GREMLIN Database
HISZ - ATP phosphoribosyltransferase regulatory subunit
UniProt: O34459 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (366)
Sequences: 6060 (3816)
Seq/√Len: 199.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
228_E244_K4.3011.00
158_A262_D3.9851.00
299_G304_P3.8661.00
102_Y124_G3.6651.00
251_E259_V3.2651.00
137_A249_I2.7961.00
30_D149_N2.7351.00
66_L70_G2.6981.00
27_S149_N2.6531.00
32_I123_V2.5981.00
143_V279_V2.5531.00
10_M45_L2.4631.00
28_L146_A2.4551.00
347_A357_V2.4401.00
35_W145_G2.4091.00
145_G348_N2.3291.00
34_K149_N2.3011.00
342_Q345_A2.2781.00
156_K260_R2.2771.00
243_L261_L2.2131.00
17_L322_H2.2031.00
26_R30_D2.1961.00
22_K39_F2.1891.00
64_K72_T2.1411.00
20_T322_H2.1371.00
23_K27_S2.1111.00
143_V289_G2.0731.00
181_V233_S2.0541.00
127_L135_A2.0531.00
48_Y74_V2.0461.00
167_A239_V2.0421.00
99_R358_V2.0161.00
141_A253_Y2.0111.00
76_R104_A1.9611.00
368_I381_F1.9571.00
31_L149_N1.9491.00
48_Y64_K1.9261.00
154_S283_N1.9051.00
105_N119_E1.8951.00
199_K202_P1.8831.00
336_S339_Q1.8821.00
167_A236_G1.8521.00
125_V142_L1.8501.00
7_P45_L1.8341.00
44_T107_F1.8271.00
84_A298_L1.7971.00
334_I347_A1.7921.00
252_D341_A1.7361.00
156_K282_E1.7331.00
29_T39_F1.7191.00
180_D184_R1.7111.00
247_W261_L1.6991.00
248_D341_A1.6801.00
241_D245_A1.6791.00
247_W259_V1.6781.00
158_A260_R1.6761.00
237_K241_D1.6421.00
22_K29_T1.6411.00
345_A349_E1.6381.00
158_A280_Y1.6261.00
37_Y127_L1.6071.00
347_A359_L1.6061.00
44_T104_A1.6041.00
200_S203_L1.5921.00
195_R203_L1.5911.00
338_E384_A1.5911.00
154_S282_E1.5851.00
244_K248_D1.5801.00
331_D356_K1.5741.00
67_D71_K1.5641.00
360_Q364_G1.5621.00
79_M124_G1.5271.00
247_W251_E1.5231.00
202_P217_L1.4891.00
144_V157_I1.4831.00
221_I251_E1.4791.00
368_I372_T1.4691.00
44_T119_E1.4691.00
331_D335_F1.4551.00
28_L123_V1.4461.00
236_G239_V1.4461.00
219_G223_V1.4451.00
186_L214_L1.4301.00
25_R41_E1.4291.00
48_Y72_T1.4261.00
144_V148_K1.4241.00
19_E38_Q1.4071.00
8_H111_E1.4061.00
79_M106_V1.4051.00
349_E352_M1.4031.00
121_E315_D1.3931.00
238_S241_D1.3891.00
79_M102_Y1.3861.00
336_S384_A1.3831.00
40_M86_V1.3791.00
71_K109_A1.3771.00
331_D334_I1.3731.00
254_G258_N1.3641.00
39_F101_G1.3591.00
157_I279_V1.3581.00
7_P73_L1.3471.00
7_P47_F1.3431.00
139_V308_T1.3421.00
65_L73_L1.3421.00
346_Y349_E1.3391.00
19_E33_D1.3381.00
332_A355_N1.3271.00
240_V244_K1.3251.00
30_D34_K1.3221.00
279_V289_G1.3221.00
83_I124_G1.3211.00
125_V139_V1.3201.00
164_I239_V1.3091.00
7_P10_M1.2921.00
331_D355_N1.2911.00
84_A128_I1.2901.00
24_V318_I1.2831.00
199_K217_L1.2801.00
187_Y207_D1.2771.00
245_A248_D1.2611.00
64_K74_V1.2591.00
44_T105_N1.2531.00
145_G352_M1.2481.00
145_G149_N1.2481.00
246_L275_I1.2461.00
348_N352_M1.2461.00
128_I298_L1.2451.00
204_S208_K1.2451.00
88_A301_F1.2431.00
164_I236_G1.2421.00
123_V314_I1.2411.00
366_E369_D1.2361.00
28_L32_I1.2351.00
69_D109_A1.2241.00
16_G19_E1.2191.00
