GREMLIN Database
G3P2 - Glyceraldehyde-3-phosphate dehydrogenase 2
UniProt: O34425 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 340 (328)
Sequences: 5439 (2479)
Seq/√Len: 136.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_D222_H4.2641.00
77_S82_Q3.6551.00
171_E249_K3.3771.00
162_K166_E3.1761.00
274_D290_H3.0911.00
107_M111_E2.8011.00
136_E329_H2.7921.00
204_S283_T2.7591.00
251_D305_R2.7421.00
79_D82_Q2.7151.00
168_F260_A2.4901.00
261_F294_I2.4781.00
167_E263_R2.4641.00
181_Y202_G2.4511.00
4_K28_Q2.4511.00
56_K68_N2.4281.00
292_A311_A2.3491.00
64_S71_K2.3201.00
147_I330_V2.2951.00
61_G71_K2.2541.00
105_K108_G2.2411.00
102_A105_K2.2071.00
172_S247_D2.1771.00
232_L241_L2.1721.00
291_S322_R2.1141.00
238_N286_N2.0861.00
257_V307_V2.0321.00
250_T256_E2.0231.00
140_D143_R2.0131.00
132_M136_E2.0091.00
61_G64_S1.9411.00
46_K278_E1.9411.00
22_M54_Y1.9171.00
180_A236_V1.9051.00
28_Q70_K1.8961.00
217_S224_K1.8791.00
21_A29_V1.8731.00
259_E263_R1.8691.00
80_P100_F1.8621.00
205_I232_L1.8601.00
40_T195_L1.8521.00
251_D304_D1.8511.00
103_K107_M1.8401.00
51_H238_N1.8111.00
239_V285_Y1.7951.00
161_V223_L1.7941.00
84_P87_E1.7811.00
81_K111_E1.7631.00
10_F45_I1.7621.00
262_K277_D1.7611.00
81_K108_G1.7291.00
18_F29_V1.7191.00
275_Y296_G1.7181.00
228_H300_M1.7101.00
128_V138_Q1.6921.00
116_K145_V1.6911.00
248_L307_V1.6761.00
274_D288_N1.6591.00
20_K321_C1.6541.00
118_I327_I1.6351.00
96_A120_T1.6201.00
18_F45_I1.6111.00
279_P297_L1.6081.00
94_V327_I1.5791.00
18_F67_V1.5791.00
161_V170_I1.5781.00
322_R325_D1.5781.00
258_N299_T1.5761.00
171_E305_R1.5741.00
120_T323_V1.5511.00
49_T203_E1.5491.00
262_K266_K1.5441.00
171_E247_D1.5351.00
73_L87_E1.5131.00
184_D192_H1.4931.00
64_S73_L1.4841.00
102_A124_K1.4751.00
4_K89_D1.4651.00
101_N119_L1.4551.00
38_A74_L1.4431.00
123_G126_E1.4261.00
43_H198_A1.4151.00
107_M110_I1.4101.00
168_F248_L1.4011.00
203_E237_P1.3911.00
103_K127_D1.3801.00
276_S285_Y1.3771.00
49_T283_T1.3721.00
288_N293_V1.3691.00
24_D328_R1.3571.00
160_V311_A1.3541.00
187_N201_C1.3501.00
53_R288_N1.3451.00
75_L88_Y1.3351.00
253_T256_E1.3291.00
218_L224_K1.3211.00
43_H195_L1.3111.00
276_S280_L1.2991.00
183_N188_I1.2981.00
106_A119_L1.2981.00
160_V292_A1.2961.00
94_V323_V1.2931.00
31_A75_L1.2881.00
254_A299_T1.2821.00
172_S303_E1.2691.00
23_L55_D1.2641.00
290_H293_V1.2641.00
197_R208_T1.2631.00
247_D305_R1.2581.00
262_K275_Y1.2461.00
164_L261_F1.2421.00
280_L285_Y1.2411.00
173_G227_L1.2401.00
200_A203_E1.2391.00
163_V273_L1.2351.00
96_A323_V1.2301.00
92_I327_I1.2071.00
79_D108_G1.1941.00
172_S305_R1.1921.00
167_E260_A1.1841.00
