GREMLIN Database
MGTE - Magnesium transporter MgtE
UniProt: O34442 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 451 (437)
Sequences: 2920 (2047)
Seq/√Len: 97.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_N181_Q6.0181.00
212_D215_Q4.1401.00
22_K25_D3.9781.00
100_Q138_R3.8851.00
149_Q183_V3.7961.00
198_E202_D3.7661.00
136_A220_V3.7431.00
215_Q219_E3.4641.00
228_D252_D3.4511.00
211_A234_V3.3851.00
132_P135_S3.3041.00
236_E240_V3.2931.00
199_K202_D3.2431.00
357_F361_R3.2291.00
147_I173_L3.1371.00
213_A242_V3.0061.00
147_I200_V2.8641.00
225_E255_I2.8561.00
149_Q201_Q2.7221.00
282_A369_V2.6431.00
290_I294_F2.6391.00
147_I156_A2.6131.00
408_I412_I2.5861.00
247_V251_I2.5841.00
332_T425_G2.5431.00
210_S239_N2.4921.00
136_A245_V2.4681.00
154_K158_V2.4141.00
78_L86_A2.3671.00
218_E261_D2.3651.00
122_S126_Q2.3281.00
211_A232_I2.3231.00
103_E138_R2.2881.00
139_M253_V2.2361.00
325_G429_T2.2361.00
175_V200_V2.2211.00
412_I416_L2.1991.00
132_P214_L2.1771.00
320_M324_S2.1731.00
98_L125_V2.0941.00
214_L237_E2.0831.00
303_I318_F2.0791.00
211_A223_L2.0561.00
188_Y192_I2.0481.00
194_G198_E2.0431.00
217_Q257_E2.0121.00
37_D226_R1.9701.00
372_V376_I1.9361.00
308_D311_K1.9351.00
393_S443_I1.9341.00
106_D109_L1.9261.00
194_G203_L1.8961.00
181_Q239_N1.8901.00
220_V232_I1.8861.00
176_I241_L1.8761.00
280_V283_Y1.8711.00
307_E311_K1.8681.00
257_E261_D1.8661.00
118_E121_E1.8661.00
211_A220_V1.8631.00
212_D239_N1.8531.00
397_L439_I1.8511.00
16_I20_D1.8301.00
151_Y159_K1.8181.00
215_Q223_L1.8091.00
34_Q227_Y1.7821.00
211_A215_Q1.7731.00
169_S244_I1.7691.00
221_A254_V1.7471.00
308_D312_Q1.7431.00
223_L232_I1.7201.00
220_V245_V1.7091.00
398_T436_S1.6831.00
259_D263_E1.6781.00
58_T61_D1.6761.00
99_A128_L1.6741.00
303_I320_M1.6581.00
30_I38_M1.6511.00
148_P178_E1.6451.00
286_L369_V1.6441.00
153_V203_L1.6051.00
96_D246_T1.5871.00
309_A445_T1.5831.00
82_G85_K1.5761.00
379_I388_G1.5701.00
319_F440_Y1.5691.00
45_M53_Y1.5681.00
151_Y155_D1.5671.00
437_L440_Y1.5631.00
15_I49_H1.5631.00
431_L435_L1.5621.00
316_L444_A1.5571.00
251_I254_V1.5531.00
212_D237_E1.5531.00
172_Y185_V1.5501.00
134_D138_R1.5371.00
176_I180_K1.5181.00
14_I41_I1.4991.00
83_K112_Q1.4791.00
153_V200_V1.4571.00
327_T436_S1.4501.00
310_L320_M1.4471.00
217_Q253_V1.4441.00
46_P49_H1.4261.00
320_M437_L1.4211.00
303_I315_A1.4141.00
306_F442_G1.4131.00
293_L324_S1.4121.00
386_L389_F1.4081.00
222_R225_E1.4000.99
282_A365_F1.3890.99
371_S388_G1.3890.99
216_D257_E1.3840.99
154_K196_P1.3820.99
363_S400_I1.3770.99
78_L101_L1.3700.99
310_L437_L1.3270.99
310_L314_V1.3250.99
378_S391_V1.3240.99
297_L381_W1.3210.99
175_V204_M1.3140.99
34_Q37_D1.3060.99
99_A125_V1.3060.99
145_V160_L1.2930.99
318_F381_W1.2930.99
218_E260_E1.2800.99
35_P39_A1.2710.99
