GREMLIN Database
YLOC - UPF0701 protein YloC
UniProt: O34441 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 291 (288)
Sequences: 2345 (1772)
Seq/√Len: 104.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_E233_R4.6661.00
56_H142_K3.9181.00
174_E226_K3.7731.00
186_E190_A3.3661.00
52_T138_E3.3361.00
261_G273_V3.2241.00
82_W94_D3.1661.00
86_D98_R3.0711.00
3_R149_E2.8881.00
57_I62_I2.7841.00
26_S144_L2.7691.00
49_L137_A2.7531.00
176_L266_D2.5191.00
164_D233_R2.4871.00
81_D118_Q2.4511.00
22_V66_V2.4021.00
156_A160_L2.3911.00
57_I144_L2.3891.00
162_H279_S2.3161.00
166_L276_M2.2751.00
156_A237_A2.1801.00
11_A136_A2.1571.00
182_S186_E2.1411.00
257_A276_M2.1181.00
106_D109_D2.0761.00
257_A280_I2.0261.00
163_I232_F1.9311.00
36_A49_L1.9141.00
53_I64_L1.8911.00
56_H145_C1.8891.00
160_L233_R1.8861.00
167_E230_A1.8591.00
158_D162_H1.8541.00
158_D223_T1.8311.00
85_L95_M1.8141.00
169_L272_L1.8001.00
159_C283_I1.7921.00
190_A194_E1.7881.00
162_H219_T1.7821.00
82_W98_R1.7641.00
185_R189_Y1.7591.00
154_L227_S1.7411.00
53_I141_V1.7391.00
149_E153_L1.7221.00
3_R145_C1.7101.00
96_K103_A1.6891.00
13_K136_A1.6821.00
173_T269_I1.6611.00
218_I260_I1.6481.00
134_I138_E1.6381.00
172_E272_L1.6301.00
147_M231_Q1.5951.00
167_E171_R1.5901.00
189_Y193_K1.5871.00
89_V93_R1.5831.00
130_E134_I1.5741.00
143_G146_E1.5541.00
26_S62_I1.5541.00
171_R174_E1.5531.00
89_V99_Y1.5461.00
171_R226_K1.5271.00
29_Y61_R1.5211.00
22_V136_A1.5051.00
225_L253_L1.4911.00
176_L183_R1.4811.00
250_V283_I1.4781.00
56_H138_E1.4611.00
174_E222_I1.4531.00
86_D99_Y1.4501.00
279_S282_K1.4301.00
168_E172_E1.4301.00
146_E150_K1.4181.00
235_I249_L1.4161.00
166_L229_F1.4131.00
138_E142_K1.4111.00
179_D182_S1.3971.00
35_N61_R1.3881.00
146_E149_E1.3801.00
13_K139_E1.3500.99
42_L68_V1.3480.99
11_A140_A1.3430.99
273_V280_I1.3380.99
34_V53_I1.3370.99
232_F253_L1.3350.99
173_T272_L1.3300.99
165_Q279_S1.3290.99
53_I137_A1.3230.99
176_L268_Q1.3170.99
160_L164_D1.3060.99
19_S69_D1.3060.99
212_F216_S1.2840.99
165_Q168_E1.2800.99
48_K130_E1.2720.99
9_G140_A1.2680.99
229_F253_L1.2660.99
157_K161_M1.2590.99
86_D90_A1.2580.99
189_Y202_E1.2530.99
190_A193_K1.2370.99
169_L172_E1.2360.99
167_E226_K1.2360.99
163_I229_F1.2330.99
218_I269_I1.2260.99
20_V136_A1.2050.99
172_E175_L1.2050.99
11_A139_E1.2040.99
267_H270_T1.2010.99
22_V137_A1.1880.99
153_L156_A1.1600.98
159_C287_V1.1560.98
53_I57_I1.1420.98
88_F113_L1.1410.98
182_S185_R1.1340.98
200_L205_L1.1260.98
52_T137_A1.1200.98
153_L157_K1.1150.98
52_T134_I1.1130.98
55_Q138_E1.1120.98
81_D84_L1.1110.98
12_S21_S1.1110.98
176_L179_D1.1100.98
103_A106_D1.1060.98
48_K134_I1.1020.98
161_M165_Q1.1000.98
51_Q55_Q1.0830.98
85_L116_V1.0820.97
125_Q128_K1.0800.97
222_I226_K1.0780.97
254_N262_S1.0760.97
76_K81_D1.0750.97
165_Q169_L1.0750.97
150_K234_D1.0730.97
95_M110_F1.0690.97
82_W86_D1.0660.97
180_V269_I1.0620.97
230_A234_D1.0620.97
232_F246_L1.0600.97
164_D167_E1.0570.97
257_A273_V1.0550.97
154_L157_K1.0520.97
58_Q241_A1.0490.97
165_Q275_E1.0460.97
169_L275_E1.0400.97
132_L135_D1.0380.97
92_A111_F1.0380.97
