GREMLIN Database
YJFC - Uncharacterized protein YjfC
UniProt: O34458 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (260)
Sequences: 321 (257)
Seq/√Len: 15.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_H88_E4.4821.00
183_D287_A3.2670.99
193_S269_Q3.1010.99
190_L200_G3.0090.98
38_M116_G3.0030.98
160_A198_L2.8110.97
136_G168_R2.7210.97
164_H191_A2.5910.96
90_A155_I2.4920.95
168_R190_L2.3630.93
101_A160_A2.3460.93
168_R200_G2.2980.92
192_E195_A2.2350.91
7_K10_E2.1590.89
120_A135_G2.0740.87
13_E82_K2.0490.86
143_V164_H2.0200.85
100_F229_V1.8400.79
286_D289_T1.8270.79
271_F285_L1.8140.78
101_A282_A1.7940.78
69_R115_F1.7930.77
169_F183_D1.7740.77
35_F39_W1.7500.76
97_C101_A1.7290.75
192_E258_F1.6860.73
137_I283_T1.6820.73
119_I275_H1.6770.72
133_G290_I1.6520.71
131_Y223_I1.6160.70
181_V229_V1.6110.69
161_H189_G1.5870.68
165_H189_G1.5870.68
162_E241_G1.5870.68
165_H241_G1.5870.68
241_G261_Y1.5870.68
189_G261_Y1.5870.68
162_E261_Y1.5870.68
161_H261_Y1.5870.68
165_H261_Y1.5870.68
161_H165_H1.5870.68
162_E165_H1.5870.68
189_G241_G1.5870.68
162_E189_G1.5870.68
161_H241_G1.5870.68
8_T11_Q1.5770.68
72_E103_R1.5550.66
86_V117_L1.5150.64
8_T157_S1.5110.64
260_G268_V1.5000.64
239_M260_G1.4990.64
155_I185_L1.4980.63
160_A199_F1.4940.63
192_E265_Y1.4920.63
15_L26_V1.4650.62
138_P166_N1.4640.62
28_R167_V1.4640.62
168_R260_G1.4540.61
184_Y235_V1.4390.60
279_I283_T1.4360.60
183_D187_I1.4310.60
117_L144_W1.4160.59
157_S239_M1.4140.59
91_E99_F1.4130.59
147_P279_I1.3970.58
5_M118_Y1.3950.58
55_D242_D1.3840.57
151_N239_M1.3710.56
11_Q239_M1.3610.56
61_K67_D1.3440.55
185_L266_H1.3370.54
36_E40_T1.3360.54
34_P227_L1.3250.54
135_G174_F1.3130.53
218_Y289_T1.3120.53
16_F78_L1.3010.52
10_E18_M1.2950.52
178_S230_K1.2870.52
205_G208_V1.2750.51
117_L202_E1.2610.50
215_D278_T1.2480.49
223_I292_S1.2480.49
237_R242_D1.2420.49
256_S261_Y1.2400.49
162_E256_S1.2400.49
241_G256_S1.2400.49
189_G256_S1.2400.49
165_H256_S1.2400.49
161_H256_S1.2400.49
32_M59_A1.2200.48
164_H240_F1.2140.47
196_R270_S1.2110.47
14_K148_N1.2040.47
12_Y27_F1.1860.46
143_V230_K1.1810.45
9_F87_S1.1660.45
5_M8_T1.1600.44
226_V267_A1.1560.44
108_V195_A1.1510.44
188_E261_Y1.1470.44
165_H188_E1.1470.44
188_E241_G1.1470.44
161_H188_E1.1470.44
162_E188_E1.1470.44
285_L289_T1.1430.43
166_N259_A1.1410.43
56_V164_H1.1380.43
13_E33_R1.1270.42
226_V288_K1.1200.42
228_D288_K1.1130.42
86_V143_V1.1100.41
190_L260_G1.1080.41
76_K149_S1.1040.41
25_D256_S1.1040.41
101_A164_H1.1020.41
119_I140_F1.0990.41
267_A294_C1.0990.41
35_F59_A1.0940.41
202_E263_V1.0920.40
169_F187_I1.0870.40
14_K79_Q1.0820.40
272_M277_I1.0780.40
180_S293_Q1.0770.40
134_F163_F1.0570.38
223_I226_V1.0560.38
218_Y256_S1.0470.38
268_V274_Q1.0450.38
136_G200_G1.0430.38
54_Y164_H1.0400.38
76_K91_E1.0330.37
261_Y264_G1.0310.37
