88_A0.8021.00
226_L298_S0.7991.00
124_H128_W0.7971.00
63_L68_L0.7971.00
224_L228_V0.7961.00
235_W246_G0.7911.00
223_C254_V0.7901.00
272_M276_V0.7891.00
253_N298_S0.7871.00
46_L178_M0.7871.00
119_L123_N0.7821.00
303_G313_I0.7801.00
200_R345_H0.7791.00
223_C227_G0.7751.00
140_I144_E0.7731.00
184_L187_K0.7691.00
121_V125_T0.7691.00
249_S286_V0.7681.00
269_L273_T0.7651.00
298_S302_V0.7631.00
137_D140_I0.7601.00
222_V302_V0.7601.00
53_S175_V0.7591.00
158_I162_L0.7581.00
62_W67_G0.7571.00
122_H126_D0.7531.00
207_D341_V0.7501.00
175_V179_V0.7501.00
119_L125_T0.7471.00
225_I297_L0.7441.00
160_N163_D0.7421.00
22_V26_F0.7411.00
163_D167_I0.7341.00
221_L301_I0.7321.00
114_Y117_L0.7321.00
249_S253_N0.7301.00
200_R203_A0.7301.00
190_W193_T0.7301.00
100_L104_S0.7291.00
193_T197_W0.7291.00
102_D106_N0.7231.00
56_L59_V0.7231.00
69_P73_S0.7211.00
184_L188_T0.7181.00
96_L100_L0.7161.00
30_M33_S0.7151.00
268_L272_M0.7141.00
219_Q253_N0.7131.00
310_P314_M0.7121.00
80_L83_G0.7121.00
306_L333_V0.7101.00
194_P197_W0.7101.00
227_G243_L0.7091.00
120_H123_N0.7081.00
95_V98_V0.7071.00
199_K203_A0.7051.00
320_G335_A0.7041.00
78_Y176_F0.7031.00
142_Q146_F0.7021.00
263_G267_A0.6991.00
145_A149_G0.6981.00
84_G87_W0.6971.00
34_P37_L0.6931.00
211_S214_D0.6921.00
63_L73_S0.6921.00
198_R202_S0.6861.00
298_S301_I0.6861.00
207_D211_S0.6861.00
201_G205_L0.6851.00
219_Q223_C0.6851.00
91_K95_V0.6841.00
151_I154_A0.6841.00
48_I52_I0.6831.00
249_S263_G0.6821.00
208_V341_V0.6811.00
118_L123_N0.6801.00
53_S57_L0.6791.00
166_L170_T0.6751.00
202_S206_R0.6751.00
57_L179_V0.6711.00
45_P303_G0.6701.00
23_Y28_L0.6701.00
213_G217_R0.6681.00
223_C226_L0.6671.00
223_C250_G0.6651.00
130_D135_R0.6631.00
257_Y310_P0.6621.00
87_W91_K0.6611.00
336_T340_K0.6581.00
222_V301_I0.6571.00
226_L290_Q0.6571.00
139_M143_T0.6551.00
63_L76_V0.6541.00
239_L274_I0.6531.00
27_M30_M0.6511.00
77_I81_F0.6491.00
212_L215_Y0.6481.00
291_F294_G0.6481.00
28_L32_W0.6481.00
187_K202_S0.6471.00
64_H69_P0.6451.00
260_P263_G0.6441.00
56_L175_V0.6441.00
226_L293_E0.6431.00
148_A152_E0.6431.00
144_E148_A0.6431.00
263_G290_Q0.6401.00
155_I159_R0.6391.00
230_A246_G0.6391.00
45_P167_I0.6361.00
136_I140_I0.6351.00
313_I333_V0.6351.00
227_G247_L0.6311.00
219_Q222_V0.6290.99
317_L333_V0.6260.99
92_G96_L0.6230.99
229_I233_S0.6220.99
248_I266_P0.6210.99
240_P243_L0.6170.99
221_L224_L0.6160.99
149_G152_E0.6150.99
237_F281_V0.6140.99
114_Y118_L0.6130.99
33_S36_W0.6120.99
53_S179_V0.6120.99
249_S260_P0.6120.99
