GREMLIN Database
HIS9 - Histidinol-phosphatase
UniProt: O34411 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 268 (223)
Sequences: 2759 (2091)
Seq/√Len: 140.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_R77_E4.1961.00
27_E31_K3.9371.00
200_S237_E3.7911.00
204_N241_K3.4751.00
27_E30_K3.2051.00
115_I175_G2.9741.00
37_T113_D2.8511.00
117_S175_G2.7111.00
36_I84_I2.5151.00
71_I86_T2.4561.00
8_I36_I2.4171.00
25_A82_L2.3861.00
35_S85_R2.3091.00
22_R26_E2.2811.00
163_V205_A2.2531.00
72_S75_K2.1401.00
156_R198_L2.0901.00
237_E240_Q1.9831.00
39_T113_D1.9431.00
70_E73_G1.9371.00
35_S83_S1.9271.00
159_Y201_L1.9061.00
256_D259_Y1.9061.00
6_G35_S1.8821.00
159_Y202_C1.8691.00
122_R153_Q1.8241.00
29_L82_L1.8091.00
68_I86_T1.7791.00
21_L74_L1.7771.00
12_F70_E1.7721.00
253_Q256_D1.7651.00
29_L81_Q1.7301.00
203_L234_M1.7081.00
238_A243_I1.7031.00
72_S86_T1.6821.00
146_S149_A1.6531.00
113_D173_R1.6451.00
203_L241_K1.6171.00
6_G37_T1.6161.00
159_Y205_A1.6111.00
232_D236_N1.6081.00
19_D23_Q1.5921.00
213_L238_A1.5841.00
21_L38_F1.5621.00
205_A208_E1.5311.00
251_A256_D1.5241.00
29_L78_Y1.5131.00
20_T23_Q1.5031.00
19_D254_A1.4941.00
5_D249_S1.4701.00
76_K79_R1.4691.00
3_K34_E1.4561.00
260_A263_A1.4421.00
199_V234_M1.4341.00
33_F258_G1.4181.00
94_A160_S1.4081.00
162_I206_I1.4061.00
64_L88_L1.4011.00
205_A209_N1.4001.00
203_L237_E1.3771.00
203_L238_A1.3761.00
200_S240_Q1.3551.00
210_G244_P1.3541.00
163_V208_E1.3331.00
10_T38_F1.3291.00
237_E241_K1.3281.00
8_I24_Y1.2971.00
101_T105_D1.2801.00
152_E198_L1.2751.00
23_Q26_E1.2701.00
26_E29_L1.2671.00
173_R212_E1.2571.00
104_L114_S1.2471.00
207_E238_A1.2461.00
217_T264_F1.2351.00
207_E241_K1.2261.00
207_E243_I1.2251.00
221_R256_D1.2131.00
65_E106_T1.2031.00
88_L114_S1.2001.00
22_R78_Y1.1901.00
11_P20_T1.1891.00
26_E30_K1.1811.00
177_I234_M1.1650.99
200_S241_K1.1620.99
149_A152_E1.1590.99
4_R35_S1.1560.99
163_V209_N1.1550.99
22_R74_L1.1510.99
148_E194_H1.1510.99
160_S163_V1.1410.99
16_G19_D1.1240.99
153_Q157_S1.1170.99
78_Y81_Q1.1160.99
101_T168_V1.1090.99
6_G85_R1.1080.99
98_D102_L1.1070.99
167_G211_M1.1060.99
73_G77_E1.1000.99
63_S66_R1.0980.99
88_L111_L1.0900.99
151_Y184_I1.0830.99
167_G209_N1.0770.99
159_Y163_V1.0770.99
102_L105_D1.0600.99
25_A29_L1.0560.99
158_I202_C1.0550.99
66_R69_H1.0300.99
203_L243_I1.0200.99
92_Y116_L1.0160.99
235_L245_L1.0150.99
151_Y180_V1.0150.99
78_Y82_L1.0110.99