61_G66_I1.1800.99
38_A60_A1.1790.99
128_V143_R1.1770.99
163_V260_A1.1750.99
194_D197_R1.1650.99
291_S325_D1.1590.99
277_D296_G1.1570.99
186_K190_N1.1540.99
165_D220_L1.1530.99
283_T286_N1.1530.99
83_L88_Y1.1490.99
269_M273_L1.1350.99
102_A125_N1.1340.99
18_F72_V1.1300.99
317_W321_C1.1270.99
164_L309_V1.1270.99
54_Y68_N1.1180.99
248_L252_V1.1170.99
183_N190_N1.1150.99
167_E171_E1.1090.99
160_V261_F1.1070.99
17_V320_S1.1000.99
16_M51_H1.0920.99
17_V323_V1.0870.99
104_D125_N1.0830.99
17_V94_V1.0750.99
259_E262_K1.0700.99
26_Q328_R1.0690.99
298_T310_L1.0670.99
252_V301_V1.0660.99
289_P317_W1.0640.99
66_I71_K1.0600.99
42_A58_V1.0590.99
178_V232_L1.0550.99
319_Y323_V1.0550.99
6_A83_L1.0550.99
168_F252_V1.0520.99
119_L123_G1.0520.99
36_Y191_P1.0510.99
169_G248_L1.0460.99
301_V307_V1.0460.99
23_L287_T1.0430.99
230_L310_L1.0380.99
41_L74_L1.0270.99
47_Y278_E1.0220.99
45_I56_K1.0190.98
165_D249_K1.0180.98
66_I69_G1.0170.98
252_V256_E1.0160.98
241_L310_L1.0150.98
37_S40_T1.0140.98
160_V309_V1.0120.98
139_F147_I1.0100.98
50_I237_P1.0070.98
103_K126_E1.0060.98
139_F145_V1.0000.98
164_L248_L1.0000.98
6_A90_I0.9980.98
63_D73_L0.9970.98
138_Q222_H0.9930.98
116_K139_F0.9920.98
83_L112_A0.9890.98
129_T218_L0.9830.98
123_G129_T0.9810.98
255_E259_E0.9790.98
265_A268_S0.9780.98
168_F257_V0.9760.98
92_I118_I0.9700.98
236_V239_V0.9670.98
196_R295_D0.9650.98
276_S297_L0.9620.98
172_S306_K0.9600.98
22_M70_K0.9580.98
254_A258_N0.9570.98
157_L175_M0.9550.98
289_P321_C0.9520.98
260_A263_R0.9490.98
118_I147_I0.9490.98
91_D115_K0.9440.98
35_S97_T0.9440.98
104_D107_M0.9420.97
108_G112_A0.9360.97
184_D197_R0.9260.97
73_L88_Y0.9260.97
163_V269_M0.9250.97
232_L310_L0.9200.97
51_H287_T0.9180.97
50_I238_N0.9160.97
301_V304_D0.9080.97
3_V27_I0.8980.97
31_A90_I0.8970.97
252_V260_A0.8950.97
90_I93_V0.8900.96
273_L292_A0.8800.96
164_L246_V0.8770.96
75_L84_P0.8760.96
132_M329_H0.8760.96
92_I331_A0.8670.96
275_Y294_I0.8640.96
274_D293_V0.8630.96
156_C242_V0.8620.96
131_V150_A0.8610.96
252_V257_V0.8590.96
21_A324_V0.8550.96
132_M326_L0.8540.96
27_I328_R0.8490.95
46_K53_R0.8470.95
276_S296_G0.8460.95
139_F143_R0.8450.95
107_M146_I0.8390.95
263_R267_T0.8390.95
287_T317_W0.8390.95
239_V286_N0.8380.95
192_H197_R0.8380.95
258_N294_I0.8380.95
50_I188_I0.8340.95
10_F32_I0.8300.95
51_H286_N0.8270.95
34_A191_P0.8260.95
39_E60_A0.8260.95
31_A88_Y0.8250.95
36_Y41_L0.8230.95
60_A66_I0.8170.94
200_A237_P0.8140.94
30_V90_I0.8100.94
160_V294_I0.8070.94
183_N206_I0.8050.94
119_L126_E0.8030.94
102_A108_G0.8020.94
41_L191_P0.7970.94
130_I139_F0.7970.94
102_A107_M0.7930.93
