GREMLIN Database
YFKH - Putative ribonuclease-like protein YfkH
UniProt: O34437 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (261)
Sequences: 5339 (3909)
Seq/√Len: 241.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_H257_E5.9001.00
15_E108_H3.9341.00
211_W248_S3.2731.00
17_Q250_I3.1991.00
203_G259_N3.0431.00
214_V247_L2.9991.00
206_F258_I2.9261.00
106_L256_G2.8831.00
123_L127_F2.8171.00
21_A26_F2.8031.00
18_S22_E2.6521.00
100_N122_R2.5541.00
63_S66_S2.5461.00
11_Y16_G2.4981.00
184_S204_A2.4601.00
184_S197_L2.4421.00
7_L254_L2.4181.00
206_F210_G2.3481.00
11_Y250_I2.1811.00
117_S120_I2.0791.00
187_Y207_A2.0121.00
15_E104_R2.0041.00
14_H111_D1.9781.00
106_L190_A1.9681.00
56_I60_A1.9471.00
180_L205_V1.9181.00
107_N191_P1.9071.00
180_L201_M1.8941.00
200_V204_A1.8891.00
187_Y255_G1.8831.00
7_L258_I1.8721.00
23_L249_G1.8331.00
6_E265_R1.8231.00
218_F222_V1.8221.00
202_P259_N1.8161.00
110_Y259_N1.8041.00
105_S253_I1.7791.00
107_N192_N1.7711.00
188_V197_L1.7191.00
207_A255_G1.6821.00
51_D54_G1.6641.00
10_R14_H1.6541.00
96_S122_R1.6471.00
217_L220_F1.6321.00
220_F224_T1.6301.00
119_I123_L1.6181.00
73_H77_N1.5961.00
103_V125_S1.5771.00
115_N192_N1.5761.00
212_I215_S1.5741.00
66_S69_E1.5721.00
180_L208_T1.5671.00
10_R111_D1.5671.00
222_V240_V1.5511.00
30_S98_G1.5501.00
6_E261_L1.5391.00
122_R125_S1.5131.00
85_S89_I1.5111.00
7_L261_L1.5031.00
165_S169_A1.4821.00
8_F12_T1.4631.00
89_I93_W1.4501.00
5_K9_S1.4441.00
195_L200_V1.4401.00
183_F252_I1.4401.00
10_R257_E1.4391.00
15_E18_S1.4321.00
70_S73_H1.4191.00
10_R261_L1.4171.00
184_S200_V1.4081.00
109_A253_I1.3991.00
20_S250_I1.3981.00
7_L16_G1.3831.00
126_I130_I1.3761.00
107_N112_V1.3641.00
176_P208_T1.3611.00
69_E73_H1.3581.00
66_S70_S1.3581.00
103_V190_A1.3531.00
20_S253_I1.3471.00
9_S13_L1.3251.00
210_G251_L1.3171.00
196_S199_F1.3121.00
209_I213_I1.2821.00
116_R124_T1.2791.00
199_F263_H1.2791.00
10_R260_A1.2751.00
183_F208_T1.2571.00
26_F30_S1.2551.00
199_F262_L1.2531.00
201_M205_V1.2501.00
215_S244_W1.2491.00
53_L65_M1.2301.00
180_L184_S1.2241.00
23_L253_I1.2211.00
86_F90_A1.2161.00
118_F122_R1.1891.00
188_V200_V1.1801.00
23_L105_S1.1781.00
64_A67_L1.1701.00
202_P206_F1.1421.00
57_E65_M1.1341.00
18_S104_R1.1331.00
162_L166_V1.1281.00
62_A66_S1.1271.00
180_L204_A1.1101.00
4_L7_L1.1101.00
228_Y232_Y1.1061.00
186_L190_A1.0901.00
202_P205_V1.0731.00
50_D54_G1.0721.00
24_A249_G1.0621.00
195_L199_F1.0591.00
258_I262_L1.0581.00
27_F245_F1.0521.00
37_F84_L1.0451.00
11_Y254_L1.0401.00
234_S237_G1.0301.00
109_A257_E1.0291.00
185_A189_I1.0231.00
201_M204_A1.0171.00
16_G250_I1.0111.00
25_Y243_I1.0081.00
68_V71_I1.0051.00
19_K105_S1.0001.00
25_Y242_M0.9981.00
120_I124_T0.9981.00
16_G254_L0.9941.00
95_A129_T0.9881.00
53_L69_E0.9881.00
184_S188_V0.9871.00
236_G240_V0.9781.00