187_S190_D1.2690.99
216_D260_E1.2690.99
161_K196_P1.2670.99
277_K280_V1.2640.99
340_R344_K1.2620.99
235_V239_N1.2610.99
318_F382_Q1.2490.99
96_D249_D1.2430.99
327_T398_T1.2410.99
281_A337_V1.2360.99
38_M65_M1.2270.99
146_W176_I1.2250.99
310_L317_A1.2210.99
37_D227_Y1.2180.99
90_M117_M1.2070.98
74_Q104_E1.2070.98
50_R73_F1.2020.98
14_I26_F1.2020.98
401_I435_L1.1980.98
326_M399_L1.1900.98
159_K163_F1.1730.98
87_T98_L1.1700.98
135_S217_Q1.1650.98
371_S392_A1.1640.98
68_E228_D1.1640.98
220_V224_I1.1580.98
296_G330_T1.1520.98
95_N141_T1.1460.98
152_T155_D1.1440.98
437_L441_F1.1380.98
136_A211_A1.1370.98
224_I247_V1.1300.98
50_R76_V1.1260.98
304_S307_E1.1180.97
368_A372_V1.1140.97
325_G329_N1.1120.97
17_L22_K1.1100.97
337_V427_L1.1090.97
278_A362_T1.1010.97
250_I254_V1.1000.97
360_F400_I1.0940.97
253_V257_E1.0850.97
413_L423_A1.0780.97
326_M434_I1.0770.97
364_I400_I1.0760.97
353_V357_F1.0740.97
96_D248_D1.0710.97
260_E264_K1.0710.97
263_E268_S1.0680.97
326_M430_T1.0680.97
278_A282_A1.0600.97
13_R29_V1.0570.96
91_N118_E1.0540.96
180_K240_V1.0540.96
386_L447_F1.0500.96
157_V161_K1.0420.96
352_I411_I1.0400.96
296_G434_I1.0360.96
300_G395_L1.0360.96
393_S447_F1.0360.96
31_D58_T1.0320.96
182_L208_V1.0310.96
195_E198_E1.0300.96
273_T355_L1.0290.96
177_N183_V1.0270.96
293_L326_M1.0250.96
282_A286_L1.0230.96
153_V191_L1.0210.96
292_L426_P1.0180.96
96_D168_E1.0160.96
119_A123_K1.0090.95
234_V245_V1.0070.95
298_I302_I0.9970.95
153_V186_L0.9950.95
35_P61_D0.9950.95
300_G441_F0.9930.95
320_M323_V0.9910.95
426_P440_Y0.9900.95
149_Q200_V0.9890.95
139_M217_Q0.9880.95
262_Y265_F0.9880.95
342_L411_I0.9860.95
379_I385_A0.9850.95
100_Q103_E0.9850.95
182_L210_S0.9850.95
171_N230_L0.9830.95
442_G446_A0.9820.95
174_Y231_A0.9810.95
358_R402_G0.9800.95
310_L324_S0.9720.94
317_A437_L0.9710.94
150_H178_E0.9690.94
338_V347_M0.9660.94
218_E257_E0.9660.94
432_N441_F0.9610.94
299_S322_M0.9610.94
141_T144_Y0.9590.94
337_V402_G0.9580.94
292_L295_I0.9570.94
294_F298_I0.9560.94
217_Q261_D0.9560.94
216_D261_D0.9550.94
375_A392_A0.9550.94
157_V196_P0.9530.94
39_A68_E0.9480.94
93_M101_L0.9430.93
97_D249_D0.9410.93
151_Y156_A0.9390.93
73_F76_V0.9390.93
105_M110_K0.9360.93
299_S320_M0.9360.93
292_L441_F0.9350.93
132_P138_R0.9310.93
174_Y182_L0.9300.93
292_L440_Y0.9250.93
148_P151_Y0.9250.93
292_L299_S0.9220.93
103_E129_M0.9190.93
393_S396_F0.9150.92
144_Y241_L0.9130.92
221_A253_V0.9090.92
97_D246_T0.9060.92
153_V194_G0.9050.92
327_T432_N0.9030.92
200_V203_L0.9020.92
98_L121_E0.8940.91
224_I250_I0.8870.91
174_Y233_P0.8870.91
290_I373_L0.8850.91
129_M135_S0.8840.91
397_L443_I0.8840.91
324_S437_L0.8840.91
13_R17_L0.8820.91
278_A365_F0.8800.91
155_D158_V0.8770.91
353_V376_I0.8750.91
310_L321_P0.8750.91
325_G339_I0.8720.90
50_R54_L0.8710.90
