GREMLIN Database
YTLQ - Uncharacterized protein YtlQ
UniProt: O34471 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (299)
Sequences: 109 (99)
Seq/√Len: 5.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_L271_K4.1850.94
175_I226_V4.1850.94
139_Y263_A4.1230.94
3_Q120_T3.5100.87
5_I151_M3.4290.85
189_Y199_K2.8960.73
106_K143_Q2.6170.65
196_F247_D2.5760.64
182_E242_R2.5720.64
17_D259_D2.5560.63
114_L127_L2.5360.63
177_C196_F2.4880.61
169_I239_L2.4160.59
112_F120_T2.3000.55
20_H24_Q2.2480.53
176_Y238_L2.2100.52
25_F160_Q2.1740.50
112_F209_L2.1290.49
32_R277_I2.1100.48
106_K282_V2.0840.47
109_L160_Q2.0760.47
218_T231_A2.0760.47
10_Y131_V2.0700.47
275_A294_S2.0690.47
138_R149_F2.0560.46
168_V256_E2.0290.45
267_I271_K2.0290.45
196_F255_L2.0140.45
150_I296_S2.0080.45
7_I22_I1.9680.43
167_I218_T1.9560.43
150_I169_I1.9480.43
9_D210_N1.9240.42
171_S273_N1.9040.41
108_H184_E1.8810.40
232_E272_K1.8720.40
23_N162_A1.8390.39
100_A296_S1.8380.39
20_H218_T1.8110.38
170_I223_S1.8090.38
141_T271_K1.7980.38
187_S199_K1.7450.36
174_E259_D1.7310.35
180_F251_P1.7280.35
143_Q271_K1.7050.35
102_A244_S1.6970.34
106_K144_L1.6430.33
166_S179_S1.6150.32
158_I268_E1.6070.32
196_F261_R1.6060.32
30_K105_Y1.5980.31
20_H259_D1.5510.30
132_K273_N1.5330.29
183_A199_K1.5320.29
140_L169_I1.5110.29
40_A195_R1.5040.29
105_Y282_V1.4890.28
3_Q112_F1.4860.28
155_V240_L1.4690.28
221_V247_D1.4660.27
15_E144_L1.4580.27
107_R155_V1.4200.26
64_S275_A1.4160.26
66_K208_V1.4070.26
296_S299_R1.3920.25
106_K271_K1.3880.25
64_S231_A1.3830.25
114_L118_S1.3730.25
244_S270_Q1.3690.25
151_M229_K1.3520.24
149_F160_Q1.3500.24
151_M210_N1.3370.24
106_K156_L1.3350.24
1_M17_D1.3260.24
138_R282_V1.3220.24
192_S196_F1.3210.24
24_Q147_S1.3190.24
191_G196_F1.3150.23
244_S247_D1.2970.23
95_P253_Y1.2940.23
19_Y282_V1.2890.23
93_R163_V1.2870.23
202_A214_S1.2830.23
155_V204_Q1.2770.23
120_T147_S1.2740.22
25_F181_L1.2730.22
112_F199_K1.2700.22
144_L156_L1.2690.22
190_I200_K1.2650.22
179_S235_V1.2630.22
9_D161_A1.2630.22
237_K252_P1.2630.22
143_Q267_I1.2600.22
50_S258_A1.2540.22
31_E191_G1.2530.22
121_L240_L1.2520.22
87_E240_L1.2490.22
151_M156_L1.2320.21
270_Q300_Q1.2210.21
199_K249_P1.2150.21
4_I102_A1.2120.21
125_S299_R1.2120.21
191_G254_G1.2110.21
138_R142_Q1.2100.21
120_T242_R1.2050.21
138_R205_T1.2040.21
136_I180_F1.1990.21
168_V235_V1.1970.21
26_V112_F1.1950.21
