GREMLIN Database
YTNM - UPF0721 transmembrane protein YtnM
UniProt: O34430 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 300 (245)
Sequences: 9677 (6681)
Seq/√Len: 426.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_L225_L3.7511.00
83_G143_V3.6551.00
248_R252_N3.1981.00
90_F147_F3.0811.00
69_D174_K2.8971.00
8_A214_G2.7381.00
232_Q236_V2.5521.00
63_I70_K2.5301.00
233_L236_V2.4301.00
57_A216_I2.4101.00
77_V185_A2.3731.00
112_G116_I2.3631.00
53_V212_M2.3601.00
10_I32_L2.3601.00
141_L163_I2.3451.00
79_P139_I2.2891.00
224_W228_K2.1221.00
73_V181_T2.1211.00
171_S174_K2.1121.00
48_H190_A2.0971.00
104_S253_E2.0771.00
104_S246_N1.9871.00
85_F193_G1.9831.00
57_A220_P1.9601.00
247_A251_I1.9141.00
111_G246_N1.8881.00
69_D72_T1.8841.00
42_V45_A1.8801.00
12_L217_I1.8221.00
71_Q74_Y1.7951.00
49_L208_V1.7891.00
111_G243_I1.7831.00
72_T170_L1.7821.00
46_S208_V1.7821.00
230_H233_L1.7681.00
14_S28_T1.7231.00
61_S223_A1.7211.00
108_L246_N1.6881.00
62_H67_N1.6551.00
115_L239_G1.6511.00
105_L109_L1.6411.00
12_L218_A1.6411.00
11_G211_L1.6301.00
145_A159_V1.6081.00
71_Q75_Q1.5991.00
74_Y77_V1.5851.00
16_L221_I1.5821.00
33_L211_L1.5721.00
89_A93_Q1.5631.00
81_S189_S1.5461.00
236_V240_G1.5251.00
74_Y78_I1.5111.00
243_I247_A1.5081.00
143_V147_F1.4901.00
204_N207_W1.4801.00
104_S250_L1.4531.00
86_L143_V1.4461.00
62_H226_V1.4091.00
56_A184_F1.4061.00
111_G239_G1.4011.00
52_V188_V1.3991.00
73_V178_T1.3981.00
220_P224_W1.3941.00
209_F213_A1.3871.00
98_V102_Y1.3761.00
206_L210_S1.3761.00
9_F13_L1.3721.00
70_K74_Y1.3711.00
58_S180_D1.3681.00
65_F227_Q1.3631.00
39_T42_V1.3601.00
213_A217_I1.3461.00
160_T182_S1.3451.00
8_A210_S1.3421.00
195_L205_W1.3301.00
85_F89_A1.3201.00
83_G87_G1.3171.00
42_V204_N1.3161.00
59_G181_T1.3121.00
4_L210_S1.3031.00
60_V64_K1.3021.00
80_G186_I1.3001.00
5_I9_F1.2971.00
67_N177_G1.2961.00
192_A196_I1.2951.00
84_A190_A1.2781.00
136_K140_P1.2591.00
161_T175_V1.2541.00
67_N227_Q1.2291.00
119_L122_Y1.2261.00
59_G63_I1.2251.00
11_G214_G1.2031.00
240_G244_L1.2031.00
106_F152_G1.1901.00
56_A60_V1.1811.00
58_S219_A1.1791.00
116_I119_L1.1761.00
34_L40_P1.1661.00
193_G197_S1.1571.00
136_K139_I1.1451.00
21_L237_L1.1281.00
88_A190_A1.1251.00
218_A221_I1.1131.00
38_I207_W1.1091.00
54_T215_G1.1061.00
70_K73_V1.0981.00
76_L182_S1.0801.00
62_H223_A1.0771.00
79_P142_G1.0691.00
134_N137_Q1.0691.00
88_A193_G1.0631.00
114_V238_V1.0411.00
45_A203_V1.0411.00
233_L237_L1.0411.00
173_R226_V1.0391.00
94_L151_T1.0391.00
83_G147_F1.0271.00
96_G100_K1.0221.00
44_S194_F1.0201.00
79_P83_G1.0141.00
59_G184_F1.0121.00
98_V101_P1.0121.00
218_A222_A1.0111.00