139_M245_V0.8680.90
359_E419_D0.8680.90
91_N120_S0.8660.90
236_E242_V0.8650.90
290_I370_C0.8650.90
17_L29_V0.8610.90
98_L102_L0.8580.90
371_S396_F0.8580.90
246_T249_D0.8580.90
77_V81_V0.8560.90
107_E111_E0.8540.89
106_D110_K0.8540.89
388_G392_A0.8530.89
254_V258_A0.8520.89
232_I250_I0.8500.89
62_I89_A0.8490.89
212_D219_E0.8480.89
366_I432_N0.8470.89
295_I324_S0.8440.89
296_G325_G0.8420.89
295_I426_P0.8420.89
401_I439_I0.8390.89
259_D340_R0.8380.89
315_A378_S0.8370.89
134_D216_D0.8300.88
378_S388_G0.8230.88
14_I29_V0.8230.88
281_A358_R0.8230.88
216_D253_V0.8230.88
367_G396_F0.8220.88
398_T432_N0.8210.88
127_L142_N0.8210.88
361_R364_I0.8170.87
172_Y231_A0.8140.87
55_S106_D0.8140.87
401_I431_L0.8100.87
142_N242_V0.8090.87
147_I151_Y0.8090.87
432_N437_L0.8060.87
366_I436_S0.8040.86
323_V326_M0.8030.86
281_A362_T0.8020.86
297_L374_I0.8020.86
325_G431_L0.8010.86
99_A142_N0.8000.86
33_L38_M0.7980.86
363_S367_G0.7970.86
319_F391_V0.7950.86
66_I89_A0.7950.86
100_Q253_V0.7950.86
342_L414_H0.7920.86
54_L65_M0.7910.86
432_N440_Y0.7900.85
97_D248_D0.7900.85
131_Y137_G0.7870.85
203_L371_S0.7850.85
435_L439_I0.7850.85
367_G424_S0.7850.85
292_L326_M0.7830.85
371_S397_L0.7790.85
141_T169_S0.7770.85
303_I321_P0.7760.84
259_D344_K0.7760.84
343_S421_A0.7740.84
262_Y266_A0.7740.84
148_P177_N0.7720.84
273_T377_V0.7710.84
322_M374_I0.7710.84
186_L200_V0.7710.84
45_M49_H0.7700.84
158_V196_P0.7700.84
286_L370_C0.7690.84
335_L338_V0.7670.84
211_A245_V0.7650.84
326_M370_C0.7650.84
341_G347_M0.7640.84
131_Y213_A0.7620.83
21_G52_R0.7600.83
55_S59_V0.7580.83
170_I244_I0.7580.83
302_I438_L0.7560.83
303_I437_L0.7540.83
185_V189_R0.7520.83
49_H388_G0.7490.82
334_S406_G0.7480.82
164_A193_L0.7480.82
314_V317_A0.7470.82
325_G398_T0.7440.82
301_S310_L0.7440.82
296_G426_P0.7420.82
187_S207_R0.7420.82
84_T88_L0.7400.82
181_Q240_V0.7400.82
374_I377_V0.7390.81
172_Y187_S0.7370.81
169_S200_V0.7360.81
280_V284_R0.7350.81
390_V444_A0.7330.81
293_L296_G0.7320.81
95_N98_L0.7320.81
392_A417_K0.7300.81
322_M398_T0.7280.81
26_F30_I0.7280.81
332_T339_I0.7250.80
169_S189_R0.7230.80
141_T244_I0.7220.80
307_E429_T0.7220.80
132_P154_K0.7200.80
230_L247_V0.7190.80
63_T100_Q0.7180.80
134_D217_Q0.7170.79
36_Y226_R0.7170.79
370_C395_L0.7150.79
274_F346_E0.7140.79
325_G371_S0.7130.79
94_D113_L0.7130.79
66_I69_L0.7120.79
298_I301_S0.7110.79
322_M440_Y0.7110.79
248_D252_D0.7100.79
130_N138_R0.7090.79
362_T427_L0.7090.79
326_M418_V0.7060.78
33_L41_I0.7050.78
38_M61_D0.7020.78
309_A312_Q0.7020.78
292_L398_T0.7020.78
292_L432_N0.7020.78
364_I368_A0.7010.78
67_G97_D0.7000.78
319_F428_I0.6970.78
295_I337_V0.6970.78
96_D141_T0.6970.78
395_L403_T0.6950.77
281_A335_L0.6930.77
383_G401_I0.6920.77
27_R31_D0.6900.77
114_L117_M0.6890.77
