GREMLIN Database
ACDC - Probable acyl-CoA dehydrogenase YngJ
UniProt: O34421 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (366)
Sequences: 33897 (19040)
Seq/√Len: 995.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_E219_R4.0621.00
151_N217_D3.7301.00
292_E330_R3.3861.00
23_E44_K3.2171.00
143_S222_A2.8961.00
113_P118_T2.8761.00
195_T216_E2.8641.00
144_N219_R2.7961.00
104_E108_Q2.7901.00
30_H34_T2.7861.00
65_D68_S2.7161.00
17_K75_E2.6971.00
183_S225_L2.4971.00
285_K334_Q2.4411.00
113_P119_A2.3671.00
264_A268_E2.3411.00
153_E214_L2.2771.00
256_Q297_R2.2431.00
305_W309_H2.1121.00
18_D22_K2.0851.00
228_D231_K2.0241.00
104_E107_K2.0151.00
170_A185_L1.9811.00
346_K351_E1.9611.00
144_N147_E1.9611.00
275_P278_S1.9401.00
351_E355_R1.9361.00
103_T106_Q1.8921.00
166_V189_T1.8891.00
266_A338_I1.8841.00
74_E297_R1.8471.00
153_E212_E1.8321.00
56_P99_Y1.8241.00
9_Q68_S1.7931.00
259_L293_I1.7931.00
144_N149_V1.7771.00
231_K234_K1.7691.00
44_K47_E1.7591.00
326_E367_S1.7531.00
78_K260_D1.7521.00
43_K47_E1.7311.00
148_Y185_L1.7231.00
160_A211_A1.6791.00
75_E78_K1.6671.00
143_S229_P1.6671.00
281_A284_F1.6591.00
122_S166_V1.6551.00
256_Q260_D1.6531.00
270_K275_P1.6501.00
142_I151_N1.6371.00
191_T218_V1.6291.00
306_L316_E1.6231.00
221_P224_N1.6151.00
109_T223_A1.5971.00
149_V219_R1.5921.00
266_A282_I1.5911.00
149_V217_D1.5741.00
195_T214_L1.5711.00
289_M331_A1.5671.00
57_E63_G1.5671.00
225_L229_P1.5591.00
274_Q278_S1.5541.00
146_D219_R1.5461.00
188_P224_N1.5451.00
302_K306_L1.5441.00
109_T113_P1.5361.00
126_T156_W1.5351.00
10_Q13_R1.5201.00
14_E18_D1.5071.00
295_L323_F1.5001.00
11_M14_E1.4981.00
108_Q112_T1.4951.00
197_T212_E1.4871.00
342_S348_Y1.4871.00
9_Q65_D1.4811.00
258_A332_C1.4791.00
148_Y222_A1.4761.00
20_A79_A1.4731.00
151_N216_E1.4721.00
296_A324_A1.4611.00
161_S211_A1.4551.00
127_E154_K1.4541.00
271_Q279_F1.4521.00
197_T214_L1.4511.00
113_P116_S1.4361.00
80_C83_T1.4281.00
261_A349_G1.4251.00
263_L267_K1.4181.00
261_A264_A1.4181.00
11_M15_M1.4061.00
257_A261_A1.4051.00
282_I338_I1.4041.00
146_D222_A1.3981.00
329_T361_E1.3961.00
143_S147_E1.3901.00
222_A225_L1.3861.00
294_D302_K1.3831.00
59_Y107_K1.3771.00
9_Q71_L1.3761.00
105_E109_T1.3751.00
330_R334_Q1.3721.00
67_I305_W1.3651.00
201_D346_K1.3651.00
39_M43_K1.3611.00
141_A185_L1.3561.00
333_N358_K1.3391.00
289_M334_Q1.3381.00
74_E256_Q1.3341.00
78_K256_Q1.3321.00
74_E301_L1.3311.00
101_F238_Y1.3291.00
150_I185_L1.3191.00
106_Q110_H1.3191.00
322_L367_S1.3151.00
16_V50_L1.3131.00
66_T308_D1.3111.00
53_I72_A1.3081.00
220_V224_N1.2831.00
147_E222_A1.2801.00
13_R75_E1.2751.00
33_Q201_D1.2651.00
262_S335_A1.2531.00
188_P191_T1.2521.00
255_A293_I1.2491.00
124_G157_I1.2361.00
255_A331_A1.2331.00
10_Q14_E1.2291.00
112_T116_S1.2261.00
143_S148_Y1.2171.00
288_D371_R1.2171.00
105_E223_A1.2141.00
189_T194_L1.2071.00
107_K111_L1.2061.00
70_A304_A1.2001.00
328_A357_A1.1881.00
