GREMLIN Database
NOSO - Nitric oxide synthase oxygenase
UniProt: O34453 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (352)
Sequences: 456 (337)
Seq/√Len: 18.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
272_N277_K4.8481.00
54_H58_M4.6631.00
198_T294_K4.1731.00
47_H230_Y4.0741.00
87_E185_Y4.0221.00
80_R111_T3.7221.00
198_T295_Q3.5891.00
197_I249_L3.5201.00
151_L173_I3.3731.00
12_K16_A3.3401.00
222_K229_H3.2900.99
137_E153_A3.1920.99
155_C173_I3.1850.99
138_S141_E3.0620.99
10_E352_K2.9370.99
263_S269_A2.9020.99
18_C22_L2.8190.98
197_I205_F2.7550.98
331_I336_P2.7160.98
156_E162_G2.7160.98
275_L289_L2.6760.98
49_K53_E2.6750.98
250_A337_A2.5270.96
64_N324_T2.5100.96
151_L155_C2.5090.96
210_L257_K2.4520.96
38_E46_V2.3720.95
15_I35_I2.3260.94
293_K298_S2.2460.93
204_A264_V2.1720.92
325_G330_L2.1590.92
126_W358_Q2.1030.91
326_D342_F2.0970.90
128_H220_D2.0960.90
126_W173_I2.0960.90
18_C54_H2.0880.90
18_C58_M2.0750.90
67_I306_A2.0110.88
312_F324_T1.9730.87
63_S354_N1.9310.86
197_I204_A1.9290.86
78_I107_R1.9190.86
326_D345_S1.8780.85
136_Y168_D1.8740.85
312_F330_L1.8380.83
202_I265_I1.8350.83
246_A250_A1.8170.83
78_I92_A1.8020.82
282_V334_I1.7730.81
279_Q286_K1.7650.81
135_G149_C1.7520.80
97_I217_I1.7500.80
133_Y194_E1.7400.80
167_F211_K1.7390.80
94_F191_L1.7270.79
83_V88_E1.7240.79
313_E346_Y1.7110.79
38_E42_T1.6980.78
241_G245_G1.6650.77
128_H147_A1.6600.76
118_K121_K1.6530.76
204_A265_I1.6440.76
85_T88_E1.6410.76
78_I109_T1.6340.75
90_R94_F1.6270.75
193_I196_P1.6120.74
35_I39_I1.6100.74
273_T293_K1.6070.74
54_H57_K1.6000.74
305_A308_Q1.5770.73
148_S151_L1.5450.71
101_T193_I1.5410.71
194_E211_K1.5300.70
78_I99_T1.5210.70
86_K179_D1.5000.69
57_K112_I1.4990.69
12_K36_K1.4900.68
55_G225_V1.4870.68
205_F264_V1.4690.67
80_R95_H1.4690.67
312_F336_P1.4670.67
86_K183_V1.4600.66
67_I240_M1.4530.66
162_G335_S1.4480.66
165_T168_D1.4310.65
14_F75_L1.3980.63
250_A284_L1.3940.63
17_A58_M1.3820.62
311_R314_E1.3800.62
198_T206_S1.3780.62
210_L249_L1.3620.61
95_H143_I1.3410.60
158_L184_W1.3390.60
292_Y317_E1.3350.59
99_T109_T1.3290.59
22_L58_M1.3250.59
8_W32_L1.3240.59
205_F245_G1.3130.58
240_M305_A1.2960.57
162_G165_T1.2860.56
300_V308_Q1.2750.56
306_A341_I1.2730.56
306_A337_A1.2720.56
310_K340_H1.2670.55
71_F308_Q1.2540.54
77_V289_L1.2410.54
143_I164_R1.2360.53
300_V305_A1.2290.53
83_V89_V1.2050.51
110_I355_Y1.1990.51
80_R83_V1.1930.51
126_W182_P1.1870.50
54_H323_L1.1840.50
8_W292_Y1.1710.49
246_A337_A1.1700.49
175_R182_P1.1590.49
47_H52_L1.1550.48
326_D344_R1.1400.47
119_G165_T1.1380.47
77_V292_Y1.1360.47
224_E352_K1.1360.47
22_L27_E1.1310.47
241_G275_L1.1260.47
128_H218_I1.1260.47
307_S322_K1.1170.46
162_G249_L1.1140.46
312_F323_L1.1030.45
197_I265_I1.0990.45
197_I260_K1.0980.45
108_P299_I1.0980.45
