GREMLIN Database
YCEF - Uncharacterized membrane protein YceF
UniProt: O34447 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (222)
Sequences: 4528 (2450)
Seq/√Len: 164.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_F168_L3.7011.00
60_E63_R3.6451.00
99_A211_A3.5611.00
77_F147_L3.2391.00
73_G143_E3.1661.00
125_N130_R2.8421.00
198_T235_T2.8331.00
106_V204_G2.6851.00
33_I173_L2.6531.00
36_L157_A2.5761.00
28_V32_L2.5511.00
237_I241_I2.3361.00
79_F83_G2.2961.00
242_N246_Q2.2861.00
64_K183_K2.2381.00
33_I169_I2.2261.00
183_K187_V2.1171.00
107_I111_W2.0821.00
39_L160_V2.0671.00
222_S226_I2.0511.00
66_A142_V2.0361.00
165_W169_I1.9371.00
37_V173_L1.9301.00
201_V231_A1.9181.00
244_Q247_V1.8941.00
108_K112_I1.8501.00
236_L240_Y1.8411.00
69_Y73_G1.8391.00
61_K65_K1.8351.00
83_G164_V1.8071.00
73_G77_F1.7941.00
75_Y172_M1.7601.00
59_P62_Q1.7511.00
104_W108_K1.7381.00
58_L138_T1.7341.00
95_K213_S1.7331.00
235_T238_I1.7211.00
96_V214_A1.6911.00
64_K68_T1.6841.00
27_P30_W1.6721.00
31_G35_S1.6591.00
108_K111_W1.6531.00
234_V238_I1.6521.00
62_Q65_K1.6381.00
235_T239_H1.6201.00
34_G38_V1.6161.00
72_F76_I1.5861.00
223_V227_I1.5491.00
112_I115_K1.5331.00
224_F228_I1.5091.00
193_P242_N1.4891.00
240_Y244_Q1.4831.00
29_S166_V1.4781.00
223_V226_I1.4751.00
103_A207_A1.4691.00
65_K69_Y1.4621.00
22_E26_D1.4511.00
240_Y243_K1.4101.00
76_I80_I1.3891.00
88_L94_I1.3811.00
201_V234_V1.3791.00
77_F143_E1.3551.00
29_S163_K1.3461.00
82_I171_G1.3411.00
241_I245_K1.3281.00
212_G217_Y1.3251.00
231_A234_V1.3241.00
110_F197_N1.3071.00
161_S166_V1.2931.00
140_I144_L1.2921.00
187_V191_K1.2721.00
85_G147_L1.2671.00
230_A234_V1.2581.00
68_T72_F1.2541.00
169_I173_L1.2511.00
69_Y139_V1.2491.00
126_S131_T1.2271.00
26_D29_S1.2261.00
99_A207_A1.2091.00
40_E44_S1.2081.00
236_L239_H1.1991.00
56_K190_D1.1911.00
84_L88_L1.1811.00
238_I241_I1.1691.00
80_I84_L1.1671.00
241_I244_Q1.1641.00
197_N201_V1.1541.00
220_P223_V1.1491.00
227_I231_A1.1431.00
25_T29_S1.1431.00
107_I204_G1.1291.00
194_E242_N1.1171.00
126_S129_V1.1061.00
115_K192_I1.0971.00
115_K118_E1.0951.00
133_G138_T1.0841.00
111_W115_K1.0730.99
111_W194_E1.0730.99
101_Y151_V1.0720.99
58_L66_A1.0430.99
136_W140_I1.0410.99
32_L166_V1.0380.99
132_F137_A1.0250.99
37_V41_G1.0090.99
48_A51_L1.0060.99
109_H200_F0.9950.99
230_A237_I0.9910.99
127_W131_T0.9860.99
95_K206_I0.9830.99
52_A186_L0.9750.99
30_W34_G0.9720.99
208_L212_G0.9640.99