9_S12_T0.9771.00
26_F94_S0.9761.00
110_Y215_S0.9741.00
15_E19_K0.9701.00
16_G257_E0.9671.00
46_P50_D0.9631.00
55_V58_Q0.9621.00
19_K22_E0.9541.00
112_V192_N0.9531.00
187_Y256_G0.9501.00
19_K108_H0.9491.00
29_L239_I0.9471.00
79_R82_G0.9381.00
99_M103_V0.9351.00
10_R264_K0.9331.00
261_L264_K0.9301.00
140_L144_V0.9281.00
71_I75_T0.9241.00
23_L102_I0.9241.00
244_W248_S0.9211.00
183_F207_A0.9191.00
76_L79_R0.9171.00
49_T52_V0.9151.00
151_R155_D0.9141.00
74_Q77_N0.9141.00
21_A246_Y0.9131.00
4_L8_F0.9111.00
150_G154_S0.9081.00
26_F101_A0.9071.00
221_Y225_F0.9061.00
254_L258_I0.9051.00
71_I74_Q0.8991.00
208_T212_I0.8981.00
18_S101_A0.8951.00
204_A208_T0.8951.00
176_P180_L0.8941.00
84_L88_I0.8911.00
24_A245_F0.8901.00
245_F249_G0.8891.00
183_F211_W0.8851.00
36_I40_T0.8830.99
218_F240_V0.8800.99
40_T87_G0.8770.99
241_L244_W0.8720.99
218_F241_L0.8720.99
19_K25_Y0.8630.99
54_G57_E0.8620.99
37_F87_G0.8580.99
24_A246_Y0.8580.99
206_F255_G0.8530.99
231_T234_S0.8490.99
62_A65_M0.8420.99
29_L243_I0.8410.99
188_V194_K0.8400.99
101_A104_R0.8380.99
218_F228_Y0.8360.99
154_S158_G0.8350.99
166_V169_A0.8280.99
214_V248_S0.8250.99
11_Y17_Q0.8240.99
55_V59_Y0.8240.99
227_N230_A0.8200.99
96_S129_T0.8180.99
152_L156_F0.8150.99
120_I123_L0.8070.99
229_S233_G0.8020.99
22_E101_A0.7990.99
51_D55_V0.7990.99
87_G90_A0.7980.99
225_F228_Y0.7950.99
213_I217_L0.7920.99
32_F238_I0.7890.99
12_T17_Q0.7850.99
217_L247_L0.7830.99
184_S201_M0.7780.99
177_L180_L0.7720.99
27_F249_G0.7700.99
53_L57_E0.7690.99
17_Q20_S0.7680.99
169_A173_G0.7680.99
202_P262_L0.7670.99
16_G253_I0.7590.98
147_R151_R0.7570.98
97_N122_R0.7570.98
24_A28_L0.7530.98
25_Y29_L0.7510.98
21_A25_Y0.7490.98
24_A242_M0.7480.98
100_N104_R0.7450.98
224_T227_N0.7440.98
160_S163_F0.7430.98
34_F129_T0.7400.98
211_W234_S0.7380.98
56_I65_M0.7380.98
57_E69_E0.7340.98
193_K263_H0.7330.98
98_G249_G0.7310.98
70_S74_Q0.7280.98
163_F167_W0.7210.98
159_A162_L0.7190.98
124_T127_F0.7100.98
71_I76_L0.7090.98
198_R201_M0.7010.97
38_M41_L0.7010.97
94_S101_A0.6980.97
143_P212_I0.6940.97
114_E121_V0.6930.97
137_L140_L0.6920.97
60_A65_M0.6900.97
103_V121_V0.6890.97
177_L181_I0.6880.97
71_I90_A0.6870.97
96_S125_S0.6860.97
79_R83_L0.6840.97
13_L113_E0.6820.97
32_F61_P0.6800.97
246_Y251_L0.6750.97
36_I87_G0.6740.97
112_V193_K0.6740.97
170_I173_G0.6720.97
261_L265_R0.6710.97
32_F239_I0.6710.97
147_R150_G0.6700.97
131_A236_G0.6690.97
200_V259_N0.6650.96
153_A157_V0.6600.96
186_L252_I0.6600.96
206_F209_I0.6600.96
212_I216_T0.6580.96
254_L257_E0.6570.96
143_P215_S0.6570.96
179_L208_T0.6560.96
33_P233_G0.6530.96
23_L30_S0.6530.96
103_V122_R0.6490.96
86_F148_E0.6480.96
114_E192_N0.6460.96
87_G250_I0.6450.96
99_M128_L0.6430.96
54_G155_D0.6410.96
17_Q246_Y0.6380.96
7_L11_Y0.6340.95
211_W245_F0.6300.95
