PIT - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

PIT - Probable low-affinity inorganic phosphate transporter

UniProt:	O34436	Sequences: MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRHAIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYGIPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKLIFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIPTWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLPVSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	333 (321)
Sequences:	2688 (1408)
Seq/√Len:	78.6

ECOLI - PITB PITA
BACSU - PIT SULP
HALSA - Q9HN03 Q9HHS6 O54523 Q9HRD0 Q9HHW5
SULSO - Q97VZ0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
41_K	44_H	4.671	1.00
62_G	274_H	4.293	1.00
20_F	235_I	4.132	1.00
48_L	183_A	3.092	1.00
324_I	328_I	2.851	1.00
153_I	157_I	2.783	1.00
116_A	133_F	2.684	1.00
137_I	141_I	2.657	1.00
158_V	258_S	2.588	1.00
72_V	119_A	2.511	1.00
138_E	142_L	2.431	1.00
83_V	118_A	2.423	1.00
25_H	98_T	2.403	1.00
16_L	228_A	2.368	1.00
132_G	135_K	2.347	1.00
90_A	321_L	2.285	1.00
98_T	105_S	2.270	1.00
40_L	179_I	2.252	1.00
54_F	227_T	2.247	1.00
16_L	224_A	2.239	1.00
205_L	221_V	2.227	1.00
11_I	204_A	2.222	1.00
148_F	292_A	2.203	1.00
34_S	182_A	2.198	1.00
65_K	69_K	2.192	1.00
299_V	304_A	2.190	1.00
121_A	323_A	2.183	1.00
120_I	125_F	2.164	1.00
97_I	101_Y	2.158	1.00
93_A	97_I	2.147	1.00
22_N	107_S	2.133	1.00
240_I	243_T	2.128	1.00
47_I	51_V	2.073	1.00
99_W	240_I	2.050	1.00
49_A	186_S	2.022	1.00
33_T	260_D	2.021	1.00
14_C	85_L	2.021	1.00
31_I	35_V	2.020	1.00
25_H	99_W	1.972	1.00
263_G	283_I	1.952	1.00
73_D	76_T	1.932	1.00
9_I	13_I	1.929	1.00
177_V	257_V	1.922	1.00
109_H	281_H	1.920	1.00
317_I	321_L	1.900	1.00
55_V	187_Y	1.899	1.00
53_N	233_T	1.897	1.00
99_W	105_S	1.816	1.00
95_N	107_S	1.814	1.00
46_I	234_S	1.808	1.00
52_M	183_A	1.803	1.00
188_T	267_I	1.784	1.00
244_V	284_S	1.775	1.00
53_N	189_H	1.750	1.00
154_L	258_S	1.737	1.00
137_I	317_I	1.706	1.00
271_T	274_H	1.686	1.00
142_L	146_I	1.685	1.00
320_T	324_I	1.679	1.00
174_F	257_V	1.626	1.00
244_V	287_I	1.621	1.00
191_T	271_T	1.592	1.00
30_A	185_Q	1.589	1.00
17_A	96_L	1.589	1.00
19_D	228_A	1.587	1.00
159_K	294_H	1.587	1.00
103_I	310_T	1.574	1.00
184_L	264_A	1.558	0.99
156_S	160_L	1.555	0.99
25_H	95_N	1.516	0.99
58_M	219_T	1.514	0.99
40_L	260_D	1.508	0.99
152_F	293_S	1.503	0.99
160_L	163_K	1.495	0.99
39_A	260_D	1.477	0.99
93_A	325_A	1.470	0.99
