GREMLIN Database
PIT - Probable low-affinity inorganic phosphate transporter
UniProt: O34436 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (321)
Sequences: 2688 (1408)
Seq/√Len: 78.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_K44_H4.6711.00
62_G274_H4.2931.00
20_F235_I4.1321.00
48_L183_A3.0921.00
324_I328_I2.8511.00
153_I157_I2.7831.00
116_A133_F2.6841.00
137_I141_I2.6571.00
158_V258_S2.5881.00
72_V119_A2.5111.00
138_E142_L2.4311.00
83_V118_A2.4231.00
25_H98_T2.4031.00
16_L228_A2.3681.00
132_G135_K2.3471.00
90_A321_L2.2851.00
98_T105_S2.2701.00
40_L179_I2.2521.00
54_F227_T2.2471.00
16_L224_A2.2391.00
205_L221_V2.2271.00
11_I204_A2.2221.00
148_F292_A2.2031.00
34_S182_A2.1981.00
65_K69_K2.1921.00
299_V304_A2.1901.00
121_A323_A2.1831.00
120_I125_F2.1641.00
97_I101_Y2.1581.00
93_A97_I2.1471.00
22_N107_S2.1331.00
240_I243_T2.1281.00
47_I51_V2.0731.00
99_W240_I2.0501.00
49_A186_S2.0221.00
33_T260_D2.0211.00
14_C85_L2.0211.00
31_I35_V2.0201.00
25_H99_W1.9721.00
263_G283_I1.9521.00
73_D76_T1.9321.00
9_I13_I1.9291.00
177_V257_V1.9221.00
109_H281_H1.9201.00
317_I321_L1.9001.00
55_V187_Y1.8991.00
53_N233_T1.8971.00
99_W105_S1.8161.00
95_N107_S1.8141.00
46_I234_S1.8081.00
52_M183_A1.8031.00
188_T267_I1.7841.00
244_V284_S1.7751.00
53_N189_H1.7501.00
154_L258_S1.7371.00
137_I317_I1.7061.00
271_T274_H1.6861.00
142_L146_I1.6851.00
320_T324_I1.6791.00
174_F257_V1.6261.00
244_V287_I1.6211.00
191_T271_T1.5921.00
30_A185_Q1.5891.00
17_A96_L1.5891.00
19_D228_A1.5871.00
159_K294_H1.5871.00
103_I310_T1.5741.00
184_L264_A1.5580.99
156_S160_L1.5550.99
25_H95_N1.5160.99
58_M219_T1.5140.99
40_L260_D1.5080.99
152_F293_S1.5030.99
160_L163_K1.4950.99
39_A260_D1.4770.99
93_A325_A1.4700.99
56_G226_A1.4550.99
25_H105_S1.4520.99
21_I96_L1.4520.99
323_A327_F1.4430.99
73_D77_L1.4010.99
181_T261_L1.3960.99
277_V282_V1.3780.99
157_I160_L1.3760.99
322_G325_A1.3580.99
141_I312_V1.3570.99
87_A114_A1.3560.99
90_A318_S1.3550.99
26_D29_N1.3470.98
112_I136_I1.3320.98
185_Q251_I1.3210.98
34_S48_L1.3150.98
25_H107_S1.3080.98
309_I313_I1.3030.98
68_T215_N1.3030.98
94_W314_T1.2990.98
25_H240_I1.2870.98
46_I50_A1.2830.98
134_I137_I1.2820.98
319_A323_A1.2800.98
65_K68_T1.2780.98
157_I161_I1.2720.98
318_S322_G1.2670.98
243_T307_M1.2440.97
252_R294_H1.2400.97
194_A229_M1.2270.97
8_T208_A1.2240.97
88_L264_A1.2150.97
30_A256_G1.2150.97
49_A233_T1.2130.97
105_S240_I1.2070.97
113_G318_S1.1910.97
145_I149_V1.1830.96
176_R180_V1.1770.96
267_I282_V1.1720.96
60_F191_T1.1710.96
24_F99_W1.1680.96
88_L187_Y1.1680.96