196_F244_S1.1930.21
177_C244_S1.1920.21
27_R235_V1.1900.21
26_V120_T1.1790.20
94_L104_F1.1670.20
156_L225_I1.1630.20
141_T282_V1.1630.20
106_K140_L1.1620.20
202_A245_Y1.1530.20
160_Q202_A1.1490.20
203_S260_K1.1460.20
72_I166_S1.1430.19
8_H219_D1.1430.19
177_C286_K1.1370.19
97_S167_I1.1280.19
52_E260_K1.1240.19
288_L301_E1.1130.19
189_Y261_R1.1100.19
178_V240_L1.0980.19
189_Y200_K1.0970.18
37_V98_R1.0920.18
66_K121_L1.0870.18
140_L240_L1.0810.18
87_E239_L1.0800.18
61_K69_K1.0670.18
3_Q242_R1.0610.18
227_K232_E1.0570.18
118_S259_D1.0490.18
247_D261_R1.0460.17
96_K230_Q1.0450.17
212_G255_L1.0410.17
20_H162_A1.0380.17
32_R196_F1.0370.17
155_V295_D1.0330.17
112_F296_S1.0260.17
82_Q179_S1.0220.17
143_Q147_S1.0180.17
200_K245_Y1.0170.17
156_L159_Q1.0150.17
3_Q26_V1.0110.17
20_H195_R1.0080.17
155_V293_M1.0070.17
113_Q145_P1.0070.17
29_K145_P1.0070.17
29_K113_Q1.0070.17
13_R29_K1.0070.17
113_Q116_W1.0070.17
29_K116_W1.0070.17
116_W145_P1.0070.17
13_R116_W1.0070.17
13_R145_P1.0070.17
13_R113_Q1.0070.17
50_S121_L1.0020.17
174_E188_V0.9980.17
139_Y144_L0.9970.16
32_R244_S0.9920.16
10_Y22_I0.9890.16
50_S235_V0.9880.16
17_D140_L0.9790.16
184_E210_N0.9740.16
177_C199_K0.9720.16
118_S137_L0.9710.16
170_I255_L0.9700.16
209_L241_S0.9670.16
106_K139_Y0.9670.16
7_I23_N0.9660.16
4_I141_T0.9640.16
95_P237_K0.9630.16
97_S232_E0.9610.16
221_V233_I0.9590.16
63_F198_D0.9540.16
181_L204_Q0.9530.16
102_A166_S0.9460.16
263_A287_A0.9460.16
138_R143_Q0.9420.15
155_V178_V0.9390.15
107_R199_K0.9370.15
15_E19_Y0.9340.15
196_F245_Y0.9300.15
161_A210_N0.9260.15
3_Q101_L0.9250.15
11_I283_K0.9200.15
25_F101_L0.9170.15
146_D152_Y0.9160.15
32_R226_V0.9150.15
25_F149_F0.9110.15
249_P254_G0.9100.15
147_S267_I0.9050.15
111_D133_Q0.9000.15
232_E264_E0.8990.15
18_P22_I0.8940.15
140_L180_F0.8930.15
24_Q259_D0.8900.15
112_F200_K0.8850.14
155_V207_S0.8840.14
177_C255_L0.8820.14
191_G248_Y0.8790.14
36_L178_V0.8720.14
151_M170_I0.8690.14
79_E255_L0.8690.14
32_R254_G0.8640.14
10_Y123_E0.8620.14
227_K294_S0.8570.14
95_P178_V0.8480.14
255_L300_Q0.8470.14
26_V187_S0.8460.14
37_V41_E0.8410.14
144_L282_V0.8350.14
50_S238_L0.8300.14
138_R283_K0.8290.14
139_Y282_V0.8270.13
22_I185_E0.8260.13
22_I155_V0.8250.13
199_K261_R0.8230.13
143_Q156_L0.8210.13
95_P252_P0.8200.13
65_L171_S0.8190.13
182_E209_L0.8190.13
43_Q124_I0.8160.13
105_Y147_S0.8160.13
143_Q277_I0.8120.13