129_N138_Q1.1841.00
333_N361_E1.1831.00
302_K305_W1.1821.00
31_V207_G1.1821.00
114_L121_G1.1811.00
172_T183_S1.1801.00
43_K46_G1.1781.00
194_L218_V1.1761.00
243_G364_E1.1721.00
290_A294_D1.1691.00
241_D314_T1.1671.00
257_A353_M1.1601.00
249_A300_V1.1591.00
293_I331_A1.1541.00
55_F115_A1.1521.00
259_L263_L1.1511.00
64_G68_S1.1501.00
109_T224_N1.1491.00
65_D308_D1.1461.00
261_A339_H1.1451.00
274_Q279_F1.1451.00
189_T196_I1.1431.00
29_E33_Q1.1411.00
27_H31_V1.1401.00
44_K48_L1.1391.00
142_I149_V1.1381.00
191_T224_N1.1341.00
318_A370_Q1.1341.00
119_A164_R1.1321.00
15_M48_L1.1291.00
70_A249_A1.1291.00
169_T184_A1.1271.00
306_L311_R1.1261.00
13_R71_L1.1261.00
233_F237_L1.1221.00
335_A350_V1.1221.00
110_H165_T1.1191.00
285_K368_E1.1161.00
358_K361_E1.1121.00
77_G84_G1.1101.00
329_T333_N1.1011.00
296_A327_M1.0991.00
148_Y229_P1.0931.00
292_E334_Q1.0921.00
193_G218_V1.0731.00
121_G165_T1.0711.00
124_G166_V1.0691.00
43_K118_T1.0631.00
168_V187_V1.0621.00
169_T182_I1.0621.00
141_A170_A1.0531.00
139_T150_I1.0531.00
15_M50_L1.0501.00
150_I168_V1.0481.00
140_K151_N1.0441.00
46_G51_M1.0431.00
292_E327_M1.0401.00
361_E367_S1.0391.00
102_G106_Q1.0371.00
100_Y238_Y1.0351.00
16_V20_A1.0261.00
194_L213_I1.0251.00
105_E108_Q1.0241.00
291_M319_Y1.0221.00
326_E330_R1.0181.00
148_Y172_T1.0111.00
94_G121_G1.0101.00
106_Q186_I1.0101.00
252_V293_I1.0081.00
168_V215_L0.9991.00
142_I217_D0.9971.00
40_Q43_K0.9971.00
329_T354_L0.9961.00
322_L371_R0.9951.00
58_E108_Q0.9941.00
27_H30_H0.9911.00
133_D136_G0.9891.00
298_Q302_K0.9851.00
267_K277_S0.9821.00
251_A360_M0.9821.00
124_G215_L0.9791.00
166_V194_L0.9781.00
332_C357_A0.9661.00
19_F44_K0.9611.00
219_R222_A0.9611.00
142_I173_G0.9591.00
266_A276_I0.9591.00
16_V72_A0.9551.00
327_M330_R0.9431.00
263_L286_L0.9431.00
252_V300_V0.9431.00
17_K21_K0.9391.00
266_A277_S0.9381.00
109_T188_P0.9351.00
166_V213_I0.9341.00
183_S229_P0.9341.00
288_D292_E0.9331.00
205_V359_L0.9291.00
326_E361_E0.9261.00
258_A353_M0.9241.00
160_A196_I0.9211.00
367_S371_R0.9191.00
101_F235_Q0.9191.00
185_L225_L0.9141.00
156_W342_S0.9111.00
325_S367_S0.9071.00
165_T188_P0.9061.00
150_I170_A0.9041.00
155_C212_E0.9031.00
32_D355_R0.9011.00
106_Q224_N0.8971.00
336_I354_L0.8931.00
82_S207_G0.8911.00
203_M354_L0.8911.00
326_E371_R0.8901.00
192_P219_R0.8891.00
67_I308_D0.8861.00
55_F95_A0.8831.00
150_I220_V0.8831.00
359_L363_G0.8811.00
303_A320_A0.8751.00
56_P59_Y0.8741.00
19_F48_L0.8741.00
290_A319_Y0.8721.00
360_M363_G0.8701.00
145_G219_R0.8691.00
260_D264_A0.8681.00
125_L240_L0.8671.00
94_G167_I0.8601.00
292_E323_F0.8601.00
122_S189_T0.8591.00
132_S369_I0.8561.00
27_H40_Q0.8551.00
254_I328_A0.8541.00
58_E104_E0.8541.00
171_V182_I0.8521.00
191_T194_L0.8521.00
33_Q346_K0.8471.00
264_A267_K0.8431.00
266_A286_L0.8431.00
329_T358_K0.8401.00
39_M164_R0.8391.00
122_S163_A0.8391.00
103_T107_K0.8391.00
254_I353_M0.8381.00
284_F372_L0.8361.00
