GREMLIN Database
APT - Adenine phosphoribosyltransferase
UniProt: O34443 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 170 (161)
Sequences: 4488 (2465)
Seq/√Len: 194.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_R140_V3.1691.00
86_E105_K2.6821.00
51_L112_Q2.6791.00
9_I19_Q2.6181.00
154_D157_N2.5091.00
90_V132_K2.5011.00
90_V136_E2.4381.00
149_E156_R2.4071.00
91_D100_V2.2921.00
156_R160_E2.2851.00
8_T85_R2.1881.00
38_D69_A2.1661.00
50_D112_Q2.1651.00
93_G98_K2.1621.00
134_V139_G2.1361.00
127_I146_F1.9681.00
128_E132_K1.9471.00
9_I21_K1.9091.00
89_K100_V1.8911.00
43_Y165_L1.8711.00
34_R69_A1.8591.00
109_K112_Q1.8141.00
53_V77_V1.7791.00
77_V130_T1.7781.00
41_V69_A1.7771.00
128_E158_K1.7761.00
91_D98_K1.7611.00
55_P130_T1.7411.00
12_D16_E1.7381.00
135_E162_Y1.7331.00
88_I137_L1.7311.00
42_E45_K1.7221.00
89_K102_T1.6781.00
49_I72_V1.6491.00
48_Q113_R1.6291.00
113_R142_A1.5181.00
11_P19_Q1.4931.00
47_K163_D1.4871.00
131_I144_I1.4851.00
67_A74_F1.4711.00
110_P138_G1.4541.00
39_Q42_E1.4451.00
34_R68_Y1.4441.00
33_Y64_C1.4361.00
88_I105_K1.4351.00
53_V134_V1.4051.00
40_I145_A1.3931.00
24_T104_H1.3841.00
127_I144_I1.3781.00
44_A145_A1.3761.00
31_D71_G1.3521.00
54_G74_F1.3121.00
117_T145_A1.3001.00
94_L97_G1.2961.00
44_A143_G1.2941.00
157_N160_E1.2901.00
157_N161_D1.2861.00
108_I139_G1.2841.00
85_R104_H1.2781.00
51_L75_A1.2691.00
120_L148_I1.2561.00
63_G74_F1.2341.00
21_K152_Y1.1771.00
80_E100_V1.1731.00
40_I66_V1.1731.00
44_A115_L1.1651.00
38_D68_Y1.1611.00
36_A147_L1.1541.00
48_Q72_V1.1491.00
80_E99_D1.1411.00
34_R38_D1.1351.00
116_I130_T1.1341.00
34_R71_G1.1211.00
43_Y143_G1.1061.00
41_V66_V1.1011.00
52_V72_V1.1011.00
41_V70_L1.0991.00
51_L73_G1.0791.00
108_I134_V1.0731.00
35_Y38_D1.0731.00
132_K135_E1.0721.00
44_A49_I1.0561.00
49_I115_L1.0531.00
134_V141_V1.0461.00
131_I135_E1.0351.00
41_V45_K1.0301.00
49_I70_L1.0111.00
115_L143_G1.0101.00
24_T76_P0.9931.00
115_L142_A0.9840.99
135_E140_V0.9770.99
33_Y65_P0.9710.99
39_Q43_Y0.9590.99
88_I136_E0.9400.99
8_T25_T0.9330.99
156_R164_I0.9200.99
55_P101_L0.9130.99
53_V130_T0.9090.99
116_I127_I0.9020.99
50_D111_G0.8910.99
64_C74_F0.8870.99
61_I76_P0.8850.99
131_I141_V0.8820.99
51_L108_I0.8780.99
37_T66_V0.8740.99
9_I152_Y0.8630.99
66_V117_T0.8630.99
116_I131_I0.8620.99
62_I147_L0.8430.98
65_P68_Y0.8420.98
35_Y39_Q0.8410.98
15_K18_V0.8360.98
111_G140_V0.8320.98
37_T65_P0.8300.98
33_Y37_T0.8290.98
53_V103_I0.8210.98
36_A40_I0.8160.98
143_G163_D0.8160.98
26_L36_A0.8100.98
149_E155_G0.8070.98
39_Q167_L0.8010.98
92_Y96_Y0.7970.98
53_V116_I0.7920.98
121_L146_F0.7870.97
10_V85_R0.7720.97
132_K136_E0.7710.97
37_T68_Y0.7660.97
