GREMLIN Database
YJLA - Uncharacterized protein YjlA
UniProt: O34428 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (300)
Sequences: 287 (223)
Seq/√Len: 12.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_F79_V4.9431.00
53_R193_D4.1231.00
32_L216_G4.0701.00
109_V112_S3.9911.00
150_I298_I3.7940.99
107_A174_A3.7370.99
74_S204_A3.5860.99
92_G166_S3.5060.99
59_L63_M3.4180.99
11_S269_G3.3160.98
12_L16_V3.0380.97
22_R26_L2.9630.96
62_E191_R2.7670.94
168_L172_I2.6320.93
275_L295_L2.4570.90
94_G284_G2.4530.90
10_A285_V2.4030.89
63_M204_A2.3630.88
278_E284_G2.2870.86
3_A107_A2.2040.84
270_E274_A2.1660.83
16_V237_S2.1620.83
80_L84_P2.1240.82
43_V206_L2.1220.82
233_I237_S2.0870.80
139_T308_A2.0350.79
35_S282_L2.0190.78
7_G18_F2.0050.78
156_E232_F1.9900.77
269_G274_A1.9220.74
11_S92_G1.8990.74
89_A274_A1.8010.69
209_W234_V1.7880.69
23_A26_L1.7510.67
56_F60_L1.7380.67
69_Y187_E1.7340.66
210_L214_A1.7300.66
171_V213_A1.7120.65
3_A86_T1.7110.65
15_A147_A1.6940.64
68_F72_K1.6900.64
148_A167_V1.6670.63
79_V270_E1.6630.63
182_R264_E1.6490.62
32_L213_A1.6190.61
164_L298_I1.6080.60
87_F169_P1.6000.60
85_I285_V1.5890.59
48_L241_I1.5850.59
79_V98_A1.5700.58
83_A271_V1.5630.58
50_V193_D1.5550.58
6_I76_V1.5540.58
19_I72_K1.5390.57
11_S270_E1.5320.56
3_A274_A1.5300.56
24_M34_S1.4860.54
43_V202_T1.4690.53
116_Y129_R1.4680.53
12_L86_T1.4560.52
79_V208_F1.4470.52
98_A136_S1.4360.51
105_I278_E1.4150.50
86_T255_D1.4080.50
108_G182_R1.4020.50
108_G264_E1.4020.50
166_S170_V1.3880.49
218_W279_I1.3710.48
198_V244_V1.3690.48
3_A269_G1.3670.48
193_D278_E1.3470.47
39_F242_A1.3410.46
3_A244_V1.3390.46
215_Y256_N1.3380.46
169_P277_G1.3340.46
56_F145_I1.3320.46
214_A303_M1.3170.45
86_T298_I1.3160.45
19_I149_L1.3160.45
11_S106_V1.3160.45
250_T264_E1.3100.45
182_R250_T1.3100.45
70_W200_G1.3070.45
85_I189_G1.3040.45
53_R278_E1.3020.44
58_P196_Q1.2940.44
15_A251_D1.2920.44
254_R285_V1.2890.44
85_I195_F1.2890.44
161_R222_L1.2860.44
93_P262_A1.2790.43
140_S305_H1.2710.43
6_I212_L1.2630.42
143_I201_M1.2590.42
20_L34_S1.2530.42
74_S253_V1.2510.42
35_S215_Y1.2420.41
113_P221_G1.2340.41
106_V222_L1.2210.40
102_Q133_P1.2200.40
111_L151_Q1.2030.39
275_L291_S1.2020.39
85_I144_L1.1990.39
79_V275_L1.1810.38
115_F186_E1.1740.38
205_S208_F1.1650.38
112_S216_G1.1600.37
193_D199_L1.1590.37
144_L148_A1.1580.37
19_I171_V1.1520.37
195_F255_D1.1480.37
