GREMLIN Database
MOAB - Molybdenum cofactor biosynthesis protein B
UniProt: O34457 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 170 (142)
Sequences: 7887 (5087)
Seq/√Len: 426.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_K73_T3.7051.00
61_Q96_P3.5761.00
40_L45_H3.2651.00
95_T101_E2.2711.00
57_K96_P2.1961.00
107_E110_R2.1241.00
57_K61_Q2.0911.00
48_A73_T2.0321.00
35_L148_K1.9581.00
23_D87_R1.8761.00
15_R46_H1.8511.00
16_C40_L1.8491.00
54_K59_A1.8271.00
39_F152_N1.8261.00
51_E63_S1.8221.00
61_Q65_L1.8181.00
138_F155_I1.8161.00
37_I41_E1.7981.00
57_K93_A1.7901.00
94_I139_S1.7711.00
56_E59_A1.7681.00
18_V37_I1.7421.00
63_S66_A1.7081.00
17_K67_G1.6881.00
19_I67_G1.6641.00
43_A151_M1.6411.00
65_L97_L1.6061.00
43_A156_I1.6031.00
57_K92_E1.6021.00
156_I160_A1.5961.00
84_I102_L1.5611.00
151_M155_I1.5251.00
61_Q97_L1.5251.00
15_R48_A1.5121.00
101_E125_S1.4851.00
53_V63_S1.4281.00
13_I46_H1.4201.00
36_M151_M1.3901.00
68_C135_T1.3761.00
110_R154_L1.3621.00
32_S79_N1.3571.00
94_I137_V1.3461.00
76_V135_T1.3321.00
75_A159_L1.3091.00
37_I50_Y1.2991.00
31_K144_S1.2721.00
63_S67_G1.2161.00
108_I154_L1.2091.00
138_F158_E1.2041.00
20_T79_N1.1941.00
21_V53_V1.1851.00
108_I111_M1.1781.00
145_G149_L1.1761.00
40_L47_I1.1621.00
39_F151_M1.1441.00
122_A139_S1.1271.00
19_I63_S1.1211.00
35_L144_S1.1161.00
66_A72_Q1.1161.00
24_T28_E1.1141.00
59_A63_S1.1131.00
99_S133_Q1.1111.00
58_D61_Q1.1031.00
58_D62_R1.0981.00
21_V60_L1.0911.00
40_L151_M1.0841.00
62_R66_A1.0811.00
152_N156_I1.0771.00
59_A62_R1.0751.00
51_E66_A1.0621.00
78_L137_V1.0471.00
35_L39_F1.0441.00
92_E95_T1.0431.00
77_L140_T1.0361.00
103_P125_S1.0351.00
17_K50_Y1.0331.00
140_T150_A1.0261.00
57_K89_V1.0171.00
81_G90_T1.0131.00
38_S42_E1.0081.00
34_K38_S1.0051.00
30_D33_G0.9981.00
61_Q93_A0.9891.00
35_L147_V0.9671.00
39_F43_A0.9631.00
19_I53_V0.9601.00
23_D54_K0.9521.00
20_T33_G0.9501.00
109_F150_A0.9471.00
75_A138_F0.9341.00
160_A165_E0.9261.00
14_V45_H0.9251.00
26_T29_T0.9081.00
35_L38_S0.9031.00
68_C132_I0.8971.00
67_G73_T0.8961.00
50_Y73_T0.8961.00
91_I95_T0.8951.00
110_R150_A0.8911.00
18_V47_I0.8891.00
33_G49_A0.8821.00
77_L155_I0.8821.00
50_Y67_G0.8801.00
121_A154_L0.8791.00
91_I106_G0.8761.00
30_D34_K0.8761.00
21_V90_T0.8641.00
20_T52_I0.8601.00
15_R74_D0.8581.00
19_I51_E0.8471.00
91_I122_A0.8431.00
36_M79_N0.8361.00
60_L93_A0.8351.00
57_K60_L0.8311.00
121_A150_A0.8281.00
