GREMLIN Database
ATCL - Calcium-transporting ATPase
UniProt: O34431 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 890 (836)
Sequences: 10603 (6851)
Seq/√Len: 236.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_V206_G7.0351.00
25_E121_E4.9591.00
138_V150_V4.1421.00
321_S626_H4.0601.00
452_K509_P4.0181.00
597_S623_E3.9441.00
35_H134_P3.8751.00
28_V32_L3.8611.00
39_E130_K3.8551.00
340_H498_Q3.7621.00
570_A605_V3.7551.00
27_E31_R3.6041.00
428_R447_E3.5721.00
592_S595_E3.4811.00
382_F528_L3.4701.00
550_E749_K3.3971.00
27_E30_K3.3721.00
686_E750_R3.2651.00
481_S484_R3.2601.00
619_K643_Q3.1941.00
601_E624_N3.1851.00
160_I199_V3.1771.00
593_Q616_K3.1701.00
30_K34_K3.1611.00
150_V193_A3.0621.00
134_P211_T3.0061.00
115_H126_K2.9991.00
454_Y509_P2.9251.00
62_L66_A2.8941.00
457_T525_L2.8611.00
469_S524_D2.8341.00
333_Q539_P2.8281.00
138_V206_G2.7911.00
137_I153_V2.7491.00
430_I453_R2.7411.00
546_K550_E2.7201.00
41_Q213_M2.7201.00
507_Y526_T2.7031.00
491_V494_H2.6931.00
32_L211_T2.6591.00
158_L204_G2.6531.00
154_E205_V2.6311.00
304_Q676_S2.5821.00
119_L205_V2.5341.00
138_V147_G2.4611.00
382_F456_I2.4521.00
160_I193_A2.4421.00
192_M209_V2.4421.00
540_E670_N2.4401.00
47_S50_L2.4081.00
378_Q507_Y2.3891.00
119_L124_W2.3861.00
447_E453_R2.3861.00
32_L37_P2.3811.00
441_M467_R2.3571.00
589_N613_H2.3531.00
231_S239_E2.3471.00
443_T455_I2.3361.00
649_S662_S2.3321.00
46_T54_A2.3171.00
457_T464_L2.3021.00
506_A525_L2.2921.00
124_W139_K2.2721.00
622_Q643_Q2.2711.00
216_A219_K2.2621.00
37_P131_E2.2341.00
554_K604_Y2.2321.00
495_L532_G2.2231.00
37_P130_K2.1781.00
140_F146_I2.1741.00
304_Q679_K2.1731.00
601_E626_H2.1701.00
189_I194_F2.1581.00
846_V850_Y2.1341.00
25_E125_T2.1221.00
553_I678_I2.1191.00
597_S620_A2.1161.00
193_A206_G2.0931.00
486_A490_A2.0591.00
581_K602_D2.0561.00
260_G270_M2.0461.00
485_K489_E2.0431.00
92_I96_F2.0351.00
863_T866_D2.0331.00
567_K571_K2.0311.00
152_I155_A2.0291.00
493_R564_E2.0271.00
133_V211_T2.0261.00
488_T527_M2.0251.00
29_K33_D2.0251.00
117_M141_T2.0231.00
48_A95_F2.0191.00
543_Q547_E2.0171.00
132_L208_V2.0101.00
150_V209_V2.0051.00
56_F91_G2.0011.00
25_E29_K1.9971.00
119_L139_K1.9771.00
547_E679_K1.9761.00
443_T457_T1.9591.00
597_S624_N1.9531.00
115_H128_P1.9491.00
196_G217_M1.9431.00
146_I199_V1.9401.00
152_I193_A1.9271.00
411_T415_K1.9251.00
545_I575_L1.9231.00
117_M124_W1.9121.00
48_A52_F1.8981.00
556_V621_Y1.8931.00
308_V664_L1.8881.00
464_L506_A1.8861.00
583_M591_L1.8731.00
548_C675_K1.8661.00
428_R446_V1.8591.00
540_E543_Q1.8541.00
549_R577_P1.8471.00
484_R487_E1.8411.00
30_K33_D1.8411.00
132_L138_V1.8341.00
563_V582_I1.8331.00
158_L199_V1.8311.00
24_T121_E1.8221.00
306_S673_T1.8151.00
508_R524_D1.8061.00
29_K32_L1.7911.00
470_R526_T1.7861.00
466_Q485_K1.7841.00
504_A527_M1.7831.00
257_V274_G1.7811.00
490_A494_H1.7671.00
148_A208_V1.7541.00
443_T522_E1.7511.00