122_A326_Y1.1650.96
86_A325_A1.1640.96
129_N132_G1.1600.96
18_F91_A1.1560.96
184_L265_A1.1550.96
77_L81_S1.1530.96
63_V66_T1.1530.96
38_K246_G1.1490.96
98_T107_S1.1460.96
260_D283_I1.1460.96
270_A277_V1.1430.96
33_T283_I1.1380.96
90_A319_A1.1350.96
158_V162_F1.1330.95
13_I17_A1.1330.95
70_D73_D1.1290.95
75_Y81_S1.1210.95
248_I303_T1.1180.95
35_V45_A1.1170.95
325_A329_L1.1090.95
202_T217_I1.1060.95
193_D280_T1.1060.95
263_G286_S1.0900.94
54_F230_G1.0900.94
252_R255_N1.0750.94
13_I145_I1.0730.94
162_F165_S1.0660.94
67_I199_G1.0650.94
146_I269_G1.0640.94
231_L235_I1.0620.94
198_M225_C1.0600.94
139_A191_T1.0590.93
178_Q256_G1.0490.93
188_T271_T1.0400.93
148_F285_S1.0390.93
35_V241_I1.0350.93
188_T274_H1.0270.92
114_A118_A1.0200.92
217_I221_V1.0170.92
131_K320_T1.0090.92
242_K247_K1.0040.92
211_H215_N1.0020.91
206_I215_N0.9940.91
20_F236_G0.9920.91
197_A225_C0.9870.91
211_H214_A0.9850.91
178_Q260_D0.9790.91
295_R298_G0.9780.90
242_K246_G0.9730.90
110_A121_A0.9700.90
282_V286_S0.9690.90
93_A231_L0.9680.90
302_G305_K0.9670.90
29_N189_H0.9650.90
21_I197_A0.9620.90
48_L52_M0.9580.90
14_C187_Y0.9570.89
12_V16_L0.9500.89
58_M226_A0.9460.89
305_K309_I0.9410.89
60_F185_Q0.9350.88
284_S288_L0.9310.88
322_G326_Y0.9290.88
95_N111_I0.9270.88
47_I160_L0.9260.88
63_V274_H0.9220.88
230_G233_T0.9220.88
37_T53_N0.9200.88
259_A283_I0.9200.88
8_T204_A0.9200.88
89_L93_A0.9150.87
206_I217_I0.9150.87
152_F156_S0.9130.87
62_G65_K0.9120.87
254_V258_S0.9050.87
58_M223_F0.9010.86
243_T303_T0.9000.86
201_I225_C0.8980.86
37_T47_I0.8980.86
70_D128_L0.8950.86
181_T260_D0.8860.86
6_I208_A0.8860.86
120_I127_A0.8830.85
29_N53_N0.8820.85
165_S170_T0.8790.85
7_L85_L0.8780.85
113_G117_G0.8780.85
192_N267_I0.8770.85
177_V180_V0.8750.85
182_A186_S0.8740.85
27_T233_T0.8720.85
10_L82_V0.8700.84
85_L329_L0.8700.84
172_K176_R0.8680.84
324_I327_F0.8660.84
95_N99_W0.8630.84
58_M222_Q0.8610.84
120_I123_A0.8600.84
68_T108_S0.8580.84
308_L312_V0.8550.83
68_T214_A0.8540.83
173_Q177_V0.8530.83
59_T187_Y0.8500.83
87_A115_I0.8470.83
194_A200_I0.8460.83
50_A186_S0.8460.83
136_I318_S0.8390.82
95_N105_S0.8390.82
48_L56_G0.8370.82
65_K216_D0.8330.82
102_G114_A0.8330.82
119_A315_L0.8330.82
209_N213_S0.8270.81
50_A230_G0.8260.81
34_S179_I0.8260.81
95_N98_T0.8260.81
57_A226_A0.8230.81
86_A90_A0.8220.81
32_A236_G0.8210.81
110_A314_T0.8140.80
185_Q263_G0.8130.80
70_D76_T0.8110.80
29_N279_T0.8110.80
219_T223_F0.8080.80
24_F107_S0.8050.80
59_T229_M0.8010.79
241_I260_D0.8000.79
68_T84_I0.7990.79
29_N314_T0.7960.79
248_I287_I0.7960.79
