GREMLIN Database
YODR - Probable coenzyme A transferase subunit beta
UniProt: O34466 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (208)
Sequences: 3139 (1538)
Seq/√Len: 106.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_S115_D4.0351.00
200_D204_R3.5051.00
150_D154_R3.4421.00
181_L210_I3.2021.00
87_D90_M3.1511.00
184_D187_H3.1491.00
173_L182_E3.0151.00
159_E207_E2.9411.00
193_L202_V2.6611.00
184_D189_I2.5971.00
182_E191_K2.5461.00
193_L199_I2.5331.00
79_A83_A2.3581.00
112_Q159_E2.3561.00
178_K205_L2.3501.00
157_L188_F2.3181.00
14_R192_E2.2861.00
183_V188_F2.2561.00
190_L212_I2.2311.00
20_K23_M2.1951.00
199_I212_I2.1911.00
201_E205_L2.1771.00
79_A85_Y2.0521.00
15_A145_V1.9961.00
59_S75_Y1.9481.00
61_E64_E1.9341.00
189_I213_D1.9221.00
53_V79_A1.8741.00
199_I203_T1.7701.00
198_T201_E1.7671.00
113_S160_R1.7601.00
189_I211_K1.7561.00
112_Q209_E1.7411.00
48_Q95_I1.7331.00
11_I145_V1.7231.00
174_I183_V1.7171.00
15_A104_I1.7041.00
203_T210_I1.6941.00
201_E204_R1.6811.00
178_K197_S1.6741.00
190_L199_I1.6721.00
15_A175_I1.6661.00
35_V104_I1.6561.00
148_H206_T1.6271.00
9_E38_F1.6251.00
96_R134_E1.6051.00
161_C165_L1.5961.00
23_M102_I1.5951.00
191_K213_D1.5061.00
19_I35_V1.5021.00
173_L191_K1.5001.00
194_M197_S1.4851.00
203_T209_E1.4791.00
101_D140_K1.4101.00
107_A146_M1.4041.00
141_K171_V1.3681.00
157_L174_I1.3441.00
154_R157_L1.3010.99
18_E175_I1.2920.99
155_P207_E1.2870.99
49_A53_V1.2850.99
19_I25_V1.2690.99
7_E10_Q1.2680.99
174_I188_F1.2630.99
18_E173_L1.2520.99
206_T210_I1.2440.99
182_E189_I1.2430.99
143_V175_I1.2260.99
179_A202_V1.2250.99
109_Q162_T1.2170.99
159_E209_E1.1880.99
61_E65_E1.1760.99
149_T205_L1.1690.99
53_V56_I1.1680.99
187_H211_K1.1670.99
200_D203_T1.1510.98
107_A116_L1.1290.98
158_T162_T1.1140.98
141_K173_L1.1080.98
186_H211_K1.1080.98
102_I141_K1.1040.98
155_P163_L1.1010.98
31_I145_V1.0940.98
153_G161_C1.0860.98
165_L168_A1.0830.98
8_R147_S1.0800.98
180_V192_E1.0760.98
102_I143_V1.0530.97
193_L197_S1.0430.97
71_N75_Y1.0400.97
8_R34_L1.0400.97
181_L203_T1.0320.97
160_R163_L1.0270.97
154_R163_L1.0240.97
149_T177_E1.0140.97
152_K155_P1.0110.96
21_Q43_M1.0000.96
143_V173_L1.0000.96
58_E80_V0.9960.96
153_G164_P0.9950.96
145_V175_I0.9950.96
6_A10_Q0.9910.96
21_Q44_Q0.9880.96
8_R31_I0.9810.96
109_Q155_P0.9790.96
154_R162_T0.9780.96
159_E208_A0.9710.96
104_I145_V0.9690.95
36_P39_L0.9660.95
178_K201_E0.9590.95
94_M100_I0.9460.95
186_H189_I0.9440.95
153_G163_L0.9380.95
10_Q13_K0.9360.95
39_L47_F0.9360.95
32_P106_G0.9340.94
113_S169_G0.9210.94
197_S201_E0.9170.94
66_D69_L0.9130.94
190_L202_V0.9110.94
12_A35_V0.8990.93
57_G78_R0.8980.93
29_I51_N0.8970.93
54_L86_F0.8970.93
160_R164_P0.8850.93
109_Q163_L0.8800.93
136_A167_A0.8770.92
188_F208_A0.8720.92
19_I45_V0.8620.92
156_K163_L0.8590.92
19_I104_I0.8570.92
18_E141_K0.8560.91
159_E162_T0.8540.91
110_V116_L0.8460.91
6_A11_I0.8410.91
107_A110_V0.8390.91
60_P78_R0.8370.91
14_R180_V0.8340.90
161_C164_P0.8340.90
15_A35_V0.8290.90
9_E42_D0.8290.90
148_H178_K0.8290.90
158_T161_C0.8260.90
109_Q158_T0.8260.90
24_I94_M0.8250.90
184_D211_K0.8220.90
53_V85_Y0.8200.90
154_R161_C0.8200.90
86_F91_S0.8120.89
190_L210_I0.8060.89
155_P160_R0.8050.89
62_K65_E0.8010.89
57_G60_P0.7960.88
36_P59_S0.7950.88
10_Q195_N0.7950.88
9_E34_L0.7910.88
197_S202_V0.7900.88
109_Q150_D0.7890.88
153_G160_R0.7850.88
184_D213_D0.7840.87
108_L122_P0.7790.87
157_L160_R0.7680.86
