GREMLIN Database
YFLP - UPF0065 protein YflP
UniProt: O34439 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 319 (303)
Sequences: 10888 (8373)
Seq/√Len: 481.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
257_G261_M3.1391.00
58_K275_K3.1181.00
136_N139_D3.0831.00
284_R288_E2.8521.00
143_E147_H2.7831.00
230_R242_E2.7771.00
195_A200_E2.7321.00
147_H150_K2.7021.00
135_T221_T2.6941.00
134_L143_E2.6191.00
263_E267_S2.6161.00
53_S57_Q2.3571.00
254_G301_T2.3261.00
313_Q317_T2.3161.00
155_F183_F2.2741.00
186_Y195_A2.2571.00
70_K81_Y2.2081.00
154_G201_I2.1851.00
168_V171_A2.1421.00
212_K216_R2.0751.00
267_S271_Q2.0451.00
171_A177_D1.9721.00
140_V203_A1.9681.00
280_P284_R1.9351.00
192_L204_A1.9041.00
54_V279_S1.9021.00
241_K246_P1.9001.00
114_T263_E1.8981.00
138_K142_N1.8881.00
135_T139_D1.8711.00
271_Q275_K1.8181.00
82_V91_S1.8161.00
297_N300_E1.8071.00
303_R307_E1.8051.00
54_V57_Q1.7861.00
115_P302_K1.7761.00
270_D298_S1.7551.00
90_I269_W1.7461.00
274_K278_S1.7301.00
283_K287_N1.7281.00
152_R202_E1.6951.00
228_D248_V1.6711.00
58_K272_A1.6581.00
255_I273_L1.6581.00
27_L88_Q1.6461.00
270_D274_K1.6441.00
142_N146_M1.6441.00
302_K306_E1.6331.00
261_M266_I1.6321.00
144_I151_V1.6281.00
117_A273_L1.6221.00
114_T266_I1.6201.00
79_W91_S1.6171.00
215_E222_L1.6071.00
33_E68_V1.5881.00
61_V272_A1.5871.00
310_A314_S1.5741.00
300_E303_R1.5591.00
37_P78_G1.5471.00
30_G88_Q1.5231.00
278_S283_K1.5041.00
181_I203_A1.4811.00
114_T260_N1.4791.00
54_V281_E1.4761.00
133_A221_T1.4671.00
143_E151_V1.4621.00
80_K84_K1.4611.00
120_S291_W1.4601.00
171_A181_I1.4601.00
80_K107_K1.4371.00
36_V67_I1.4361.00
152_R182_Q1.4291.00
90_I257_G1.4291.00
256_L305_L1.4281.00
53_S56_R1.4261.00
127_A211_A1.4041.00
303_R306_E1.3981.00
153_I167_F1.3921.00
93_T256_L1.3881.00
285_K288_E1.3841.00
230_R236_N1.3831.00
125_T222_L1.3721.00
129_P132_S1.3721.00
224_A240_W1.3701.00
32_I65_V1.3651.00
306_E310_A1.3441.00
133_A143_E1.3401.00
299_R303_R1.3381.00
34_I255_I1.3381.00
130_K219_D1.3061.00
144_I176_I1.3061.00
50_A282_W1.3061.00
197_I214_Y1.3001.00
76_E103_L1.2961.00
76_E100_N1.2961.00
55_L273_L1.2871.00
272_A275_K1.2761.00
117_A295_Y1.2761.00
132_S143_E1.2721.00
25_P29_D1.2721.00
154_G192_L1.2641.00
308_Q311_F1.2631.00
214_Y219_D1.2581.00
274_K295_Y1.2541.00
53_S285_K1.2521.00
118_I301_T1.2521.00
35_V82_V1.2521.00
139_D142_N1.2431.00
222_L237_V1.2401.00
189_S206_M1.2371.00
91_S256_L1.2331.00
