GREMLIN Database
NAGA - N-acetylglucosamine-6-phosphate deacetylase
UniProt: O34450 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 396 (371)
Sequences: 26788 (22775)
Seq/√Len: 1182.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
381_I386_I5.2461.00
359_S364_K4.9701.00
53_S378_I4.5821.00
27_N32_S4.2901.00
7_I50_P4.2801.00
379_L386_I4.1391.00
335_S338_D3.5661.00
50_P370_I3.5501.00
56_L371_V3.5201.00
10_I50_P3.4291.00
361_T364_K3.3321.00
357_K365_D3.1431.00
8_K47_I3.1081.00
33_T362_V2.9111.00
353_I357_K2.8131.00
365_D383_R2.7441.00
29_G365_D2.7021.00
58_G93_T2.6781.00
56_L369_V2.6411.00
298_Q302_V2.5581.00
341_N345_E2.5441.00
6_L25_G2.3471.00
338_D341_N2.2691.00
380_T388_F2.2561.00
29_G383_R2.2171.00
24_V55_L2.2001.00
55_L370_I2.1851.00
360_V368_L2.1561.00
35_S38_R2.1471.00
23_Y38_R2.1301.00
26_I368_L2.0951.00
5_L381_I2.0771.00
88_P387_A2.0681.00
30_K365_D2.0601.00
53_S372_S2.0601.00
372_S378_I2.0061.00
368_L381_I1.9531.00
89_E388_F1.9461.00
12_I22_G1.9361.00
53_S370_I1.9171.00
56_L59_M1.9071.00
346_N349_K1.8171.00
349_K354_F1.8151.00
341_N346_N1.8051.00
190_H193_D1.7991.00
306_T349_K1.7901.00
25_G45_K1.7661.00
10_I55_L1.7491.00
55_L368_L1.7481.00
345_E359_S1.7421.00
326_R330_E1.6881.00
9_D49_A1.6851.00
369_V377_V1.6651.00
8_K23_Y1.6351.00
24_V360_V1.6341.00
87_L95_F1.6231.00
31_I360_V1.6211.00
355_D364_K1.6141.00
345_E349_K1.6131.00
130_L133_I1.6061.00
340_A344_S1.5811.00
25_G33_T1.5671.00
42_P45_K1.5561.00
211_S215_K1.5501.00
206_D209_L1.5381.00
16_N361_T1.5261.00
5_L26_I1.4971.00
253_I256_G1.4961.00
252_L256_G1.4801.00
241_T244_A1.4791.00
279_I282_S1.4771.00
329_R339_I1.4681.00
34_V362_V1.4601.00
134_H137_G1.4591.00
349_K359_S1.4551.00
62_I351_L1.4251.00
296_G299_S1.4171.00
7_I26_I1.4031.00
9_D52_D1.3921.00
112_V116_E1.3921.00
22_G36_T1.3871.00
54_V373_S1.3791.00
23_Y37_E1.3671.00
24_V368_L1.3631.00
190_H194_E1.3531.00
114_A117_W1.3471.00
162_K167_E1.3421.00
382_C387_A1.3401.00
128_A132_G1.3391.00
56_L340_A1.3371.00
115_R118_K1.3301.00
131_L134_H1.3291.00
370_I379_L1.3261.00
111_L114_A1.2971.00
275_K282_S1.2941.00
162_K166_Q1.2871.00
50_P55_L1.2851.00
26_I381_I1.2661.00
6_L23_Y1.2621.00
11_A20_K1.2491.00
127_G130_L1.2441.00
159_E163_K1.2371.00
128_A131_L1.2281.00
321_M325_A1.2231.00
289_K292_V1.2231.00
60_I357_K1.2231.00
185_F189_R1.2221.00
60_I347_A1.2111.00
163_K167_E1.2101.00
370_I381_I1.2061.00
371_V377_V1.2011.00
130_L134_H1.2001.00
25_G32_S1.1991.00
7_I368_L1.1981.00
174_I177_L1.1971.00
240_G244_A1.1911.00
269_L272_G1.1911.00
60_I94_S1.1891.00
238_V242_A1.1871.00
9_D51_A1.1801.00
300_V305_R1.1751.00
62_I347_A1.1711.00
242_A246_D1.1691.00
342_I346_N1.1601.00
278_L282_S1.1571.00
14_T17_E1.1461.00
127_G131_L1.1461.00
9_D21_N1.1441.00
22_G35_S1.1431.00
265_K269_L1.1391.00
297_G300_V1.1381.00
173_K178_A1.1311.00
12_I24_V1.1241.00
84_S88_P1.1211.00
229_S233_H1.1171.00
15_E345_E1.1101.00
113_N117_W1.0981.00
131_L136_E1.0961.00
287_G290_D1.0821.00