32_L212_L1.1390.36
63_M253_V1.1320.36
290_L295_L1.1240.36
79_V205_S1.1200.35
50_V53_R1.1080.35
40_I268_S1.1030.35
61_L64_R1.0940.34
55_T89_A1.0910.34
63_M193_D1.0850.34
213_A237_S1.0820.34
135_V231_S1.0800.34
167_V216_G1.0790.33
59_L199_L1.0780.33
33_W213_A1.0780.33
147_A226_S1.0730.33
27_S215_Y1.0660.33
101_W173_A1.0610.33
280_V285_V1.0610.33
80_L176_A1.0600.33
3_A276_L1.0590.33
26_L297_I1.0570.32
191_R251_D1.0530.32
199_L278_E1.0470.32
147_A154_H1.0450.32
78_F234_V1.0360.32
278_E305_H1.0360.32
97_I155_A1.0350.31
63_M305_H1.0300.31
215_Y281_L1.0210.31
158_L291_S1.0170.31
58_P149_L1.0160.31
199_L305_H1.0030.30
185_L306_T0.9990.30
29_G34_S0.9960.30
153_Q257_P0.9910.30
108_G250_T0.9880.29
24_M230_Q0.9870.29
248_W252_M0.9870.29
101_W224_T0.9830.29
54_G236_V0.9820.29
256_N259_K0.9800.29
153_Q253_V0.9800.29
36_S100_T0.9690.29
200_G264_E0.9660.28
182_R200_G0.9660.28
88_A92_G0.9650.28
236_V240_I0.9630.28
61_L131_K0.9630.28
12_L39_F0.9620.28
64_R283_S0.9580.28
29_G234_V0.9560.28
15_A19_I0.9560.28
237_S252_M0.9560.28
182_R247_F0.9550.28
247_F264_E0.9550.28
65_K281_L0.9510.28
167_V299_I0.9460.28
175_F198_V0.9420.27
42_M74_S0.9390.27
30_S219_S0.9290.27
11_S144_L0.9270.27
237_S241_I0.9260.27
83_A208_F0.9250.27
22_R278_E0.9200.27
85_I134_L0.9200.27
48_L211_I0.9180.26
42_M234_V0.9170.26
48_L272_I0.9100.26
219_S236_V0.9090.26
292_F299_I0.9090.26
11_S153_Q0.9080.26
176_A193_D0.9040.26
234_V243_T0.9040.26
43_V97_I0.9020.26
228_T231_S0.8980.26
78_F209_W0.8940.26
253_V259_K0.8890.25
87_F281_L0.8890.25
8_I61_L0.8860.25
73_W264_E0.8830.25
73_W182_R0.8830.25
138_G155_A0.8790.25
142_I164_L0.8740.25
151_Q200_G0.8660.24
142_I161_R0.8630.24
183_R306_T0.8570.24
111_L278_E0.8540.24
182_R221_G0.8520.24
221_G264_E0.8520.24
98_A275_L0.8390.23
81_F177_Y0.8390.23
160_G217_W0.8340.23
113_P264_E0.8340.23
113_P182_R0.8340.23
32_L74_S0.8310.23
107_A175_F0.8300.23
76_V79_V0.8280.23
57_T276_L0.8270.23
79_V130_Q0.8220.23
115_F129_R0.8220.23
2_K304_L0.8220.23
53_R147_A0.8210.23
57_T61_L0.8190.23
22_R98_A0.8170.23
2_K148_A0.8150.23
33_W97_I0.8140.22
73_W108_G0.8130.22
237_S279_I0.8120.22
25_E204_A0.8110.22
10_A88_A0.8100.22
59_L70_W0.8090.22
48_L279_I0.8070.22
8_I269_G0.8050.22
17_T21_N0.8050.22
105_I268_S0.8040.22
20_L29_G0.8040.22
83_A205_S0.8030.22
32_L103_I0.8030.22
174_A231_S0.7940.22
36_S175_F0.7910.22
111_L298_I0.7870.22
