GREMLIN Database
YLBL - Uncharacterized protein YlbL
UniProt: O34470 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 341 (313)
Sequences: 1056 (817)
Seq/√Len: 46.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
265_D269_K6.1981.00
114_A326_M5.3591.00
167_D171_S5.2951.00
153_S181_K5.2531.00
182_I191_V4.6021.00
177_K192_T3.8811.00
118_K327_Q3.8701.00
263_T271_G3.7241.00
36_T230_I3.7241.00
165_L169_I3.4881.00
293_A320_I3.3251.00
327_Q331_D3.1901.00
181_K188_E2.9601.00
55_S257_D2.9331.00
290_I336_L2.9131.00
174_A205_A2.7651.00
295_N324_D2.7071.00
51_K251_D2.6431.00
182_I189_K2.5691.00
179_T190_R2.4671.00
167_D170_S2.4661.00
91_E99_R2.4521.00
276_I293_A2.4051.00
165_L171_S2.3451.00
48_Y248_T2.3421.00
92_S95_E2.2771.00
237_L323_V2.2541.00
272_P296_Q2.2471.00
146_E184_R2.2461.00
138_N142_K2.2001.00
119_A244_Y2.1941.00
290_I321_V2.1581.00
292_F332_Y2.1351.00
42_I242_E2.1161.00
244_Y326_M2.1001.00
240_S326_M2.0931.00
52_G255_G2.0801.00
122_K127_F2.0621.00
166_I169_I2.0580.99
168_Y171_S2.0350.99
237_L270_V1.9680.99
81_V86_I1.9240.99
116_Y223_I1.8620.99
321_V332_Y1.8530.99
53_S257_D1.8460.99
180_L207_I1.8400.99
152_I183_E1.8340.99
258_I333_L1.7960.99
35_A55_S1.7460.98
238_M260_G1.7400.98
19_V23_I1.6840.98
324_D328_D1.6060.97
173_K176_D1.5950.97
137_E142_K1.5910.97
69_Y80_I1.5800.97
55_S288_K1.5570.96
295_N322_P1.5520.96
135_V139_M1.5290.96
150_K183_E1.4880.95
56_L230_I1.4820.95
118_K326_M1.4770.95
118_K244_Y1.4300.94
29_I72_A1.4280.94
77_Y313_D1.4170.94
166_I170_S1.4100.94
168_Y172_K1.3960.94
152_I181_K1.3720.93
256_Y289_D1.3620.93
321_V336_L1.3610.93
100_Q103_M1.3600.93
21_S67_F1.3440.92
31_K78_Y1.3350.92
166_I171_S1.3340.92
162_A213_T1.3110.91
195_L205_A1.3090.91
165_L168_Y1.3090.91
290_I333_L1.3050.91
280_V318_M1.3030.91
225_F243_I1.2920.91
261_T294_P1.2910.91
36_T56_L1.2830.90
244_Y330_I1.2830.90
8_S12_V1.2770.90
237_L329_A1.2770.90
50_E251_D1.2760.90
72_A78_Y1.2690.90
169_I172_K1.2650.90
333_L337_K1.2600.89
114_A240_S1.2500.89
197_Q203_D1.2450.89
184_R191_V1.2290.88
48_Y249_K1.2210.88
44_V69_Y1.2180.88
37_E53_S1.2040.87
209_V213_T1.1980.87
296_Q324_D1.1920.87
96_Y100_Q1.1910.87
108_Q239_M1.1900.87
290_I332_Y1.1820.86
112_V223_I1.1810.86
42_I195_L1.1760.86
240_S244_Y1.1750.86
70_V74_M1.1730.86
140_P196_K1.1670.86
237_L240_S1.1640.85
75_H78_Y1.1540.85
79_E278_Q1.1530.85
272_P297_N1.1520.85
256_Y336_L1.1490.85
57_M280_V1.1480.85
293_A314_I1.1420.84
92_S120_G1.1400.84
161_S166_I1.1400.84
253_T258_I1.1280.84
152_I188_E1.1270.83