256_D273_T1.0960.45
12_K32_L1.0930.45
331_I341_I1.0910.44
311_R315_Q1.0880.44
220_D360_K1.0820.44
98_E191_L1.0780.44
243_E247_R1.0730.43
236_N355_Y1.0720.43
166_D260_K1.0700.43
178_G181_Q1.0690.43
155_C158_L1.0630.43
16_A20_Q1.0570.42
156_E164_R1.0570.42
328_T348_N1.0510.42
265_I279_Q1.0500.42
260_K264_V1.0400.41
144_G152_T1.0390.41
78_I95_H1.0380.41
13_A17_A1.0370.41
115_P262_A1.0280.41
60_W69_R1.0240.40
330_L336_P1.0220.40
241_G289_L1.0170.40
225_V348_N1.0110.40
34_D274_D1.0110.40
172_L187_L1.0100.40
303_H331_I1.0100.40
112_I322_K1.0060.39
94_F188_P1.0040.39
233_A248_N1.0040.39
292_Y322_K0.9990.39
148_S213_Y0.9960.39
187_L192_V0.9920.39
286_K334_I0.9870.38
215_V304_T0.9830.38
73_N257_K0.9810.38
162_G284_L0.9750.38
112_I192_V0.9730.37
97_I112_I0.9710.37
24_K27_E0.9700.37
128_H148_S0.9660.37
340_H344_R0.9640.37
246_A282_V0.9610.37
324_T336_P0.9530.36
198_T290_H0.9490.36
18_C47_H0.9470.36
173_I273_T0.9430.36
153_A156_E0.9370.35
18_C24_K0.9320.35
64_N338_A0.9310.35
15_I28_V0.9300.35
116_E122_Q0.9270.35
78_I111_T0.9250.35
207_D263_S0.9240.35
93_L323_L0.9170.34
152_T168_D0.9160.34
172_L245_G0.9140.34
114_P306_A0.9120.34
56_A88_E0.9100.34
131_I355_Y0.9070.34
64_N337_A0.9070.34
22_L50_E0.9050.34
240_M244_I0.9050.34
10_E137_E0.9050.34
243_E254_R0.9020.33
16_A28_V0.9000.33
279_Q283_E0.8990.33
325_G336_P0.8980.33
110_I221_M0.8970.33
57_K119_G0.8950.33
263_S290_H0.8920.33
350_I356_F0.8910.33
177_K211_K0.8910.33
352_K356_F0.8900.33
326_D348_N0.8870.33
38_E261_V0.8850.33
8_W35_I0.8830.32
38_E44_S0.8820.32
237_G254_R0.8780.32
306_A339_T0.8720.32
63_S219_S0.8720.32
222_K358_Q0.8710.32
324_T337_A0.8670.32
328_T342_F0.8660.32
282_V335_S0.8650.31
106_I217_I0.8620.31
144_G168_D0.8600.31
241_G334_I0.8580.31
324_T351_V0.8560.31
56_A77_V0.8520.31
250_A338_A0.8440.30
25_E34_D0.8420.30
132_R255_Y0.8400.30
333_P339_T0.8400.30
174_F185_Y0.8390.30
149_C153_A0.8370.30
163_E189_R0.8350.30
173_I355_Y0.8330.30
214_G295_Q0.8330.30
242_T334_I0.8310.30
95_H98_E0.8250.29
235_F247_R0.8230.29
196_P257_K0.8230.29
253_K344_R0.8220.29
265_I290_H0.8210.29
213_Y239_Y0.8130.29
71_F305_A0.8110.29
175_R272_N0.8060.28
84_R231_N0.8060.28
143_I163_E0.8050.28
248_N309_F0.8030.28
312_F325_G0.8030.28
313_E324_T0.7990.28
142_R156_E0.7950.28
308_Q325_G0.7930.28
105_K311_R0.7920.28
123_V230_Y0.7910.28
246_A338_A0.7900.28
101_T214_G0.7880.28
118_K177_K0.7870.27
9_N26_E0.7870.27
75_L231_N0.7870.27
257_K260_K0.7850.27
143_I149_C0.7840.27
336_P341_I0.7790.27
135_G144_G0.7760.27
340_H356_F0.7680.27
207_D264_V0.7680.27
312_F341_I0.7670.27
33_A317_E0.7660.26
270_D274_D0.7650.26
231_N352_K0.7630.26
329_W333_P0.7600.26
154_A157_E0.7580.26
213_Y240_M0.7570.26
114_P164_R0.7550.26
11_A19_Y0.7550.26
147_A150_S0.7550.26
89_V123_V0.7540.26
285_N289_L0.7540.26
246_A296_G0.7520.26