33_D101_G1.2161.00
330_I333_V1.2121.00
6_K89_S1.2101.00
163_G242_E1.2091.00
144_V258_N1.1941.00
228_E241_D1.1931.00
339_Q342_Q1.1921.00
11_R315_D1.1861.00
68_Q109_A1.1841.00
347_A351_R1.1801.00
120_F311_G1.1771.00
131_G306_P1.1731.00
29_T101_G1.1701.00
222_E225_G1.1701.00
184_R187_Y1.1661.00
136_D293_R1.1621.00
66_L72_T1.1591.00
25_R29_T1.1571.00
29_T103_A1.1461.00
167_A235_Q1.1461.00
48_Y52_G1.1431.00
164_I167_A1.1351.00
45_L75_L1.1331.00
87_A305_A1.1301.00
179_A183_R1.1301.00
204_S207_D1.1251.00
248_D251_E1.1251.00
248_D252_D1.1241.00
342_Q382_I1.1161.00
280_Y287_V1.1131.00
37_Y138_E1.1101.00
25_R314_I1.1061.00
137_A253_Y1.1051.00
289_G312_L1.1001.00
155_F279_V1.0991.00
34_K145_G1.0981.00
67_D70_G1.0951.00
148_K155_F1.0911.00
103_A123_V1.0881.00
249_I253_Y1.0851.00
332_A357_V1.0811.00
252_D345_A1.0811.00
42_T82_P1.0781.00
349_E353_K1.0701.00
11_R17_L1.0701.00
144_V155_F1.0681.00
369_D372_T1.0631.00
22_K26_R1.0621.00
241_D244_K1.0601.00
242_E274_G1.0571.00
147_L289_G1.0521.00
213_E226_R1.0471.00
34_K355_N1.0441.00
11_R117_P1.0421.00
368_I379_T1.0421.00
87_A128_I1.0401.00
319_E322_H1.0321.00
147_L155_F1.0261.00
131_G295_N1.0221.00
87_A96_H1.0171.00
156_K258_N1.0141.00
22_K25_R1.0071.00
22_K33_D1.0051.00
161_H242_E1.0011.00
79_M104_A1.0001.00
26_R29_T0.9971.00
148_K352_M0.9931.00
25_R39_F0.9881.00
130_D135_A0.9861.00
35_W351_R0.9831.00
365_I369_D0.9811.00
250_L259_V0.9811.00
341_A345_A0.9791.00
31_L145_G0.9771.00
133_T246_L0.9760.99
313_R316_R0.9760.99
206_I214_L0.9750.99
334_I343_A0.9750.99
143_V310_F0.9740.99
296_K304_P0.9680.99
146_A312_L0.9650.99
33_D356_K0.9600.99
369_D373_K0.9580.99
18_Y39_F0.9520.99
127_L139_V0.9510.99
24_V150_A0.9490.99
133_T242_E0.9460.99
245_A249_I0.9420.99
360_Q363_S0.9410.99
137_A246_L0.9400.99
164_I235_Q0.9270.99
372_T379_T0.9250.99
27_S31_L0.9210.99
45_L73_L0.9200.99
46_E85_R0.9190.99
75_L107_F0.9190.99
161_H274_G0.9190.99
222_E226_R0.9190.99
201_L204_S0.9110.99
105_N121_E0.9070.99
6_K90_K0.9060.99
27_S30_D0.9010.99
156_K280_Y0.8970.99
244_K247_W0.8940.99
358_V374_S0.8940.99
40_M100_V0.8920.99
183_R187_Y0.8880.99
134_S340_R0.8880.99
67_D73_L0.8870.99
281_A288_I0.8830.99
335_F379_T0.8790.99
145_G148_K0.8780.99
40_M83_I0.8780.99
253_Y344_I0.8750.99
196_E200_S0.8750.99
187_Y195_R0.8730.99
107_F119_E0.8690.99
29_T33_D0.8660.99
30_D33_D0.8640.99
331_D377_N0.8630.99
152_L321_L0.8620.99
27_S150_A0.8600.99
99_R127_L0.8590.99
195_R198_V0.8570.99
133_T245_A0.8550.99
83_I100_V0.8490.99
136_D139_V0.8470.99
298_L305_A0.8460.99
237_K240_V0.8450.99
50_T301_F0.8430.99
332_A335_F0.8410.99
296_K299_G0.8410.99
118_A268_H0.8390.98
332_A380_Y0.8360.98
83_I102_Y0.8360.98
267_S290_S0.8340.98
133_T137_A0.8330.98
178_R181_V0.8280.98
102_Y126_E0.8230.98
10_M42_T0.8210.98
13_T21_K0.8200.98
141_A348_N0.8190.98
199_K205_S0.8160.98
186_L224_C0.8150.98
63_F73_L0.8140.98
20_T318_I0.8110.98
221_I225_G0.8100.98