42_I243_I1.1270.83
58_T235_A1.1240.83
165_L170_S1.1210.83
141_A193_L1.1170.83
38_L238_M1.1140.83
153_S156_G1.1100.83
56_L242_E1.1090.82
155_D170_S1.1000.82
284_D316_S1.0950.82
183_E188_E1.0800.81
145_I180_L1.0740.80
35_A318_M1.0650.80
108_Q227_I1.0540.79
180_L193_L1.0520.79
181_K190_R1.0450.79
108_Q235_A1.0370.78
54_L245_N1.0300.77
292_F323_V1.0240.77
41_L227_I1.0220.77
154_A180_L1.0150.76
50_E245_N1.0080.76
252_E330_I0.9980.75
140_P207_I0.9890.75
240_S330_I0.9870.74
57_M259_A0.9720.73
112_V225_F0.9690.73
44_V246_Q0.9690.73
254_K337_K0.9650.73
118_K330_I0.9640.73
292_F321_V0.9640.73
183_E186_E0.9630.73
250_P337_K0.9590.72
180_L191_V0.9590.72
134_S210_S0.9570.72
14_L17_I0.9560.72
28_Y292_F0.9460.71
245_N252_E0.9420.71
34_E58_T0.9410.71
233_P274_G0.9390.71
191_V195_L0.9390.71
104_M227_I0.9300.70
25_L69_Y0.9290.70
42_I227_I0.9230.69
56_L60_K0.9180.69
315_D318_M0.9170.69
277_D313_D0.9160.69
56_L235_A0.9130.68
231_G235_A0.9090.68
227_I239_M0.9050.68
323_V329_A0.9040.68
18_A22_F0.9040.68
284_D318_M0.8980.67
299_A310_T0.8950.67
227_I244_Y0.8910.67
104_M108_Q0.8900.66
328_D331_D0.8900.66
120_G182_I0.8870.66
88_E91_E0.8800.66
173_K312_K0.8790.66
118_K240_S0.8780.65
56_L104_M0.8660.64
245_N250_P0.8650.64
99_R225_F0.8550.63
277_D309_K0.8540.63
58_T239_M0.8540.63
41_L276_I0.8520.63
94_K137_E0.8520.63
108_Q243_I0.8470.63
270_V329_A0.8470.63
144_K191_V0.8410.62
171_S178_V0.8380.62
298_G324_D0.8370.62
295_N298_G0.8320.61
209_V322_P0.8300.61
132_A207_I0.8250.61
113_I159_Y0.8240.60
113_I217_V0.8220.60
330_I333_L0.8210.60
196_K199_P0.8200.60
176_D195_L0.8170.60
282_A286_A0.8150.60
13_I17_I0.8090.59
30_T278_Q0.8070.59
84_E89_E0.8070.59
293_A312_K0.8050.59
178_V207_I0.8010.58
51_K222_D0.7990.58
296_Q299_A0.7950.58
138_N196_K0.7950.58
31_K60_K0.7920.57
95_E98_K0.7900.57
230_I235_A0.7890.57
200_D203_D0.7890.57
250_P334_N0.7890.57
28_Y280_V0.7880.57
56_L228_E0.7880.57
284_D317_N0.7870.57
116_Y219_V0.7810.56
56_L227_I0.7780.56
63_P83_D0.7780.56
107_S239_M0.7780.56
227_I230_I0.7750.56
252_E333_L0.7740.56
41_L55_S0.7710.55
83_D87_K0.7690.55
272_P298_G0.7670.55
138_N143_G0.7670.55
150_K214_D0.7660.55
172_K204_R0.7660.55
37_E242_E0.7630.55
104_M228_E0.7620.54
146_E158_N0.7570.54
71_W75_H0.7550.54
34_E297_N0.7540.54
282_A310_T0.7530.54
31_K62_G0.7520.54
57_M291_F0.7510.53
167_D180_L0.7500.53
237_L320_I0.7460.53
241_L333_L0.7460.53
73_K119_A0.7430.53
330_I337_K0.7430.53
69_Y73_K0.7420.53
185_E224_D0.7390.52
108_Q231_G0.7380.52
187_K192_T0.7370.52
157_K170_S0.7360.52