268_Y272_A1.2291.00
214_Y217_N1.2201.00
114_T261_M1.2141.00
48_A92_M1.2081.00
149_G177_D1.2081.00
28_P88_Q1.2071.00
206_M211_A1.2061.00
116_L257_G1.2051.00
284_R287_N1.2041.00
304_F308_Q1.1931.00
117_A296_L1.1871.00
121_K250_S1.1861.00
55_L272_A1.1741.00
126_V137_G1.1671.00
128_L203_A1.1651.00
50_A285_K1.1641.00
266_I298_S1.1611.00
54_V276_V1.1551.00
280_P283_K1.1371.00
58_K276_V1.1301.00
307_E311_F1.1261.00
33_E81_Y1.1231.00
117_A274_K1.1211.00
176_I181_I1.1161.00
270_D297_N1.1131.00
128_L221_T1.0951.00
26_R29_D1.0861.00
36_V48_A1.0851.00
39_E188_S1.0851.00
61_V65_V1.0811.00
261_M265_E1.0781.00
92_M119_L1.0781.00
58_K279_S1.0771.00
76_E80_K1.0741.00
118_I296_L1.0721.00
249_F312_Y1.0701.00
285_K289_Q1.0671.00
266_I270_D1.0561.00
22_A25_P1.0561.00
257_G269_W1.0461.00
114_T259_K1.0351.00
35_V89_T1.0351.00
115_P256_L1.0341.00
129_P202_E1.0311.00
145_N175_G1.0291.00
195_A201_I1.0281.00
310_A313_Q1.0231.00
188_S191_Q1.0071.00
229_K292_E1.0071.00
61_V268_Y1.0061.00
55_L276_V1.0021.00
137_G243_Q1.0001.00
137_G170_A0.9991.00
160_G164_Q0.9981.00
128_L132_S0.9981.00
224_A243_Q0.9951.00
134_L140_V0.9951.00
240_W247_F0.9951.00
226_T240_W0.9931.00
27_L269_W0.9851.00
173_M247_F0.9841.00
267_S270_D0.9831.00
137_G240_W0.9801.00
97_I256_L0.9771.00
263_E299_R0.9771.00
118_I294_F0.9701.00
228_D241_K0.9691.00
144_I181_I0.9631.00
43_G253_R0.9611.00
141_L174_Y0.9611.00
21_Q24_A0.9571.00
234_F237_V0.9521.00
268_Y271_Q0.9411.00
102_L316_M0.9381.00
230_R239_T0.9381.00
54_V58_K0.9341.00
39_E191_Q0.9311.00
142_N145_N0.9301.00
281_E284_R0.9271.00
117_A270_D0.9201.00
309_S313_Q0.9191.00
196_L220_I0.9161.00
279_S282_W0.9151.00
35_V78_G0.9131.00
126_V240_W0.9101.00
55_L65_V0.9091.00
212_K234_F0.9081.00
191_Q194_Q0.9081.00
257_G266_I0.9071.00
34_I48_A0.9071.00
191_Q195_A0.9071.00
127_A220_I0.9051.00
114_T257_G0.9031.00
83_N113_F0.9021.00
116_L266_I0.8951.00
34_I65_V0.8911.00
126_V140_V0.8911.00
76_E106_S0.8911.00
35_V81_Y0.8891.00
277_T282_W0.8891.00
141_L170_A0.8861.00
45_D49_Q0.8861.00
29_D88_Q0.8851.00
264_E267_S0.8851.00
115_P305_L0.8851.00
153_I183_F0.8821.00
307_E310_A0.8821.00
314_S317_T0.8791.00
296_L300_E0.8781.00
169_R173_M0.8761.00
189_S210_E0.8741.00
81_Y84_K0.8601.00
76_E108_L0.8581.00
216_R236_N0.8561.00
166_S247_F0.8521.00
34_I52_Q0.8451.00
232_P287_N0.8441.00
49_Q69_Y0.8321.00
141_L145_N0.8301.00
128_L223_A0.8291.00
271_Q274_K0.8291.00
239_T242_E0.8231.00