288_L291_G1.0811.00
278_L281_D1.0711.00
334_C342_I1.0701.00
177_L180_E1.0631.00
175_V178_A1.0621.00
7_I381_I1.0611.00
10_I370_I1.0601.00
23_Y35_S1.0571.00
25_G44_S1.0541.00
191_L194_E1.0521.00
160_L163_K1.0511.00
280_T284_R1.0491.00
129_E132_G1.0491.00
238_V241_T1.0441.00
282_S285_A1.0431.00
207_S211_S1.0411.00
109_Q112_V1.0371.00
173_K176_T1.0351.00
11_A21_N1.0291.00
320_K325_A1.0251.00
186_E189_R1.0251.00
127_G132_G1.0241.00
266_L270_A1.0221.00
132_G135_L1.0191.00
372_S376_E1.0191.00
114_A118_K1.0111.00
113_N116_E1.0081.00
296_G300_V1.0071.00
6_L41_E1.0041.00
18_V337_T1.0031.00
214_A217_G0.9981.00
157_D161_F0.9981.00
129_E133_I0.9961.00
272_G275_K0.9951.00
287_G291_G0.9921.00
275_K279_I0.9901.00
48_Q381_I0.9901.00
157_D160_L0.9871.00
217_G223_H0.9851.00
22_G34_V0.9841.00
268_F271_K0.9841.00
189_R193_D0.9791.00
277_I280_T0.9771.00
176_T180_E0.9761.00
320_K323_E0.9761.00
151_E155_P0.9731.00
126_L129_E0.9711.00
297_G301_T0.9671.00
108_S114_A0.9661.00
132_G136_E0.9641.00
126_L130_L0.9601.00
267_A272_G0.9581.00
236_P241_T0.9581.00
236_P240_G0.9571.00
164_W167_E0.9561.00
81_D85_S0.9551.00
96_L351_L0.9511.00
7_I55_L0.9501.00
173_K177_L0.9461.00
13_V340_A0.9451.00
354_F364_K0.9441.00
275_K284_R0.9421.00
265_K303_R0.9401.00
25_G42_P0.9401.00
108_S112_V0.9401.00
228_M233_H0.9351.00
163_K166_Q0.9291.00
235_E238_V0.9281.00
267_A271_K0.9281.00
281_D285_A0.9271.00
176_T179_P0.9241.00
225_Y228_M0.9181.00
109_Q113_N0.9181.00
277_I281_D0.9151.00
266_L269_L0.9151.00
243_L246_D0.9141.00
159_E162_K0.9111.00
288_L292_V0.9041.00
345_E364_K0.9011.00
301_T338_D0.9011.00
60_I351_L0.8991.00
32_S362_V0.8981.00
271_K275_K0.8971.00
172_I175_V0.8961.00
206_D210_L0.8951.00
201_G204_D0.8921.00
46_E386_I0.8911.00
133_I136_E0.8901.00
160_L165_Q0.8871.00
94_S357_K0.8871.00
289_K293_Y0.8851.00
202_H205_A0.8831.00
281_D284_R0.8821.00
194_E197_I0.8811.00
298_Q301_T0.8811.00
208_A211_S0.8791.00
308_L350_Q0.8791.00
48_Q379_L0.8791.00
228_M231_F0.8761.00
11_A54_V0.8731.00
234_R238_V0.8731.00
242_A245_H0.8711.00
279_I284_R0.8711.00
241_T245_H0.8711.00
268_F272_G0.8711.00
327_H331_F0.8701.00
230_P233_H0.8681.00
252_L255_D0.8671.00
5_L46_E0.8671.00
322_N326_R0.8611.00
165_Q168_A0.8611.00
62_I308_L0.8591.00
164_W169_G0.8581.00
239_I243_L0.8541.00
275_K280_T0.8521.00
172_I178_A0.8521.00
251_E255_D0.8521.00
369_V380_T0.8511.00
343_T347_A0.8481.00
136_E139_F0.8321.00
276_L280_T0.8311.00
171_L174_I0.8291.00
44_S47_I0.8291.00
7_I48_Q0.8291.00
128_A134_H0.8241.00
322_N325_A0.8231.00
203_T206_D0.8211.00
255_D259_S0.8181.00
138_P141_S0.8171.00
236_P239_I0.8171.00
111_L118_K0.8141.00
8_K49_A0.8131.00
172_I176_T0.8111.00
165_Q169_G0.8101.00
88_P382_C0.8061.00
323_E326_R0.8051.00
172_I177_L0.8051.00
88_P380_T0.8041.00
234_R237_G0.8011.00
319_L324_G0.8011.00
158_V162_K0.8001.00
61_D64_I0.7981.00
39_P42_P0.7951.00
189_R192_K0.7951.00
228_M232_H0.7941.00
160_L164_W0.7941.00
130_L136_E0.7901.00
