GREMLIN Database
YVRB - Uncharacterized ABC transporter permease protein YvrB
UniProt: O34451 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 353 (320)
Sequences: 13908 (9941)
Seq/√Len: 555.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
234_N293_D5.0591.00
85_A302_A3.8031.00
121_T139_L3.6571.00
93_A226_L3.6331.00
28_S311_L3.6281.00
29_I77_V3.4261.00
249_S252_Q3.2851.00
86_A219_F3.2611.00
81_A306_A3.1791.00
93_A257_I3.1191.00
80_A204_V2.9851.00
286_T304_L2.9071.00
79_L207_R2.7471.00
86_A264_L2.6701.00
86_A268_A2.6141.00
44_A65_Y2.5521.00
29_I81_A2.4401.00
89_I302_A2.4221.00
240_E254_K2.3731.00
116_V181_F2.3711.00
24_F307_G2.3611.00
44_A47_R2.3461.00
25_L307_G2.3381.00
89_I223_T2.2761.00
83_V268_A2.2561.00
116_V178_L2.2341.00
34_S42_I2.1761.00
92_A301_S2.1621.00
290_W300_L2.1441.00
234_N294_H2.1211.00
83_V272_S2.1091.00
76_R313_D2.0821.00
32_G77_V2.0431.00
62_D65_Y2.0281.00
81_A310_V2.0141.00
25_L81_A2.0091.00
82_L216_L1.9511.00
218_F267_S1.9351.00
96_G294_H1.9231.00
28_S307_G1.8711.00
232_E253_R1.8541.00
41_P44_A1.8391.00
120_V124_L1.8131.00
94_F261_G1.7961.00
119_V182_I1.7891.00
207_R211_Y1.7711.00
235_V248_V1.7571.00
18_Y300_L1.7171.00
144_A266_G1.6911.00
229_N232_E1.6871.00
225_L260_A1.6301.00
315_L319_I1.6081.00
25_L303_L1.6081.00
43_P47_R1.6061.00
278_V309_L1.5991.00
316_S327_I1.5731.00
78_V212_V1.5641.00
118_A140_S1.5561.00
63_P66_T1.5401.00
222_G264_L1.5321.00
252_Q256_M1.5311.00
117_G139_L1.5191.00
229_N256_M1.5081.00
46_F50_W1.5041.00
28_S310_V1.4971.00
31_L34_S1.4971.00
148_M262_S1.4961.00
222_G263_L1.4871.00
66_T70_M1.4621.00
286_T297_L1.4621.00
315_L330_I1.4521.00
21_G303_L1.4461.00
92_A297_L1.4381.00
48_V70_M1.4361.00
21_G300_L1.4291.00
90_A264_L1.4281.00
17_A300_L1.4281.00
115_S182_I1.4181.00
213_I217_P1.4151.00
213_I216_L1.3861.00
204_V309_L1.3801.00
208_G211_Y1.3761.00
31_L35_C1.3711.00
229_N253_R1.3671.00
79_L271_V1.3611.00
296_H299_P1.3291.00
222_G260_A1.3231.00
32_G314_L1.3161.00
111_S265_T1.3121.00
282_I308_F1.3061.00
317_R324_E1.3001.00
117_G143_A1.3001.00
177_F336_A1.2931.00
88_S282_I1.2861.00
286_T300_L1.2661.00
217_P221_L1.2561.00
294_H297_L1.2411.00
82_L212_V1.2301.00
147_T178_L1.2271.00
225_L229_N1.2261.00
229_N257_I1.2251.00
21_G304_L1.2171.00
92_A294_H1.2071.00
151_V174_T1.1931.00
115_S200_L1.1911.00
141_V263_L1.1901.00
113_G143_A1.1821.00
97_L257_I1.1771.00
18_Y296_H1.1741.00
253_R256_M1.1621.00
282_I304_L1.1611.00
244_K251_Q1.1551.00
252_Q255_M1.1471.00
119_V196_I1.1431.00
275_I309_L1.1411.00
116_V120_V1.1371.00