58_T231_G0.7320.52
138_N141_A0.7290.51
147_V151_I0.7290.51
68_T245_N0.7290.51
30_T91_E0.7250.51
65_N68_T0.7250.51
314_I318_M0.7250.51
58_T282_A0.7250.51
52_G253_T0.7240.51
143_G146_E0.7240.51
156_G159_Y0.7200.50
177_K195_L0.7190.50
151_I207_I0.7170.50
311_A320_I0.7160.50
71_W309_K0.7120.50
64_A83_D0.7120.50
129_G150_K0.7100.49
136_V139_M0.7100.49
332_Y336_L0.7100.49
259_A288_K0.7060.49
321_V333_L0.7050.49
153_S188_E0.7010.48
132_A209_V0.7010.48
110_N265_D0.6990.48
239_M293_A0.6970.48
99_R139_M0.6950.48
237_L244_Y0.6940.48
272_P324_D0.6940.48
310_T313_D0.6930.48
273_I276_I0.6900.47
51_K187_K0.6880.47
24_K63_P0.6870.47
57_M113_I0.6860.47
42_I56_L0.6850.47
13_I105_K0.6820.47
281_V314_I0.6820.47
113_I117_Q0.6790.46
146_E216_N0.6790.46
57_M281_V0.6750.46
99_R116_Y0.6730.46
44_V65_N0.6720.46
58_T230_I0.6720.46
240_S265_D0.6710.46
77_Y285_K0.6710.46
173_K205_A0.6660.45
184_R189_K0.6650.45
103_M106_S0.6650.45
225_F239_M0.6640.45
217_V278_Q0.6630.45
132_A145_I0.6610.45
244_Y318_M0.6580.44
157_K181_K0.6580.44
56_L336_L0.6540.44
207_I323_V0.6540.44
131_Y214_D0.6520.44
154_A205_A0.6500.44
48_Y139_M0.6500.44
51_K80_I0.6490.43
40_S137_E0.6480.43
237_L310_T0.6470.43
310_T314_I0.6440.43
44_V47_G0.6440.43
156_G179_T0.6420.43
311_A314_I0.6400.43
155_D224_D0.6390.42
166_I325_T0.6380.42
121_K219_V0.6380.42
42_I80_I0.6380.42
233_P291_F0.6370.42
276_I298_G0.6370.42
82_P240_S0.6370.42
153_S172_K0.6360.42
182_I193_L0.6350.42
41_L239_M0.6320.42
154_A207_I0.6290.41
38_L242_E0.6280.41
42_I249_K0.6280.41
55_S100_Q0.6280.41
309_K315_D0.6260.41
61_V68_T0.6260.41
109_E215_R0.6240.41
7_F176_D0.6240.41
145_I182_I0.6230.41
34_E278_Q0.6200.41
57_M61_V0.6200.41
54_L57_M0.6200.41
23_I326_M0.6200.41
156_G328_D0.6190.41
92_S162_A0.6180.40
52_G251_D0.6170.40
72_A80_I0.6170.40
23_I26_P0.6160.40
112_V217_V0.6150.40
92_S146_E0.6130.40
59_V325_T0.6120.40
154_A311_A0.6090.40
135_V145_I0.6080.39
310_T320_I0.6060.39
328_D332_Y0.6050.39
187_K237_L0.6050.39
173_K299_A0.6040.39
44_V243_I0.6030.39
116_Y222_D0.6030.39
230_I239_M0.6020.39
167_D172_K0.6020.39
18_A155_D0.6020.39
132_A151_I0.6000.39
237_L281_V0.5990.39
148_G187_K0.5970.38
42_I284_D0.5970.38
117_Q122_K0.5970.38
10_M137_E0.5960.38
182_I190_R0.5960.38
64_A96_Y0.5950.38
106_S130_I0.5920.38
206_G210_S0.5920.38
104_M230_I0.5920.38
90_G332_Y0.5920.38
105_K150_K0.5920.38
195_L276_I0.5910.38
120_G203_D0.5900.38
22_F136_V0.5900.38
76_P313_D0.5890.38
293_A310_T0.5880.38
27_Y199_P0.5870.38
21_S24_K0.5860.37
181_K194_T0.5830.37