201_D279_Q0.7520.26
131_I169_L0.7510.26
140_G150_S0.7510.26
196_P211_K0.7500.26
35_I169_L0.7500.26
140_G209_E0.7500.26
35_I45_Y0.7490.26
253_K345_S0.7490.26
346_Y354_N0.7480.26
323_L330_L0.7470.26
116_E231_N0.7450.25
60_W65_R0.7410.25
74_S315_Q0.7410.25
11_A47_H0.7400.25
139_D150_S0.7390.25
108_P173_I0.7380.25
148_S241_G0.7350.25
258_L280_A0.7330.25
272_N307_S0.7330.25
11_A14_F0.7320.25
231_N266_G0.7310.25
142_R149_C0.7280.25
126_W154_A0.7260.25
70_L105_K0.7260.25
124_E174_F0.7200.24
260_K263_S0.7190.24
21_E321_R0.7190.24
324_T330_L0.7170.24
30_D142_R0.7110.24
28_V35_I0.7100.24
309_F316_E0.7100.24
241_G285_N0.7100.24
313_E340_H0.7090.24
115_P163_E0.7080.24
82_D151_L0.7050.24
31_R45_Y0.7040.24
197_I323_L0.7040.24
32_L75_L0.7010.23
167_F257_K0.7010.23
275_L303_H0.7000.23
62_N69_R0.7000.23
65_R69_R0.7000.23
148_S155_C0.6970.23
278_D302_H0.6970.23
262_A269_A0.6970.23
101_T104_G0.6950.23
57_K351_V0.6940.23
41_L153_A0.6930.23
172_L188_P0.6930.23
238_W247_R0.6910.23
193_I214_G0.6880.23
321_R328_T0.6840.23
216_P254_R0.6840.23
21_E47_H0.6830.23
308_Q321_R0.6830.23
60_W68_G0.6820.23
328_T344_R0.6820.23
61_R72_W0.6820.23
242_T333_P0.6790.23
283_E343_H0.6750.22
146_P345_S0.6750.22
197_I340_H0.6720.22
97_I191_L0.6720.22
241_G273_T0.6710.22
351_V357_Y0.6690.22
60_W67_I0.6650.22
164_R261_V0.6640.22
182_P307_S0.6600.22
64_N228_I0.6590.22
99_T107_R0.6570.22
321_R346_Y0.6570.22
62_N67_I0.6560.22
18_C23_G0.6550.22
84_R249_L0.6540.21
42_T46_V0.6540.21
34_D38_E0.6540.21
131_I141_E0.6540.21
276_W303_H0.6540.21
268_A290_H0.6520.21
125_I220_D0.6520.21
158_L249_L0.6520.21
92_A197_I0.6510.21
86_K334_I0.6490.21
186_E261_V0.6480.21
63_S73_N0.6470.21
121_K177_K0.6470.21
312_F337_A0.6460.21
249_L284_L0.6460.21
123_V176_M0.6450.21
243_E251_D0.6440.21
204_A207_D0.6430.21
15_I32_L0.6420.21
197_I264_V0.6420.21
248_N254_R0.6410.21
59_A66_C0.6410.21
68_G321_R0.6410.21
328_T345_S0.6390.21
61_R66_C0.6390.21
316_E327_W0.6380.21
103_N157_E0.6380.21
100_A158_L0.6370.21
220_D249_L0.6350.21
17_A185_Y0.6350.21
59_A72_W0.6340.21
214_G218_I0.6330.21
114_P231_N0.6330.21
21_E230_Y0.6320.21
117_E120_E0.6310.21
213_Y293_K0.6300.20
298_S349_S0.6290.20
326_D359_D0.6270.20
225_V355_Y0.6260.20
115_P349_S0.6250.20
45_Y230_Y0.6250.20
237_G329_W0.6240.20
51_E55_G0.6230.20
184_W292_Y0.6220.20
35_I274_D0.6220.20
257_K284_L0.6190.20
15_I286_K0.6190.20
67_I341_I0.6180.20
121_K147_A0.6180.20
261_V284_L0.6160.20
196_P355_Y0.6160.20
54_H351_V0.6140.20
22_L54_H0.6140.20
148_S220_D0.6130.20
281_L334_I0.6120.20
24_K315_Q0.6120.20
298_S311_R0.6120.20
10_E108_P0.6090.20
155_C213_Y0.6080.20
21_E132_R0.6050.20
322_K349_S0.6050.20
175_R181_Q0.6050.20
67_I70_L0.6040.19
60_W66_C0.6040.19
201_D334_I0.6030.19
316_E321_R0.6010.19
94_F187_L0.6000.19
139_D207_D0.5990.19
