GREMLIN Database
YTCC - Putative glycosyltransferase YtcC
UniProt: O34413 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 407 (345)
Sequences: 52438 (44220)
Seq/√Len: 2380.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_L274_A4.8481.00
224_V257_I3.6551.00
132_M156_K3.2671.00
238_E242_V3.2551.00
277_F294_A3.1441.00
84_H373_Y2.9101.00
193_V226_V2.8171.00
215_R332_A2.7871.00
355_H359_L2.7851.00
191_K224_V2.7171.00
226_V259_T2.6721.00
196_F206_P2.6541.00
211_H328_P2.2251.00
192_K339_F2.1701.00
141_K145_I2.1691.00
219_Q336_D2.1621.00
39_T80_F2.1621.00
205_G208_L2.1271.00
39_T78_S2.0991.00
211_H244_Y2.0901.00
334_A337_R2.0481.00
305_N310_G2.0361.00
213_M225_L1.9961.00
228_A270_L1.9941.00
36_Y370_N1.9691.00
193_V224_V1.9651.00
226_V257_I1.9551.00
215_R329_S1.9481.00
341_D344_L1.9381.00
4_A80_F1.9231.00
313_V319_G1.9181.00
194_I276_V1.8921.00
337_R344_L1.8741.00
298_G353_R1.8731.00
192_K275_D1.8491.00
237_S240_Q1.8431.00
345_M349_T1.8291.00
193_V273_M1.8251.00
132_M372_V1.8061.00
39_T60_I1.8051.00
318_T355_H1.7911.00
320_L334_A1.7881.00
314_K317_V1.7781.00
364_H368_R1.7771.00
161_G362_F1.7721.00
84_H107_S1.7341.00
323_D330_S1.7181.00
220_H336_D1.7141.00
138_E141_K1.7131.00
305_N323_D1.7121.00
156_K375_S1.7091.00
205_G282_Q1.7071.00
244_Y250_L1.7001.00
336_D340_T1.6991.00
277_F299_T1.6921.00
209_L225_L1.6871.00
230_G238_E1.6771.00
35_R367_K1.6741.00
106_L130_V1.6721.00
35_R370_N1.6621.00
141_K157_V1.6521.00
370_N374_Q1.6371.00
314_K355_H1.6321.00
197_A267_I1.6271.00
337_R341_D1.6171.00
31_Y366_A1.5661.00
263_P266_D1.5581.00
135_T155_T1.5471.00
320_L337_R1.5441.00
138_E311_E1.5411.00
213_M223_A1.5411.00
26_D30_P1.5241.00
31_Y363_T1.5051.00
317_V351_N1.5051.00
209_L278_V1.5021.00
138_E157_V1.4981.00
326_N330_S1.4881.00
330_S334_A1.4871.00
344_L347_K1.4781.00
31_Y34_S1.4741.00
214_R250_L1.4711.00
39_T58_H1.4621.00
347_K351_N1.4601.00
246_R253_R1.4601.00
203_T283_W1.4481.00
266_D269_N1.4301.00
314_K318_T1.4271.00
354_K358_A1.4201.00
303_T309_N1.4061.00
4_A41_F1.4001.00
216_I336_D1.4001.00
228_A259_T1.3841.00
208_L328_P1.3781.00
141_K155_T1.3771.00
85_V104_I1.3591.00
134_T372_V1.3531.00
274_A299_T1.3201.00
262_I266_D1.3201.00
226_V270_L1.3111.00
215_R328_P1.3091.00
214_R218_Q1.3051.00
208_L282_Q1.3021.00
135_T141_K1.3011.00
207_H244_Y1.3011.00
328_P332_A1.2991.00
322_I334_A1.2961.00
268_P297_A1.2941.00
212_S331_F1.2931.00
5_F32_F1.2891.00
193_V275_D1.2861.00
194_I335_I1.2741.00
200_L227_I1.2731.00
5_F86_F1.2731.00
368_R371_T1.2651.00
145_I152_E1.2631.00
134_T369_L1.2581.00
194_I278_V1.2571.00
220_H340_T1.2541.00
196_F209_L1.2491.00
287_L292_Y1.2441.00
195_L228_A1.2371.00
330_S333_K1.2291.00
206_P227_I1.2261.00
132_M375_S1.2251.00
351_N354_K1.2051.00
364_H367_K1.2051.00
226_V274_A1.1991.00