56_G	226_A	1.455	0.99
25_H	105_S	1.452	0.99
21_I	96_L	1.452	0.99
323_A	327_F	1.443	0.99
73_D	77_L	1.401	0.99
181_T	261_L	1.396	0.99
277_V	282_V	1.378	0.99
157_I	160_L	1.376	0.99
322_G	325_A	1.358	0.99
141_I	312_V	1.357	0.99
87_A	114_A	1.356	0.99
90_A	318_S	1.355	0.99
26_D	29_N	1.347	0.98
112_I	136_I	1.332	0.98
185_Q	251_I	1.321	0.98
34_S	48_L	1.315	0.98
25_H	107_S	1.308	0.98
309_I	313_I	1.303	0.98
68_T	215_N	1.303	0.98
94_W	314_T	1.299	0.98
25_H	240_I	1.287	0.98
46_I	50_A	1.283	0.98
134_I	137_I	1.282	0.98
319_A	323_A	1.280	0.98
65_K	68_T	1.278	0.98
157_I	161_I	1.272	0.98
318_S	322_G	1.267	0.98
243_T	307_M	1.244	0.97
252_R	294_H	1.240	0.97
194_A	229_M	1.227	0.97
8_T	208_A	1.224	0.97
88_L	264_A	1.215	0.97
30_A	256_G	1.215	0.97
49_A	233_T	1.213	0.97
105_S	240_I	1.207	0.97
113_G	318_S	1.191	0.97
145_I	149_V	1.183	0.96
176_R	180_V	1.177	0.96
267_I	282_V	1.172	0.96
60_F	191_T	1.171	0.96
24_F	99_W	1.168	0.96
88_L	187_Y	1.168	0.96
122_A	326_Y	1.165	0.96
86_A	325_A	1.164	0.96
129_N	132_G	1.160	0.96
18_F	91_A	1.156	0.96
184_L	265_A	1.155	0.96
77_L	81_S	1.153	0.96
63_V	66_T	1.153	0.96
38_K	246_G	1.149	0.96
98_T	107_S	1.146	0.96
260_D	283_I	1.146	0.96
270_A	277_V	1.143	0.96
33_T	283_I	1.138	0.96
90_A	319_A	1.135	0.96
158_V	162_F	1.133	0.95
13_I	17_A	1.133	0.95
70_D	73_D	1.129	0.95
75_Y	81_S	1.121	0.95
248_I	303_T	1.118	0.95
35_V	45_A	1.117	0.95
325_A	329_L	1.109	0.95
202_T	217_I	1.106	0.95
193_D	280_T	1.106	0.95
263_G	286_S	1.090	0.94
54_F	230_G	1.090	0.94
252_R	255_N	1.075	0.94
13_I	145_I	1.073	0.94
162_F	165_S	1.066	0.94
67_I	199_G	1.065	0.94
146_I	269_G	1.064	0.94
231_L	235_I	1.062	0.94
198_M	225_C	1.060	0.94
139_A	191_T	1.059	0.93
178_Q	256_G	1.049	0.93
188_T	271_T	1.040	0.93
148_F	285_S	1.039	0.93
35_V	241_I	1.035	0.93
188_T	274_H	1.027	0.92
114_A	118_A	1.020	0.92
217_I	221_V	1.017	0.92
131_K	320_T	1.009	0.92
242_K	247_K	1.004	0.92
211_H	215_N	1.002	0.91
206_I	215_N	0.994	0.91
20_F	236_G	0.992	0.91
197_A	225_C	0.987	0.91
211_H	214_A	0.985	0.91
178_Q	260_D	0.979	0.91
295_R	298_G	0.978	0.90
242_K	246_G	0.973	0.90
110_A	121_A	0.970	0.90
282_V	286_S	0.969	0.90
93_A	231_L	0.968	0.90
302_G	305_K	0.967	0.90
29_N	189_H	0.965	0.90
21_I	197_A	0.962	0.90
48_L	52_M	0.958	0.90
14_C	187_Y	0.957	0.89
12_V	16_L	0.950	0.89
58_M	226_A	0.946	0.89
305_K	309_I	0.941	0.89
60_F	185_Q	0.935	0.88
284_S	288_L	0.931	0.88
322_G	326_Y	0.929	0.88
95_N	111_I	0.927	0.88
47_I	160_L	0.926	0.88