286_L290_I0.6860.76
341_G424_S0.6860.76
360_F404_M0.6850.76
253_V261_D0.6810.76
326_M394_S0.6810.76
38_M105_M0.6810.76
374_I378_S0.6790.76
292_L322_M0.6770.75
323_V398_T0.6760.75
404_M431_L0.6760.75
319_F322_M0.6750.75
330_T395_L0.6750.75
298_I434_I0.6740.75
356_I360_F0.6740.75
302_I434_I0.6730.75
99_A103_E0.6700.75
171_N187_S0.6700.75
327_T336_A0.6680.75
219_E222_R0.6680.75
295_I437_L0.6670.74
267_A373_L0.6660.74
355_L407_T0.6660.74
185_V233_P0.6660.74
186_L191_L0.6650.74
325_G413_L0.6650.74
86_A109_L0.6640.74
78_L113_L0.6630.74
23_I52_R0.6620.74
190_D205_F0.6610.74
262_Y336_A0.6600.74
374_I399_L0.6590.74
319_F437_L0.6590.74
426_P437_L0.6580.73
418_V422_I0.6550.73
12_L16_I0.6550.73
182_L233_P0.6550.73
321_P324_S0.6550.73
136_A217_Q0.6540.73
25_D28_S0.6530.73
385_A389_F0.6530.73
277_K281_A0.6520.73
391_V440_Y0.6510.73
292_L437_L0.6510.73
95_N128_L0.6480.72
95_N142_N0.6480.72
154_K197_E0.6480.72
325_G440_Y0.6480.72
154_K194_G0.6460.72
296_G425_G0.6460.72
288_W420_P0.6460.72
307_E310_L0.6440.72
13_R200_V0.6430.72
292_L340_R0.6420.72
349_K353_V0.6420.72
442_G445_T0.6410.71
62_I85_K0.6410.71
356_I404_M0.6400.71
381_W392_A0.6380.71
105_M252_D0.6370.71
17_L25_D0.6360.71
293_L374_I0.6360.71
104_E110_K0.6350.71
145_V163_F0.6330.71
267_A292_L0.6320.70
300_G324_S0.6320.70
279_Y365_F0.6310.70
360_F364_I0.6310.70
308_D315_A0.6310.70
292_L335_L0.6270.70
217_Q247_V0.6260.70
157_V188_Y0.6230.69
303_I317_A0.6230.69
392_A395_L0.6210.69
199_K376_I0.6200.69
150_H201_Q0.6180.69
29_V32_E0.6180.69
295_I441_F0.6180.69
144_Y244_I0.6160.68
358_R395_L0.6150.68
47_E76_V0.6150.68
332_T399_L0.6100.68
344_K391_V0.6100.68
128_L142_N0.6100.68
293_L335_L0.6090.68
375_A390_V0.6090.68
139_M220_V0.6080.67
89_A174_Y0.6070.67
67_G102_L0.6070.67
161_K195_E0.6060.67
297_L377_V0.6040.67
255_I259_D0.6040.67
190_D194_G0.6030.67
381_W405_S0.6030.67
404_M408_I0.6020.67
24_R28_S0.6010.67
146_W180_K0.6000.66
361_R365_F0.5990.66
330_T334_S0.5990.66
51_A80_K0.5980.66
165_E193_L0.5980.66
169_S231_A0.5980.66
215_Q255_I0.5970.66
31_D61_D0.5960.66
69_L73_F0.5960.66
29_V368_A0.5950.66
66_I74_Q0.5940.66
297_L301_S0.5930.66
208_V211_A0.5920.65
158_V161_K0.5910.65
184_G204_M0.5910.65
147_I175_V0.5880.65
185_V208_V0.5880.65
224_I231_A0.5860.65
296_G432_N0.5860.65
303_I426_P0.5850.65
174_Y185_V0.5840.64
145_V167_A0.5830.64
274_F330_T0.5830.64
224_I232_I0.5820.64
113_L229_F0.5810.64
95_N138_R0.5800.64
300_G425_G0.5790.64
335_L424_S0.5780.64
327_T338_V0.5780.64
132_P213_A0.5780.64
198_E203_L0.5770.63
337_V356_I0.5770.63
156_A200_V0.5760.63
70_E73_F0.5760.63
258_A344_K0.5750.63
375_A387_L0.5750.63
292_L366_I0.5750.63
63_T92_K0.5740.63
299_S358_R0.5730.63
116_S341_G0.5730.63
186_L203_L0.5730.63
402_G427_L0.5730.63
299_S303_I0.5720.63
15_I19_R0.5720.63