38_L68_I1.1321.00
239_G243_A1.1221.00
149_A153_F1.1211.00
25_L306_A1.1181.00
313_D317_R1.1141.00
48_V66_T1.1131.00
82_L215_F1.1081.00
242_K245_L1.1051.00
67_N71_N1.1011.00
251_Q254_K1.0971.00
70_M74_L1.0921.00
39_H42_I1.0871.00
92_A298_L1.0821.00
123_F185_I1.0791.00
21_G307_G1.0751.00
138_V142_A1.0741.00
48_V61_D1.0721.00
80_A309_L1.0711.00
33_I77_V1.0711.00
79_L212_V1.0711.00
215_F271_V1.0691.00
272_S275_I1.0681.00
85_A88_S1.0671.00
61_D66_T1.0621.00
51_H61_D1.0571.00
29_I310_V1.0511.00
315_L318_T1.0511.00
235_V246_L1.0501.00
78_V209_W1.0461.00
332_S337_P1.0381.00
146_A150_A1.0361.00
28_S314_L1.0341.00
80_A310_V1.0341.00
226_L260_A1.0301.00
64_M67_N1.0291.00
48_V69_M1.0271.00
307_G311_L1.0261.00
222_G267_S1.0261.00
225_L256_M1.0221.00
215_F219_F1.0141.00
299_P302_A1.0131.00
294_H299_P1.0121.00
77_V314_L1.0111.00
45_V69_M1.0041.00
85_A306_A0.9991.00
139_L143_A0.9871.00
16_A19_I0.9811.00
132_G135_T0.9811.00
35_C318_T0.9791.00
156_R251_Q0.9741.00
282_I286_T0.9691.00
113_G147_T0.9671.00
120_V185_I0.9661.00
184_L188_L0.9611.00
15_Y18_Y0.9561.00
290_W296_H0.9531.00
224_I228_I0.9531.00
221_L224_I0.9511.00
30_I34_S0.9451.00
241_D244_K0.9421.00
112_S178_L0.9401.00
175_N179_G0.9391.00
297_L301_S0.9321.00
111_S274_T0.9281.00
251_Q255_M0.9271.00
34_S45_V0.9141.00
152_L251_Q0.9121.00
209_W212_V0.9121.00
296_H300_L0.9111.00
316_S330_I0.9111.00
214_L217_P0.9041.00
116_V182_I0.9021.00
23_S27_V0.9001.00
22_F26_A0.8981.00
156_R159_H0.8931.00
316_S326_P0.8931.00
311_L315_L0.8921.00
253_R257_I0.8911.00
91_G283_P0.8881.00
248_V253_R0.8871.00
118_A136_L0.8861.00
268_A272_S0.8831.00
60_S63_P0.8751.00
116_V185_I0.8741.00
47_R50_W0.8651.00
47_R51_H0.8631.00
30_I42_I0.8621.00
48_V65_Y0.8601.00
86_A90_A0.8601.00
338_V341_L0.8581.00
320_I323_I0.8571.00
233_L257_I0.8571.00
15_Y19_I0.8561.00
16_A20_I0.8541.00
112_S115_S0.8541.00
17_A20_I0.8521.00
76_R317_R0.8511.00
106_Y111_S0.8501.00
226_L257_I0.8491.00
217_P220_L0.8491.00
156_R161_S0.8481.00
66_T71_N0.8461.00
234_N295_R0.8461.00
82_L219_F0.8461.00
85_A223_T0.8411.00
122_L136_L0.8371.00
36_G73_R0.8351.00
289_L304_L0.8331.00
293_D296_H0.8251.00
230_G295_R0.8241.00
144_A262_S0.8231.00
110_V144_A0.8171.00
90_A261_G0.8161.00
319_I322_P0.8161.00
220_L224_I0.8131.00
17_A21_G0.8051.00
196_I200_L0.8021.00
26_A30_I0.8011.00
76_R324_E0.8001.00
225_L228_I0.8001.00
40_I69_M0.7991.00
240_E244_K0.7991.00
218_F222_G0.7961.00
229_N260_A0.7951.00
318_T321_E0.7941.00
77_V310_V0.7941.00
114_A144_A0.7931.00
337_P341_L0.7921.00
333_L337_P0.7911.00
142_A146_A0.7881.00