63_V	274_H	0.922	0.88
230_G	233_T	0.922	0.88
37_T	53_N	0.920	0.88
259_A	283_I	0.920	0.88
8_T	204_A	0.920	0.88
89_L	93_A	0.915	0.87
206_I	217_I	0.915	0.87
152_F	156_S	0.913	0.87
62_G	65_K	0.912	0.87
254_V	258_S	0.905	0.87
58_M	223_F	0.901	0.86
243_T	303_T	0.900	0.86
201_I	225_C	0.898	0.86
37_T	47_I	0.898	0.86
70_D	128_L	0.895	0.86
181_T	260_D	0.886	0.86
6_I	208_A	0.886	0.86
120_I	127_A	0.883	0.85
29_N	53_N	0.882	0.85
165_S	170_T	0.879	0.85
7_L	85_L	0.878	0.85
113_G	117_G	0.878	0.85
192_N	267_I	0.877	0.85
177_V	180_V	0.875	0.85
182_A	186_S	0.874	0.85
27_T	233_T	0.872	0.85
10_L	82_V	0.870	0.84
85_L	329_L	0.870	0.84
172_K	176_R	0.868	0.84
324_I	327_F	0.866	0.84
95_N	99_W	0.863	0.84
58_M	222_Q	0.861	0.84
120_I	123_A	0.860	0.84
68_T	108_S	0.858	0.84
308_L	312_V	0.855	0.83
68_T	214_A	0.854	0.83
173_Q	177_V	0.853	0.83
59_T	187_Y	0.850	0.83
87_A	115_I	0.847	0.83
194_A	200_I	0.846	0.83
50_A	186_S	0.846	0.83
136_I	318_S	0.839	0.82
95_N	105_S	0.839	0.82
48_L	56_G	0.837	0.82
65_K	216_D	0.833	0.82
102_G	114_A	0.833	0.82
119_A	315_L	0.833	0.82
209_N	213_S	0.827	0.81
50_A	230_G	0.826	0.81
34_S	179_I	0.826	0.81
95_N	98_T	0.826	0.81
57_A	226_A	0.823	0.81
86_A	90_A	0.822	0.81
32_A	236_G	0.821	0.81
110_A	314_T	0.814	0.80
185_Q	263_G	0.813	0.80
70_D	76_T	0.811	0.80
29_N	279_T	0.811	0.80
219_T	223_F	0.808	0.80
24_F	107_S	0.805	0.80
59_T	229_M	0.801	0.79
241_I	260_D	0.800	0.79
68_T	84_I	0.799	0.79
29_N	314_T	0.796	0.79
248_I	287_I	0.796	0.79
51_V	55_V	0.796	0.79
199_G	287_I	0.789	0.78
223_F	227_T	0.784	0.78
262_T	285_S	0.783	0.78
195_Q	280_T	0.779	0.77
255_N	294_H	0.770	0.77
59_T	308_L	0.770	0.77
109_H	189_H	0.769	0.76
120_I	153_I	0.768	0.76
187_Y	261_L	0.765	0.76
28_A	144_P	0.765	0.76
153_I	324_I	0.765	0.76
208_A	211_H	0.762	0.76
18_F	107_S	0.761	0.76
118_A	183_A	0.748	0.74
192_N	271_T	0.748	0.74
49_A	53_N	0.742	0.74
206_I	212_T	0.741	0.74
17_A	21_I	0.738	0.73
38_K	41_K	0.738	0.73
86_A	329_L	0.737	0.73
288_L	304_A	0.735	0.73
134_I	138_E	0.735	0.73
20_F	96_L	0.734	0.73
82_V	329_L	0.733	0.73
186_S	257_V	0.733	0.73
300_N	303_T	0.732	0.73
255_N	274_H	0.727	0.72
140_L	144_P	0.727	0.72
256_G	260_D	0.724	0.72
118_A	252_R	0.722	0.72
256_G	279_T	0.719	0.71
89_L	227_T	0.719	0.71
283_I	287_I	0.716	0.71
34_S	39_A	0.714	0.71
89_L	325_A	0.714	0.71
71_I	199_G	0.713	0.71
24_F	95_N	0.713	0.71
21_I	95_N	0.710	0.71
271_T	281_H	0.709	0.70
19_D	107_S	0.708	0.70
24_F	98_T	0.708	0.70