151_M156_I0.8271.00
56_E60_L0.8241.00
65_L132_I0.8021.00
100_K124_M0.8021.00
37_I47_I0.7971.00
34_K50_Y0.7931.00
64_V94_I0.7861.00
100_K126_R0.7671.00
106_G110_R0.7661.00
132_I137_V0.7661.00
18_V40_L0.7601.00
16_C45_H0.7571.00
114_Y146_A0.7431.00
11_P163_V0.7371.00
105_F123_I0.7311.00
20_T30_D0.7291.00
112_L154_L0.7231.00
123_I138_F0.7231.00
125_S136_A0.7161.00
39_F148_K0.7151.00
113_S150_A0.7141.00
12_D74_D0.7001.00
108_I114_Y0.6941.00
78_L90_T0.6931.00
21_V24_T0.6921.00
15_R73_T0.6911.00
60_L89_V0.6911.00
65_L133_Q0.6871.00
123_I136_A0.6871.00
17_K49_A0.6841.00
30_D52_I0.6841.00
68_C76_V0.6811.00
78_L139_S0.6761.00
37_I49_A0.6701.00
103_P106_G0.6671.00
125_S134_H0.6651.00
160_A163_V0.6610.99
48_A72_Q0.6600.99
141_P146_A0.6590.99
106_G122_A0.6580.99
75_A136_A0.6560.99
136_A162_V0.6530.99
64_V78_L0.6520.99
50_Y72_Q0.6450.99
16_C75_A0.6440.99
111_M114_Y0.6380.99
18_V33_G0.6380.99
41_E46_H0.6300.99
125_S133_Q0.6210.99
126_R133_Q0.6210.99
108_I112_L0.6090.99
44_G47_I0.6040.99
140_T147_V0.6020.99
18_V36_M0.6000.99
21_V78_L0.5950.99
53_V59_A0.5940.99
93_A97_L0.5920.99
150_A154_L0.5920.99
158_E162_V0.5890.99
162_V165_E0.5890.99
78_L94_I0.5870.99
64_V76_V0.5740.99
112_L153_K0.5740.99
20_T51_E0.5730.99
102_L106_G0.5700.99
67_G76_V0.5660.98
36_M140_T0.5620.98
20_T32_S0.5620.98
40_L77_L0.5590.98
82_T139_S0.5590.98
24_T27_D0.5570.98
89_V92_E0.5520.98
78_L82_T0.5510.98
92_E96_P0.5500.98
136_A158_E0.5480.98
45_H159_L0.5450.98
36_M147_V0.5440.98
33_G50_Y0.5370.98
82_T90_T0.5330.98
101_E106_G0.5320.98
144_S148_K0.5310.98
60_L64_V0.5300.98
126_R135_T0.5260.97
66_A71_E0.5260.97
27_D50_Y0.5240.97
82_T91_I0.5200.97
55_D142_G0.5170.97
56_E89_V0.5100.97
31_K34_K0.5090.97
148_K152_N0.5080.97
90_T137_V0.5060.97
82_T122_A0.5060.97
84_I107_E0.5040.97
102_L122_A0.5020.97
88_D146_A0.5010.97
141_P150_A0.5010.97
38_S41_E0.5000.97
83_G120_S0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd0A 2 0.9412 100 0.203 Contact Map
1g8lA 2 0.9059 100 0.21 Contact Map
1uz5A 1 0.8765 100 0.215 Contact Map
1wu2A 2 0.8176 100 0.246 Contact Map
1jljA 3 0.8824 100 0.254 Contact Map
3rfqA 5 0.8882 100 0.256 Contact Map
1y5eA 4 0.9118 100 0.258 Contact Map
4lhbA 4 0.8765 100 0.273 Contact Map
3iwtA 4 0.8941 100 0.287 Contact Map
4xcwA 3 0.9235 100 0.29 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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