65_K135_F0.9630.99
63_R187_V0.9480.99
232_F235_T0.9460.99
86_M158_F0.9430.99
48_A210_M0.9410.99
79_F171_G0.9310.99
189_I210_M0.9290.99
232_F239_H0.9280.99
228_I231_A0.9270.98
35_S160_V0.9240.98
26_D30_W0.9230.98
29_S169_I0.9200.98
52_A189_I0.9170.98
28_V31_G0.9150.98
209_K213_S0.9140.98
161_S165_W0.9130.98
55_V186_L0.9130.98
92_W96_V0.9110.98
220_P227_I0.9030.98
23_V26_D0.8990.98
75_Y175_I0.8980.98
139_V142_V0.8970.98
229_I233_A0.8940.98
158_F161_S0.8930.98
52_A185_F0.8890.98
191_K243_K0.8870.98
205_I209_K0.8870.98
84_L87_L0.8800.98
174_G185_F0.8770.98
48_A185_F0.8730.98
24_L27_P0.8680.98
128_M131_T0.8640.98
22_E30_W0.8640.98
29_S32_L0.8640.98
77_F80_I0.8630.98
23_V30_W0.8580.98
22_E25_T0.8580.98
36_L167_L0.8570.97
25_T30_W0.8500.97
41_G176_L0.8470.97
83_G87_L0.8430.97
177_M185_F0.8410.97
90_K93_W0.8400.97
157_A167_L0.8380.97
221_H225_F0.8340.97
53_V196_E0.8320.97
209_K224_F0.8310.97
36_L161_S0.8220.97
226_I230_A0.8210.97
87_L90_K0.8200.97
227_I230_A0.8180.97
159_A206_I0.8170.97
106_V203_I0.8160.97
75_Y179_R0.8140.97
55_V183_K0.8100.96
233_A237_I0.8090.96
147_L154_I0.8080.96
195_L239_H0.8050.96
197_N237_I0.7920.96
163_K166_V0.7910.96
193_P243_K0.7890.96
45_A48_A0.7890.96
40_E82_I0.7870.96
89_I154_I0.7810.96
127_W130_R0.7790.96
205_I227_I0.7730.95
58_L139_V0.7720.95
66_A135_F0.7720.95
133_G137_A0.7710.95
168_L172_M0.7690.95
106_V207_A0.7680.95
71_L179_R0.7670.95
52_A139_V0.7640.95
126_S130_R0.7610.95
171_G175_I0.7610.95
27_P31_G0.7610.95
138_T145_M0.7590.95
155_L209_K0.7550.95
171_G174_G0.7500.95
159_A213_S0.7480.95
242_N245_K0.7450.94
137_A140_I0.7440.94
103_A107_I0.7420.94
230_A233_A0.7420.94
101_Y105_L0.7390.94
225_F228_I0.7390.94
125_N129_V0.7370.94
194_E197_N0.7270.94
212_G215_F0.7230.93
136_W139_V0.7180.93
82_I206_I0.7110.93
219_M223_V0.7110.93
94_I97_L0.7030.92
55_V142_V0.7020.92
202_L231_A0.7010.92
194_E238_I0.6970.92
40_E167_L0.6960.92
109_H196_E0.6920.92
44_S81_F0.6880.92
125_N128_M0.6880.92
220_P235_T0.6880.92
126_S247_V0.6830.91
224_F235_T0.6820.91
35_S39_L0.6780.91
63_R190_D0.6730.91
139_V143_E0.6720.91
96_V211_A0.6680.90
99_A197_N0.6670.90
44_S178_M0.6670.90
54_M142_V0.6650.90
189_I195_L0.6630.90
36_L166_V0.6630.90
76_I83_G0.6620.90
228_I239_H0.6600.90
132_F136_W0.6590.90
187_V190_D0.6580.90
110_F114_E0.6580.90
42_L206_I0.6560.90
117_E120_D0.6550.90
63_R182_A0.6540.90
237_I240_Y0.6510.89
40_E149_F0.6510.89
67_L179_R0.6510.89
222_S230_A0.6480.89