194_A	225_C	0.707	0.70
154_L	261_L	0.701	0.70
52_M	234_S	0.701	0.70
14_C	72_V	0.699	0.69
136_I	192_N	0.698	0.69
155_Y	254_V	0.698	0.69
91_A	144_P	0.697	0.69
212_T	215_N	0.697	0.69
71_I	74_P	0.696	0.69
6_I	131_K	0.695	0.69
10_L	309_I	0.694	0.69
90_A	322_G	0.691	0.68
214_A	328_I	0.689	0.68
267_I	271_T	0.688	0.68
217_I	222_Q	0.688	0.68
251_I	259_A	0.686	0.68
175_R	239_K	0.685	0.68
14_C	92_I	0.685	0.68
56_G	140_L	0.681	0.67
99_W	107_S	0.680	0.67
224_A	228_A	0.680	0.67
249_M	294_H	0.680	0.67
14_C	318_S	0.677	0.67
40_L	259_A	0.677	0.67
19_D	36_S	0.675	0.67
191_T	204_A	0.673	0.66
188_T	192_N	0.671	0.66
99_W	239_K	0.671	0.66
280_T	314_T	0.670	0.66
318_S	321_L	0.668	0.66
193_D	279_T	0.668	0.66
250_K	305_K	0.666	0.66
267_I	315_L	0.666	0.66
180_V	207_T	0.666	0.66
292_A	299_V	0.662	0.65
18_F	42_P	0.662	0.65
83_V	183_A	0.661	0.65
178_Q	253_P	0.661	0.65
182_A	185_Q	0.660	0.65
60_F	226_A	0.659	0.65
109_H	310_T	0.658	0.65
195_Q	198_M	0.657	0.65
89_L	133_F	0.652	0.64
188_T	282_V	0.650	0.64
262_T	266_I	0.649	0.64
27_T	229_M	0.647	0.63
24_F	236_G	0.647	0.63
193_D	196_K	0.645	0.63
34_S	294_H	0.645	0.63
213_S	216_D	0.642	0.63
152_F	295_R	0.638	0.62
236_G	239_K	0.638	0.62
39_A	175_R	0.638	0.62
141_I	261_L	0.637	0.62
9_I	12_V	0.636	0.62
184_L	268_F	0.634	0.62
198_M	201_I	0.633	0.62
188_T	268_F	0.632	0.62
150_L	262_T	0.629	0.61
38_K	217_I	0.627	0.61
142_L	145_I	0.627	0.61
293_S	318_S	0.624	0.61
315_L	318_S	0.623	0.60
168_A	172_K	0.622	0.60
68_T	206_I	0.622	0.60
110_A	197_A	0.622	0.60
169_K	180_V	0.622	0.60
281_H	310_T	0.621	0.60
269_G	329_L	0.621	0.60
18_F	25_H	0.619	0.60
156_S	159_K	0.619	0.60
82_V	85_L	0.618	0.60
47_I	166_N	0.618	0.60
140_L	196_K	0.613	0.59
122_A	318_S	0.612	0.59
26_D	280_T	0.612	0.59
326_Y	329_L	0.611	0.59
105_S	110_A	0.610	0.59
224_A	227_T	0.610	0.59
290_V	298_G	0.609	0.59
73_D	209_N	0.604	0.58
142_L	327_F	0.602	0.58
147_A	263_G	0.599	0.57
97_I	321_L	0.599	0.57
55_V	59_T	0.599	0.57
146_I	266_I	0.599	0.57
301_W	304_A	0.597	0.57
271_T	297_K	0.596	0.57
26_D	314_T	0.596	0.57
37_T	108_S	0.593	0.57
38_K	304_A	0.593	0.57
66_T	70_D	0.592	0.57
8_T	81_S	0.591	0.56
212_T	216_D	0.590	0.56
223_F	264_A	0.588	0.56
30_A	34_S	0.588	0.56
154_L	288_L	0.588	0.56
152_F	192_N	0.588	0.56
124_G	132_G	0.587	0.56
133_F	272_F	0.587	0.56
33_T	181_T	0.587	0.56
131_K	149_V	0.586	0.56
90_A	317_I	0.584	0.56
42_P	238_W	0.583	0.55
191_T	282_V	0.581	0.55
30_A	37_T	0.580	0.55