44_A47_K0.7600.97
151_S154_D0.7590.97
40_I43_Y0.7530.97
39_Q165_L0.7490.97
61_I74_F0.7430.96
23_I27_M0.7410.96
40_I117_T0.7340.96
45_K69_A0.7280.96
106_D137_L0.7230.96
46_E49_I0.7220.96
25_T28_D0.7210.96
128_E162_Y0.7190.96
32_V35_Y0.7190.96
145_A165_L0.7180.96
87_V102_T0.7150.96
146_F164_I0.7120.95
19_Q152_Y0.7120.95
15_K99_D0.7090.95
143_G165_L0.7020.95
131_I162_Y0.6970.95
151_S156_R0.6970.95
29_K32_V0.6950.95
49_I52_V0.6930.95
85_R105_K0.6860.94
33_Y61_I0.6860.94
24_T147_L0.6850.94
80_E102_T0.6830.94
80_E97_G0.6820.94
10_V104_H0.6810.94
149_E166_T0.6790.94
44_A165_L0.6790.94
120_L150_L0.6760.94
116_I144_I0.6730.94
20_F148_I0.6710.94
80_E89_K0.6680.94
105_K136_E0.6630.93
114_V134_V0.6630.93
33_Y62_I0.6600.93
51_L109_K0.6580.93
31_D35_Y0.6560.93
84_P96_Y0.6550.93
37_T69_A0.6490.93
25_T120_L0.6470.93
135_E144_I0.6450.92
50_D72_V0.6440.92
43_Y145_A0.6440.92
88_I103_I0.6390.92
47_K113_R0.6360.92
9_I120_L0.6360.92
53_V108_I0.6320.92
132_K162_Y0.6310.92
125_G158_K0.6290.92
94_L99_D0.6260.91
36_A62_I0.6250.91
121_L155_G0.6240.91
30_G68_Y0.6170.91
86_E106_D0.6100.90
116_I134_V0.6090.90
93_G96_Y0.6040.90
52_V70_L0.6020.90
61_I64_C0.6020.90
158_K161_D0.6010.90
43_Y163_D0.5960.89
81_G97_G0.5930.89
112_Q139_G0.5840.88
49_I143_G0.5810.88
128_E161_D0.5810.88
13_Y18_V0.5810.88
51_L114_V0.5800.88
81_G102_T0.5740.87
160_E163_D0.5730.87
86_E104_H0.5730.87
7_V21_K0.5680.87
8_T106_D0.5630.86
73_G76_P0.5630.86
21_K150_L0.5610.86
23_I26_L0.5610.86
52_V67_A0.5590.86
7_V26_L0.5580.86
36_A39_Q0.5530.85
78_R99_D0.5500.85
78_R83_L0.5490.85
127_I164_I0.5460.85
144_I159_L0.5450.85
27_M62_I0.5440.84
27_M61_I0.5430.84
104_H107_A0.5390.84
83_L96_Y0.5360.84
90_V100_V0.5350.83
12_D19_Q0.5320.83
44_A52_V0.5320.83
23_I148_I0.5320.83
40_I147_L0.5290.83
17_G22_D0.5280.83
33_Y117_T0.5270.83
28_D109_K0.5270.83
30_G64_C0.5250.82
121_L149_E0.5220.82
52_V66_V0.5220.82
9_I151_S0.5210.82
85_R106_D0.5200.82
108_I112_Q0.5140.81
93_G99_D0.5130.81
63_G67_A0.5120.81
103_I137_L0.5110.81
135_E141_V0.5090.80
13_Y51_L0.5080.80
20_F82_K0.5050.80
12_D17_G0.5050.80
53_V75_A0.5030.80
50_D109_K0.5030.80
82_K102_T0.5010.79
146_F166_T0.5010.79
87_V104_H0.5010.79
92_Y95_E0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lzaA 2 1 100 0.292 Contact Map
4m0kA 2 0.9941 100 0.316 Contact Map
1qb7A 2 1 100 0.427 Contact Map
2dy0A 2 1 100 0.456 Contact Map
1g2qA 2 0.9824 100 0.462 Contact Map
1zn8A 2 1 100 0.464 Contact Map
1l1qA 2 0.9941 100 0.475 Contact Map
1o57A 2 0.9529 100 0.534 Contact Map
1vchA 5 0.9353 99.9 0.541 Contact Map
1y0bA 2 1 99.9 0.555 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0068 seconds.