20_A76_V0.8311.00
262_S338_I0.8271.00
283_Q372_L0.8271.00
215_L218_V0.8231.00
203_M351_E0.8221.00
156_W345_M0.8211.00
67_I301_L0.8141.00
327_M331_A0.8101.00
196_I213_I0.8071.00
15_M18_D0.8071.00
67_I71_L0.8061.00
54_P69_Y0.8061.00
148_Y225_L0.8061.00
332_C353_M0.8021.00
141_A148_Y0.8021.00
40_Q44_K0.8001.00
336_I350_V0.8001.00
30_H33_Q0.7991.00
204_G356_D0.7981.00
294_D297_R0.7971.00
9_Q67_I0.7971.00
333_N354_L0.7941.00
284_F288_D0.7941.00
147_E221_P0.7941.00
45_M50_L0.7931.00
119_A165_T0.7921.00
167_I184_A0.7911.00
13_R17_K0.7911.00
19_F45_M0.7891.00
58_E61_G0.7891.00
171_V174_K0.7891.00
165_T186_I0.7841.00
21_K78_K0.7841.00
255_A327_M0.7841.00
262_S339_H0.7831.00
294_D298_Q0.7831.00
354_L358_K0.7831.00
124_G168_V0.7801.00
41_T83_T0.7791.00
254_I357_A0.7781.00
71_L75_E0.7761.00
288_D334_Q0.7751.00
247_I364_E0.7751.00
137_T169_T0.7731.00
252_V296_A0.7731.00
185_L220_V0.7691.00
139_T154_K0.7681.00
285_K338_I0.7671.00
262_S266_A0.7641.00
19_F23_E0.7641.00
291_M323_F0.7581.00
259_L290_A0.7571.00
183_S230_T0.7571.00
261_A353_M0.7561.00
248_A320_A0.7541.00
289_M335_A0.7531.00
323_F327_M0.7521.00
124_G213_I0.7521.00
141_A172_T0.7501.00
29_E352_R0.7461.00
332_C354_L0.7451.00
164_R190_D0.7451.00
205_V363_G0.7451.00
71_L301_L0.7451.00
137_T182_I0.7441.00
330_R333_N0.7441.00
59_Y104_E0.7441.00
173_G230_T0.7431.00
265_Y342_S0.7421.00
288_D330_R0.7411.00
280_Q284_F0.7411.00
313_F316_E0.7371.00
256_Q290_A0.7371.00
299_M320_A0.7341.00
276_I279_F0.7291.00
258_A335_A0.7281.00
21_K79_A0.7271.00
78_K257_A0.7271.00
164_R189_T0.7261.00
299_M319_Y0.7251.00
147_E223_A0.7251.00
110_H186_I0.7231.00
295_L299_M0.7181.00
18_D21_K0.7161.00
58_E107_K0.7161.00
53_I64_G0.7101.00
248_A300_V0.7091.00
279_F283_Q0.7081.00
123_F236_F0.7061.00
337_Q358_K0.7051.00
21_K25_A0.7031.00
291_M322_L0.7011.00
161_S209_N0.7001.00
332_C350_V0.7001.00
352_R356_D0.6991.00
24_I41_T0.6981.00
190_D194_L0.6951.00
13_R74_E0.6931.00
173_G181_I0.6931.00
110_H224_N0.6921.00
251_A325_S0.6911.00
370_Q373_V0.6911.00
183_S227_G0.6871.00
372_L376_R0.6841.00
127_E139_T0.6831.00
171_V181_I0.6831.00
336_I343_G0.6821.00
225_L228_D0.6781.00
95_A114_L0.6771.00
304_A308_D0.6771.00
20_A24_I0.6751.00
339_H350_V0.6741.00
110_H119_A0.6731.00
206_R346_K0.6711.00
150_I187_V0.6621.00
231_K235_Q0.6621.00
297_R301_L0.6611.00
248_A324_A0.6591.00
269_R272_F0.6581.00
175_N181_I0.6561.00
328_A332_C0.6561.00
55_F59_Y0.6521.00
300_V324_A0.6521.00
167_I226_L0.6491.00
41_T44_K0.6491.00
137_T171_V0.6471.00
299_M323_F0.6461.00
125_L134_A0.6461.00
169_T236_F0.6451.00
366_T369_I0.6441.00
102_G107_K0.6441.00
153_E197_T0.6431.00
97_P239_T0.6421.00
283_Q375_A0.6411.00
145_G149_V0.6391.00
58_E63_G0.6381.00
39_M162_Y0.6371.00
255_A296_A0.6371.00
204_G344_Y0.6331.00
144_N222_A0.6321.00
282_I286_L0.6321.00
114_L165_T0.6281.00
56_P61_G0.6281.00
249_A253_G0.6281.00
17_K78_K0.6271.00
143_S149_V0.6261.00
172_T229_P0.6261.00