72_G80_A1.7421.00
26_K30_K1.7371.00
388_N429_V1.7331.00
119_L137_I1.7241.00
378_Q381_L1.7231.00
482_N486_A1.7221.00
24_T28_V1.7221.00
139_K205_V1.7211.00
468_S506_A1.6991.00
502_T530_L1.6951.00
868_M872_G1.6871.00
854_Q861_A1.6861.00
683_N743_P1.6731.00
537_P573_L1.6651.00
159_E201_R1.6601.00
180_K184_V1.6571.00
583_M603_V1.6521.00
455_I510_I1.6461.00
338_V412_A1.6451.00
320_A629_A1.6451.00
507_Y528_L1.6411.00
57_K62_L1.6371.00
584_D587_M1.6291.00
542_R546_K1.6121.00
128_P131_E1.6071.00
247_V251_L1.6041.00
796_Y866_D1.6021.00
489_E493_R1.5891.00
445_I510_I1.5891.00
377_Q381_L1.5721.00
152_I206_G1.5601.00
46_T50_L1.5571.00
382_F505_V1.5521.00
814_F837_V1.5461.00
24_T27_E1.5451.00
400_L407_G1.5421.00
258_A262_I1.5391.00
32_L131_E1.5391.00
342_W491_V1.5381.00
68_T84_I1.5371.00
596_L600_V1.5361.00
379_M383_G1.5341.00
380_L412_A1.5331.00
331_M573_L1.5241.00
619_K623_E1.5211.00
430_I447_E1.5181.00
383_G386_C1.5111.00
794_L798_Q1.5031.00
99_R103_Q1.5011.00
620_A623_E1.5001.00
482_N485_K1.5001.00
238_L290_V1.4981.00
127_I131_E1.4921.00
445_I521_A1.4901.00
206_G209_V1.4891.00
493_R497_S1.4691.00
250_L254_V1.4671.00
307_I667_V1.4651.00
153_V207_V1.4631.00
591_L599_V1.4621.00
882_A885_L1.4591.00
81_V85_A1.4591.00
140_F199_V1.4551.00
500_L532_G1.4481.00
95_F99_R1.4441.00
543_Q546_K1.4421.00
339_T572_D1.4381.00
420_K424_E1.4381.00
669_D674_I1.4301.00
137_I207_V1.4281.00
42_E109_K1.4221.00
140_F193_A1.4161.00
669_D672_A1.4101.00
563_V584_D1.3991.00
629_A648_V1.3941.00
116_V132_L1.3931.00
439_R522_E1.3921.00
440_K460_A1.3911.00
384_A413_A1.3901.00
65_L87_V1.3871.00
641_I658_A1.3871.00
567_K582_I1.3831.00
152_I204_G1.3811.00
159_E173_V1.3791.00
336_M406_E1.3781.00
117_M126_K1.3771.00
378_Q456_I1.3721.00
558_I617_I1.3691.00
505_V531_S1.3681.00
622_Q645_D1.3661.00
305_K667_V1.3661.00
54_A57_K1.3631.00
490_A493_R1.3631.00
597_S600_V1.3621.00
384_A387_N1.3621.00
652_I658_A1.3581.00
347_T495_L1.3511.00
497_S564_E1.3511.00
240_Q244_I1.3481.00
835_G839_S1.3401.00
305_K668_D1.3381.00
454_Y507_Y1.3361.00
382_F386_C1.3261.00
151_R209_V1.3231.00
52_F95_F1.3221.00
322_I556_V1.3201.00
320_A646_I1.3171.00
441_M522_E1.3121.00
340_H349_R1.3071.00
559_T566_A1.3061.00
834_I838_L1.3051.00
509_P526_T1.3041.00
581_K599_V1.3041.00
448_N452_K1.3011.00
230_L622_Q1.2971.00
508_R523_K1.2961.00
442_M458_K1.2951.00
271_F275_V1.2941.00
389_S410_L1.2821.00
600_V620_A1.2821.00
464_L468_S1.2751.00
864_P868_M1.2751.00
495_L500_L1.2701.00
468_S527_M1.2601.00
65_L69_L1.2601.00
380_L383_G1.2561.00
596_L616_K1.2441.00
672_A675_K1.2421.00
85_A89_V1.2411.00
803_A844_M1.2401.00
795_A798_Q1.2331.00
446_V456_I1.2321.00
725_W844_M1.2311.00
449_Q452_K1.2291.00
847_V857_F1.2251.00
461_P492_L1.2251.00
547_E550_E1.2251.00
409_L531_S1.2201.00
875_A879_F1.2201.00
540_E672_A1.2191.00
494_H498_Q1.2151.00
382_F387_N1.2151.00
599_V603_V1.2141.00