161_H264_G1.0310.37
241_G264_G1.0310.37
162_E264_G1.0310.37
165_H264_G1.0310.37
189_G264_G1.0310.37
168_R195_A1.0250.37
98_I199_F1.0200.36
121_D133_G1.0190.36
271_F277_I1.0160.36
172_I183_D1.0110.36
228_D292_S1.0100.36
79_Q85_H1.0080.36
130_G231_G1.0040.36
25_D229_V1.0030.36
272_M282_A1.0030.36
211_F258_F1.0010.35
200_G260_G0.9890.35
182_G239_M0.9830.35
75_Q103_R0.9820.34
161_H191_A0.9810.34
162_E191_A0.9810.34
191_A241_G0.9810.34
191_A261_Y0.9810.34
165_H191_A0.9810.34
13_E75_Q0.9810.34
156_P160_A0.9770.34
187_I207_W0.9750.34
54_Y59_A0.9700.34
88_E278_T0.9690.34
55_D291_I0.9690.34
279_I282_A0.9680.34
166_N169_F0.9620.33
124_K210_R0.9590.33
121_D255_L0.9520.33
22_K25_D0.9440.33
10_E158_I0.9400.32
39_W267_A0.9380.32
59_A62_M0.9360.32
60_A68_V0.9310.32
114_K194_F0.9300.32
234_E290_I0.9290.32
5_M243_P0.9280.32
32_M39_W0.9260.32
184_Y240_F0.9190.31
19_E175_H0.9140.31
148_N223_I0.9110.31
100_F149_S0.9110.31
199_F227_L0.9100.31
75_Q288_K0.9090.31
108_V211_F0.9090.31
62_M138_P0.9030.30
13_E37_K0.9030.30
164_H236_S0.9020.30
27_F67_D0.8950.30
195_A207_W0.8920.30
61_K278_T0.8900.30
145_I212_D0.8830.30
101_A200_G0.8820.29
127_L155_I0.8800.29
134_F211_F0.8800.29
98_I167_V0.8770.29
87_S256_S0.8760.29
167_V283_T0.8760.29
206_P231_G0.8750.29
184_Y239_M0.8710.29
88_E289_T0.8600.28
143_V155_I0.8590.28
270_S294_C0.8540.28
39_W200_G0.8530.28
118_Y239_M0.8530.28
180_S213_H0.8520.28
72_E221_D0.8500.28
88_E228_D0.8500.28
219_S256_S0.8500.28
183_D236_S0.8430.28
20_E91_E0.8390.27
278_T292_S0.8360.27
78_L212_D0.8340.27
144_W192_E0.8330.27
227_L260_G0.8320.27
14_K143_V0.8320.27
123_N266_H0.8300.27
16_F74_G0.8270.27
16_F19_E0.8220.27
178_S202_E0.8210.27
159_I280_S0.8190.27
138_P258_F0.8170.26
131_Y138_P0.8170.26
73_S78_L0.8130.26
150_Y160_A0.8120.26
65_Y156_P0.8110.26
282_A290_I0.8080.26
39_W59_A0.8020.26
69_R112_E0.8010.26
164_H243_P0.8010.26
107_R271_F0.8000.26
228_D289_T0.7980.26
186_V225_E0.7950.25
167_V194_F0.7930.25
22_K26_V0.7920.25
120_A147_P0.7910.25
135_G166_N0.7880.25
187_I238_Y0.7860.25
20_E229_V0.7830.25
167_V286_D0.7810.25
98_I220_I0.7790.25
35_F207_W0.7750.25
131_Y216_L0.7720.24
138_P254_G0.7700.24
269_Q273_N0.7700.24
72_E91_E0.7680.24
212_D220_I0.7680.24
154_R282_A0.7640.24
79_Q109_N0.7630.24
8_T260_G0.7620.24
17_S75_Q0.7590.24
194_F239_M0.7560.24
66_L110_A0.7540.24
115_F119_I0.7540.24
6_E267_A0.7510.24
27_F265_Y0.7500.24
269_Q272_M0.7480.23
20_E36_E0.7460.23
103_R217_Q0.7420.23
179_V231_G0.7370.23
133_G242_D0.7350.23
240_F265_Y0.7340.23
36_E268_V0.7320.23
271_F289_T0.7270.23
124_K290_I0.7250.23
158_I186_V0.7230.22
223_I238_Y0.7220.22
90_A164_H0.7200.22
19_E23_R0.7170.22
25_D40_T0.7160.22
23_R115_F0.7140.22
87_S190_L0.7130.22
168_R192_E0.7100.22
79_Q83_E0.7090.22
102_E181_V0.7080.22
213_H292_S0.7030.22
18_M22_K0.7010.22
180_S257_A0.6920.21