29_S211_L1.0061.00
165_L175_V1.0041.00
156_W160_T0.9991.00
78_I82_I0.9971.00
6_V9_F0.9941.00
199_G206_L0.9891.00
86_L89_A0.9841.00
101_P105_L0.9751.00
57_A219_A0.9731.00
104_S108_L0.9701.00
214_G218_A0.9641.00
59_G70_K0.9631.00
124_P127_E0.9611.00
63_I68_V0.9591.00
209_F212_M0.9581.00
80_G182_S0.9551.00
8_A213_A0.9541.00
244_L248_R0.9521.00
246_N250_L0.9491.00
61_S220_P0.9481.00
138_S168_K0.9471.00
172_P176_V0.9441.00
97_D101_P0.9431.00
62_H177_G0.9421.00
61_S65_F0.9411.00
109_L113_Y0.9361.00
248_R251_I0.9351.00
108_L243_I0.9331.00
7_F210_S0.9271.00
140_P144_I0.9231.00
142_G160_T0.9151.00
76_L164_L0.9091.00
165_L172_P0.9091.00
156_W162_P0.9081.00
224_W227_Q0.9041.00
89_A92_S0.9041.00
12_L214_G0.9041.00
161_T179_V0.9031.00
52_V191_T0.9001.00
68_V178_T0.8991.00
226_V234_M0.8971.00
194_F199_G0.8951.00
7_F207_W0.8941.00
219_A223_A0.8931.00
37_G43_A0.8911.00
154_G158_P0.8811.00
117_R120_F0.8771.00
47_V51_E0.8751.00
30_T47_V0.8681.00
61_S224_W0.8671.00
65_F224_W0.8661.00
244_L247_A0.8641.00
87_G147_F0.8631.00
91_L194_F0.8631.00
183_E186_I0.8571.00
14_S29_S0.8561.00
86_L147_F0.8481.00
119_L123_K0.8441.00
112_G243_I0.8351.00
90_F93_Q0.8331.00
12_L221_I0.8331.00
217_I220_P0.8321.00
108_L112_G0.8261.00
117_R235_G0.8201.00
8_A12_L0.8171.00
149_D186_I0.8101.00
92_S197_S0.8091.00
46_S203_V0.8091.00
57_A61_S0.8011.00
161_T176_V0.7961.00
101_P253_E0.7951.00
88_A189_S0.7941.00
16_L218_A0.7941.00
7_F211_L0.7911.00
19_G58_S0.7781.00
84_A88_A0.7781.00
49_L191_T0.7771.00
53_V216_I0.7751.00
97_D100_K0.7731.00
42_V46_S0.7721.00
86_L90_F0.7721.00
34_L43_A0.7701.00
206_L209_F0.7691.00
89_A197_S0.7681.00
88_A194_F0.7671.00
45_A191_T0.7651.00
75_Q135_R0.7621.00
55_T183_E0.7501.00
79_P82_I0.7491.00
137_Q140_P0.7481.00
110_L158_P0.7471.00
26_G150_A0.7461.00
229_F233_L0.7451.00
63_I66_G0.7401.00
6_V10_I0.7391.00
82_I86_L0.7381.00
210_S214_G0.7261.00
29_S33_L0.7251.00
60_V63_I0.7231.00
19_G223_A0.7231.00
73_V182_S0.7221.00
238_V242_I0.7211.00
68_V73_V0.7201.00
61_S64_K0.7201.00
95_P98_V0.7191.00
20_S222_A0.7171.00
70_K181_T0.7161.00
123_K127_E0.7151.00
163_I167_R0.7141.00
145_A156_W0.7101.00
12_L16_L0.7081.00
71_Q135_R0.7071.00
159_V162_P0.7071.00
18_D26_G0.7031.00
175_V179_V0.7011.00
169_G175_V0.6991.00
11_G29_S0.6981.00
15_Q25_Y0.6971.00
50_A215_G0.6961.00
131_V134_N0.6921.00
75_Q78_I0.6911.00
221_I224_W0.6881.00
51_E55_T0.6861.00
195_L203_V0.6851.00
216_I220_P0.6851.00
80_G160_T0.6841.00
181_T185_A0.6791.00
188_V192_A0.6781.00
191_T208_V0.6711.00
56_A59_G0.6691.00
149_D156_W0.6661.00
17_I28_T0.6641.00
27_V107_L0.6641.00
100_K252_N0.6600.99
55_T153_G0.6480.99
139_I142_G0.6460.99