704_L776_G1.2141.00
31_R35_H1.2131.00
383_G387_N1.2021.00
103_Q106_Q1.2001.00
669_D675_K1.1981.00
708_F776_G1.1971.00
324_C621_Y1.1961.00
779_T801_A1.1941.00
69_L73_F1.1941.00
340_H495_L1.1921.00
146_I193_A1.1901.00
236_R645_D1.1871.00
566_A607_A1.1871.00
486_A489_E1.1861.00
563_V567_K1.1851.00
689_R757_E1.1851.00
619_K622_Q1.1851.00
193_A199_V1.1851.00
760_F764_L1.1851.00
464_L504_A1.1841.00
324_C558_I1.1821.00
151_R192_M1.1821.00
117_M139_K1.1791.00
338_V409_L1.1731.00
439_R443_T1.1721.00
455_I525_L1.1691.00
803_A848_I1.1671.00
676_S679_K1.1661.00
142_S436_D1.1641.00
633_D636_N1.1611.00
379_M529_G1.1531.00
151_R207_V1.1511.00
116_V129_S1.1411.00
77_Y81_V1.1391.00
383_G531_S1.1371.00
300_R680_E1.1341.00
793_N796_Y1.1321.00
598_H602_D1.1321.00
117_M144_D1.1321.00
153_V205_V1.1301.00
463_V466_Q1.1271.00
702_E730_T1.1261.00
383_G505_V1.1261.00
28_V37_P1.1251.00
585_G613_H1.1221.00
407_G411_T1.1211.00
781_L785_I1.1181.00
445_I455_I1.1181.00
598_H601_E1.1151.00
162_E174_K1.1141.00
780_I784_I1.1121.00
534_I572_D1.1081.00
470_R524_D1.0961.00
231_S236_R1.0951.00
487_E490_A1.0951.00
405_T533_I1.0941.00
337_T415_K1.0901.00
223_M612_E1.0901.00
26_K29_K1.0861.00
872_G876_I1.0851.00
600_V624_N1.0851.00
32_L35_H1.0841.00
299_Q303_K1.0821.00
152_I176_A1.0811.00
812_H815_D1.0791.00
236_R240_Q1.0761.00
189_I216_A1.0761.00
567_K576_L1.0761.00
419_S422_F1.0751.00
45_K106_Q1.0751.00
180_K191_N1.0741.00
121_E125_T1.0701.00
72_G84_I1.0691.00
656_D659_K1.0671.00
487_E491_V1.0661.00
570_A575_L1.0641.00
879_F883_G1.0611.00
854_Q859_T1.0601.00
680_E683_N1.0551.00
388_N432_E1.0541.00
463_V467_R1.0521.00
870_V874_S1.0491.00
127_I132_L1.0481.00
427_Y456_I1.0481.00
548_C555_T1.0461.00
769_V773_F1.0461.00
261_V267_L1.0441.00
669_D673_T1.0441.00
433_F443_T1.0401.00
25_E28_V1.0401.00
378_Q382_F1.0381.00
210_G214_N1.0371.00
596_L620_A1.0361.00
341_V379_M1.0351.00
782_A800_I1.0331.00
832_Y835_G1.0331.00
342_W495_L1.0311.00
155_A176_A1.0291.00
28_V31_R1.0271.00
236_R755_P1.0271.00
849_Y861_A1.0241.00
186_L189_I1.0211.00
243_K247_V1.0191.00
786_V800_I1.0181.00
465_M489_E1.0161.00
606_F621_Y1.0141.00
51_L99_R1.0111.00
26_K121_E1.0111.00
374_K377_Q1.0101.00
754_H757_E1.0091.00
488_T530_L1.0081.00
498_Q572_D1.0081.00
741_D817_R1.0061.00
185_S188_D1.0061.00
52_F91_G1.0021.00
627_I645_D1.0001.00
412_A531_S0.9991.00
440_K463_V0.9981.00
775_I808_A0.9961.00
199_V204_G0.9931.00
576_L580_G0.9931.00
113_T130_K0.9911.00
447_E451_R0.9911.00
441_M457_T0.9891.00
695_L735_A0.9891.00
391_I410_L0.9871.00
557_M566_A0.9831.00
52_F56_F0.9821.00
305_K673_T0.9821.00
323_I629_A0.9801.00
648_V674_I0.9801.00
831_L835_G0.9801.00
845_L849_Y0.9801.00
155_A193_A0.9791.00
145_R660_E0.9791.00
385_L446_V0.9781.00
339_T534_I0.9761.00
548_C671_F0.9761.00
709_A717_P0.9751.00
496_A564_E0.9731.00
800_I866_D0.9721.00
51_L95_F0.9721.00
46_T51_L0.9701.00