166_D279_Q0.5980.19
126_W175_R0.5960.19
143_I162_G0.5950.19
272_N358_Q0.5950.19
116_E292_Y0.5950.19
320_G344_R0.5940.19
47_H90_R0.5930.19
237_G240_M0.5910.19
224_E358_Q0.5890.19
35_I203_E0.5890.19
31_R35_I0.5890.19
340_H346_Y0.5870.19
8_W98_E0.5830.19
71_F293_K0.5830.19
101_T261_V0.5820.19
298_S305_A0.5810.19
41_L252_E0.5800.19
125_I248_N0.5800.19
91_D295_Q0.5790.19
172_L318_E0.5770.18
238_W243_E0.5760.18
292_Y319_A0.5740.18
204_A210_L0.5730.18
298_S341_I0.5730.18
64_N348_N0.5720.18
84_R88_E0.5720.18
325_G346_Y0.5700.18
268_A299_I0.5690.18
65_R68_G0.5690.18
89_V232_A0.5680.18
272_N315_Q0.5660.18
215_V221_M0.5660.18
238_W242_T0.5660.18
65_R169_L0.5650.18
103_N193_I0.5630.18
97_I305_A0.5610.18
201_D266_G0.5590.18
116_E229_H0.5590.18
57_K85_T0.5580.18
42_T45_Y0.5580.18
57_K202_I0.5580.18
30_D112_I0.5580.18
108_P230_Y0.5570.18
63_S101_T0.5570.18
32_L58_M0.5560.18
98_E103_N0.5550.18
17_A46_V0.5550.18
9_N12_K0.5540.18
337_A345_S0.5520.18
76_N99_T0.5510.18
293_K311_R0.5510.18
124_E358_Q0.5500.17
247_R254_R0.5480.17
236_N240_M0.5480.17
167_F218_I0.5480.17
42_T73_N0.5470.17
146_P251_D0.5450.17
167_F255_Y0.5450.17
330_L346_Y0.5450.17
222_K356_F0.5450.17
34_D186_E0.5440.17
90_R174_F0.5430.17
68_G221_M0.5430.17
155_C232_A0.5410.17
33_A37_S0.5410.17
328_T347_D0.5400.17
216_P251_D0.5400.17
98_E190_S0.5400.17
193_I331_I0.5390.17
71_F331_I0.5380.17
125_I144_G0.5370.17
193_I265_I0.5370.17
93_L222_K0.5370.17
25_E197_I0.5340.17
335_S339_T0.5330.17
114_P123_V0.5310.17
135_G210_L0.5300.17
289_L345_S0.5290.17
265_I338_A0.5280.17
113_F200_P0.5260.17
89_V174_F0.5250.17
8_W40_D0.5240.17
99_T155_C0.5230.17
70_L250_A0.5200.16
197_I233_A0.5180.16
307_S358_Q0.5170.16
337_A351_V0.5160.16
109_T355_Y0.5150.16
216_P243_E0.5130.16
308_Q336_P0.5130.16
80_R306_A0.5120.16
326_D347_D0.5120.16
134_A160_W0.5120.16
47_H228_I0.5110.16
63_S324_T0.5110.16
120_E153_A0.5100.16
192_V209_E0.5100.16
37_S85_T0.5100.16
24_K58_M0.5100.16
272_N359_D0.5090.16
322_K351_V0.5090.16
332_P335_S0.5090.16
71_F324_T0.5070.16
124_E211_K0.5050.16
14_F268_A0.5050.16
19_Y28_V0.5040.16
325_G341_I0.5040.16
125_I232_A0.5030.16
71_F312_F0.5030.16
334_I360_K0.5020.16
325_G340_H0.5020.16
93_L258_L0.5010.16
65_R329_W0.5010.16
13_A41_L0.5010.16
239_Y249_L0.5010.16
251_D254_R0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fvyA 2 0.9972 100 0.005 Contact Map
4d3tA 2 0.9945 100 0.02 Contact Map
1d0cA 2 0.9945 100 0.021 Contact Map
3e7mA 2 0.9972 100 0.021 Contact Map
2ortA 2 0.7603 100 0.022 Contact Map
2flqA 2 0.9862 100 0.028 Contact Map
1mjtA 2 0.9532 100 0.055 Contact Map
4bwjA 1 0.4132 21.3 0.984 Contact Map
1sauA 1 0.1818 17.8 0.984 Contact Map
4atiA 2 0.0716 15.9 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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