94_S97_N0.6290.95
135_T139_A0.6250.95
102_I130_I0.6240.95
179_L215_S0.6240.95
207_A251_L0.6240.95
31_L210_G0.6220.95
143_P172_W0.6200.95
21_A24_A0.6200.95
210_G214_V0.6190.95
106_L252_I0.6130.95
216_T220_F0.6130.95
203_G207_A0.6090.94
22_E100_N0.6090.94
214_V251_L0.6090.94
100_N125_S0.6080.94
35_L150_G0.6060.94
89_I223_S0.6040.94
60_A68_V0.6040.94
117_S122_R0.6030.94
260_A264_K0.6010.94
234_S238_I0.6010.94
107_N116_R0.5950.94
30_S81_G0.5940.94
72_T101_A0.5930.93
154_S159_A0.5920.93
185_A188_V0.5910.93
156_F160_S0.5890.93
35_L72_T0.5870.93
72_T76_L0.5860.93
54_G58_Q0.5850.93
14_H246_Y0.5850.93
33_P92_L0.5830.93
226_A240_V0.5820.93
139_A178_V0.5820.93
37_F133_V0.5800.93
203_G206_F0.5790.93
49_T53_L0.5790.93
152_L157_V0.5790.93
93_W251_L0.5770.93
195_L263_H0.5760.92
221_Y226_A0.5740.92
121_V136_I0.5740.92
100_N103_V0.5720.92
146_G167_W0.5720.92
4_L151_R0.5710.92
48_S51_D0.5690.92
69_E72_T0.5680.92
177_L196_S0.5680.92
27_F37_F0.5680.92
26_F93_W0.5670.92
128_L190_A0.5670.92
85_S92_L0.5640.92
183_F200_V0.5640.92
138_V141_L0.5620.92
110_Y260_A0.5600.91
111_D138_V0.5600.91
30_S95_A0.5600.91
92_L138_V0.5570.91
93_W96_S0.5540.91
173_G177_L0.5520.91
29_L67_L0.5520.91
34_F143_P0.5490.91
164_L168_A0.5480.91
54_G66_S0.5480.91
28_L242_M0.5450.90
220_F223_S0.5450.90
110_Y191_P0.5440.90
134_F138_V0.5440.90
218_F221_Y0.5420.90
253_I257_E0.5420.90
31_L90_A0.5410.90
105_S257_E0.5370.90
25_Y97_N0.5370.90
93_W202_P0.5360.90
189_I197_L0.5340.89
25_Y28_L0.5340.89
96_S100_N0.5320.89
24_A235_I0.5310.89
7_L10_R0.5310.89
50_D69_E0.5300.89
99_M183_F0.5280.89
138_V165_S0.5270.89
153_A156_F0.5260.89
104_R108_H0.5260.89
25_Y252_I0.5250.89
211_W215_S0.5230.88
159_A165_S0.5230.88
111_D114_E0.5170.88
102_I253_I0.5170.88
187_Y204_A0.5170.88
163_F170_I0.5150.88
103_V243_I0.5140.88
252_I255_G0.5130.87
30_S252_I0.5110.87
14_H261_L0.5110.87
98_G101_A0.5110.87
5_K12_T0.5100.87
151_R154_S0.5100.87
90_A201_M0.5090.87
37_F91_A0.5090.87
106_L112_V0.5080.87
103_V239_I0.5080.87
145_F234_S0.5070.87
37_F99_M0.5060.87
60_A72_T0.5060.87
169_A174_V0.5060.87
22_E246_Y0.5060.87
176_P212_I0.5040.87
213_I216_T0.5040.87
100_N121_V0.5040.87
179_L212_I0.5040.87
29_L94_S0.5020.86
235_I239_I0.5020.86
145_F148_E0.5020.86
29_L225_F0.5010.86
96_S235_I0.5010.86
165_S168_A0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlfF 1 0.44 38.8 0.936 Contact Map
3dh4A 3 0.8582 11.1 0.951 Contact Map
3j9pD 4 0.7782 7.3 0.954 Contact Map
4gx0A 3 0.3818 6.9 0.955 Contact Map
2k1eA 3 0.3709 6.6 0.955 Contact Map
3effK 4 0.3927 6.3 0.956 Contact Map
4od4A 1 0.6582 5.8 0.956 Contact Map
2kluA 1 0.1636 5.4 0.957 Contact Map
2xq2A 2 0.8436 5 0.958 Contact Map
4humA 1 0.8145 4.5 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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