176_V180_D0.8060.98
18_Y21_K0.8050.98
78_D81_G0.8030.98
339_Q384_A0.8030.98
42_T83_I0.7990.98
298_L303_S0.7980.98
51_V74_V0.7930.98
31_L146_A0.7900.98
370_Q374_S0.7880.98
118_A313_R0.7860.98
31_L35_W0.7800.98
161_H239_V0.7800.98
225_G244_K0.7790.98
345_A348_N0.7780.98
197_H223_V0.7750.97
185_F189_K0.7750.97
125_V310_F0.7740.97
177_E180_D0.7730.97
181_V185_F0.7730.97
132_T245_A0.7720.97
167_A274_G0.7710.97
214_L223_V0.7690.97
22_K101_G0.7670.97
62_L74_V0.7650.97
21_K25_R0.7640.97
265_M276_L0.7620.97
164_I274_G0.7610.97
274_G295_N0.7610.97
350_E357_V0.7570.97
189_K223_V0.7560.97
148_K258_N0.7540.97
332_A350_E0.7540.97
37_Y125_V0.7510.97
195_R206_I0.7510.97
342_Q346_Y0.7500.97
8_H112_R0.7490.97
355_N359_L0.7480.97
18_Y22_K0.7460.97
332_A378_V0.7460.97
140_I250_L0.7440.97
37_Y99_R0.7430.97
159_I247_W0.7420.97
134_S249_I0.7420.97
65_L74_V0.7410.97
87_A98_L0.7380.97
34_K357_V0.7360.97
189_K197_H0.7360.97
12_D85_R0.7340.96
242_E246_L0.7310.96
32_I142_L0.7310.96
37_Y135_A0.7310.96
221_I248_D0.7310.96
267_S278_E0.7300.96
83_I128_I0.7280.96
48_Y65_L0.7240.96
83_I126_E0.7230.96
198_V208_K0.7220.96
21_K315_D0.7220.96
37_Y142_L0.7180.96
32_I125_V0.7180.96
365_I368_I0.7150.96
110_Q116_R0.7140.96
298_L307_A0.7120.96
288_I317_L0.7100.96
52_G62_L0.7090.96
203_L207_D0.7060.96
358_V361_D0.7020.95
226_R229_E0.7020.95
147_L317_L0.6960.95
232_D235_Q0.6930.95
152_L320_A0.6930.95
184_R188_E0.6930.95
234_A238_S0.6930.95
343_A382_I0.6920.95
195_R207_D0.6920.95
250_L255_C0.6890.95
139_V142_L0.6860.95
18_Y41_E0.6860.95
243_L247_W0.6860.95
203_L206_I0.6850.95
129_G306_P0.6830.95
251_E254_G0.6800.95
355_N362_L0.6780.95
215_L218_R0.6780.95
212_L216_E0.6760.94
340_R343_A0.6750.94
217_L223_V0.6730.94
141_A255_C0.6690.94
328_C356_K0.6690.94
31_L142_L0.6680.94
340_R363_S0.6680.94
108_R120_F0.6680.94
20_T23_K0.6650.94
185_F197_H0.6630.94
35_W142_L0.6620.94
162_A276_L0.6610.94
63_F67_D0.6600.94
225_G228_E0.6580.94
135_A308_T0.6560.94
15_P18_Y0.6550.93
135_A361_D0.6540.93
210_R213_E0.6540.93
14_L86_V0.6530.93
21_K41_E0.6520.93
41_E105_N0.6490.93
140_I159_I0.6480.93
217_L224_C0.6460.93
44_T76_R0.6430.93
372_T383_G0.6420.93
199_K219_G0.6420.93
185_F227_A0.6390.93
12_D46_E0.6360.92
100_V126_E0.6350.92
161_H275_I0.6340.92
346_Y382_I0.6330.92
198_V201_L0.6330.92
273_T296_K0.6320.92
99_R361_D0.6310.92
65_L71_K0.6310.92
141_A145_G0.6310.92
47_F71_K0.6310.92
242_E245_A0.6300.92
281_A320_A0.6300.92
181_V184_R0.6290.92
25_R103_A0.6290.92
245_A337_K0.6290.92
96_H305_A0.6270.92
355_N358_V0.6230.92
329_E356_K0.6220.92
58_E208_K0.6220.92
120_F313_R0.6210.92
202_P219_G0.6180.91
178_R182_L0.6180.91
159_I261_L0.6170.91
43_P85_R0.6160.91
221_I224_C0.6160.91
251_E258_N0.6160.91
355_N360_Q0.6150.91
86_V90_K0.6150.91
331_D376_A0.6140.91
185_F226_R0.6130.91
366_E370_Q0.6130.91
117_P319_E0.6120.91
21_K121_E0.6120.91
68_Q73_L0.6110.91
144_V279_V0.6100.91
5_E89_S0.6060.91
