GREMLIN Database
YOAV - Uncharacterized transporter YoaV
UniProt: O34416 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 292 (274)
Sequences: 37878 (28095)
Seq/√Len: 1697.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_G154_V3.5221.00
7_G232_W2.9411.00
93_K151_E2.8971.00
232_W236_Q2.7471.00
257_G263_E2.7121.00
84_Y153_C2.5801.00
43_A186_M2.5271.00
81_I156_V2.4891.00
124_G279_G2.4741.00
36_G193_L2.4071.00
21_A217_F2.3821.00
104_F158_A2.3041.00
232_W235_N2.2871.00
60_Q63_H2.2541.00
108_I166_V2.1811.00
115_E169_K2.1641.00
23_K263_E2.1221.00
81_I153_C2.1171.00
16_G252_L2.1051.00
95_S253_A2.0481.00
22_M83_T1.9991.00
110_H117_M1.9951.00
40_F189_A1.9611.00
41_I219_G1.9571.00
8_I233_V1.9471.00
89_V151_E1.8761.00
109_S115_E1.8701.00
77_G160_S1.8611.00
105_V243_S1.8181.00
106_T125_L1.8101.00
219_G224_G1.8041.00
152_L156_V1.7981.00
47_F182_A1.7921.00
100_T104_F1.7591.00
89_V150_G1.7541.00
63_H174_H1.7281.00
16_G256_F1.7251.00
118_N121_K1.7041.00
190_V194_V1.6731.00
81_I160_S1.6621.00
88_F149_F1.6431.00
43_A189_A1.6431.00
48_L51_F1.6281.00
209_Y213_W1.6261.00
128_G247_M1.6211.00
194_V197_F1.6171.00
13_L252_L1.6081.00
176_D179_H1.6011.00
238_Q241_K1.6011.00
17_Y217_F1.5931.00
29_I211_A1.5841.00
104_F162_G1.5651.00
266_T269_I1.5401.00
94_T154_V1.5211.00
84_Y88_F1.4781.00
148_L151_E1.4721.00
11_V233_V1.4701.00
108_I112_S1.4301.00
36_G189_A1.4291.00
104_F159_L1.4291.00
124_G283_N1.4251.00
47_F51_F1.4061.00
62_E66_S1.4021.00
267_I271_L1.3941.00
168_S231_F1.3751.00
256_F260_Q1.3701.00
28_D211_A1.3581.00
89_V93_K1.3531.00
91_S257_G1.3531.00
44_V48_L1.3511.00
270_I274_L1.3421.00
88_F153_C1.3411.00
134_F275_L1.3361.00
42_G185_L1.3361.00
208_T211_A1.3341.00
109_S113_L1.3281.00
62_E65_K1.3221.00
48_L52_I1.3201.00
45_P224_G1.3181.00
15_W226_T1.3121.00
25_G34_F1.3091.00
210_Q213_W1.2911.00
7_G229_V1.2851.00
252_L256_F1.2651.00
61_K65_K1.2651.00
84_Y87_Q1.2611.00
162_G166_V1.2591.00
61_K64_L1.2561.00
20_V256_F1.2551.00
68_I71_S1.2551.00
108_I163_I1.2541.00
119_V123_M1.2541.00
131_G272_G1.2501.00
24_V214_S1.2471.00
274_L278_C1.2461.00
96_V273_A1.2451.00
90_D93_K1.2441.00
134_F268_N1.2371.00
34_F218_N1.2351.00
128_G279_G1.2321.00
122_T126_V1.2301.00
92_G254_L1.2211.00
265_I270_I1.2191.00
120_Y282_M1.2121.00
126_V130_F1.2111.00
248_F252_L1.2061.00
14_I221_L1.2031.00
148_L152_L1.2001.00
65_K69_I1.1961.00
191_M194_V1.1901.00
30_P33_L1.1871.00
49_I53_Q1.1741.00
210_Q214_S1.1741.00
6_L10_S1.1631.00
124_G282_M1.1611.00
213_W217_F1.1431.00
86_M94_T1.1411.00
169_K238_Q1.1391.00
23_K27_H1.1361.00
105_V239_A1.1171.00
88_F150_G1.1141.00
21_A214_S1.1131.00
11_V229_V1.1081.00
135_I272_G1.1081.00
43_A182_A1.1061.00
36_G40_F1.1011.00
36_G196_S1.0991.00
38_R223_T1.0971.00
66_S167_F1.0971.00
65_K68_I1.0911.00
113_L166_V1.0911.00
206_E209_Y1.0911.00
17_Y256_F1.0901.00
234_L242_A1.0871.00
10_S229_V1.0791.00
115_E121_K1.0761.00
68_I187_M1.0761.00
117_M122_T1.0721.00