309_L331_T0.7881.00
61_D65_Y0.7841.00
145_L266_G0.7841.00
98_L168_I0.7831.00
51_H60_S0.7791.00
85_A219_F0.7771.00
243_A250_V0.7771.00
40_I65_Y0.7711.00
26_A29_I0.7691.00
120_V125_G0.7651.00
22_F303_L0.7631.00
240_E250_V0.7631.00
25_L29_I0.7621.00
287_R297_L0.7611.00
45_V48_V0.7591.00
131_I135_T0.7591.00
104_D107_T0.7581.00
121_T136_L0.7551.00
88_S302_A0.7511.00
194_L197_V0.7501.00
152_L255_M0.7491.00
88_S92_A0.7491.00
189_T192_N0.7471.00
119_V186_I0.7441.00
74_L209_W0.7431.00
27_V30_I0.7391.00
141_V145_L0.7391.00
258_L262_S0.7371.00
147_T151_V0.7371.00
156_R162_M0.7361.00
295_R299_P0.7361.00
25_L310_V0.7321.00
148_M258_L0.7321.00
89_I226_L0.7291.00
286_T290_W0.7291.00
286_T289_L0.7281.00
87_L278_V0.7261.00
38_L41_P0.7251.00
278_V331_T0.7251.00
320_I325_L0.7231.00
94_F108_L0.7221.00
115_S274_T0.7221.00
151_V155_S0.7191.00
34_S39_H0.7181.00
250_V254_K0.7171.00
78_V82_L0.7161.00
255_M259_I0.7151.00
308_F312_A0.7151.00
38_L42_I0.7131.00
32_G317_R0.7101.00
234_N299_P0.7091.00
60_S66_T0.7091.00
285_I304_L0.7091.00
17_A289_L0.7051.00
96_G237_T0.7051.00
219_F268_A0.7031.00
303_L307_G0.7031.00
313_D324_E0.6991.00
211_Y271_V0.6981.00
267_S270_A0.6951.00
79_L215_F0.6871.00
215_F267_S0.6861.00
51_H66_T0.6861.00
135_T138_V0.6851.00
267_S271_V0.6841.00
110_V148_M0.6741.00
40_I48_V0.6731.00
27_V31_L0.6721.00
288_L342_I0.6721.00
104_D279_G0.6701.00
197_V200_L0.6691.00
227_I230_G0.6671.00
21_G25_L0.6651.00
153_F156_R0.6641.00
33_I69_M0.6631.00
275_I327_I0.6631.00
83_V204_V0.6601.00
89_I298_L0.6591.00
210_S213_I0.6581.00
341_L345_R0.6571.00
120_V181_F0.6571.00
244_K250_V0.6561.00
67_N72_I0.6531.00
90_A265_T0.6531.00
312_A330_I0.6521.00
216_L220_L0.6511.00
191_D194_L0.6501.00
189_T193_L0.6461.00
306_A310_V0.6441.00
155_S170_T0.6441.00
63_P67_N0.6391.00
228_I232_E0.6371.00
122_L195_P0.6371.00
261_G266_G0.6361.00
113_G178_L0.6361.00
154_F170_T0.6331.00
222_G226_L0.6301.00
30_I46_F0.6291.00
94_F103_A0.6291.00
232_E248_V0.6281.00
285_I288_L0.6271.00
74_L78_V0.6271.00
33_I74_L0.6261.00
234_N237_T0.6261.00
123_F189_T0.6251.00
67_N70_M0.6241.00
94_F110_V0.6191.00
42_I46_F0.6181.00
98_L101_P0.6181.00
218_F263_L0.6181.00
302_A306_A0.6171.00
283_P301_S0.6171.00
93_A260_A0.6171.00
280_L342_I0.6171.00
85_A89_I0.6161.00
191_D195_P0.6151.00
145_L262_S0.6121.00
43_P46_F0.6091.00
117_G121_T0.6081.00
308_F334_A0.6081.00
156_R160_A0.6071.00
311_L314_L0.6071.00
80_A327_I0.6061.00
165_S168_I0.6061.00
42_I45_V0.6061.00
29_I33_I0.6031.00
111_S114_A0.6011.00
25_L77_V0.5991.00
186_I197_V0.5991.00
