GREMLIN Database
YTEJ - Uncharacterized membrane protein YteJ
UniProt: O34424 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 164 (131)
Sequences: 3346 (2595)
Seq/√Len: 226.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_Q150_Y3.7141.00
87_M95_L3.5891.00
141_S150_Y3.4181.00
31_V158_H3.2231.00
113_L118_V2.9451.00
106_S117_T2.8461.00
108_K111_S2.5721.00
107_V145_Q2.5551.00
38_L100_F2.4701.00
86_L90_Y2.4191.00
138_V146_G2.3641.00
27_A102_L2.2401.00
105_V157_V2.2391.00
113_L154_T2.2161.00
93_Q98_M2.1721.00
34_W100_F2.0371.00
141_S145_Q1.9731.00
129_D134_L1.9431.00
89_K115_W1.9001.00
137_V147_I1.8801.00
103_K159_E1.7661.00
129_D148_H1.7611.00
136_I140_F1.7241.00
52_S56_T1.7111.00
106_S111_S1.6851.00
81_L119_I1.6061.00
39_D96_G1.5931.00
125_G151_I1.5201.00
137_V141_S1.5101.00
105_V155_T1.5061.00
114_T117_T1.4681.00
88_T97_K1.4451.00
38_L99_V1.4391.00
87_M98_M1.3891.00
85_A119_I1.3551.00
84_F88_T1.3481.00
26_Y155_T1.3261.00
25_A158_H1.3111.00
89_K118_V1.2911.00
143_T155_T1.2491.00
106_S114_T1.2241.00
35_A102_L1.2151.00
120_F124_V1.2091.00
129_D146_G1.1991.00
134_L137_V1.1971.00
91_F98_M1.1641.00
61_P68_T1.1341.00
29_F138_V1.1231.00
46_L79_V1.1051.00
28_G31_V1.0931.00
93_Q159_E1.0861.00
41_L45_G1.0821.00
50_L75_T1.0721.00
107_V155_T1.0691.00
36_F40_W1.0491.00
125_G129_D1.0381.00
107_V143_T1.0271.00
29_F139_A1.0171.00
83_Y87_M1.0091.00
36_F84_F1.0081.00
126_R129_D1.0021.00
102_L156_V0.9901.00
104_V118_V0.9881.00
107_V153_D0.9841.00
81_L85_A0.9801.00
120_F151_I0.9721.00
106_S153_D0.9671.00
126_R135_Y0.9371.00
106_S113_L0.9211.00
88_T146_G0.9201.00
38_L42_V0.9120.99
27_A156_V0.9090.99
37_L41_L0.9080.99
116_S120_F0.8840.99
88_T148_H0.8560.99
35_A97_K0.8480.99
28_G138_V0.8430.99
31_V100_F0.8380.99
103_K157_V0.8310.99
134_L148_H0.8250.99
44_W48_H0.8240.99
133_I147_I0.8230.99
121_R149_D0.8150.99
147_I151_I0.8140.99
136_I139_A0.8070.99
55_F58_L0.8060.99
134_L146_G0.8050.99
92_R103_K0.8010.99
134_L147_I0.8000.99
82_A86_L0.7870.98
95_L99_V0.7810.98
42_V99_V0.7810.98
51_V55_F0.7790.98
117_T120_F0.7740.98
74_V78_I0.7710.98
38_L97_K0.7700.98
88_T126_R0.7690.98
33_F36_F0.7680.98
30_W34_W0.7610.98
85_A118_V0.7600.98
47_N80_Y0.7600.98
81_L123_V0.7580.98
84_F94_T0.7540.98
149_D152_A0.7430.98
21_L25_A0.7400.98
97_K156_V0.7370.98
26_Y29_F0.7350.98
26_Y144_K0.7340.98
104_V156_V0.7280.98
24_H105_V0.7220.97
143_T150_Y0.7220.97
89_K114_T0.7200.97
35_A96_G0.7180.97
77_L123_V0.7180.97
46_L49_L0.7160.97
31_V102_L0.7150.97
85_A123_V0.7050.97
92_R105_V0.7040.97
88_T104_V0.7010.97
42_V45_G0.6970.97
31_V34_W0.6920.97
134_L138_V0.6870.96
70_S74_V0.6850.96
39_D146_G0.6800.96
129_D147_I0.6680.96
88_T118_V0.6670.96
83_Y94_T0.6640.96
79_V82_A0.6630.96
132_W135_Y0.6620.96
33_F138_V0.6610.96
85_A115_W0.6550.95
124_V129_D0.6490.95
132_W137_V0.6460.95
131_I134_L0.6420.95
83_Y95_L0.6400.95
83_Y88_T0.6390.95
56_T61_P0.6380.95
42_V95_L0.6360.95
97_K100_F0.6340.95
72_Y76_T0.6330.94
88_T94_T0.6330.94
132_W136_I0.6300.94
47_N72_Y0.6270.94
42_V46_L0.6260.94
115_W118_V0.6250.94
113_L117_T0.6180.94
131_I152_A0.6180.94
87_M91_F0.6150.94
96_G146_G0.6130.93
43_I47_N0.6050.93
129_D135_Y0.6030.93
119_I124_V0.5990.93
53_P56_T0.5960.93
29_F135_Y0.5950.92
126_R148_H0.5940.92
73_S76_T0.5900.92
26_Y145_Q0.5840.92
93_Q118_V0.5840.92
56_T59_D0.5750.91
85_A89_K0.5740.91
31_V101_G0.5720.91
73_S77_L0.5650.90
55_F69_F0.5640.90
27_A31_V0.5620.90
130_K135_Y0.5610.90
26_Y143_T0.5600.90
93_Q102_L0.5590.90
145_Q155_T0.5590.90
93_Q101_G0.5560.90
36_F126_R0.5500.89
90_Y115_W0.5480.89
61_P78_I0.5440.89
135_Y138_V0.5410.88
27_A158_H0.5400.88
47_N58_L0.5390.88
125_G148_H0.5350.88
38_L96_G0.5340.88
148_H152_A0.5340.88
40_W126_R0.5320.88
137_V150_Y0.5310.88
123_V127_Y0.5310.88
30_W138_V0.5300.87
49_L53_P0.5280.87
45_G49_L0.5270.87
25_A136_I0.5260.87
89_K104_V0.5230.87
28_G139_A0.5210.87
135_Y146_G0.5190.86
33_F94_T0.5180.86
41_L44_W0.5160.86
90_Y112_K0.5150.86
132_W142_P0.5110.85
80_Y84_F0.5110.85
83_Y89_K0.5090.85
115_W119_I0.5060.85
69_F72_Y0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mmuA 1 0.2927 7.1 0.939 Contact Map
4lp8A 4 0.811 5.8 0.941 Contact Map
4pirA 3 0.3232 5 0.943 Contact Map
1oedE 1 0.2134 3.5 0.947 Contact Map
1oedB 1 0.2134 3.5 0.947 Contact Map
1oedC 1 0.2134 3.4 0.948 Contact Map
1oedA 1 0.2134 3 0.949 Contact Map
4q28A 1 0.4085 3 0.949 Contact Map
4aq5A 1 0.3476 3 0.949 Contact Map
4aq5B 1 0.3841 2.9 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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