157_I213_I0.6231.00
285_K288_D0.6231.00
292_E295_L0.6221.00
302_K316_E0.6201.00
106_Q109_T0.6181.00
25_A28_A0.6171.00
12_V68_S0.6131.00
257_A260_D0.6131.00
262_S289_M0.6111.00
128_P153_E0.6111.00
85_L205_V0.6091.00
39_M120_L0.6091.00
140_K174_K0.6091.00
319_Y374_I0.6091.00
322_L374_I0.6061.00
162_Y209_N0.6061.00
28_A352_R0.6061.00
172_T181_I0.6051.00
272_F279_F0.6041.00
12_V72_A0.6031.00
245_I304_A0.6021.00
292_E326_E0.6021.00
139_T215_L0.6021.00
187_V215_L0.6001.00
285_K337_Q0.6001.00
140_K173_G0.5991.00
201_D206_R0.5981.00
271_Q276_I0.5911.00
296_A323_F0.5891.00
341_G344_Y0.5881.00
143_S146_D0.5871.00
222_A229_P0.5851.00
95_A111_L0.5831.00
17_K79_A0.5811.00
329_T357_A0.5751.00
307_K313_F0.5751.00
202_K210_T0.5751.00
255_A258_A0.5731.00
252_V256_Q0.5721.00
257_A349_G0.5721.00
241_D317_A0.5711.00
160_A213_I0.5711.00
99_Y107_K0.5681.00
168_V218_V0.5671.00
299_M303_A0.5641.00
69_Y246_S0.5631.00
139_T152_G0.5631.00
12_V16_V0.5611.00
35_G206_R0.5611.00
291_M295_L0.5601.00
282_I285_K0.5601.00
71_L74_E0.5601.00
194_L215_L0.5581.00
294_D299_M0.5561.00
125_L169_T0.5551.00
45_M83_T0.5541.00
66_T307_K0.5541.00
139_T168_V0.5531.00
178_G181_I0.5531.00
36_E39_M0.5521.00
96_S100_Y0.5521.00
265_Y348_Y0.5521.00
185_L224_N0.5511.00
256_Q293_I0.5511.00
81_G254_I0.5501.00
358_K362_I0.5501.00
52_G62_S0.5491.00
187_V218_V0.5471.00
31_V80_C0.5461.00
289_M338_I0.5461.00
229_P232_G0.5461.00
35_G201_D0.5421.00
322_L326_E0.5411.00
52_G115_A0.5411.00
288_D326_E0.5401.00
32_D206_R0.5401.00
139_T170_A0.5401.00
35_G346_K0.5391.00
296_A320_A0.5381.00
165_T224_N0.5381.00
23_E26_P0.5371.00
158_T210_T0.5361.00
97_P101_F0.5341.00
82_S86_S0.5341.00
276_I282_I0.5321.00
370_Q374_I0.5311.00
240_L244_R0.5311.00
279_F282_I0.5301.00
325_S360_M0.5301.00
369_I372_L0.5291.00
94_G114_L0.5281.00
288_D291_M0.5261.00
97_P235_Q0.5241.00
349_G352_R0.5221.00
310_N313_F0.5221.00
59_Y112_T0.5221.00
174_K181_I0.5211.00
296_A331_A0.5191.00
98_L102_G0.5171.00
130_A138_Q0.5161.00
24_I83_T0.5151.00
186_I226_L0.5141.00
203_M355_R0.5141.00
122_S157_I0.5131.00
185_L222_A0.5121.00
94_G97_P0.5121.00
15_M62_S0.5121.00
265_Y268_E0.5101.00
270_K278_S0.5101.00
109_T112_T0.5091.00
240_L243_G0.5091.00
245_I300_V0.5071.00
234_K238_Y0.5071.00
196_I211_A0.5061.00
57_E60_G0.5051.00
110_H113_P0.5051.00
50_L72_A0.5051.00
70_A301_L0.5041.00
289_M327_M0.5041.00
292_E296_A0.5031.00
80_C207_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d29A 4 1 100 0.057 Contact Map
4l1fA 4 0.9974 100 0.059 Contact Map
1bucA 4 0.9974 100 0.062 Contact Map
1ukwA 4 0.9947 100 0.067 Contact Map
3pfdA 4 0.9711 100 0.068 Contact Map
2jifA 4 0.9947 100 0.068 Contact Map
1ivhA 4 1 100 0.069 Contact Map
4m9aA 4 0.9895 100 0.069 Contact Map
4irnA 4 0.9868 100 0.072 Contact Map
1rx0A 4 0.9921 100 0.073 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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