26_G51_E0.6450.99
121_Q124_P0.6440.99
156_W183_E0.6440.99
20_S229_F0.6440.99
20_S234_M0.6430.99
44_S91_L0.6410.99
51_E156_W0.6410.99
132_P136_K0.6400.99
46_S204_N0.6380.99
51_E149_D0.6370.99
203_V208_V0.6370.99
111_G242_I0.6370.99
69_D74_Y0.6360.99
132_P135_R0.6350.99
101_P104_S0.6340.99
113_Y117_R0.6270.99
108_L250_L0.6240.99
14_S32_L0.6200.99
145_A160_T0.6170.99
38_I42_V0.6160.99
94_L98_V0.6160.99
102_Y152_G0.6130.99
160_T164_L0.6120.99
90_F94_L0.6120.99
142_G146_G0.6100.99
205_W208_V0.6100.99
18_D149_D0.6090.99
7_F36_F0.6090.99
20_S225_L0.6080.99
11_G15_Q0.6020.99
49_L205_W0.6020.99
164_L182_S0.6010.99
221_I225_L0.6000.99
44_S99_A0.5980.99
55_T184_F0.5980.99
51_E187_A0.5940.99
170_L174_K0.5940.99
21_L219_A0.5920.99
89_A193_G0.5880.99
40_P99_A0.5870.99
41_A44_S0.5870.99
140_P143_V0.5850.99
18_D54_T0.5830.99
76_L142_G0.5800.99
137_Q163_I0.5780.99
190_A193_G0.5780.99
50_A211_L0.5760.99
174_K177_G0.5750.99
205_W209_F0.5730.99
41_A99_A0.5710.99
18_D28_T0.5700.99
82_I143_V0.5700.99
208_V212_M0.5700.99
15_Q215_G0.5700.99
12_L15_Q0.5700.99
108_L247_A0.5690.98
236_V239_G0.5690.98
18_D183_E0.5680.98
38_I43_A0.5660.98
172_P238_V0.5620.98
111_G115_L0.5570.98
163_I168_K0.5540.98
156_W179_V0.5530.98
232_Q235_G0.5500.98
75_Q139_I0.5500.98
42_V199_G0.5480.98
8_A217_I0.5470.98
239_G243_I0.5460.98
29_S51_E0.5460.98
8_A11_G0.5450.98
104_S249_T0.5450.98
149_D154_G0.5440.98
153_G179_V0.5430.98
41_A45_A0.5380.98
69_D178_T0.5380.98
36_F43_A0.5370.98
67_N174_K0.5330.98
230_H234_M0.5320.98
44_S48_H0.5290.98
40_P96_G0.5280.98
85_F196_I0.5280.98
21_L241_F0.5260.97
96_G151_T0.5260.97
157_G219_A0.5200.97
29_S50_A0.5200.97
38_I204_N0.5190.97
77_V80_G0.5170.97
225_L228_K0.5160.97
48_H153_G0.5160.97
33_L43_A0.5150.97
130_H134_N0.5150.97
194_F198_L0.5130.97
55_T187_A0.5120.97
173_R231_P0.5110.97
199_G204_N0.5100.97
18_D55_T0.5090.97
40_P100_K0.5090.97
109_L112_G0.5080.97
160_T183_E0.5080.97
48_H51_E0.5070.97
18_D23_M0.5070.97
88_A145_A0.5070.97
51_E238_V0.5060.97
49_L212_M0.5050.97
84_A189_S0.5040.97
4_L8_A0.5040.97
157_G179_V0.5030.97
41_A91_L0.5030.97
44_S88_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gfpA 2 0.8467 60.6 0.934 Contact Map
4j05A 3 0.85 60.2 0.934 Contact Map
3llqA 3 0.6367 47.2 0.939 Contact Map
1pw4A 1 0.8467 45 0.94 Contact Map
2f2bA 4 0.6267 41.6 0.941 Contact Map
4rp9A 2 0.41 34.1 0.944 Contact Map
4eneA 2 0.8567 32.4 0.944 Contact Map
4m64A 1 0.8733 32.2 0.944 Contact Map
4pypA 1 0.8533 31.8 0.945 Contact Map
3wdoA 1 0.9533 23 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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