249_L254_N1.0360.97
164_D168_E1.0310.97
24_L64_L1.0270.97
261_G274_V1.0220.96
30_R250_V1.0220.96
12_S19_S1.0150.96
160_L237_A1.0010.96
160_L236_L0.9910.96
267_H271_K0.9910.96
162_H217_D0.9880.96
90_A94_D0.9830.96
163_I253_L0.9780.95
24_L53_I0.9770.95
170_V222_I0.9770.95
13_K132_L0.9700.95
241_A244_R0.9520.95
168_E171_R0.9480.95
240_G244_R0.9470.95
247_D288_Q0.9320.94
262_S270_T0.9300.94
200_L206_V0.9290.94
229_F233_R0.9260.94
227_S231_Q0.9250.94
23_E244_R0.9240.94
184_Y216_S0.9200.94
10_S21_S0.9160.94
159_C232_F0.9120.93
34_V50_K0.9080.93
163_I233_R0.9060.93
253_L280_I0.9030.93
202_E206_V0.9030.93
166_L253_L0.9010.93
32_K62_I0.8970.93
175_L179_D0.8940.93
204_R207_T0.8900.93
138_E141_V0.8840.92
42_L280_I0.8830.92
147_M227_S0.8830.92
170_V226_K0.8800.92
247_D254_N0.8770.92
187_R191_R0.8750.92
35_N63_E0.8730.92
20_V133_I0.8640.91
167_E229_F0.8590.91
192_I205_L0.8570.91
177_A180_V0.8560.91
113_L116_V0.8520.91
186_E189_Y0.8460.91
147_M245_K0.8460.91
2_I242_V0.8440.90
214_D278_S0.8380.90
274_V278_S0.8380.90
191_R194_E0.8370.90
219_T223_T0.8360.90
14_T19_S0.8350.90
52_T55_Q0.8340.90
155_L286_Q0.8340.90
231_Q234_D0.8340.90
87_E91_A0.8260.89
234_D238_S0.8230.89
10_S23_E0.8200.89
139_E143_G0.8100.89
137_A141_V0.8090.89
135_D139_E0.8080.88
15_Q132_L0.8070.88
192_I209_C0.8060.88
219_T282_K0.8010.88
223_T282_K0.7970.88
142_K146_E0.7930.87
184_Y212_F0.7920.87
127_D131_A0.7910.87
109_D112_K0.7870.87
10_S244_R0.7850.87
271_K275_E0.7820.87
175_L178_A0.7790.87
57_I145_C0.7790.87
13_K135_D0.7780.86
155_L159_C0.7740.86
43_L63_E0.7710.86
14_T71_D0.7680.86
13_K20_V0.7680.86
90_A93_R0.7660.86
195_W206_V0.7550.85
204_R208_E0.7550.85
232_F283_I0.7530.85
11_A143_G0.7500.84
33_E204_R0.7430.84
158_D282_K0.7430.84
20_V68_V0.7410.84
150_K153_L0.7370.83
206_V209_C0.7350.83
267_H274_V0.7310.83
170_V225_L0.7260.82
45_F133_I0.7250.82
185_R206_V0.7230.82
29_Y63_E0.7220.82
232_F273_V0.7190.82
30_R281_E0.7180.82
79_E120_H0.7170.82
178_A181_V0.7150.82
238_S242_V0.7140.81
214_D282_K0.7130.81
20_V132_L0.7130.81
64_L140_A0.7120.81
133_I136_A0.7110.81
166_L170_V0.7090.81
206_V210_A0.7090.81
150_K231_Q0.7060.81
253_L257_A0.7050.81
246_L287_V0.7050.81
83_P86_D0.7020.80
80_I91_A0.7000.80
254_N270_T0.6980.80
38_L49_L0.6940.80
38_L66_V0.6940.80
181_V185_R0.6940.80
27_V63_E0.6920.79
182_S189_Y0.6900.79
139_E142_K0.6890.79
176_L180_V0.6850.79
181_V213_A0.6830.78
22_V25_K0.6780.78
78_L84_L0.6780.78
95_M107_V0.6770.78
44_Y130_E0.6760.78
84_L88_F0.6760.78
89_V105_P0.6750.78
200_L209_C0.6740.78
145_C149_E0.6730.77
216_S270_T0.6710.77
92_A113_L0.6710.77
65_F244_R0.6700.77
169_L279_S0.6680.77
177_A216_S0.6680.77
52_T141_V0.6660.77
207_T211_I0.6650.77
29_Y35_N0.6630.76
9_G214_D0.6620.76
188_L209_C0.6600.76
39_P133_I0.6570.76
170_V229_F0.6570.76
80_I117_V0.6560.76
159_C290_I0.6560.76
180_V265_N0.6550.76
50_K54_L0.6550.76
2_I156_A0.6550.76
205_L211_I0.6510.75
36_A53_I0.6500.75
8_F23_E0.6500.75
110_F116_V0.6500.75
158_D227_S0.6490.75
94_D97_K0.6460.75
225_L280_I0.6440.74
171_R175_L0.6430.74
85_L99_Y0.6420.74
89_V101_L0.6410.74