326_I329_M0.6120.99
207_D210_D0.6090.99
105_E109_M0.6080.99
204_F208_V0.6070.99
140_I143_T0.6070.99
297_L300_F0.6060.99
264_A286_V0.6040.99
123_N126_D0.6020.99
97_I101_T0.6010.99
74_I180_K0.6000.99
214_D217_R0.5990.99
160_N164_Y0.5950.99
94_P334_P0.5940.99
170_T318_L0.5920.99
187_K190_W0.5910.99
32_W36_W0.5900.99
230_A250_G0.5900.99
264_A287_F0.5880.99
250_G257_Y0.5870.99
274_I278_A0.5870.99
222_V260_P0.5870.99
178_M311_V0.5840.99
153_G157_G0.5840.99
95_V99_Q0.5830.99
135_R139_M0.5830.99
105_E108_P0.5830.99
86_G89_L0.5810.99
174_L318_L0.5790.99
64_H67_G0.5790.99
188_T312_V0.5790.99
38_V41_T0.5780.99
219_Q254_V0.5770.99
70_R74_I0.5760.99
263_G333_V0.5740.99
85_I89_L0.5730.99
99_Q102_D0.5730.99
107_I110_F0.5730.99
218_G337_A0.5710.99
208_V212_L0.5710.99
215_Y334_P0.5710.99
151_I155_I0.5680.99
129_P135_R0.5680.99
253_N293_E0.5680.99
309_H340_K0.5670.99
219_Q293_E0.5660.99
260_P290_Q0.5630.99
295_N318_L0.5630.99
226_L229_I0.5590.99
164_Y167_I0.5560.99
237_F289_L0.5550.99
25_F29_D0.5550.99
230_A285_T0.5550.99
324_A328_G0.5540.99
45_P54_Y0.5530.99
30_M37_L0.5530.99
288_I291_F0.5490.99
265_V269_L0.5480.99
27_M31_L0.5470.99
168_A172_P0.5470.99
304_R307_K0.5470.99
303_G307_K0.5460.99
235_W243_L0.5450.99
206_R210_D0.5450.99
102_D241_Y0.5420.99
35_F339_L0.5400.98
156_S159_R0.5370.98
300_F307_K0.5370.98
308_M313_I0.5370.98
35_F38_V0.5340.98
226_L250_G0.5330.98
56_L60_T0.5310.98
218_G305_S0.5300.98
79_V83_G0.5290.98
227_G264_A0.5280.98
219_Q297_L0.5270.98
250_G253_N0.5250.98
239_L242_P0.5240.98
177_Y181_D0.5240.98
261_F264_A0.5210.98
321_G334_P0.5200.98
263_G330_I0.5190.98
198_R201_G0.5180.98
217_R305_S0.5170.98
146_F149_G0.5170.98
243_L246_G0.5170.98
162_L166_L0.5160.98
275_S279_V0.5150.98
211_S341_V0.5150.98
161_V165_F0.5150.98
253_N290_Q0.5110.98
230_A233_S0.5110.98
284_I287_F0.5100.98
300_F303_G0.5090.98
263_G334_P0.5070.98
253_N263_G0.5040.98
23_Y26_F0.5040.98
149_G153_G0.5030.98
320_G332_A0.5030.98
31_L34_P0.5020.98
148_A151_I0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tx3A 2 0.5609 25 0.953 Contact Map
4b19A 1 0.085 16.3 0.957 Contact Map
2kv5A 1 0.0878 15.7 0.957 Contact Map
4lz6A 1 0.898 11.8 0.96 Contact Map
3bz1X 1 0.1048 11.3 0.96 Contact Map
4tkrA 2 0.3059 9.4 0.961 Contact Map
3mktA 1 0.9773 7.8 0.963 Contact Map
3rlbA 1 0.3286 6.6 0.964 Contact Map
4bgnA 3 0.2805 6.5 0.964 Contact Map
3w4tA 1 0.8895 6.3 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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