154_S258_N0.6050.91
167_A233_S0.6040.90
146_A150_A0.6000.90
343_A357_V0.6000.90
287_V290_S0.5990.90
267_S313_R0.5990.90
330_I334_I0.5970.90
322_H325_D0.5910.89
116_R313_R0.5910.89
66_L69_D0.5900.89
358_V363_S0.5900.89
228_E237_K0.5890.89
32_I146_A0.5880.89
196_E199_K0.5880.89
219_G222_E0.5880.89
272_Y308_T0.5870.89
334_I380_Y0.5860.89
45_L74_V0.5850.89
118_A267_S0.5850.89
55_S61_Q0.5850.89
42_T79_M0.5840.89
345_A353_K0.5840.89
219_G263_L0.5840.89
120_F316_R0.5810.89
127_L130_D0.5800.89
202_P208_K0.5800.89
329_E333_V0.5780.88
140_I246_L0.5780.88
250_L254_G0.5770.88
343_A347_A0.5760.88
197_H200_S0.5760.88
117_P315_D0.5740.88
198_V205_S0.5730.88
138_E351_R0.5730.88
235_Q239_V0.5730.88
45_L65_L0.5710.88
334_I346_Y0.5710.88
333_V360_Q0.5680.88
186_L223_V0.5680.88
370_Q376_A0.5670.87
36_G358_V0.5650.87
6_K11_R0.5640.87
131_G242_E0.5630.87
114_G323_M0.5630.87
46_E271_Y0.5620.87
17_L20_T0.5580.87
87_A100_V0.5580.87
198_V203_L0.5580.87
240_V247_W0.5550.86
155_F258_N0.5540.86
225_G229_E0.5530.86
239_V274_G0.5520.86
231_V236_G0.5520.86
143_V312_L0.5520.86
43_P46_E0.5520.86
223_V227_A0.5510.86
110_Q316_R0.5500.86
51_V77_P0.5500.86
217_L263_L0.5470.86
163_G238_S0.5450.85
238_S242_E0.5440.85
63_F109_A0.5430.85
334_I357_V0.5420.85
83_I86_V0.5400.85
16_G20_T0.5390.85
293_R306_P0.5390.85
79_M83_I0.5380.85
334_I382_I0.5370.85
140_I275_I0.5360.84
195_R212_L0.5360.84
368_I383_G0.5340.84
312_L321_L0.5340.84
45_L117_P0.5330.84
30_D248_D0.5320.84
234_A237_K0.5310.84
122_Q311_G0.5300.84
128_I307_A0.5300.84
77_P81_G0.5290.84
202_P206_I0.5290.84
217_L220_G0.5280.84
321_L325_D0.5280.84
182_L185_F0.5280.84
290_S313_R0.5270.83
67_D72_T0.5260.83
278_E290_S0.5260.83
91_L100_V0.5260.83
151_G154_S0.5220.83
217_L227_A0.5220.83
163_G239_V0.5200.83
112_R116_R0.5190.82
113_E116_R0.5190.82
141_A249_I0.5180.82
283_N324_K0.5170.82
208_K215_L0.5160.82
15_P51_V0.5160.82
163_G235_Q0.5160.82
42_T265_M0.5160.82
367_N379_T0.5150.82
104_A311_G0.5150.82
213_E216_E0.5150.82
78_D88_A0.5140.82
42_T86_V0.5140.82
58_E61_Q0.5140.82
337_K340_R0.5140.82
131_G304_P0.5140.82
350_E355_N0.5130.82
214_L217_L0.5090.81
189_K195_R0.5090.81
224_C244_K0.5080.81
290_S311_G0.5080.81
232_D237_K0.5050.81
28_L106_V0.5050.81
19_E39_F0.5050.81
137_A255_C0.5040.81
31_L34_K0.5040.81
331_D357_V0.5030.81
147_L312_L0.5020.80
278_E313_R0.5000.80
365_I372_T0.5000.80
330_I376_A0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3od1A 2 0.9693 100 0.188 Contact Map
3netA 2 0.9668 100 0.27 Contact Map
4g84A 2 0.977 100 0.273 Contact Map
4phcA 2 0.9923 100 0.274 Contact Map
3lc0A 2 0.9719 100 0.277 Contact Map
3racA 2 0.8107 100 0.286 Contact Map
1z7mA 4 0.8031 100 0.29 Contact Map
1wu7A 2 0.9693 100 0.29 Contact Map
1httA 2 0.821 100 0.331 Contact Map
1h4vB 2 0.9156 100 0.335 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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