3_Q19_Y0.8120.13
166_S210_N0.8090.13
26_V199_K0.8080.13
94_L151_M0.8060.13
156_L292_C0.8050.13
81_H239_L0.8050.13
117_A215_L0.7980.13
196_F259_D0.7930.13
18_P129_N0.7910.13
110_Y259_D0.7890.13
100_A201_T0.7860.13
151_M226_V0.7850.13
168_V300_Q0.7850.13
180_F240_L0.7790.13
141_T144_L0.7770.13
185_E225_I0.7760.13
24_Q167_I0.7740.13
266_W281_Q0.7730.13
149_F271_K0.7730.13
179_S218_T0.7730.13
209_L248_Y0.7730.13
100_A153_K0.7710.13
233_I298_R0.7640.13
33_W142_Q0.7640.13
164_E219_D0.7630.12
4_I131_V0.7620.12
20_H27_R0.7570.12
98_R241_S0.7540.12
64_S226_V0.7520.12
199_K208_V0.7520.12
106_K159_Q0.7500.12
170_I175_I0.7500.12
223_S232_E0.7490.12
158_I168_V0.7480.12
240_L255_L0.7440.12
22_I294_S0.7420.12
123_E294_S0.7410.12
54_P64_S0.7380.12
140_L144_L0.7380.12
188_V209_L0.7350.12
69_K148_Y0.7320.12
3_Q28_L0.7240.12
4_I275_A0.7240.12
297_Y301_E0.7230.12
32_R191_G0.7230.12
134_D152_Y0.7220.12
8_H267_I0.7180.12
123_E296_S0.7170.12
157_K230_Q0.7150.12
87_E129_N0.7140.12
1_M247_D0.7140.12
5_I18_P0.7120.12
83_W287_A0.7090.12
147_S279_H0.7060.12
129_N201_T0.7060.12
276_P285_A0.7010.12
24_Q150_I0.7000.12
13_R33_W0.6980.12
33_W113_Q0.6980.12
33_W116_W0.6980.12
29_K33_W0.6980.12
33_W145_P0.6980.12
116_W137_L0.6960.12
113_Q137_L0.6960.12
13_R137_L0.6960.12
137_L145_P0.6960.12
29_K137_L0.6960.12
221_V267_I0.6940.11
26_V215_L0.6930.11
5_I285_A0.6930.11
31_E188_V0.6900.11
56_P65_L0.6900.11
80_R287_A0.6880.11
144_L277_I0.6860.11
149_F226_V0.6840.11
106_K141_T0.6840.11
105_Y271_K0.6810.11
60_R74_A0.6780.11
149_F277_I0.6780.11
147_S176_Y0.6780.11
5_I39_A0.6770.11
191_G225_I0.6750.11
171_S239_L0.6750.11
278_K281_Q0.6730.11
11_I142_Q0.6720.11
205_T245_Y0.6720.11
185_E295_D0.6720.11
191_G246_I0.6710.11
106_K147_S0.6710.11
30_K170_I0.6700.11
79_E168_V0.6700.11
144_L296_S0.6690.11
277_I282_V0.6660.11
71_E158_I0.6620.11
177_C216_F0.6590.11
18_P111_D0.6590.11
77_Q92_V0.6590.11
161_A289_L0.6580.11
67_R210_N0.6550.11
67_R222_V0.6520.11
20_H167_I0.6500.11
147_S288_L0.6490.11
216_F286_K0.6470.11
191_G200_K0.6460.11
252_P271_K0.6450.11
13_R146_D0.6450.11
116_W146_D0.6450.11
29_K146_D0.6450.11
113_Q146_D0.6450.11
257_I262_S0.6450.11
79_E160_Q0.6430.11
16_L144_L0.6430.11
195_R223_S0.6420.11
3_Q147_S0.6400.11
27_R195_R0.6390.11
218_T292_C0.6350.11
98_R263_A0.6330.11
207_S235_V0.6320.11
15_E226_V0.6300.11
124_I185_E0.6280.11
194_N274_T0.6270.11
12_S155_V0.6250.11