51_V55_V0.7960.79
199_G287_I0.7890.78
223_F227_T0.7840.78
262_T285_S0.7830.78
195_Q280_T0.7790.77
255_N294_H0.7700.77
59_T308_L0.7700.77
109_H189_H0.7690.76
120_I153_I0.7680.76
187_Y261_L0.7650.76
28_A144_P0.7650.76
153_I324_I0.7650.76
208_A211_H0.7620.76
18_F107_S0.7610.76
118_A183_A0.7480.74
192_N271_T0.7480.74
49_A53_N0.7420.74
206_I212_T0.7410.74
17_A21_I0.7380.73
38_K41_K0.7380.73
86_A329_L0.7370.73
288_L304_A0.7350.73
134_I138_E0.7350.73
20_F96_L0.7340.73
82_V329_L0.7330.73
186_S257_V0.7330.73
300_N303_T0.7320.73
255_N274_H0.7270.72
140_L144_P0.7270.72
256_G260_D0.7240.72
118_A252_R0.7220.72
256_G279_T0.7190.71
89_L227_T0.7190.71
283_I287_I0.7160.71
34_S39_A0.7140.71
89_L325_A0.7140.71
71_I199_G0.7130.71
24_F95_N0.7130.71
21_I95_N0.7100.71
271_T281_H0.7090.70
19_D107_S0.7080.70
24_F98_T0.7080.70
194_A225_C0.7070.70
154_L261_L0.7010.70
52_M234_S0.7010.70
14_C72_V0.6990.69
136_I192_N0.6980.69
155_Y254_V0.6980.69
91_A144_P0.6970.69
212_T215_N0.6970.69
71_I74_P0.6960.69
6_I131_K0.6950.69
10_L309_I0.6940.69
90_A322_G0.6910.68
214_A328_I0.6890.68
267_I271_T0.6880.68
217_I222_Q0.6880.68
251_I259_A0.6860.68
175_R239_K0.6850.68
14_C92_I0.6850.68
56_G140_L0.6810.67
99_W107_S0.6800.67
224_A228_A0.6800.67
249_M294_H0.6800.67
14_C318_S0.6770.67
40_L259_A0.6770.67
19_D36_S0.6750.67
191_T204_A0.6730.66
188_T192_N0.6710.66
99_W239_K0.6710.66
280_T314_T0.6700.66
318_S321_L0.6680.66
193_D279_T0.6680.66
250_K305_K0.6660.66
267_I315_L0.6660.66
180_V207_T0.6660.66
292_A299_V0.6620.65
18_F42_P0.6620.65
83_V183_A0.6610.65
178_Q253_P0.6610.65
182_A185_Q0.6600.65
60_F226_A0.6590.65
109_H310_T0.6580.65
195_Q198_M0.6570.65
89_L133_F0.6520.64
188_T282_V0.6500.64
262_T266_I0.6490.64
27_T229_M0.6470.63
24_F236_G0.6470.63
193_D196_K0.6450.63
34_S294_H0.6450.63
213_S216_D0.6420.63
152_F295_R0.6380.62
236_G239_K0.6380.62
39_A175_R0.6380.62
141_I261_L0.6370.62
9_I12_V0.6360.62
184_L268_F0.6340.62
198_M201_I0.6330.62
188_T268_F0.6320.62
150_L262_T0.6290.61
38_K217_I0.6270.61
142_L145_I0.6270.61
293_S318_S0.6240.61
315_L318_S0.6230.60
168_A172_K0.6220.60
68_T206_I0.6220.60
110_A197_A0.6220.60
169_K180_V0.6220.60
281_H310_T0.6210.60
269_G329_L0.6210.60
18_F25_H0.6190.60
156_S159_K0.6190.60
82_V85_L0.6180.60
47_I166_N0.6180.60
140_L196_K0.6130.59
122_A318_S0.6120.59
26_D280_T0.6120.59
326_Y329_L0.6110.59
105_S110_A0.6100.59
224_A227_T0.6100.59
290_V298_G0.6090.59
73_D209_N0.6040.58
142_L327_F0.6020.58
147_A263_G0.5990.57
97_I321_L0.5990.57
55_V59_T0.5990.57
146_I266_I0.5990.57