218_S229_Y1.0110.99
162_I205_A1.0110.99
118_V158_I1.0080.99
71_I84_I1.0080.99
181_Q227_G1.0060.98
206_I213_L1.0020.98
19_D24_Y1.0010.98
25_A74_L0.9980.98
153_Q156_R0.9930.98
31_K257_V0.9900.98
15_H43_P0.9880.98
219_G229_Y0.9840.98
221_R259_Y0.9770.98
215_F235_L0.9760.98
173_R248_G0.9740.98
152_E156_R0.9690.98
25_A78_Y0.9690.98
26_E78_Y0.9590.98
162_I209_N0.9460.98
43_P91_D0.9410.98
10_T24_Y0.9390.98
21_L70_E0.9340.98
151_Y155_Y0.9340.98
69_H73_G0.9240.97
66_R70_E0.9230.97
158_I177_I0.9220.97
198_L201_L0.9220.97
74_L78_Y0.9120.97
33_F36_I0.9070.97
116_L169_Y0.9070.97
102_L106_T0.9050.97
26_E81_Q0.9010.97
116_L161_S0.8950.97
85_R112_D0.8900.97
207_E242_K0.8800.96
177_I213_L0.8730.96
65_E107_Y0.8700.96
28_A36_I0.8630.96
68_I72_S0.8630.96
115_I173_R0.8600.96
75_K86_T0.8590.96
24_Y27_E0.8550.96
161_S174_V0.8490.96
169_Y211_M0.8460.96
42_A90_V0.8430.95
99_E103_F0.8420.95
39_T87_G0.8340.95
24_Y254_A0.8260.95
156_R201_L0.8250.95
98_D105_D0.8170.95
70_E74_L0.8170.95
25_A84_I0.8120.94
99_E105_D0.8080.94
162_I202_C0.8060.94
204_N208_E0.8030.94
11_P70_E0.8020.94
13_C40_E0.8010.94
26_E77_E0.7960.94
74_L84_I0.7960.94
173_R246_V0.7930.94
5_D258_G0.7930.94
157_S160_S0.7900.94
218_S222_K0.7870.94
10_T21_L0.7860.93
227_G231_E0.7760.93
218_S221_R0.7750.93
42_A91_D0.7750.93
6_G39_T0.7740.93
219_G230_I0.7730.93
100_I103_F0.7710.93
24_Y38_F0.7630.92
27_E254_A0.7620.92
149_A153_Q0.7580.92
159_Y198_L0.7580.92
206_I211_M0.7560.92
68_I71_I0.7540.92
5_D8_I0.7500.92
156_R160_S0.7490.92
169_Y206_I0.7480.92
13_C16_G0.7470.92
201_L204_N0.7470.92
115_I248_G0.7460.92
100_I104_L0.7440.91
158_I174_V0.7430.91
8_I39_T0.7430.91
37_T173_R0.7420.91
199_V203_L0.7360.91
220_L228_I0.7350.91
118_V174_V0.7330.91
6_G246_V0.7330.91
65_E69_H0.7290.91
25_A36_I0.7250.90
212_E246_V0.7230.90
13_C43_P0.7220.90
29_L79_R0.7190.90
154_Y158_I0.7130.90
201_L205_A0.6910.88
236_N240_Q0.6880.88
118_V161_S0.6830.88
38_F71_I0.6820.88
206_I243_I0.6760.87
177_I203_L0.6750.87
64_L103_F0.6720.87
24_Y251_A0.6660.86
43_P238_A0.6600.86
233_W236_N0.6580.86
16_G20_T0.6560.85
107_Y111_L0.6560.85
113_D170_K0.6540.85
181_Q231_E0.6460.85
78_Y84_I0.6390.84
251_A257_V0.6390.84
175_G214_D0.6390.84
6_G113_D0.6390.84
8_I38_F0.6370.84
200_S204_N0.6330.83
31_K255_G0.6320.83
217_T249_S0.6310.83
98_D104_L0.6300.83
145_G153_Q0.6290.83
10_T13_C0.6270.83
39_T115_I0.6260.83
116_L166_L0.6240.83
166_L169_Y0.6240.83