81_V128_L0.5720.63
299_S434_I0.5710.63
309_A313_V0.5710.63
324_S440_Y0.5690.62
337_V422_I0.5680.62
303_I325_G0.5680.62
299_S330_T0.5670.62
150_H155_D0.5650.62
176_I183_V0.5640.62
54_L77_V0.5640.62
355_L432_N0.5620.61
313_V384_N0.5610.61
202_D205_F0.5610.61
318_F437_L0.5600.61
330_T399_L0.5590.61
222_R226_R0.5590.61
181_Q238_N0.5580.61
42_F53_Y0.5570.61
204_M209_I0.5560.61
425_G430_T0.5560.61
355_L370_C0.5550.60
349_K411_I0.5550.60
287_P291_L0.5520.60
43_K70_E0.5520.60
315_A318_F0.5520.60
324_S436_S0.5520.60
295_I425_G0.5500.60
325_G332_T0.5500.60
39_A43_K0.5490.60
125_V143_R0.5470.59
268_S337_V0.5460.59
423_A427_L0.5450.59
304_S318_F0.5440.59
296_G437_L0.5440.59
87_T91_N0.5440.59
222_R345_E0.5430.59
425_G432_N0.5430.59
340_R419_D0.5430.59
180_K191_L0.5420.59
303_I382_Q0.5420.59
82_G88_L0.5370.58
302_I318_F0.5370.58
12_L15_I0.5360.58
364_I396_F0.5360.58
63_T89_A0.5360.58
179_S294_F0.5350.58
325_G437_L0.5330.57
330_T402_G0.5290.57
282_A373_L0.5270.57
296_G324_S0.5270.57
98_L101_L0.5260.56
129_M248_D0.5260.56
332_T429_T0.5260.56
379_I383_G0.5250.56
328_G433_D0.5250.56
291_L336_A0.5250.56
107_E110_K0.5230.56
129_M247_V0.5230.56
334_S407_T0.5230.56
324_S391_V0.5220.56
324_S432_N0.5220.56
349_K352_I0.5220.56
295_I432_N0.5220.56
231_A246_T0.5210.56
68_E121_E0.5210.56
339_I414_H0.5210.56
295_I434_I0.5200.56
94_D366_I0.5200.56
30_I56_Y0.5200.56
406_G410_P0.5190.55
363_S399_L0.5190.55
189_R208_V0.5190.55
279_Y283_Y0.5190.55
48_K201_Q0.5180.55
321_P403_T0.5180.55
286_L358_R0.5160.55
358_R428_I0.5140.55
156_A257_E0.5140.55
217_Q221_A0.5130.55
356_I408_I0.5130.55
340_R421_A0.5130.55
18_L93_M0.5120.54
169_S230_L0.5110.54
16_I48_K0.5110.54
114_L129_M0.5110.54
25_D446_A0.5110.54
278_A361_R0.5100.54
386_L448_I0.5090.54
93_M153_V0.5090.54
128_L138_R0.5080.54
131_Y242_V0.5080.54
190_D203_L0.5080.54
250_I258_A0.5080.54
95_N99_A0.5080.54
172_Y189_R0.5070.54
398_T403_T0.5070.54
315_A321_P0.5060.54
79_N109_L0.5060.54
287_P335_L0.5060.54
27_R56_Y0.5060.54
30_I207_R0.5060.54
310_L338_V0.5050.53
210_S219_E0.5050.53
317_A327_T0.5030.53
304_S381_W0.5030.53
228_D248_D0.5020.53
96_D100_Q0.5020.53
155_D199_K0.5020.53
284_R337_V0.5010.53
204_M244_I0.5010.53
295_I398_T0.5000.53
265_F332_T0.5000.53
52_R55_S0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zy9A 2 0.9424 100 0.276 Contact Map
2ouxA 2 0.5632 100 0.599 Contact Map
4u9nA 2 0.3947 100 0.67 Contact Map
2yvyA 2 0.5432 100 0.68 Contact Map
3kxrA 3 0.3792 100 0.706 Contact Map
3ocoA 2 0.286 99.9 0.848 Contact Map
4hg0A 2 0.4789 99.9 0.848 Contact Map
3lhhA 1 0.2639 99.9 0.85 Contact Map
3oi8A 2 0.3326 99.8 0.852 Contact Map
3ocmA 5 0.3171 99.8 0.852 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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