18_F101_W0.7840.21
15_A24_M0.7830.21
5_V135_V0.7800.21
74_S84_P0.7780.21
51_I211_I0.7770.21
76_V152_L0.7740.21
81_F242_A0.7730.21
206_L240_I0.7720.21
107_A269_G0.7720.21
149_L297_I0.7690.21
218_W283_S0.7640.21
221_G250_T0.7610.21
185_L250_T0.7610.21
66_K187_E0.7610.21
107_A257_P0.7550.20
34_S42_M0.7530.20
112_S116_Y0.7520.20
30_S50_V0.7490.20
88_A211_I0.7480.20
47_C164_L0.7470.20
60_L271_V0.7460.20
39_F231_S0.7440.20
41_F232_F0.7430.20
177_Y234_V0.7380.20
276_L288_S0.7310.20
96_L264_E0.7310.20
96_L182_R0.7310.20
131_K292_F0.7270.19
42_M94_G0.7260.19
77_G205_S0.7220.19
61_L142_I0.7220.19
12_L270_E0.7200.19
288_S292_F0.7190.19
86_T257_P0.7190.19
47_C106_V0.7170.19
289_L292_F0.7160.19
3_A166_S0.7160.19
13_F238_S0.7160.19
11_S257_P0.7150.19
52_M171_V0.7120.19
97_I107_A0.7120.19
3_A252_M0.7110.19
73_W179_L0.7100.19
253_V272_I0.7090.19
89_A166_S0.7090.19
10_A251_D0.7080.19
54_G283_S0.7080.19
43_V241_I0.7080.19
75_F288_S0.7080.19
113_P247_F0.7040.19
142_I152_L0.7030.19
9_L222_L0.7030.19
130_Q232_F0.7030.19
5_V148_A0.7030.19
214_A299_I0.7010.19
19_I274_A0.7010.19
39_F86_T0.7000.19
15_A18_F0.7000.19
24_M36_S0.6990.19
65_K300_A0.6980.19
91_Y141_V0.6970.19
200_G247_F0.6960.18
182_R185_L0.6960.18
185_L264_E0.6960.18
68_F145_I0.6950.18
151_Q264_E0.6950.18
151_Q182_R0.6950.18
72_K296_F0.6950.18
15_A193_D0.6910.18
73_W183_R0.6900.18
99_G186_E0.6880.18
101_W105_I0.6880.18
59_L295_L0.6860.18
86_T288_S0.6850.18
97_I233_I0.6830.18
85_I198_V0.6830.18
108_G247_F0.6780.18
2_K106_V0.6770.18
91_Y190_G0.6770.18
256_N297_I0.6710.18
174_A272_I0.6710.18
108_G200_G0.6700.18
115_F175_F0.6700.18
29_G78_F0.6700.18
74_S106_V0.6690.18
128_I214_A0.6690.18
135_V211_I0.6680.18
154_H283_S0.6660.18
39_F278_E0.6630.17
77_G202_T0.6620.17
53_R196_Q0.6600.17
92_G163_L0.6580.17
262_A307_F0.6510.17
149_L203_L0.6480.17
3_A174_A0.6450.17
65_K210_L0.6450.17
44_P113_P0.6440.17
55_T216_G0.6420.17
25_E94_G0.6410.17
69_Y226_S0.6410.17
176_A278_E0.6370.17
61_L214_A0.6350.17
22_R92_G0.6350.17
159_S219_S0.6330.17
90_A99_G0.6320.17
221_G247_F0.6290.16
135_V164_L0.6280.16
79_V86_T0.6270.16
176_A199_L0.6250.16
108_G221_G0.6240.16
41_F115_F0.6230.16
93_P166_S0.6230.16
7_G105_I0.6220.16
74_S247_F0.6210.16
48_L57_T0.6190.16
60_L67_P0.6180.16
79_V297_I0.6160.16
108_G113_P0.6160.16
131_K281_L0.6150.16
11_S303_M0.6110.16
147_A261_A0.6080.16
25_E305_H0.5990.16
