GREMLIN Database
SPEH - S-adenosylmethionine decarboxylase proenzyme
UniProt: O34426 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 126 (111)
Sequences: 908 (580)
Seq/√Len: 55.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_D100_H3.1581.00
26_I99_L2.9961.00
34_A41_V2.9371.00
46_F56_G2.8981.00
14_G102_D2.6521.00
44_V58_V2.5741.00
55_S60_I2.5061.00
89_N108_E2.3131.00
29_T95_I2.2331.00
27_E31_V2.2241.00
77_S81_Y2.1951.00
23_M27_E2.1411.00
10_S92_A2.1311.00
70_F77_S2.0251.00
32_N36_K2.0041.00
22_D25_F1.9531.00
28_K32_N1.8861.00
41_V58_V1.8800.99
19_K25_F1.8570.99
9_I109_I1.7750.99
32_N35_L1.7710.99
12_L95_I1.7210.99
62_E83_C1.7100.99
14_G103_T1.6470.99
14_G101_A1.6140.98
67_I78_I1.5400.98
26_I54_V1.5140.98
25_F29_T1.4940.97
21_N51_P1.4100.96
49_F72_E1.3650.96
27_E44_V1.3350.95
29_T98_A1.3140.95
31_V44_V1.2820.94
67_I76_A1.2790.94
46_F58_V1.2690.93
10_S80_V1.2590.93
48_K52_Q1.2320.92
26_I67_I1.2250.92
30_F65_L1.2180.92
89_N93_D1.1990.91
13_W103_T1.1750.90
5_G63_S1.1500.89
72_E83_C1.1400.89
23_M54_V1.1320.89
93_D96_A1.1070.88
55_S66_T1.0980.87
23_M48_K1.0930.87
4_M73_H1.0910.87
7_H79_D1.0820.86
34_A58_V1.0580.85
46_F57_V1.0440.84
96_A104_R1.0320.84
40_E62_E1.0260.83
38_G87_D1.0130.83
105_E109_I0.9590.79
11_E52_Q0.9460.78
57_V66_T0.9430.78
27_E46_F0.9320.77
37_S82_T0.9300.77
39_A84_G0.9220.76
29_T67_I0.9050.75
56_G70_F0.8970.74
65_L95_I0.8930.74
49_F83_C0.8770.72
39_A77_S0.8750.72
43_E58_V0.8670.72
60_I82_T0.8660.71
33_A37_S0.8650.71
42_R61_S0.8630.71
31_V41_V0.8520.70
32_N94_Y0.8510.70
8_V106_N0.8500.70
19_K100_H0.8490.70
32_N69_S0.8210.67
33_A84_G0.8190.67
23_M46_F0.8090.66
23_M55_S0.7940.65
32_N98_A0.7930.65
104_R110_P0.7920.65
10_S95_I0.7750.63
15_C59_I0.7690.62
15_C101_A0.7670.62
18_D97_E0.7610.61
11_E45_A0.7610.61
4_M42_R0.7600.61
8_V12_L0.7580.61
24_D97_E0.7560.61
47_H61_S0.7520.61
34_A65_L0.7480.60
51_P71_P0.7460.60
51_P82_T0.7430.60
12_L104_R0.7380.59
12_L105_E0.7300.58
26_I78_I0.7270.58
34_A76_A0.7260.58
28_K90_V0.7230.58
107_I110_P0.7220.57
25_F100_H0.7180.57
18_D21_N0.7080.56
105_E113_M0.7050.56
8_V92_A0.6980.55
4_M81_Y0.6840.53
33_A94_Y0.6810.53
65_L82_T0.6740.52
36_K90_V0.6700.52
13_W92_A0.6680.52
82_T86_L0.6630.51
26_I56_G0.6630.51
12_L96_A0.6580.51
11_E112_G0.6510.50
31_V58_V0.6460.49
104_R107_I0.6440.49
53_G69_S0.6420.49
79_D111_R0.6390.49
19_K29_T0.6320.48
78_I101_A0.6320.48
28_K103_T0.6290.47
70_F73_H0.6280.47
25_F104_R0.6270.47
40_E87_D0.6240.47
69_S72_E0.6180.46
11_E107_I0.6060.45
21_N52_Q0.6060.45
80_V96_A0.6020.45
57_V70_F0.5990.44
44_V87_D0.5950.44
35_L93_D0.5920.44
11_E48_K0.5910.43
65_L86_L0.5880.43
4_M70_F0.5880.43
50_A102_D0.5870.43
31_V35_L0.5870.43
21_N48_K0.5840.43
49_F62_E0.5820.42
16_D29_T0.5820.42
81_Y96_A0.5820.42
78_I81_Y0.5730.42
4_M58_V0.5720.41
65_L77_S0.5710.41
93_D97_E0.5700.41
22_D35_L0.5690.41
8_V94_Y0.5660.41
71_P112_G0.5630.40
84_G88_P0.5590.40
81_Y95_I0.5540.40
92_A101_A0.5510.39
13_W105_E0.5460.39
56_G67_I0.5440.39
19_K22_D0.5420.38
6_R114_G0.5400.38
56_G112_G0.5350.38
36_K97_E0.5340.38
39_A81_Y0.5330.37
55_S70_F0.5310.37
33_A39_A0.5280.37
38_G90_V0.5230.36
76_A101_A0.5210.36
105_E110_P0.5190.36
35_L46_F0.5180.36
90_V93_D0.5130.35
53_G62_E0.5130.35
28_K108_E0.5110.35
47_H54_V0.5070.35
35_L40_E0.5050.35
41_V46_F0.5050.35
25_F98_A0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iiiA 2 0.9365 100 0.128 Contact Map
1vr7A 2 0.9444 100 0.134 Contact Map
1mhmA 1 0.9524 95.1 0.862 Contact Map
1jl0A 2 0.9206 88.3 0.888 Contact Map
3c6kA 2 0.8968 44.2 0.921 Contact Map
5c4iC 2 0.9286 23.1 0.931 Contact Map
1z84A 2 0.7778 16.7 0.936 Contact Map
1q6zA 4 0.381 14.3 0.938 Contact Map
2od0A 2 0.3095 10.5 0.941 Contact Map
2wnyA 1 0.4524 8.2 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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