270_S276_H0.6910.21
98_I229_V0.6910.21
25_D59_A0.6870.21
164_H230_K0.6800.21
32_M143_V0.6800.21
229_V273_N0.6800.21
150_Y155_I0.6790.21
20_E26_V0.6740.21
7_K30_T0.6740.21
148_N186_V0.6720.20
127_L196_R0.6720.20
67_D211_F0.6680.20
102_E268_V0.6660.20
139_G166_N0.6650.20
8_T168_R0.6640.20
17_S31_M0.6620.20
18_M26_V0.6610.20
114_K195_A0.6600.20
166_N174_F0.6560.20
273_N284_R0.6540.20
190_L205_G0.6520.20
108_V194_F0.6520.20
97_C156_P0.6490.20
205_G283_T0.6490.20
224_N292_S0.6440.19
116_G181_V0.6430.19
135_G236_S0.6410.19
115_F164_H0.6380.19
54_Y58_M0.6370.19
124_K208_V0.6370.19
63_L234_E0.6330.19
168_R239_M0.6280.19
226_V230_K0.6270.19
10_E83_E0.6250.19
216_L262_A0.6240.19
135_G216_L0.6230.19
117_L288_K0.6210.19
188_E256_S0.6200.19
102_E274_Q0.6170.18
186_V264_G0.6160.18
268_V290_I0.6160.18
76_K103_R0.6140.18
139_G194_F0.6100.18
136_G239_M0.6090.18
32_M166_N0.6090.18
145_I278_T0.6070.18
163_F184_Y0.6050.18
8_T12_Y0.6050.18
242_D254_G0.6050.18
260_G265_Y0.6030.18
113_I166_N0.6030.18
60_A67_D0.6020.18
9_F145_I0.5990.18
133_G207_W0.5980.18
163_F264_G0.5970.18
221_D240_F0.5890.17
164_H232_F0.5880.17
195_A258_F0.5880.17
192_E211_F0.5860.17
19_E88_E0.5850.17
203_R277_I0.5810.17
114_K155_I0.5780.17
53_G214_E0.5780.17
278_T281_E0.5770.17
97_C198_L0.5730.17
102_E192_E0.5720.17
170_S284_R0.5670.17
179_V185_L0.5660.17
78_L144_W0.5660.17
238_Y255_L0.5640.17
113_I220_I0.5640.17
81_L113_I0.5610.17
102_E109_N0.5600.17
170_S200_G0.5600.17
15_L18_M0.5550.16
83_E230_K0.5520.16
195_A200_G0.5500.16
112_E171_Y0.5490.16
111_K287_A0.5490.16
71_A103_R0.5490.16
139_G142_H0.5470.16
178_S288_K0.5460.16
112_E212_D0.5460.16
16_F179_V0.5440.16
134_F157_S0.5410.16
99_F155_I0.5390.16
136_G190_L0.5370.16
109_N173_D0.5360.16
80_I273_N0.5360.16
66_L111_K0.5350.16
188_E264_G0.5330.16
38_M134_F0.5320.16
169_F184_Y0.5290.16
40_T267_A0.5280.16
192_E240_F0.5260.15
147_P254_G0.5260.15
176_H198_L0.5250.15
85_H289_T0.5250.15
160_A176_H0.5230.15
221_D267_A0.5190.15
88_E186_V0.5190.15
31_M40_T0.5190.15
177_G256_S0.5180.15
196_R201_T0.5150.15
72_E75_Q0.5140.15
148_N262_A0.5140.15
203_R236_S0.5130.15
226_V231_G0.5120.15
168_R264_G0.5110.15
16_F22_K0.5100.15
110_A211_F0.5080.15
24_E88_E0.5060.15
59_A143_V0.5030.15
134_F195_A0.5000.15
7_K181_V0.5000.15
108_V142_H0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4arfA 2 0.7191 94.7 0.933 Contact Map
4ar9A 1 0.7659 93.8 0.936 Contact Map
2y3uA 1 0.8361 93.5 0.936 Contact Map
4areA 1 0.8395 90.4 0.942 Contact Map
3cqbA 4 0.3512 83.4 0.948 Contact Map
4gaaA 2 0.8395 50.2 0.959 Contact Map
4kx7A 1 0.8528 45.1 0.96 Contact Map
3b34A 1 0.8562 43.8 0.961 Contact Map
4x2uA 1 0.8562 42 0.961 Contact Map
4qhpA 1 0.8562 38.9 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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