247_F264_F0.6230.82
6_G173_R0.6220.82
40_E214_D0.6180.82
202_C205_A0.6170.82
227_G232_D0.6170.82
197_G200_S0.6160.82
75_K82_L0.6140.82
199_V202_C0.6140.82
145_G150_V0.6140.82
68_I111_L0.6130.81
118_V157_S0.6130.81
42_A175_G0.6110.81
90_V100_I0.6100.81
221_R224_Y0.6030.80
195_I198_L0.6030.80
11_P17_S0.6020.80
145_G149_A0.5980.80
42_A103_F0.5970.80
174_V206_I0.5960.80
97_E100_I0.5920.79
15_H91_D0.5900.79
178_T235_L0.5900.79
22_R73_G0.5880.79
122_R157_S0.5880.79
148_E188_P0.5880.79
155_Y195_I0.5880.79
92_Y161_S0.5850.78
187_F190_S0.5840.78
91_D118_V0.5830.78
26_E79_R0.5820.78
207_E210_G0.5810.78
22_R82_L0.5810.78
11_P21_L0.5790.78
217_T221_R0.5770.77
156_R159_Y0.5770.77
33_F257_V0.5750.77
98_D101_T0.5710.77
5_D13_C0.5700.77
13_C24_Y0.5700.77
28_A33_F0.5690.76
105_D168_V0.5670.76
235_L239_K0.5670.76
217_T247_F0.5640.76
236_N239_K0.5620.76
99_E102_L0.5620.76
239_K245_L0.5600.75
196_R200_S0.5600.75
152_E202_C0.5580.75
23_Q251_A0.5540.74
100_I105_D0.5530.74
119_H252_H0.5510.74
39_T173_R0.5510.74
174_V213_L0.5500.74
5_D36_I0.5490.74
222_K229_Y0.5490.74
30_K262_E0.5470.74
121_L150_V0.5440.73
38_F84_I0.5440.73
41_H176_H0.5430.73
233_W237_E0.5430.73
204_N207_E0.5400.73
149_A156_R0.5390.72
77_E208_E0.5360.72
14_P47_S0.5350.72
214_D247_F0.5350.72
212_E244_P0.5330.72
90_V114_S0.5320.72
148_E152_E0.5320.72
184_I188_P0.5310.71
12_F21_L0.5300.71
215_F264_F0.5240.70
62_A66_R0.5230.70
94_A97_E0.5230.70
196_R237_E0.5230.70
154_Y179_L0.5220.70
43_P62_A0.5200.70
177_I206_I0.5170.69
94_A157_S0.5170.69
148_E201_L0.5150.69
151_Y181_Q0.5110.68
221_R260_A0.5110.68
21_L40_E0.5090.68
76_K102_L0.5090.68
77_E105_D0.5080.68
60_A63_S0.5070.68
14_P60_A0.5060.68
44_L248_G0.5060.68
113_D178_T0.5060.68
4_R248_G0.5050.68
74_L77_E0.5050.68
259_Y262_E0.5050.68
173_R213_L0.5040.67
10_T16_G0.5020.67
61_Q65_E0.5010.67
43_P59_M0.5010.67
182_K248_G0.5000.67
187_F260_A0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dcpA 1 0.9888 100 0.351 Contact Map
4gc3A 1 0.8955 100 0.377 Contact Map
2yxoA 3 0.903 100 0.416 Contact Map
3b0xA 1 0.7836 100 0.497 Contact Map
2w9mA 1 0.7724 100 0.504 Contact Map
1m65A 3 0.7313 100 0.516 Contact Map
2wjeA 1 0.7873 100 0.534 Contact Map
3qy7A 1 0.7761 100 0.551 Contact Map
2anuA 5 0.7201 100 0.607 Contact Map
2yb1A 1 0.8134 100 0.608 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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