147_A310_Q0.5980.16
86_T136_S0.5970.16
141_V226_S0.5970.16
15_A231_S0.5960.16
9_L153_Q0.5930.15
116_Y295_L0.5910.15
97_I174_A0.5900.15
18_F105_I0.5890.15
6_I237_S0.5880.15
66_K157_S0.5860.15
40_I168_L0.5840.15
43_V163_L0.5840.15
62_E99_G0.5830.15
234_V271_V0.5820.15
43_V203_L0.5820.15
214_A218_W0.5800.15
76_V261_A0.5800.15
107_A158_L0.5770.15
50_V185_L0.5760.15
99_G231_S0.5760.15
247_F250_T0.5730.15
42_M78_F0.5730.15
41_F231_S0.5710.15
260_L268_S0.5710.15
236_V280_V0.5710.15
16_V135_V0.5700.15
135_V229_V0.5700.15
136_S255_D0.5700.15
163_L166_S0.5700.15
99_G150_I0.5690.15
11_S194_T0.5690.15
8_I276_L0.5670.15
162_M281_L0.5670.15
262_A282_L0.5670.15
116_Y236_V0.5660.15
217_W222_L0.5640.15
2_K254_R0.5610.15
109_V297_I0.5600.15
40_I114_L0.5600.15
113_P185_L0.5580.15
48_L60_L0.5580.15
81_F243_T0.5580.15
116_Y147_A0.5570.15
164_L303_M0.5540.14
94_G305_H0.5540.14
71_I205_S0.5500.14
12_L255_D0.5500.14
75_F208_F0.5500.14
56_F288_S0.5490.14
200_G250_T0.5490.14
225_A293_A0.5480.14
36_S173_A0.5470.14
39_F286_F0.5470.14
7_G266_T0.5440.14
21_N37_L0.5430.14
62_E65_K0.5430.14
72_K165_F0.5420.14
165_F171_V0.5420.14
63_M142_I0.5420.14
14_F21_N0.5410.14
106_V174_A0.5410.14
5_V9_L0.5390.14
35_S212_L0.5390.14
297_I308_A0.5390.14
142_I299_I0.5390.14
171_V224_T0.5380.14
106_V204_A0.5380.14
158_L174_A0.5380.14
6_I86_T0.5370.14
103_I147_A0.5370.14
23_A282_L0.5360.14
85_I270_E0.5340.14
84_P176_A0.5330.14
6_I19_I0.5330.14
53_R191_R0.5310.14
29_G37_L0.5300.14
105_I140_S0.5300.14
88_A99_G0.5290.14
174_A292_F0.5270.14
225_A299_I0.5210.14
269_G284_G0.5200.14
176_A209_W0.5180.14
97_I142_I0.5170.14
22_R28_G0.5160.13
59_L170_V0.5160.13
107_A112_S0.5150.13
90_A204_A0.5140.13
55_T91_Y0.5120.13
165_F289_L0.5110.13
113_P306_T0.5110.13
45_F75_F0.5060.13
19_I156_E0.5050.13
206_L233_I0.5020.13
79_V129_R0.5010.13
61_L164_L0.5010.13
49_I196_Q0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2284 95.1 0.957 Contact Map
3b5dA 2 0.3117 87.4 0.965 Contact Map
2cfqA 1 0.9475 52.8 0.974 Contact Map
4ikvA 1 0.9259 51.2 0.974 Contact Map
4pypA 1 0.5617 43.3 0.975 Contact Map
1pw4A 1 0.6142 37.1 0.976 Contact Map
4xnjA 1 0.8827 35.1 0.976 Contact Map
4tphA 2 0.7099 27.8 0.978 Contact Map
3o7qA 1 0.7006 22.6 0.979 Contact Map
3wdoA 1 0.892 21.9 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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