242_V246_R1.1951.00
138_E142_Q1.1811.00
151_A154_I1.1791.00
332_A336_D1.1721.00
167_Y297_A1.1661.00
192_K276_V1.1591.00
279_C291_N1.1341.00
264_A267_I1.1321.00
142_Q145_I1.1321.00
243_T247_T1.1221.00
291_N309_N1.1201.00
307_G310_G1.1181.00
349_T352_A1.1171.00
267_I271_F1.1111.00
24_M289_R1.1101.00
298_G350_K1.1021.00
272_L297_A1.1021.00
362_F365_A1.0981.00
136_V140_I1.0971.00
361_T364_H1.0961.00
282_Q325_Y1.0911.00
135_T144_V1.0901.00
244_Y247_T1.0851.00
31_Y35_R1.0841.00
166_S268_P1.0821.00
346_N350_K1.0801.00
237_S241_Y1.0771.00
207_H211_H1.0771.00
230_G261_F1.0751.00
239_N243_T1.0691.00
365_A368_R1.0691.00
239_N242_V1.0641.00
279_C290_V1.0581.00
136_V160_S1.0581.00
322_I331_F1.0491.00
192_K223_A1.0481.00
344_L348_M1.0471.00
109_H289_R1.0471.00
201_S232_W1.0401.00
281_S285_E1.0391.00
280_S331_F1.0371.00
193_V274_A1.0351.00
208_L325_Y1.0341.00
5_F29_T1.0331.00
338_A348_M1.0301.00
320_L348_M1.0291.00
303_T321_V1.0291.00
299_T349_T1.0261.00
271_F297_A1.0261.00
342_Q345_M1.0171.00
208_L211_H1.0171.00
304_T322_I1.0171.00
96_K100_P1.0141.00
208_L304_T1.0131.00
215_R219_Q1.0121.00
85_V106_L1.0121.00
27_G362_F1.0111.00
315_H334_A1.0061.00
86_F109_H1.0041.00
277_F290_V0.9981.00
156_K372_V0.9961.00
167_Y268_P0.9961.00
195_L270_L0.9941.00
259_T270_L0.9861.00
268_P272_L0.9831.00
27_G30_P0.9831.00
215_R218_Q0.9821.00
191_K222_D0.9801.00
365_A369_L0.9791.00
194_I213_M0.9791.00
333_K337_R0.9711.00
192_K222_D0.9571.00
197_A228_A0.9561.00
320_L338_A0.9551.00
288_A309_N0.9511.00
160_S289_R0.9481.00
367_K371_T0.9461.00
135_T140_I0.9431.00
19_G22_Q0.9421.00
295_M301_L0.9401.00
161_G365_A0.9341.00
197_A271_F0.9331.00
342_Q346_N0.9281.00
285_E288_A0.9281.00
69_E73_E0.9271.00
199_R203_T0.9261.00
308_G311_E0.9251.00
136_V286_P0.9251.00
295_M352_A0.9241.00
228_A262_I0.9181.00
350_K354_K0.9171.00
143_T146_E0.9161.00
164_L361_T0.9131.00
294_A299_T0.9051.00
142_Q146_E0.9051.00
216_I223_A0.8991.00
23_M27_G0.8991.00
196_F227_I0.8981.00
349_T353_R0.8961.00
303_T313_V0.8961.00
216_I335_I0.8961.00
90_L93_S0.8941.00
208_L331_F0.8921.00
209_L280_S0.8911.00
262_I270_L0.8871.00
291_N303_T0.8861.00
320_L344_L0.8841.00
207_H282_Q0.8821.00
29_T33_S0.8791.00
185_K269_N0.8761.00
346_N349_T0.8741.00
24_M109_H0.8741.00
323_D326_N0.8731.00
72_A99_S0.8711.00
224_V255_H0.8651.00
216_I339_F0.8641.00
211_H250_L0.8631.00
29_T40_I0.8581.00
25_I86_F0.8581.00
302_I322_I0.8551.00
204_K285_E0.8551.00
3_L36_Y0.8541.00
223_A339_F0.8531.00
163_D166_S0.8531.00
240_Q244_Y0.8521.00
291_N301_L0.8521.00
213_M255_H0.8501.00
300_P349_T0.8491.00
318_T352_A0.8461.00
130_V133_I0.8451.00
214_R252_Y0.8441.00
226_V273_M0.8431.00
243_T246_R0.8431.00
367_K370_N0.8381.00
212_S332_A0.8351.00
276_V338_A0.8351.00
271_F299_T0.8351.00
105_V134_T0.8341.00