45_E212_G0.6230.11
2_A136_I0.6230.11
140_L156_L0.6190.10
177_C259_D0.6160.10
289_L299_R0.6160.10
144_L236_R0.6150.10
21_Y116_W0.6140.10
21_Y145_P0.6140.10
13_R21_Y0.6140.10
21_Y29_K0.6140.10
21_Y113_Q0.6140.10
5_I229_K0.6130.10
1_M137_L0.6100.10
181_L189_Y0.6080.10
275_A295_D0.6080.10
3_Q190_I0.6040.10
1_M154_P0.6010.10
166_S239_L0.6000.10
151_M175_I0.5990.10
24_Q209_L0.5980.10
28_L112_F0.5970.10
190_I242_R0.5960.10
101_L120_T0.5940.10
209_L249_P0.5930.10
171_S265_E0.5930.10
150_I227_K0.5900.10
7_I166_S0.5840.10
3_Q299_R0.5840.10
120_T252_P0.5810.10
267_I296_S0.5810.10
239_L255_L0.5800.10
130_Q227_K0.5800.10
30_K235_V0.5790.10
8_H105_Y0.5790.10
138_R144_L0.5770.10
13_R276_P0.5750.10
29_K276_P0.5750.10
113_Q276_P0.5750.10
116_W276_P0.5750.10
145_P276_P0.5750.10
90_I260_K0.5730.10
149_F231_A0.5700.10
150_I290_S0.5630.10
222_V287_A0.5610.10
11_I243_T0.5600.10
2_A180_F0.5580.10
61_K100_A0.5560.10
76_I185_E0.5530.10
281_Q289_L0.5520.10
166_S292_C0.5520.10
23_N178_V0.5510.10
40_A97_S0.5490.10
177_C261_R0.5480.10
101_L182_E0.5460.10
19_Y120_T0.5450.10
23_N187_S0.5450.10
184_E199_K0.5430.10
118_S127_L0.5420.10
131_V251_P0.5420.10
112_F241_S0.5410.09
11_I44_H0.5390.09
225_I239_L0.5370.09
7_I294_S0.5360.09
132_K242_R0.5330.09
25_F100_A0.5320.09
188_V224_K0.5310.09
98_R210_N0.5300.09
50_S194_N0.5300.09
258_A280_H0.5280.09
168_V272_K0.5270.09
130_Q198_D0.5260.09
31_E270_Q0.5260.09
163_V247_D0.5250.09
259_D270_Q0.5210.09
32_R74_A0.5210.09
69_K220_S0.5200.09
127_L187_S0.5180.09
153_K179_S0.5170.09
176_Y245_Y0.5110.09
14_Y211_P0.5110.09
6_K197_W0.5110.09
6_K14_Y0.5110.09
14_Y197_W0.5110.09
197_W211_P0.5110.09
6_K211_P0.5110.09
4_I7_I0.5100.09
97_S158_I0.5080.09
258_A264_E0.5070.09
15_E214_S0.5070.09
2_A169_I0.5040.09
5_I159_Q0.5040.09
147_S282_V0.5040.09
168_V268_E0.5030.09
139_Y271_K0.5010.09
7_I239_L0.5000.09
111_D235_V0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fkcA 2 0.3059 18.1 0.978 Contact Map
4hxiA 1 0.2862 17 0.978 Contact Map
3ga1A 2 0.3092 14.2 0.979 Contact Map
1fs1B 2 0.2204 13.6 0.979 Contact Map
2p1mA 1 0.0888 13.5 0.979 Contact Map
1hv2A 1 0.2368 11.4 0.98 Contact Map
2astA 1 0.2204 10.5 0.98 Contact Map
1r29A 2 0.3059 10.3 0.98 Contact Map
3n54B 5 0.1842 9.6 0.98 Contact Map
2vkpA 4 0.25 8.7 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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