76_L191_M1.0711.00
88_F147_A1.0701.00
32_L195_F1.0661.00
66_S70_M1.0611.00
35_S83_T1.0591.00
63_H66_S1.0551.00
119_V122_T1.0491.00
131_G276_I1.0471.00
170_L173_K1.0441.00
91_S261_L1.0431.00
149_F153_C1.0431.00
15_W230_W1.0421.00
11_V15_W1.0401.00
22_M86_M1.0341.00
97_L158_A1.0331.00
31_P35_S1.0321.00
108_I162_G1.0321.00
89_V154_V1.0191.00
14_I229_V1.0161.00
110_H116_K1.0161.00
72_L191_M1.0121.00
105_V165_N1.0101.00
100_T132_L1.0081.00
194_V198_I1.0021.00
195_F199_F1.0001.00
25_G211_A0.9991.00
76_L192_L0.9931.00
108_I159_L0.9931.00
169_K239_A0.9921.00
106_T117_M0.9851.00
20_V260_Q0.9681.00
82_L86_M0.9641.00
137_G266_T0.9621.00
149_F152_L0.9601.00
209_Y212_V0.9591.00
195_F198_I0.9591.00
267_I270_I0.9561.00
74_M164_A0.9471.00
213_W216_L0.9461.00
97_L154_V0.9451.00
234_L238_Q0.9391.00
97_L151_E0.9331.00
55_K176_D0.9311.00
111_F114_N0.9281.00
127_C279_G0.9271.00
116_K120_Y0.9241.00
237_I242_A0.9231.00
212_V216_L0.9231.00
25_G214_S0.9211.00
158_A162_G0.9181.00
32_L80_G0.9131.00
108_I111_F0.9121.00
238_Q242_A0.9021.00
118_N122_T0.9011.00
40_F193_L0.9001.00
150_G154_V0.8961.00
63_H175_I0.8941.00
216_L219_G0.8871.00
105_V162_G0.8841.00
205_A208_T0.8791.00
69_I167_F0.8731.00
33_L196_S0.8721.00
237_I241_K0.8621.00
67_Y71_S0.8611.00
91_S263_E0.8611.00
130_F134_F0.8581.00
68_I72_L0.8571.00
12_T16_G0.8561.00
96_V133_L0.8551.00
71_S187_M0.8431.00
132_L136_F0.8411.00
45_P220_L0.8411.00
116_K119_V0.8411.00
70_M74_M0.8391.00
233_V242_A0.8331.00
39_L188_G0.8331.00
130_F275_L0.8231.00
20_V257_G0.8221.00
71_S74_M0.8191.00
80_G84_Y0.8141.00
251_V273_A0.8131.00
258_W265_I0.8121.00
66_S171_Q0.8101.00
69_I72_L0.8091.00
51_F56_K0.8071.00
254_L265_I0.8011.00
64_L187_M0.7991.00
110_H114_N0.7941.00
51_F54_R0.7921.00
145_Q148_L0.7911.00
35_S192_L0.7891.00
186_M190_V0.7841.00
163_I167_F0.7831.00
12_T252_L0.7801.00
73_L160_S0.7801.00
268_N271_L0.7801.00
64_L68_I0.7791.00
47_F186_M0.7781.00
187_M190_V0.7781.00
9_I252_L0.7741.00
134_F271_L0.7711.00
147_A151_E0.7701.00
107_V111_F0.7691.00
103_I128_G0.7651.00
161_W165_N0.7641.00
123_M127_C0.7631.00
78_Y160_S0.7591.00
248_F251_V0.7591.00
271_L275_L0.7571.00
51_F55_K0.7541.00
197_F200_E0.7531.00
104_F155_L0.7531.00
43_A47_F0.7501.00
33_L37_L0.7481.00
76_L80_G0.7481.00
46_L224_G0.7451.00
40_F44_V0.7451.00
154_V158_A0.7421.00
273_A277_C0.7411.00
106_T121_K0.7411.00
170_L174_H0.7391.00
182_A186_M0.7381.00
169_K173_K0.7351.00
214_S217_F0.7351.00
12_T248_F0.7311.00
20_V91_S0.7271.00
133_L137_G0.7201.00
254_L273_A0.7191.00
225_F229_V0.7171.00
8_I245_A0.7161.00
77_G81_I0.7161.00
50_L182_A0.7131.00
66_S170_L0.7131.00
211_A214_S0.7111.00
279_G283_N0.7071.00
64_L67_Y0.7011.00
37_L41_I0.7011.00
257_G261_L0.7001.00
117_M121_K0.7001.00
181_N184_H0.6961.00
60_Q64_L0.6941.00
22_M26_I0.6931.00
45_P48_L0.6921.00
8_I237_I0.6911.00
187_M191_M0.6901.00
183_W187_M0.6871.00
28_D208_T0.6871.00
278_C282_M0.6851.00
85_G94_T0.6821.00