259_T262_I0.8301.00
72_A76_R0.8281.00
348_M351_N0.8281.00
163_D167_Y0.8261.00
134_T158_V0.8261.00
216_I332_A0.8181.00
104_I130_V0.8181.00
295_M318_T0.8161.00
245_L258_F0.8111.00
196_F280_S0.8091.00
139_F142_Q0.8091.00
27_G163_D0.8081.00
156_K368_R0.8061.00
295_M355_H0.8041.00
279_C309_N0.8021.00
65_E69_E0.8011.00
39_T43_I0.8011.00
195_L271_F0.7991.00
333_K336_D0.7921.00
125_E129_N0.7871.00
302_I334_A0.7831.00
306_R309_N0.7821.00
278_V335_I0.7801.00
145_I155_T0.7781.00
355_H360_F0.7771.00
204_K290_V0.7761.00
361_T365_A0.7761.00
329_S333_K0.7751.00
245_L252_Y0.7751.00
24_M160_S0.7731.00
291_N312_V0.7721.00
158_V372_V0.7691.00
313_V321_V0.7671.00
121_A125_E0.7671.00
275_D345_M0.7641.00
19_G199_R0.7621.00
24_M107_S0.7591.00
362_F366_A0.7571.00
97_K104_I0.7521.00
300_P338_A0.7511.00
23_M264_A0.7511.00
212_S328_P0.7491.00
196_F277_F0.7491.00
269_N272_L0.7461.00
211_H215_R0.7461.00
216_I220_H0.7451.00
276_V335_I0.7431.00
198_G206_P0.7421.00
219_Q332_A0.7411.00
363_T367_K0.7411.00
95_Y99_S0.7411.00
204_K281_S0.7371.00
264_A268_P0.7351.00
240_Q243_T0.7341.00
170_V272_L0.7341.00
159_Y368_R0.7321.00
136_V289_R0.7301.00
159_Y311_E0.7271.00
270_L273_M0.7271.00
35_R363_T0.7261.00
84_H369_L0.7241.00
304_T324_S0.7241.00
33_S36_Y0.7221.00
326_N329_S0.7201.00
37_D58_H0.7201.00
143_T147_R0.7181.00
211_H214_R0.7181.00
305_N321_V0.7161.00
353_R356_V0.7151.00
105_V376_V0.7141.00
74_E78_S0.7121.00
202_P207_H0.7111.00
241_Y245_L0.7091.00
27_G31_Y0.7081.00
139_F143_T0.7081.00
109_H136_V0.7071.00
231_K238_E0.7061.00
310_G321_V0.7061.00
369_L373_Y0.7051.00
371_T375_S0.7051.00
33_S56_G0.7021.00
33_S38_L0.6961.00
302_I338_A0.6941.00
372_V375_S0.6931.00
197_A277_F0.6931.00
30_P55_D0.6931.00
196_F225_L0.6921.00
35_R366_A0.6901.00
337_R340_T0.6871.00
269_N273_M0.6861.00
348_M352_A0.6851.00
110_N203_T0.6841.00
185_K266_D0.6841.00
292_Y360_F0.6841.00
347_K350_K0.6811.00
210_I245_L0.6801.00
231_K237_S0.6791.00
121_A124_K0.6761.00
23_M26_D0.6751.00
194_I339_F0.6751.00
194_I223_A0.6751.00
105_V373_Y0.6741.00
132_M376_V0.6741.00
207_H240_Q0.6691.00
315_H318_T0.6691.00
86_F107_S0.6671.00
192_K342_Q0.6651.00
82_L373_Y0.6651.00
371_T374_Q0.6631.00
288_A291_N0.6631.00
279_C288_A0.6621.00
329_S332_A0.6621.00
7_C25_I0.6581.00
124_K128_D0.6581.00
219_Q333_K0.6551.00
220_H223_A0.6541.00
343_E347_K0.6531.00
287_L360_F0.6531.00
207_H237_S0.6531.00
24_M369_L0.6521.00
141_K152_E0.6511.00
158_V369_L0.6501.00
89_P92_V0.6501.00
68_R72_A0.6471.00
238_E241_Y0.6441.00
318_T351_N0.6431.00
202_P282_Q0.6421.00
69_E72_A0.6421.00
164_L296_A0.6421.00
278_V331_F0.6411.00
73_E77_A0.6401.00
103_K131_S0.6391.00
105_V132_M0.6381.00
372_V376_V0.6321.00
156_K159_Y0.6321.00
9_E22_Q0.6291.00
66_H70_A0.6291.00
145_I149_P0.6281.00
324_S330_S0.6271.00