62_D66_T0.5981.00
183_S199_W0.5971.00
122_L196_I0.5961.00
45_V49_F0.5941.00
35_C39_H0.5931.00
223_T227_I0.5921.00
41_P65_Y0.5911.00
215_F218_F0.5901.00
236_M250_V0.5881.00
114_A140_S0.5871.00
281_V339_F0.5871.00
316_S324_E0.5861.00
310_V314_L0.5861.00
170_T173_I0.5841.00
143_A147_T0.5841.00
204_V327_I0.5841.00
88_S305_G0.5831.00
136_L139_L0.5821.00
127_H131_I0.5811.00
265_T269_V0.5801.00
266_G270_A0.5801.00
280_L283_P0.5801.00
221_L225_L0.5780.99
209_W213_I0.5760.99
233_L294_H0.5750.99
103_A110_V0.5720.99
44_A51_H0.5720.99
285_I308_F0.5700.99
192_N195_P0.5670.99
285_I338_V0.5660.99
134_F138_V0.5660.99
309_L327_I0.5650.99
286_T301_S0.5640.99
69_M74_L0.5640.99
34_S46_F0.5640.99
344_I347_H0.5640.99
146_A149_A0.5630.99
20_I24_F0.5610.99
44_A61_D0.5610.99
187_A329_I0.5610.99
183_S187_A0.5600.99
193_L196_I0.5600.99
314_L318_T0.5590.99
186_I200_L0.5580.99
232_E235_V0.5570.99
219_F224_I0.5540.99
47_R61_D0.5540.99
281_V338_V0.5500.99
256_M260_A0.5490.99
278_V308_F0.5480.99
97_L261_G0.5470.99
104_D274_T0.5470.99
110_V203_S0.5460.99
92_A286_T0.5460.99
104_D331_T0.5450.99
37_S322_P0.5450.99
275_I331_T0.5430.99
214_L267_S0.5410.99
179_G183_S0.5410.99
29_I78_V0.5380.99
228_I231_R0.5360.99
262_S266_G0.5360.99
204_V272_S0.5360.99
124_L127_H0.5340.99
112_S175_N0.5340.99
152_L156_R0.5330.99
313_D322_P0.5330.99
79_L83_V0.5320.99
110_V151_V0.5310.99
179_G200_L0.5300.99
212_V216_L0.5290.99
18_Y22_F0.5290.99
163_S166_T0.5290.99
112_S179_G0.5280.99
19_I23_S0.5280.99
17_A290_W0.5270.99
316_S319_I0.5270.99
118_A139_L0.5240.99
249_S256_M0.5240.99
231_R234_N0.5230.99
291_G299_P0.5210.99
35_C314_L0.5200.99
31_L314_L0.5190.99
78_V216_L0.5190.99
148_M152_L0.5170.99
257_I261_G0.5160.99
89_I219_F0.5160.99
45_V50_W0.5130.99
214_L218_F0.5130.99
121_T125_G0.5130.99
184_L329_I0.5120.99
281_V285_I0.5100.99
170_T174_T0.5090.99
155_S167_L0.5080.99
194_L200_L0.5070.99
180_A281_V0.5070.99
28_S31_L0.5070.99
113_G174_T0.5060.99
142_A145_L0.5050.99
98_L166_T0.5050.99
186_I193_L0.5040.99
276_G281_V0.5040.99
20_I23_S0.5030.99
23_S26_A0.5010.99
150_A153_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g1uA 2 0.8385 100 0.23 Contact Map
2nq2A 2 0.8697 100 0.232 Contact Map
2qi9A 2 0.9065 100 0.244 Contact Map
2m8rA 1 0.1076 50 0.957 Contact Map
3rlbA 1 0.4788 16.4 0.967 Contact Map
2m20A 2 0.0822 16.4 0.967 Contact Map
4z7fA 2 0.4646 14 0.968 Contact Map
4huqS 1 0.4391 13 0.968 Contact Map
4tkrA 2 0.4873 9.1 0.97 Contact Map
3wajA 1 0.7564 9.1 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0111 seconds.