306_S677_A0.9691.00
445_I453_R0.9671.00
380_L416_G0.9661.00
338_V531_S0.9651.00
583_M588_L0.9641.00
124_W205_V0.9641.00
50_L54_A0.9631.00
386_C390_N0.9621.00
508_R522_E0.9621.00
427_Y446_V0.9621.00
586_K590_E0.9611.00
386_C389_S0.9571.00
52_F92_I0.9551.00
387_N391_I0.9551.00
646_I664_L0.9541.00
534_I537_P0.9531.00
772_G776_G0.9531.00
491_V495_L0.9521.00
489_E492_L0.9481.00
865_G868_M0.9471.00
387_N390_N0.9471.00
28_V35_H0.9451.00
50_L53_F0.9441.00
838_L842_L0.9431.00
492_L502_T0.9311.00
807_L841_I0.9301.00
340_H500_L0.9301.00
821_S882_A0.9291.00
807_L874_S0.9291.00
618_V630_M0.9281.00
39_E42_E0.9271.00
386_C442_M0.9261.00
352_G415_K0.9261.00
348_W352_G0.9251.00
310_K663_S0.9251.00
28_V131_E0.9241.00
70_I271_F0.9221.00
330_T636_N0.9221.00
465_M488_T0.9221.00
381_L427_Y0.9221.00
343_S379_M0.9211.00
49_L53_F0.9201.00
787_Y797_A0.9181.00
379_M505_V0.9181.00
222_D226_S0.9171.00
338_V533_I0.9141.00
414_R419_S0.9131.00
719_V858_H0.9121.00
866_D870_V0.9121.00
492_L496_A0.9111.00
219_K612_E0.9111.00
340_H532_G0.9061.00
406_E503_I0.9061.00
438_A612_E0.9041.00
447_E512_A0.9031.00
544_A672_A0.9021.00
549_R555_T0.8981.00
429_V432_E0.8981.00
598_H624_N0.8971.00
118_A127_I0.8961.00
55_Q94_G0.8951.00
348_W376_L0.8941.00
595_E598_H0.8930.99
256_V278_A0.8920.99
381_L387_N0.8910.99
541_V573_L0.8890.99
730_T809_Q0.8890.99
429_V444_V0.8880.99
757_E761_A0.8870.99
719_V722_Q0.8870.99
588_L609_V0.8860.99
118_A125_T0.8850.99
132_L147_G0.8850.99
774_L778_A0.8840.99
588_L613_H0.8820.99
433_F521_A0.8820.99
492_L530_L0.8820.99
499_A568_A0.8790.99
146_I160_I0.8790.99
231_S235_Q0.8790.99
556_V600_V0.8770.99
175_H190_T0.8760.99
441_M464_L0.8750.99
134_P210_G0.8750.99
558_I609_V0.8750.99
382_F385_L0.8750.99
77_Y80_A0.8740.99
380_L384_A0.8730.99
429_V446_V0.8700.99
591_L595_E0.8690.99
821_S824_S0.8640.99
653_T659_K0.8600.99
68_T80_A0.8600.99
184_V187_G0.8600.99
699_N731_D0.8590.99
141_T144_D0.8580.99
453_R512_A0.8580.99
309_R662_S0.8570.99
558_I630_M0.8560.99
563_V607_A0.8560.99
453_R513_G0.8560.99
597_S601_E0.8550.99
322_I621_Y0.8550.99
462_D562_H0.8550.99
840_S844_M0.8540.99
594_E597_S0.8540.99
113_T128_P0.8520.99
257_V271_F0.8520.99
679_K745_G0.8500.99
774_L880_L0.8500.99
580_G604_Y0.8490.99
563_V587_M0.8480.99
826_N829_Q0.8480.99
568_A572_D0.8460.99
420_K423_V0.8450.99
297_G684_I0.8450.99
345_G487_E0.8450.99
542_R572_D0.8440.99
836_A840_S0.8400.99
546_K574_R0.8400.99
809_Q812_H0.8390.99
384_A390_N0.8370.99
251_L255_L0.8370.99
782_A873_M0.8360.99
160_I204_G0.8360.99
833_L836_A0.8340.99
296_L740_M0.8340.99
343_S346_K0.8320.99
699_N727_N0.8320.99
383_G409_L0.8310.99
691_F695_L0.8310.99
455_I521_A0.8300.99
47_S53_F0.8270.99
76_E79_D0.8260.99
741_D744_E0.8240.99
797_A801_A0.8220.99
433_F439_R0.8220.99
448_N454_Y0.8200.99
800_I870_V0.8200.99
394_R399_V0.8200.99
595_E599_V0.8190.99
514_E517_S0.8190.99
700_V772_G0.8180.99