304_T331_F0.6271.00
7_C21_I0.6241.00
159_Y360_F0.6231.00
5_F38_L0.6181.00
338_A345_M0.6171.00
295_M349_T0.6161.00
198_G204_K0.6091.00
313_V318_T0.6081.00
100_P103_K0.6071.00
341_D345_M0.6031.00
158_V368_R0.6021.00
210_I256_I0.6021.00
34_S363_T0.6001.00
316_E337_R0.6001.00
205_G280_S0.6001.00
270_L274_A0.5991.00
107_S369_L0.5981.00
29_T38_L0.5981.00
139_F310_G0.5951.00
31_Y362_F0.5951.00
366_A370_N0.5921.00
202_P237_S0.5921.00
277_F301_L0.5901.00
89_P93_S0.5901.00
315_H320_L0.5871.00
222_D255_H0.5871.00
250_L253_R0.5871.00
30_P34_S0.5871.00
189_E192_K0.5851.00
28_V369_L0.5841.00
352_A355_H0.5841.00
83_I97_K0.5841.00
271_F290_V0.5821.00
216_I221_P0.5781.00
212_S335_I0.5771.00
96_K99_S0.5771.00
36_Y374_Q0.5761.00
343_E346_N0.5761.00
359_L364_H0.5751.00
275_D342_Q0.5741.00
80_F102_S0.5731.00
97_K100_P0.5721.00
205_G325_Y0.5711.00
98_A129_N0.5691.00
209_L213_M0.5671.00
21_I87_N0.5671.00
351_N355_H0.5661.00
192_K195_L0.5631.00
221_P340_T0.5621.00
302_I335_I0.5611.00
247_T250_L0.5601.00
29_T57_V0.5601.00
137_S140_I0.5591.00
195_L277_F0.5591.00
213_M216_I0.5581.00
262_I267_I0.5571.00
200_L206_P0.5571.00
24_M28_V0.5541.00
76_R100_P0.5541.00
276_V302_I0.5521.00
192_K345_M0.5501.00
200_L238_E0.5491.00
55_D58_H0.5471.00
109_H160_S0.5451.00
165_N168_P0.5431.00
229_G260_K0.5431.00
168_P272_L0.5391.00
18_G261_F0.5391.00
322_I330_S0.5381.00
305_N324_S0.5371.00
5_F373_Y0.5371.00
135_T157_V0.5361.00
280_S304_T0.5361.00
75_L80_F0.5341.00
27_G289_R0.5311.00
228_A267_I0.5301.00
290_V294_A0.5291.00
24_M86_F0.5271.00
82_L105_V0.5271.00
74_E77_A0.5261.00
242_V245_L0.5251.00
168_P171_W0.5251.00
220_H339_F0.5241.00
200_L231_K0.5241.00
283_W286_P0.5231.00
108_L140_I0.5211.00
163_D362_F0.5201.00
195_L299_T0.5171.00
138_E159_Y0.5161.00
368_R372_V0.5151.00
42_S59_Y0.5141.00
159_Y287_L0.5121.00
295_M356_V0.5101.00
350_K353_R0.5101.00
221_P336_D0.5101.00
208_L212_S0.5101.00
33_S57_V0.5081.00
166_S264_A0.5081.00
107_S134_T0.5071.00
306_R310_G0.5051.00
83_I102_S0.5051.00
205_G304_T0.5051.00
79_S102_S0.5041.00
276_V345_M0.5041.00
110_N115_E0.5041.00
225_L256_I0.5041.00
164_L356_V0.5041.00
300_P345_M0.5021.00
4_A39_T0.5021.00
292_Y356_V0.5021.00
271_F277_F0.5011.00
328_P331_F0.5001.00
112_M115_E0.5001.00
214_R251_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c48A 2 0.9091 100 0.202 Contact Map
2r60A 1 0.9189 100 0.203 Contact Map
3froA 3 0.914 100 0.211 Contact Map
1rzuA 1 0.8943 100 0.212 Contact Map
4n9wA 1 0.8428 100 0.213 Contact Map
3okpA 1 0.8796 100 0.227 Contact Map
2qzsA 1 0.887 100 0.229 Contact Map
2x6qA 1 0.8722 100 0.243 Contact Map
3oy2A 2 0.86 100 0.244 Contact Map
2jjmA 4 0.8403 100 0.253 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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