249_M	252_R	0.580	0.55
110_A	317_I	0.578	0.55
266_I	287_I	0.577	0.55
6_I	213_S	0.576	0.55
25_H	144_P	0.575	0.54
130_Y	134_I	0.575	0.54
214_A	217_I	0.573	0.54
13_I	309_I	0.573	0.54
58_M	317_I	0.573	0.54
11_I	85_L	0.573	0.54
7_L	328_I	0.571	0.54
153_I	320_T	0.571	0.54
189_H	193_D	0.570	0.54
92_I	224_A	0.570	0.54
193_D	316_P	0.570	0.54
33_T	259_A	0.569	0.54
102_G	289_G	0.567	0.53
109_H	314_T	0.566	0.53
18_F	108_S	0.565	0.53
70_D	75_Y	0.562	0.53
279_T	314_T	0.562	0.53
99_W	236_G	0.561	0.53
139_A	143_S	0.559	0.52
44_H	47_I	0.553	0.52
162_F	221_V	0.553	0.52
70_D	84_I	0.553	0.52
211_H	218_P	0.552	0.51
131_K	219_T	0.552	0.51
167_L	170_T	0.552	0.51
99_W	108_S	0.551	0.51
56_G	185_Q	0.551	0.51
209_N	322_G	0.549	0.51
258_S	262_T	0.548	0.51
22_N	196_K	0.545	0.51
87_A	143_S	0.544	0.50
47_I	125_F	0.542	0.50
101_Y	120_I	0.542	0.50
60_F	116_A	0.541	0.50
182_A	229_M	0.540	0.50
51_V	231_L	0.540	0.50
189_H	279_T	0.539	0.50
186_S	285_S	0.537	0.50
91_A	306_R	0.535	0.49
43_R	47_I	0.534	0.49
249_M	291_G	0.533	0.49
20_F	107_S	0.533	0.49
161_I	234_S	0.531	0.49
248_I	285_S	0.531	0.49
281_H	315_L	0.529	0.49
164_D	322_G	0.529	0.49
8_T	218_P	0.529	0.49
33_T	178_Q	0.528	0.48
320_T	327_F	0.527	0.48
166_N	320_T	0.527	0.48
195_Q	236_G	0.523	0.48
108_S	179_I	0.523	0.48
153_I	269_G	0.522	0.48
119_A	123_A	0.521	0.48
34_S	260_D	0.520	0.47
19_D	108_S	0.520	0.47
321_L	325_A	0.520	0.47
59_T	62_G	0.517	0.47
25_H	189_H	0.517	0.47
108_S	196_K	0.516	0.47
73_D	78_E	0.515	0.47
147_A	275_L	0.515	0.47
30_A	53_N	0.514	0.47
177_V	184_L	0.514	0.47
171_N	252_R	0.512	0.46
312_V	323_A	0.512	0.46
104_P	307_M	0.512	0.46
175_R	248_I	0.512	0.46
156_S	329_L	0.511	0.46
93_A	321_L	0.510	0.46
22_N	195_Q	0.509	0.46
292_A	295_R	0.509	0.46
38_K	239_K	0.508	0.46
294_H	298_G	0.508	0.46
87_A	91_A	0.507	0.46
87_A	118_A	0.506	0.46
260_D	266_I	0.506	0.46
120_I	227_T	0.505	0.45
156_S	317_I	0.505	0.45
150_L	154_L	0.504	0.45
35_V	304_A	0.504	0.45
277_V	290_V	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4nefA	4	0.5105	25.6	0.964	Contact Map
3cn5A	3	0.4625	16.1	0.967	Contact Map
3zojA	3	0.4925	11.8	0.969	Contact Map
3c02A	3	0.4865	7.6	0.972	Contact Map
1j4nA	4	0.5045	7	0.972	Contact Map
3gd8A	4	0.4625	6.7	0.973	Contact Map
3qe7A	2	0.4745	5.5	0.974	Contact Map
1jb0I	1	0.1141	5.4	0.974	Contact Map
4l6vi	1	0.1141	4.2	0.975	Contact Map
1ldfA	3	0.4805	4.2	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.