258_W264_Q0.6791.00
215_L219_G0.6791.00
78_Y164_A0.6781.00
221_L225_F0.6771.00
216_L220_L0.6751.00
105_V166_V0.6741.00
265_I269_I0.6681.00
82_L94_T0.6671.00
67_Y70_M0.6671.00
19_W82_L0.6661.00
127_C282_M0.6651.00
100_T103_I0.6651.00
89_V94_T0.6621.00
179_H183_W0.6621.00
24_V261_L0.6611.00
189_A193_L0.6601.00
217_F221_L0.6601.00
49_I178_I0.6591.00
67_Y175_I0.6581.00
97_L155_L0.6571.00
131_G279_G0.6471.00
228_V232_W0.6471.00
161_W230_W0.6461.00
29_I34_F0.6421.00
175_I180_M0.6391.00
73_L163_I0.6391.00
115_E240_S0.6351.00
102_P247_M0.6291.00
99_Y132_L0.6291.00
204_S207_W0.6281.00
52_I56_K0.6261.00
186_M189_A0.6231.00
181_N231_F0.6221.00
113_L169_K0.6211.00
18_T222_S0.6141.00
19_W95_S0.6131.00
112_S163_I0.6121.00
41_I45_P0.6071.00
190_V193_L0.6061.00
14_I226_T0.6061.00
66_S69_I0.6021.00
137_G140_M0.5991.00
81_I157_A0.5981.00
106_T110_H0.5951.00
183_W186_M0.5941.00
264_Q268_N0.5941.00
71_S76_L0.5921.00
153_C156_V0.5921.00
45_P219_G0.5901.00
269_I273_A0.5881.00
82_L157_A0.5851.00
85_G150_G0.5811.00
121_K238_Q0.5801.00
17_Y222_S0.5781.00
42_G224_G0.5751.00
205_A209_Y0.5731.00
247_M280_I0.5731.00
266_T270_I0.5721.00
146_S149_F0.5721.00
76_L195_F0.5711.00
196_S200_E0.5691.00
201_A204_S0.5681.00
280_I283_N0.5681.00
254_L258_W0.5661.00
99_Y158_A0.5661.00
164_A231_F0.5631.00
49_I52_I0.5621.00
207_W212_V0.5611.00
208_T212_V0.5601.00
30_P200_E0.5601.00
255_F258_W0.5591.00
165_N230_W0.5591.00
83_T87_Q0.5581.00
26_I86_M0.5551.00
67_Y180_M0.5531.00
255_F259_L0.5511.00
12_T249_V0.5491.00
100_T158_A0.5491.00
35_S80_G0.5481.00
244_M283_N0.5461.00
9_I12_T0.5461.00
96_V135_I0.5451.00
165_N243_S0.5451.00
136_F151_E0.5451.00
99_Y102_P0.5431.00
229_V232_W0.5421.00
95_S99_Y0.5361.00
10_S14_I0.5301.00
96_V136_F0.5301.00
19_W23_K0.5281.00
258_W270_I0.5251.00
188_G192_L0.5251.00
16_G253_A0.5241.00
18_T83_T0.5231.00
68_I191_M0.5231.00
123_M130_F0.5231.00
256_F259_L0.5231.00
264_Q269_I0.5201.00
60_Q65_K0.5191.00
44_V47_F0.5191.00
233_V237_I0.5181.00
107_V125_L0.5171.00
113_L170_L0.5161.00
145_Q149_F0.5151.00
159_L163_I0.5151.00
164_A184_H0.5141.00
246_L249_V0.5121.00
63_H67_Y0.5121.00
16_G249_V0.5111.00
35_S39_L0.5101.00
80_G192_L0.5091.00
14_I222_S0.5081.00
277_C281_F0.5071.00
85_G89_V0.5061.00
191_M195_F0.5061.00
181_N185_L0.5051.00
109_S240_S0.5041.00
32_L199_F0.5041.00
53_Q56_K0.5031.00
8_I230_W0.5021.00
103_I125_L0.5011.00
50_L179_H0.5011.00
270_I273_A0.5011.00
29_I33_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2637 98.7 0.76 Contact Map
3b5dA 2 0.3459 98.4 0.778 Contact Map
1u7gA 3 0.7945 29.8 0.928 Contact Map
1pw4A 1 0.9623 8.5 0.944 Contact Map
4xnjA 1 0.7466 6.5 0.947 Contact Map
4j05A 3 0.9418 6.5 0.947 Contact Map
3wdoA 1 0.7671 5.3 0.949 Contact Map
4pgrA 1 0.6575 5.3 0.949 Contact Map
3j01B 1 0.1918 4.9 0.95 Contact Map
2gfpA 2 0.7671 4.9 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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