140_P144_K0.5820.37
23_I103_M0.5820.37
331_D335_K0.5810.37
35_A281_V0.5800.37
153_S190_R0.5790.37
113_I210_S0.5780.37
273_I293_A0.5780.37
109_E112_V0.5770.37
35_A53_S0.5770.37
72_A104_M0.5760.37
57_M66_P0.5750.36
198_F206_G0.5750.36
41_L240_S0.5750.36
293_A322_P0.5740.36
38_L73_K0.5710.36
38_L61_V0.5710.36
57_M237_L0.5710.36
37_E228_E0.5710.36
69_Y114_A0.5690.36
70_V154_A0.5690.36
37_E257_D0.5680.36
106_S214_D0.5670.36
38_L56_L0.5630.35
25_L114_A0.5620.35
148_G209_V0.5620.35
120_G321_V0.5600.35
105_K112_V0.5590.35
96_Y206_G0.5560.35
16_L65_N0.5560.35
55_S286_A0.5560.35
154_A167_D0.5520.34
144_K182_I0.5510.34
48_Y250_P0.5480.34
26_P52_G0.5480.34
290_I323_V0.5470.34
62_G114_A0.5470.34
240_S264_I0.5450.34
245_N253_T0.5440.34
35_A257_D0.5420.33
47_G50_E0.5410.33
258_I290_I0.5380.33
155_D161_S0.5380.33
10_M18_A0.5370.33
74_M169_I0.5360.33
297_N324_D0.5360.33
8_S16_L0.5360.33
39_A171_S0.5350.33
187_K224_D0.5340.33
280_V309_K0.5340.33
224_D289_D0.5320.33
130_I318_M0.5320.33
111_A225_F0.5320.33
177_K194_T0.5310.33
16_L153_S0.5310.33
186_E216_N0.5290.32
15_I19_V0.5270.32
159_Y167_D0.5270.32
290_I330_I0.5260.32
12_V226_E0.5260.32
240_S269_K0.5250.32
161_S165_L0.5250.32
80_I218_K0.5240.32
12_V80_I0.5240.32
35_A110_N0.5240.32
82_P272_P0.5240.32
140_P199_P0.5230.32
35_A286_A0.5230.32
42_I228_E0.5210.32
43_K249_K0.5210.32
94_K185_E0.5200.32
237_L333_L0.5190.31
55_S113_I0.5180.31
64_A87_K0.5180.31
256_Y337_K0.5170.31
211_L240_S0.5170.31
146_E331_D0.5170.31
90_G137_E0.5160.31
281_V285_K0.5160.31
57_M231_G0.5160.31
194_T222_D0.5150.31
54_L242_E0.5140.31
282_A294_P0.5140.31
312_K315_D0.5140.31
108_Q242_E0.5130.31
57_M122_K0.5130.31
264_I326_M0.5130.31
258_I289_D0.5120.31
309_K313_D0.5110.31
240_S334_N0.5100.31
168_Y247_L0.5100.31
325_T328_D0.5100.31
203_D328_D0.5070.30
9_W12_V0.5060.30
166_I172_K0.5060.30
108_Q278_Q0.5050.30
69_Y326_M0.5040.30
113_I266_V0.5040.30
24_K94_K0.5030.30
40_S173_K0.5020.30
128_N330_I0.5000.30
132_A264_I0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wu4A 3 0.5044 99.8 0.822 Contact Map
1z0wA 3 0.5249 99.7 0.832 Contact Map
2x36A 3 0.5191 99.7 0.833 Contact Map
3k1jA 4 0.915 99.7 0.837 Contact Map
1xhkA 2 0.4927 99.7 0.838 Contact Map
3m6aA 3 0.8299 99.7 0.84 Contact Map
4fwgA 3 0.8827 99.6 0.849 Contact Map
2kl1A 1 0.2493 99.3 0.874 Contact Map
2i4sA 1 0.2991 99.3 0.874 Contact Map
2kjpA 1 0.261 99.3 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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