250_V284_K0.6390.74
96_K104_E0.6380.74
93_R96_K0.6360.73
16_D128_K0.6360.73
92_A105_P0.6350.73
114_D162_H0.6350.73
223_T279_S0.6340.73
2_I290_I0.6330.73
215_R267_H0.6320.73
64_L137_A0.6290.73
179_D266_D0.6280.72
22_V140_A0.6260.72
68_V133_I0.6250.72
92_A107_V0.6220.72
180_V216_S0.6220.72
247_D278_S0.6210.72
29_Y33_E0.6210.72
58_Q240_G0.6190.71
188_L211_I0.6170.71
169_L276_M0.6170.71
205_L209_C0.6170.71
31_F61_R0.6120.71
61_R254_N0.6100.70
109_D113_L0.6100.70
96_K107_V0.6100.70
104_E108_M0.6100.70
103_A107_V0.6090.70
232_F250_V0.6070.70
138_E153_L0.6060.70
9_G40_R0.6060.70
226_K230_A0.6060.70
177_A181_V0.6040.70
235_I246_L0.6040.70
254_N284_K0.6030.69
218_I222_I0.6010.69
45_F48_K0.6000.69
15_Q135_D0.5980.69
45_F66_V0.5960.69
136_A205_L0.5960.69
158_D161_M0.5950.68
34_V62_I0.5910.68
43_L61_R0.5880.67
203_S207_T0.5870.67
78_L91_A0.5870.67
77_R122_E0.5860.67
206_V214_D0.5850.67
247_D287_V0.5840.67
264_A282_K0.5820.67
178_A266_D0.5810.67
247_D270_T0.5810.67
33_E232_F0.5780.66
36_A46_E0.5760.66
24_L141_V0.5750.66
266_D271_K0.5730.66
96_K101_L0.5720.65
166_L283_I0.5720.65
29_Y37_R0.5710.65
146_E153_L0.5700.65
42_L129_L0.5690.65
239_G242_V0.5680.65
88_F282_K0.5670.65
254_N290_I0.5670.65
105_P111_F0.5670.65
84_L116_V0.5660.65
229_F276_M0.5650.64
36_A50_K0.5650.64
217_D260_I0.5640.64
34_V46_E0.5640.64
36_A64_L0.5640.64
257_A260_I0.5630.64
52_T56_H0.5620.64
92_A110_F0.5610.64
173_T260_I0.5590.64
85_L110_F0.5530.63
97_K168_E0.5520.63
94_D98_R0.5510.63
72_M78_L0.5500.62
87_E90_A0.5490.62
216_S265_N0.5490.62
264_A270_T0.5490.62
214_D273_V0.5470.62
56_H141_V0.5470.62
124_T174_E0.5470.62
219_T280_I0.5460.62
136_A140_A0.5460.62
245_K278_S0.5450.62
91_A117_V0.5430.61
181_V209_C0.5420.61
260_I280_I0.5420.61
200_L213_A0.5400.61
262_S283_I0.5390.61
63_E261_G0.5390.61
76_K115_H0.5370.61
161_M164_D0.5370.61
30_R254_N0.5360.60
33_E286_Q0.5350.60
270_T274_V0.5330.60
188_L214_D0.5310.60
29_Y191_R0.5300.60
15_Q18_L0.5290.59
249_L278_S0.5290.59
186_E193_K0.5280.59
2_I239_G0.5270.59
210_A249_L0.5250.59
22_V113_L0.5210.58
18_L68_V0.5210.58
96_K99_Y0.5200.58
254_N280_I0.5200.58
250_V287_V0.5190.58
183_R266_D0.5180.58
245_K275_E0.5180.58
2_I187_R0.5130.57
264_A269_I0.5130.57
101_L104_E0.5130.57
40_R43_L0.5120.57
182_S199_V0.5110.57
169_L173_T0.5100.57
53_I188_L0.5090.57
37_R48_K0.5080.56
79_E118_Q0.5080.56
269_I273_V0.5070.56
180_V209_C0.5060.56
280_I283_I0.5060.56
81_D116_V0.5050.56
29_Y34_V0.5040.56
181_V191_R0.5040.56
173_T276_M0.5030.56
8_F71_D0.5020.56
37_R65_F0.5020.56
84_L112_K0.5010.55
51_Q54_L0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ll8A 1 0.1375 83.4 0.952 Contact Map
3al0B 1 0.8419 36.6 0.965 Contact Map
2qywA 1 0.3265 30.4 0.967 Contact Map
4cg4A 2 0.3643 22.1 0.969 Contact Map
4wj3B 2 0.8591 18.1 0.97 Contact Map
3h0lB 1 0.8625 16.5 0.971 Contact Map
3kfuF 2 0.8385 14.6 0.971 Contact Map
3onjA 1 0.323 14.4 0.971 Contact Map
3nmdA 2 0.1856 14.1 0.971 Contact Map
1nfnA 1 0.4192 13.7 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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