330_T633_D0.8180.99
135_G207_V0.8180.99
166_T172_V0.8170.99
469_S526_T0.8170.99
326_D330_T0.8170.99
385_L389_S0.8160.99
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771_R881_L0.5350.89
686_E690_K0.5350.89
74_L759_V0.5350.89
544_A547_E0.5350.89
727_N732_G0.5350.89
386_C393_K0.5350.89
186_L216_A0.5340.89
859_T862_I0.5340.89
134_P214_N0.5340.89
591_L594_E0.5340.89
508_R521_A0.5330.89
508_R514_E0.5330.89
324_C468_S0.5320.89
561_D636_N0.5320.89
385_L391_I0.5320.89
259_V263_Q0.5320.89
650_M671_F0.5320.89
609_V613_H0.5300.89
150_V199_V0.5300.89
775_I779_T0.5300.89
873_M877_P0.5280.88
577_P604_Y0.5280.88
508_R525_L0.5280.88
124_W141_T0.5270.88
372_E378_Q0.5270.88
423_V426_N0.5260.88
386_C444_V0.5260.88
698_S731_D0.5260.88
691_F739_G0.5260.88
694_Y731_D0.5260.88
441_M466_Q0.5250.88
389_S403_D0.5250.88
671_F674_I0.5240.88
265_H269_S0.5240.88
301_M308_V0.5240.88
575_L605_V0.5230.88
326_D501_R0.5230.88
432_E444_V0.5220.88
24_T30_K0.5220.88
346_K373_H0.5210.88
693_R764_L0.5210.88
807_L814_F0.5200.88
290_V688_I0.5200.88
451_R512_A0.5200.88
853_L859_T0.5200.88
849_Y854_Q0.5190.87
116_V147_G0.5190.87
86_I90_N0.5190.87
326_D560_G0.5190.87
730_T805_L0.5190.87
630_M640_A0.5180.87
101_A104_S0.5180.87
461_P573_L0.5180.87
499_A533_I0.5180.87
342_W345_G0.5170.87
698_S727_N0.5170.87
504_A509_P0.5170.87
174_K194_F0.5160.87
777_V873_M0.5160.87
168_E634_G0.5160.87
740_M832_Y0.5160.87
145_R198_I0.5150.87
408_A533_I0.5140.87
679_K748_M0.5140.87
171_P200_T0.5140.87
837_V840_S0.5140.87
827_P834_I0.5140.87
437_S501_R0.5130.87
161_E170_I0.5130.87
379_M528_L0.5130.87
760_F765_G0.5120.87
705_V718_L0.5120.87
344_G375_P0.5110.87
560_G565_T0.5110.87
742_Q829_Q0.5100.87
406_E458_K0.5100.87
70_I74_L0.5090.86
803_A862_I0.5090.86
384_A392_E0.5090.86
771_R775_I0.5080.86
51_L54_A0.5080.86
786_V789_R0.5080.86
449_Q454_Y0.5080.86
326_D329_G0.5070.86
424_E427_Y0.5070.86
331_M541_V0.5070.86
68_T71_S0.5070.86
548_C629_A0.5060.86
841_I844_M0.5060.86
808_A877_P0.5060.86
339_T500_L0.5060.86
719_V798_Q0.5060.86
855_P861_A0.5050.86
120_R123_S0.5050.86
791_P795_A0.5050.86
224_L227_A0.5040.86
486_A493_R0.5040.86
175_H178_K0.5030.86
435_F634_G0.5030.86
818_S825_R0.5030.86
470_R484_R0.5020.86
878_T881_L0.5020.86
379_M389_S0.5020.86
638_A661_A0.5020.86
693_R771_R0.5010.86
728_L731_D0.5010.86
49_L52_F0.5010.86
126_K141_T0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ixzA 1 0.9876 100 0.18 Contact Map
3ar4A 1 0.9989 100 0.18 Contact Map
2zxeA 1 0.9865 100 0.181 Contact Map
1mhsA 2 0.9034 100 0.295 Contact Map
3b8cA 1 0.9079 100 0.299 Contact Map
4bbjA 1 0.6921 100 0.569 Contact Map
4umwA 1 0.6528 100 0.578 Contact Map
3j09A 2 0.6798 100 0.58 Contact Map
3j08A 2 0.6753 100 0.585 Contact Map
3a1cA 2 0.3067 100 0.855 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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