158_V161_F0.7901.00
164_W168_A0.7851.00
153_I156_S0.7851.00
86_R89_E0.7831.00
133_I137_G0.7831.00
157_D168_A0.7801.00
130_L135_L0.7791.00
321_M328_M0.7761.00
279_I283_M0.7751.00
226_N229_S0.7711.00
276_L283_M0.7681.00
171_L176_T0.7671.00
202_H206_D0.7671.00
132_G137_G0.7651.00
276_L282_S0.7651.00
134_H138_P0.7641.00
23_Y39_P0.7601.00
276_L279_I0.7591.00
290_D294_E0.7591.00
213_A217_G0.7561.00
321_M324_G0.7531.00
237_G241_T0.7531.00
377_V380_T0.7531.00
266_L271_K0.7511.00
162_K165_Q0.7511.00
31_I368_L0.7491.00
256_G259_S0.7481.00
127_G134_H0.7481.00
132_G139_F0.7461.00
111_L115_R0.7441.00
299_S332_T0.7421.00
205_A210_L0.7401.00
134_H139_F0.7401.00
59_M343_T0.7381.00
173_K179_P0.7371.00
60_I348_A0.7371.00
130_L138_P0.7371.00
132_G138_P0.7361.00
129_E134_H0.7361.00
150_K154_R0.7341.00
318_I322_N0.7341.00
166_Q169_G0.7341.00
141_S144_R0.7331.00
161_F164_W0.7331.00
291_G295_F0.7321.00
174_I178_A0.7281.00
15_E340_A0.7271.00
320_K324_G0.7241.00
85_S89_E0.7241.00
157_D164_W0.7241.00
170_G173_K0.7231.00
125_L129_E0.7231.00
225_Y229_S0.7231.00
220_H224_L0.7211.00
16_N359_S0.7211.00
112_V115_R0.7201.00
108_S115_R0.7201.00
308_L347_A0.7191.00
110_A113_N0.7191.00
66_G95_F0.7181.00
297_G303_R0.7171.00
266_L272_G0.7161.00
222_T225_Y0.7161.00
210_L214_A0.7151.00
283_M286_K0.7151.00
324_G328_M0.7091.00
127_G133_I0.7071.00
173_K180_E0.7061.00
221_M225_Y0.7051.00
161_F165_Q0.7051.00
13_V54_V0.7051.00
9_D50_P0.7051.00
160_L168_A0.7031.00
88_P388_F0.7031.00
212_D216_A0.6991.00
367_D383_R0.6961.00
280_T285_A0.6911.00
110_A117_W0.6901.00
236_P243_L0.6891.00
277_I282_S0.6891.00
263_A266_L0.6891.00
308_L346_N0.6881.00
187_L191_L0.6851.00
41_E45_K0.6841.00
208_A212_D0.6841.00
53_S379_L0.6841.00
260_H263_A0.6821.00
299_S302_V0.6811.00
66_G83_M0.6791.00
313_T316_G0.6791.00
149_P152_W0.6771.00
10_I368_L0.6771.00
290_D293_Y0.6761.00
5_L48_Q0.6731.00
304_G307_A0.6721.00
186_E190_H0.6711.00
236_P246_D0.6711.00
158_V165_Q0.6701.00
131_L135_L0.6681.00
50_P53_S0.6641.00
299_S303_R0.6621.00
237_G240_G0.6621.00
188_I191_L0.6611.00
175_V179_P0.6601.00
127_G136_E0.6581.00
25_G35_S0.6581.00
59_M321_M0.6571.00
62_I350_Q0.6561.00
220_H225_Y0.6541.00
142_P145_A0.6541.00
93_T367_D0.6521.00
359_S362_V0.6511.00
15_E19_I0.6491.00
152_W156_S0.6471.00
184_H188_I0.6471.00
145_A150_K0.6461.00
325_A339_I0.6441.00
64_I87_L0.6441.00
150_K155_P0.6431.00
248_F252_L0.6421.00
250_T255_D0.6401.00
11_A374_D0.6401.00
128_A133_I0.6391.00
172_I180_E0.6391.00
275_K281_D0.6391.00
16_N19_I0.6381.00
21_N51_A0.6381.00
13_V337_T0.6381.00
22_G360_V0.6371.00
267_A270_A0.6371.00
248_F255_D0.6361.00
129_E136_E0.6351.00
125_L134_H0.6351.00
207_S210_L0.6351.00
107_I110_A0.6341.00
251_E254_A0.6331.00
305_R308_L0.6321.00
192_K219_S0.6321.00
157_D165_Q0.6311.00
234_R242_A0.6291.00
126_L131_L0.6291.00
160_L169_G0.6281.00
217_G225_Y0.6281.00
161_F166_Q0.6281.00
110_A114_A0.6281.00
175_V180_E0.6271.00
282_S286_K0.6271.00
236_P242_A0.6271.00