35_S78_R0.7920.93
92_I330_V0.7900.93
181_Y187_N0.7880.93
118_I326_L0.7820.93
132_M272_V0.7790.93
126_E218_L0.7770.93
6_A112_A0.7720.92
3_V331_A0.7680.92
243_D308_K0.7670.92
108_G111_E0.7660.92
186_K198_A0.7660.92
99_K105_K0.7650.92
43_H47_Y0.7640.92
17_V324_V0.7630.92
59_V66_I0.7580.92
137_D329_H0.7570.92
137_D268_S0.7570.92
192_H198_A0.7550.92
50_I203_E0.7530.92
57_E68_N0.7520.91
174_L230_L0.7500.91
263_R268_S0.7470.91
103_K146_I0.7470.91
248_L301_V0.7460.91
38_A42_A0.7450.91
78_R99_K0.7420.91
101_N105_K0.7420.91
45_I54_Y0.7410.91
252_V307_V0.7400.91
195_L198_A0.7390.91
84_P88_Y0.7360.91
175_M242_V0.7330.90
196_R298_T0.7330.90
77_S83_L0.7300.90
75_L83_L0.7290.90
35_S191_P0.7290.90
176_T245_V0.7270.90
256_E259_E0.7260.90
167_E264_A0.7240.90
205_I310_L0.7230.90
42_A60_A0.7220.90
35_S76_N0.7210.90
266_K270_Y0.7200.90
216_L220_L0.7200.90
130_I143_R0.7200.90
50_I200_A0.7180.89
267_T270_Y0.7150.89
46_K57_E0.7120.89
31_A73_L0.7080.89
327_I330_V0.7070.89
150_A319_Y0.7070.89
160_V242_V0.7060.89
32_I65_L0.7050.89
230_L308_K0.7050.89
139_F329_H0.7030.88
181_Y237_P0.6980.88
130_I138_Q0.6970.88
294_I297_L0.6970.88
260_A264_A0.6960.88
183_N186_K0.6960.88
230_L300_M0.6940.88
169_G249_K0.6920.88
262_K265_A0.6910.88
7_I18_F0.6900.88
246_V307_V0.6880.87
131_V134_V0.6870.87
23_L56_K0.6850.87
168_F250_T0.6830.87
58_V67_V0.6830.87
157_L161_V0.6810.87
161_V227_L0.6810.87
246_V309_V0.6790.87
60_A64_S0.6790.87
22_M68_N0.6780.87
149_N320_S0.6770.87
34_A99_K0.6760.86
32_I74_L0.6730.86
119_L146_I0.6720.86
176_T232_L0.6690.86
216_L227_L0.6670.86
139_F330_V0.6650.86
35_S77_S0.6640.85
209_T214_K0.6640.85
63_D71_K0.6620.85
57_E69_G0.6570.85
49_T237_P0.6560.85
62_E66_I0.6560.85
75_L87_E0.6550.85
103_K145_V0.6540.85
15_R19_R0.6540.85
274_D292_A0.6520.84
86_R112_A0.6520.84
174_L302_M0.6510.84
3_V26_Q0.6510.84
245_V306_K0.6510.84
20_K324_V0.6500.84
239_V242_V0.6500.84
263_R266_K0.6500.84
141_A145_V0.6480.84
248_L257_V0.6420.84
4_K91_D0.6390.83
261_F273_L0.6390.83
202_G237_P0.6380.83
142_E145_V0.6380.83
93_V114_A0.6370.83
96_A327_I0.6360.83
36_Y40_T0.6350.83
118_I330_V0.6340.83
24_D321_C0.6330.83
128_V140_D0.6310.82
130_I326_L0.6310.82
211_G240_S0.6290.82
39_E195_L0.6280.82
104_D111_E0.6260.82
43_H194_D0.6250.82
106_A146_I0.6230.82
132_M149_N0.6220.82
45_I67_V0.6220.82
55_D68_N0.6210.81
119_L127_D0.6210.81
167_E250_T0.6200.81
110_I145_V0.6200.81
6_A88_Y0.6200.81
303_E306_K0.6160.81
157_L242_V0.6140.81
45_I58_V0.6130.81
161_V244_L0.6110.80
164_L244_L0.6090.80
195_L279_P0.6080.80
46_K58_V0.6080.80
261_F309_V0.6060.80
5_V327_I0.6060.80
251_D303_E0.6050.80