25_T163_K0.6440.89
90_K100_L0.6440.89
55_V63_R0.6430.89
243_K247_V0.6420.89
174_G186_L0.6410.89
48_A199_A0.6410.89
219_M227_I0.6390.88
231_A235_T0.6370.88
202_L227_I0.6310.88
97_L100_L0.6270.88
224_F227_I0.6270.88
74_A146_D0.6250.87
228_I232_F0.6240.87
192_I195_L0.6230.87
45_A170_G0.6200.87
60_E64_K0.6140.86
189_I202_L0.6130.86
54_M145_M0.6100.86
85_G88_L0.6020.85
22_E27_P0.6000.85
58_L62_Q0.5980.85
218_E224_F0.5960.85
228_I236_L0.5930.84
151_V154_I0.5930.84
44_S151_V0.5880.84
157_A160_V0.5860.84
213_S217_Y0.5840.84
105_L109_H0.5840.84
234_V239_H0.5820.83
83_G168_L0.5810.83
65_K68_T0.5800.83
63_R186_L0.5800.83
226_I233_A0.5790.83
106_V185_F0.5790.83
95_K210_M0.5780.83
44_S150_S0.5780.83
96_V215_F0.5780.83
202_L233_A0.5770.83
78_R146_D0.5760.83
204_G208_L0.5730.82
53_V200_F0.5730.82
48_A170_G0.5690.82
33_I99_A0.5690.82
58_L134_I0.5670.82
109_H197_N0.5670.82
85_G177_M0.5670.82
44_S167_L0.5670.82
55_V66_A0.5670.82
98_G155_L0.5660.82
236_L241_I0.5650.82
148_A151_V0.5610.81
104_W107_I0.5600.81
220_P224_F0.5590.81
110_F200_F0.5570.81
44_S181_V0.5560.81
73_G139_V0.5560.81
231_A238_I0.5560.81
80_I83_G0.5540.80
81_F150_S0.5540.80
29_S165_W0.5510.80
33_I37_V0.5510.80
114_E118_E0.5500.80
219_M224_F0.5490.80
128_M133_G0.5490.80
167_L210_M0.5480.80
230_A238_I0.5470.79
50_V210_M0.5450.79
98_G199_A0.5430.79
56_K196_E0.5380.78
26_D32_L0.5340.78
49_L189_I0.5320.78
114_E117_E0.5310.77
68_T154_I0.5310.77
27_P219_M0.5300.77
228_I235_T0.5290.77
225_F239_H0.5280.77
239_H243_K0.5280.77
224_F239_H0.5270.77
81_F147_L0.5250.77
130_R133_G0.5230.76
197_N200_F0.5220.76
200_F204_G0.5220.76
49_L167_L0.5220.76
85_G158_F0.5190.76
151_V228_I0.5170.76
54_M138_T0.5170.76
44_S177_M0.5170.76
97_L246_Q0.5170.76
32_L161_S0.5120.75
101_Y104_W0.5110.75
23_V27_P0.5100.75
89_I95_K0.5080.74
66_A139_V0.5070.74
134_I137_A0.5070.74
144_L148_A0.5010.73
39_L69_Y0.5010.73
125_N131_T0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kncA 1 0.1868 54.1 0.944 Contact Map
1pw4A 1 0.9533 46.4 0.946 Contact Map
3giaA 1 0.9261 43 0.947 Contact Map
4czbA 2 0.8833 41.1 0.948 Contact Map
2gfpA 2 0.9922 34.8 0.95 Contact Map
4w6vA 1 0.4202 32.7 0.95 Contact Map
2cfqA 1 0.4981 26.8 0.952 Contact Map
4xnjA 1 0.9689 26.1 0.953 Contact Map
3wdoA 1 0.9728 23.4 0.954 Contact Map
3o7qA 1 0.428 22.9 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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