282_W286_I0.8211.00
275_K278_S0.8211.00
272_A276_V0.8201.00
213_P216_R0.8121.00
78_G91_S0.8111.00
222_L234_F0.8111.00
299_R302_K0.8071.00
167_F203_A0.8051.00
36_V69_Y0.8051.00
263_E266_I0.8051.00
170_A174_Y0.8051.00
167_F205_S0.8021.00
97_I113_F0.8001.00
164_Q168_V0.7981.00
153_I181_I0.7961.00
119_L255_I0.7941.00
286_I293_S0.7931.00
154_G204_A0.7921.00
281_E285_K0.7891.00
171_A176_I0.7891.00
45_D69_Y0.7881.00
118_I304_F0.7871.00
125_T234_F0.7861.00
38_A94_S0.7841.00
240_W243_Q0.7841.00
31_P64_D0.7831.00
122_E253_R0.7821.00
51_I277_T0.7821.00
111_S259_K0.7811.00
138_K243_Q0.7811.00
131_G199_H0.7791.00
71_S187_D0.7771.00
155_F158_G0.7761.00
47_T120_S0.7731.00
121_K294_F0.7721.00
79_W113_F0.7721.00
208_L231_L0.7721.00
92_M253_R0.7711.00
127_A215_E0.7701.00
123_W227_S0.7701.00
61_V269_W0.7681.00
51_I273_L0.7631.00
126_V205_S0.7601.00
187_D195_A0.7601.00
267_S298_S0.7571.00
73_G77_K0.7561.00
88_Q265_E0.7521.00
101_D309_S0.7501.00
137_G224_A0.7471.00
238_P243_Q0.7471.00
52_Q65_V0.7461.00
34_I92_M0.7441.00
132_S202_E0.7431.00
20_R23_A0.7361.00
127_A204_A0.7341.00
194_Q198_R0.7341.00
44_W92_M0.7321.00
90_I255_I0.7321.00
265_E268_Y0.7291.00
252_W308_Q0.7291.00
56_R64_D0.7271.00
120_S253_R0.7261.00
129_P199_H0.7251.00
143_E146_M0.7201.00
158_G161_N0.7161.00
270_D295_Y0.7151.00
153_I203_A0.7131.00
164_Q183_F0.7111.00
296_L304_F0.7101.00
75_G96_L0.7101.00
165_L316_M0.7091.00
68_V81_Y0.7091.00
134_L139_D0.7081.00
57_Q279_S0.7051.00
193_I220_I0.7021.00
114_T302_K0.7011.00
177_D182_Q0.6961.00
19_I22_A0.6931.00
196_L201_I0.6901.00
127_A222_L0.6871.00
63_D88_Q0.6861.00
113_F256_L0.6821.00
141_L245_I0.6731.00
166_S249_F0.6721.00
116_L261_M0.6721.00
277_T295_Y0.6691.00
34_I90_I0.6691.00
140_V144_I0.6661.00
95_S162_D0.6661.00
182_Q185_Q0.6661.00
262_S265_E0.6661.00
174_Y245_I0.6611.00
52_Q67_I0.6591.00
39_E71_S0.6591.00
26_R268_Y0.6561.00
139_D143_E0.6561.00
98_L309_S0.6551.00
230_R238_P0.6541.00
27_L268_Y0.6491.00
101_D110_M0.6471.00
128_L134_L0.6441.00
256_L301_T0.6431.00
121_K292_E0.6421.00
286_I291_W0.6421.00
19_I23_A0.6401.00
44_W94_S0.6391.00
193_I214_Y0.6391.00
276_V282_W0.6361.00
243_Q246_P0.6311.00
279_S283_K0.6291.00
128_L140_V0.6291.00
225_V231_L0.6271.00
208_L234_F0.6271.00
116_L270_D0.6210.99
109_K112_D0.6210.99
186_Y200_E0.6200.99
231_L292_E0.6180.99
158_G183_F0.6180.99
134_L151_V0.6170.99
274_K297_N0.6160.99
131_G219_D0.6130.99
24_A29_D0.6130.99