301_W304_A0.5970.57
271_T297_K0.5960.57
26_D314_T0.5960.57
37_T108_S0.5930.57
38_K304_A0.5930.57
66_T70_D0.5920.57
8_T81_S0.5910.56
212_T216_D0.5900.56
223_F264_A0.5880.56
30_A34_S0.5880.56
154_L288_L0.5880.56
152_F192_N0.5880.56
124_G132_G0.5870.56
133_F272_F0.5870.56
33_T181_T0.5870.56
131_K149_V0.5860.56
90_A317_I0.5840.56
42_P238_W0.5830.55
191_T282_V0.5810.55
30_A37_T0.5800.55
249_M252_R0.5800.55
110_A317_I0.5780.55
266_I287_I0.5770.55
6_I213_S0.5760.55
25_H144_P0.5750.54
130_Y134_I0.5750.54
214_A217_I0.5730.54
13_I309_I0.5730.54
58_M317_I0.5730.54
11_I85_L0.5730.54
7_L328_I0.5710.54
153_I320_T0.5710.54
189_H193_D0.5700.54
92_I224_A0.5700.54
193_D316_P0.5700.54
33_T259_A0.5690.54
102_G289_G0.5670.53
109_H314_T0.5660.53
18_F108_S0.5650.53
70_D75_Y0.5620.53
279_T314_T0.5620.53
99_W236_G0.5610.53
139_A143_S0.5590.52
44_H47_I0.5530.52
162_F221_V0.5530.52
70_D84_I0.5530.52
211_H218_P0.5520.51
131_K219_T0.5520.51
167_L170_T0.5520.51
99_W108_S0.5510.51
56_G185_Q0.5510.51
209_N322_G0.5490.51
258_S262_T0.5480.51
22_N196_K0.5450.51
87_A143_S0.5440.50
47_I125_F0.5420.50
101_Y120_I0.5420.50
60_F116_A0.5410.50
182_A229_M0.5400.50
51_V231_L0.5400.50
189_H279_T0.5390.50
186_S285_S0.5370.50
91_A306_R0.5350.49
43_R47_I0.5340.49
249_M291_G0.5330.49
20_F107_S0.5330.49
161_I234_S0.5310.49
248_I285_S0.5310.49
281_H315_L0.5290.49
164_D322_G0.5290.49
8_T218_P0.5290.49
33_T178_Q0.5280.48
320_T327_F0.5270.48
166_N320_T0.5270.48
195_Q236_G0.5230.48
108_S179_I0.5230.48
153_I269_G0.5220.48
119_A123_A0.5210.48
34_S260_D0.5200.47
19_D108_S0.5200.47
321_L325_A0.5200.47
59_T62_G0.5170.47
25_H189_H0.5170.47
108_S196_K0.5160.47
73_D78_E0.5150.47
147_A275_L0.5150.47
30_A53_N0.5140.47
177_V184_L0.5140.47
171_N252_R0.5120.46
312_V323_A0.5120.46
104_P307_M0.5120.46
175_R248_I0.5120.46
156_S329_L0.5110.46
93_A321_L0.5100.46
22_N195_Q0.5090.46
292_A295_R0.5090.46
38_K239_K0.5080.46
294_H298_G0.5080.46
87_A91_A0.5070.46
87_A118_A0.5060.46
260_D266_I0.5060.46
120_I227_T0.5050.45
156_S317_I0.5050.45
150_L154_L0.5040.45
35_V304_A0.5040.45
277_V290_V0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nefA 4 0.5105 25.6 0.964 Contact Map
3cn5A 3 0.4625 16.1 0.967 Contact Map
3zojA 3 0.4925 11.8 0.969 Contact Map
3c02A 3 0.4865 7.6 0.972 Contact Map
1j4nA 4 0.5045 7 0.972 Contact Map
3gd8A 4 0.4625 6.7 0.973 Contact Map
3qe7A 2 0.4745 5.5 0.974 Contact Map
1jb0I 1 0.1141 5.4 0.974 Contact Map
4l6vi 1 0.1141 4.2 0.975 Contact Map
1ldfA 3 0.4805 4.2 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.01 seconds.