199_I210_I0.7660.86
67_A71_N0.7620.86
31_I34_L0.7600.86
31_I147_S0.7590.86
120_L126_V0.7580.86
32_P51_N0.7490.85
13_K38_F0.7470.85
53_V77_V0.7440.85
153_G162_T0.7360.84
104_I175_I0.7350.84
76_P127_P0.7340.84
181_L212_I0.7340.84
21_Q42_D0.7310.84
162_T207_E0.7310.84
14_R18_E0.7210.83
188_F210_I0.7180.82
157_L164_P0.7180.82
167_A170_C0.7170.82
171_V182_E0.7120.82
112_Q208_A0.7100.82
13_K17_T0.7050.81
174_I181_L0.7050.81
29_I33_S0.7040.81
154_R164_P0.7030.81
56_I79_A0.7030.81
9_E13_K0.7000.81
67_A76_P0.6940.80
200_D209_E0.6900.80
178_K202_V0.6900.80
40_K43_M0.6890.80
15_A143_V0.6890.80
11_I15_A0.6860.80
24_I54_L0.6780.79
141_K172_D0.6760.79
203_T211_K0.6740.78
116_L171_V0.6720.78
136_A170_C0.6710.78
129_M133_M0.6670.78
203_T212_I0.6600.77
75_Y137_Q0.6600.77
151_Q161_C0.6590.77
178_K194_M0.6570.77
193_L198_T0.6570.77
193_L196_G0.6520.76
6_A194_M0.6490.76
152_K157_L0.6490.76
29_I106_G0.6470.75
119_W122_P0.6470.75
151_Q163_L0.6450.75
19_I102_I0.6420.75
59_S76_P0.6400.75
14_R17_T0.6380.74
121_V124_K0.6380.74
165_L172_D0.6370.74
199_I202_V0.6360.74
49_A91_S0.6320.74
110_V188_F0.6300.73
156_K161_C0.6290.73
154_R160_R0.6290.73
25_V45_V0.6280.73
155_P208_A0.6280.73
60_P65_E0.6260.73
24_I46_M0.6260.73
153_G158_T0.6210.72
18_E143_V0.6190.72
6_A9_E0.6180.72
10_Q194_M0.6160.72
150_D155_P0.6160.72
70_C73_A0.6130.71
181_L188_F0.6120.71
194_M202_V0.6090.71
70_C74_G0.6070.71
33_S70_C0.6060.71
108_L121_V0.6050.70
155_P161_C0.6040.70
15_A137_Q0.6030.70
111_S160_R0.6020.70
153_G156_K0.6000.70
7_E177_E0.5980.70
18_E180_V0.5960.69
114_G187_H0.5910.69
202_V205_L0.5900.69
24_I100_I0.5890.68
6_A179_A0.5880.68
98_G105_L0.5870.68
109_Q159_E0.5840.68
179_A191_K0.5800.67
50_E92_F0.5770.67
128_G175_I0.5760.67
32_P145_V0.5750.67
149_T155_P0.5720.66
9_E41_P0.5690.66
209_E212_I0.5670.66
178_K206_T0.5630.65
53_V83_A0.5610.65
97_K138_K0.5610.65
116_L144_V0.5600.65
100_I105_L0.5590.64
128_G143_V0.5580.64
116_L136_A0.5580.64
154_R158_T0.5510.63
12_A31_I0.5500.63
12_A34_L0.5480.63
12_A38_F0.5480.63
122_P128_G0.5460.63
16_A38_F0.5460.63
23_M101_D0.5460.63
151_Q156_K0.5440.62
65_E69_L0.5440.62
17_T203_T0.5420.62
30_G50_E0.5420.62
133_M138_K0.5420.62
179_A210_I0.5400.62
66_D71_N0.5400.62
102_I137_Q0.5390.62
54_L84_S0.5360.61
20_K43_M0.5360.61
166_T169_G0.5340.61
15_A146_M0.5330.61
137_Q167_A0.5320.61
39_L45_V0.5320.61
33_S73_A0.5320.61
186_H213_D0.5280.60
35_V39_L0.5270.60
181_L211_K0.5260.60
115_D169_G0.5250.60
25_V51_N0.5240.60
179_A193_L0.5240.60
17_T20_K0.5240.60
48_Q100_I0.5210.59
21_Q40_K0.5190.59
159_E185_S0.5150.58
23_M141_K0.5130.58
155_P164_P0.5130.58
103_T139_A0.5130.58
29_I71_N0.5120.58
125_K129_M0.5100.57
157_L161_C0.5090.57
80_V83_A0.5090.57
66_D70_C0.5080.57
197_S205_L0.5070.57
53_V82_G0.5070.57
29_I88_T0.5070.57
103_T135_L0.5040.57
121_V125_K0.5040.57
33_S36_P0.5030.56
116_L129_M0.5030.56
59_S127_P0.5030.56
134_E138_K0.5030.56
11_I177_E0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1poiB 1 0.9493 100 0.294 Contact Map
3k6mA 2 0.977 100 0.324 Contact Map
4kgbA 2 0.9724 100 0.329 Contact Map
2ahuA 3 0.9078 100 0.36 Contact Map
1xr4A 2 0.9862 100 0.458 Contact Map
2hj0A 2 0.9862 100 0.475 Contact Map
3gk7A 2 1 100 0.499 Contact Map
3rrlB 1 0.9539 100 0.504 Contact Map
3d3uA 1 0.8756 100 0.52 Contact Map
2oasA 3 0.9355 100 0.527 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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