270_D296_L0.6130.99
43_G207_T0.6120.99
170_A205_S0.6110.99
197_I219_D0.6080.99
95_S98_L0.6080.99
31_P63_D0.6060.99
274_K296_L0.6060.99
296_L301_T0.6040.99
112_D259_K0.6040.99
312_Y315_I0.6030.99
239_T243_Q0.6010.99
177_D181_I0.6000.99
125_T208_L0.5970.99
232_P292_E0.5960.99
130_K221_T0.5950.99
276_V279_S0.5940.99
12_L15_M0.5940.99
32_I269_W0.5910.99
287_N293_S0.5900.99
119_L273_L0.5890.99
76_E107_K0.5870.99
14_F17_G0.5860.99
74_G161_N0.5860.99
47_T253_R0.5840.99
239_T244_G0.5830.99
27_L265_E0.5820.99
196_L204_A0.5800.99
136_N140_V0.5780.99
20_R24_A0.5750.99
194_Q200_E0.5750.99
108_L112_D0.5740.99
206_M210_E0.5730.99
267_S299_R0.5730.99
240_W245_I0.5720.99
13_I16_Q0.5700.99
306_E309_S0.5670.99
125_T215_E0.5660.99
124_Q162_D0.5660.99
42_G188_S0.5650.99
116_L273_L0.5620.99
177_D184_S0.5620.99
86_S89_T0.5610.99
132_S139_D0.5600.99
32_I61_V0.5590.99
130_K218_G0.5550.99
111_S306_E0.5540.99
258_P261_M0.5530.99
118_I121_K0.5520.99
140_V223_A0.5500.99
121_K304_F0.5490.99
80_K83_N0.5480.99
37_P75_G0.5480.99
167_F181_I0.5460.99
57_Q62_K0.5460.99
229_K232_P0.5450.99
214_Y220_I0.5440.99
85_S258_P0.5420.99
47_T286_I0.5410.99
100_N106_S0.5400.99
137_G140_V0.5390.99
287_N292_E0.5390.99
90_I116_L0.5380.99
205_S226_T0.5380.99
132_S140_V0.5350.98
166_S226_T0.5350.98
120_S286_I0.5330.98
18_D22_A0.5330.98
141_L176_I0.5320.98
93_T97_I0.5310.98
116_L255_I0.5290.98
196_L202_E0.5290.98
18_D21_Q0.5280.98
73_G76_E0.5260.98
118_I295_Y0.5240.98
43_G122_E0.5230.98
22_A26_R0.5230.98
83_N112_D0.5220.98
199_H202_E0.5220.98
171_A174_Y0.5210.98
304_F307_E0.5190.98
163_D207_T0.5180.98
82_V89_T0.5180.98
270_D299_R0.5170.98
252_W301_T0.5170.98
33_E80_K0.5160.98
54_V282_W0.5160.98
193_I211_A0.5160.98
115_P301_T0.5150.98
241_K248_V0.5120.98
150_K177_D0.5090.98
124_Q128_L0.5090.98
211_A220_I0.5080.98
97_I101_D0.5070.98
23_A26_R0.5060.98
81_Y85_S0.5040.98
207_T251_H0.5030.98
11_L14_F0.5010.98
278_S295_Y0.5010.98
55_L61_V0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qpqA 1 0.8997 100 0.233 Contact Map
2dvzA 1 0.9028 100 0.252 Contact Map
2f5xA 1 0.9028 100 0.254 Contact Map
4x9tA 1 0.8934 100 0.26 Contact Map
1us5A 1 0.8527 100 0.591 Contact Map
4p47A 1 0.7994 100 0.607 Contact Map
3p7iA 2 0.7837 100 0.618 Contact Map
2zzvA 2 0.7962 100 0.623 Contact Map
4p8bA 1 0.7837 100 0.636 Contact Map
4nn3A 1 0.7868 100 0.644 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.021 seconds.