292_V295_F0.6261.00
240_G243_L0.6201.00
161_F168_A0.6191.00
287_G292_V0.6171.00
126_L133_I0.6171.00
163_K168_A0.6151.00
289_K295_F0.6141.00
306_T309_L0.6121.00
145_A148_Q0.6121.00
325_A330_E0.6111.00
303_R306_T0.6111.00
82_I86_R0.6111.00
357_K367_D0.6061.00
113_N118_K0.6061.00
15_E337_T0.6061.00
219_S222_T0.6041.00
319_L325_A0.5991.00
25_G38_R0.5981.00
278_L283_M0.5981.00
337_T341_N0.5971.00
205_A209_L0.5971.00
125_L133_I0.5941.00
239_I242_A0.5941.00
54_V336_W0.5941.00
279_I285_A0.5911.00
217_G222_T0.5911.00
201_G205_A0.5901.00
289_K294_E0.5891.00
139_F142_P0.5891.00
221_M224_L0.5871.00
108_S118_K0.5851.00
86_R90_E0.5851.00
5_L45_K0.5851.00
248_F251_E0.5821.00
219_S223_H0.5821.00
240_G245_H0.5811.00
277_I283_M0.5801.00
379_L388_F0.5781.00
235_E239_I0.5771.00
288_L293_Y0.5771.00
174_I180_E0.5771.00
287_G294_E0.5771.00
82_I85_S0.5761.00
255_D258_H0.5761.00
150_K153_I0.5751.00
180_E183_Q0.5731.00
131_L137_G0.5731.00
212_D215_K0.5701.00
94_S367_D0.5701.00
325_A328_M0.5691.00
280_T283_M0.5681.00
320_K326_R0.5681.00
238_V243_L0.5671.00
24_V34_V0.5661.00
324_G343_T0.5651.00
136_E141_S0.5641.00
209_L212_D0.5631.00
137_G140_V0.5631.00
125_L128_A0.5621.00
15_E359_S0.5621.00
159_E164_W0.5611.00
143_K146_G0.5601.00
108_S111_L0.5601.00
188_I192_K0.5581.00
265_K272_G0.5571.00
229_S232_H0.5571.00
157_D162_K0.5551.00
253_I259_S0.5531.00
158_V168_A0.5511.00
22_G37_E0.5501.00
66_G84_S0.5491.00
130_L137_G0.5481.00
162_K169_G0.5461.00
21_N37_E0.5461.00
181_E185_F0.5461.00
234_R246_D0.5461.00
231_F234_R0.5451.00
223_H227_A0.5451.00
63_H251_E0.5451.00
294_E299_S0.5451.00
345_E354_F0.5441.00
182_D185_F0.5431.00
204_D209_L0.5421.00
163_K169_G0.5411.00
262_L265_K0.5391.00
227_A230_P0.5381.00
133_I138_P0.5361.00
214_A219_S0.5361.00
84_S95_F0.5351.00
185_F191_L0.5321.00
171_L175_V0.5301.00
151_E154_R0.5301.00
263_A267_A0.5291.00
160_L166_Q0.5281.00
325_A343_T0.5271.00
204_D207_S0.5271.00
107_I114_A0.5261.00
31_I364_K0.5231.00
328_M331_F0.5231.00
238_V246_D0.5231.00
26_I32_S0.5221.00
305_R309_L0.5221.00
319_L322_N0.5201.00
198_A201_G0.5191.00
217_G220_H0.5181.00
348_A358_G0.5181.00
137_G141_S0.5161.00
59_M377_V0.5161.00
249_V252_L0.5131.00
65_H251_E0.5091.00
8_K37_E0.5091.00
87_L92_T0.5081.00
287_G293_Y0.5061.00
234_R239_I0.5041.00
327_H330_E0.5041.00
204_D210_L0.5031.00
238_V245_H0.5031.00
146_G149_P0.5031.00
107_I115_R0.5031.00
10_I52_D0.5021.00
157_D166_Q0.5001.00
220_H350_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vhlA 1 0.9924 100 0.26 Contact Map
1yrrA 3 0.947 100 0.306 Contact Map
3iv8A 2 0.947 100 0.33 Contact Map
1o12A 2 0.9091 100 0.353 Contact Map
3lnpA 2 0.8914 100 0.362 Contact Map
4dzhA 2 0.8889 100 0.375 Contact Map
4v1xA 5 0.9167 100 0.375 Contact Map
2ftwA 3 0.9217 100 0.382 Contact Map
2bb0A 2 0.8763 100 0.383 Contact Map
4f0rA 2 0.8864 100 0.383 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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