27_I92_I0.6020.79
101_N106_A0.5990.79
35_S99_K0.5970.79
247_D306_K0.5960.79
6_A31_A0.5950.79
161_V220_L0.5930.78
203_E286_N0.5920.78
258_N296_G0.5920.78
65_L72_V0.5920.78
173_G246_V0.5920.78
43_H280_L0.5910.78
163_V264_A0.5880.78
174_L228_H0.5860.78
18_F22_M0.5840.77
262_K296_G0.5830.77
194_D208_T0.5800.77
91_D114_A0.5800.77
39_E62_E0.5790.77
178_V205_I0.5780.77
29_V33_N0.5780.77
205_I234_V0.5750.76
123_G127_D0.5740.76
156_C311_A0.5730.76
16_M317_W0.5730.76
216_L228_H0.5720.76
30_V33_N0.5700.76
166_E220_L0.5690.76
194_D198_A0.5680.75
3_V92_I0.5650.75
110_I146_I0.5640.75
35_S41_L0.5640.75
181_Y203_E0.5640.75
38_A63_D0.5640.75
85_W109_H0.5640.75
78_R81_K0.5640.75
103_K108_G0.5640.75
132_M325_D0.5630.75
150_A215_A0.5620.75
20_K317_W0.5610.75
175_M229_G0.5600.74
88_Y112_A0.5590.74
205_I236_V0.5590.74
128_V147_I0.5590.74
32_I72_V0.5590.74
168_F246_V0.5590.74
239_V280_L0.5590.74
101_N124_K0.5590.74
323_V327_I0.5580.74
257_V261_F0.5580.74
3_V6_A0.5570.74
261_F275_Y0.5570.74
39_E43_H0.5560.74
5_V27_I0.5560.74
230_L298_T0.5530.73
6_A89_D0.5490.73
246_V261_F0.5490.73
236_V285_Y0.5490.73
181_Y201_C0.5480.73
161_V246_V0.5470.73
86_R114_A0.5460.73
175_M244_L0.5450.72
83_L109_H0.5440.72
20_K24_D0.5430.72
91_D113_G0.5420.72
162_K268_S0.5410.72
167_E248_L0.5410.72
17_V21_A0.5400.72
107_M145_V0.5400.72
173_G244_L0.5400.72
21_A24_D0.5390.72
176_T308_K0.5380.71
109_H114_A0.5370.71
40_T198_A0.5350.71
84_P112_A0.5350.71
177_T240_S0.5340.71
326_L330_V0.5330.71
53_R278_E0.5330.71
47_Y53_R0.5320.71
302_M306_K0.5310.70
167_E268_S0.5290.70
265_A274_D0.5280.70
42_A65_L0.5270.70
8_N33_N0.5260.70
278_E285_Y0.5250.70
149_N325_D0.5250.70
4_K30_V0.5240.69
255_E258_N0.5240.69
184_D198_A0.5230.69
38_A64_S0.5220.69
6_A75_L0.5220.69
320_S325_D0.5210.69
66_I70_K0.5210.69
24_D325_D0.5190.69
319_Y326_L0.5170.68
136_E268_S0.5170.68
60_A74_L0.5150.68
165_D223_L0.5140.68
252_V305_R0.5130.68
176_T243_D0.5100.67
31_A85_W0.5100.67
38_A61_G0.5090.67
40_T191_P0.5090.67
173_G217_S0.5040.67
6_A85_W0.5040.67
300_M306_K0.5020.66
36_Y76_N0.5010.66
20_K289_P0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4boyA 4 0.9824 100 0.209 Contact Map
3idsC 4 0.9971 100 0.221 Contact Map
3docA 4 0.9794 100 0.223 Contact Map
1rm4O 4 0.9794 100 0.226 Contact Map
4lsmA 4 0.9706 100 0.228 Contact Map
2ep7A 4 0.9735 100 0.229 Contact Map
2x5jO 4 0.9618 100 0.229 Contact Map
1obfO 4 0.9706 100 0.238 Contact Map
4o59O 4 0.9706 100 0.238 Contact Map
3cpsA 4 0.9765 100 0.239 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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