HIS9 - BACSU - GREMLIN Contacts

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HIS9 - Histidinol-phosphatase

UniProt:	O34411	Sequences: MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPLPPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITLFLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYSSIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTSGLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	268 (223)
Sequences:	2759 (2091)
Seq/√Len:	140.0

ECOLI - YCDX
BACSU - HIS9 POLX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
22_R	77_E	4.196	1.00
27_E	31_K	3.937	1.00
200_S	237_E	3.791	1.00
204_N	241_K	3.475	1.00
27_E	30_K	3.205	1.00
115_I	175_G	2.974	1.00
37_T	113_D	2.851	1.00
117_S	175_G	2.711	1.00
36_I	84_I	2.515	1.00
71_I	86_T	2.456	1.00
8_I	36_I	2.417	1.00
25_A	82_L	2.386	1.00
35_S	85_R	2.309	1.00
22_R	26_E	2.281	1.00
163_V	205_A	2.253	1.00
72_S	75_K	2.140	1.00
156_R	198_L	2.090	1.00
237_E	240_Q	1.983	1.00
39_T	113_D	1.943	1.00
70_E	73_G	1.937	1.00
35_S	83_S	1.927	1.00
159_Y	201_L	1.906	1.00
256_D	259_Y	1.906	1.00
6_G	35_S	1.882	1.00
159_Y	202_C	1.869	1.00
122_R	153_Q	1.824	1.00
29_L	82_L	1.809	1.00
68_I	86_T	1.779	1.00
21_L	74_L	1.777	1.00
12_F	70_E	1.772	1.00
253_Q	256_D	1.765	1.00
29_L	81_Q	1.730	1.00
203_L	234_M	1.708	1.00
238_A	243_I	1.703	1.00
72_S	86_T	1.682	1.00
146_S	149_A	1.653	1.00
113_D	173_R	1.645	1.00
203_L	241_K	1.617	1.00
6_G	37_T	1.616	1.00
159_Y	205_A	1.611	1.00
232_D	236_N	1.608	1.00
19_D	23_Q	1.592	1.00
213_L	238_A	1.584	1.00
21_L	38_F	1.562	1.00
205_A	208_E	1.531	1.00
251_A	256_D	1.524	1.00
29_L	78_Y	1.513	1.00
20_T	23_Q	1.503	1.00
19_D	254_A	1.494	1.00
5_D	249_S	1.470	1.00
76_K	79_R	1.469	1.00
3_K	34_E	1.456	1.00
260_A	263_A	1.442	1.00
199_V	234_M	1.434	1.00
33_F	258_G	1.418	1.00
94_A	160_S	1.408	1.00
162_I	206_I	1.406	1.00
64_L	88_L	1.401	1.00
205_A	209_N	1.400	1.00
203_L	237_E	1.377	1.00
203_L	238_A	1.376	1.00
200_S	240_Q	1.355	1.00
210_G	244_P	1.354	1.00
163_V	208_E	1.333	1.00
10_T	38_F	1.329	1.00
237_E	241_K	1.328	1.00
8_I	24_Y	1.297	1.00
101_T	105_D	1.280	1.00
152_E	198_L	1.275	1.00
23_Q	26_E	1.270	1.00
26_E	29_L	1.267	1.00
173_R	212_E	1.257	1.00
104_L	114_S	1.247	1.00
207_E	238_A	1.246	1.00
217_T	264_F	1.235	1.00
207_E	241_K	1.226	1.00
207_E	243_I	1.225	1.00
221_R	256_D	1.213	1.00
65_E	106_T	1.203	1.00
88_L	114_S	1.200	1.00
22_R	78_Y	1.190	1.00
11_P	20_T	1.189	1.00
26_E	30_K	1.181	1.00
177_I	234_M	1.165	0.99
200_S	241_K	1.162	0.99
149_A	152_E	1.159	0.99
4_R	35_S	1.156	0.99
163_V	209_N	1.155	0.99
22_R	74_L	1.151	0.99
148_E	194_H	1.151	0.99
160_S	163_V	1.141	0.99
16_G	19_D	1.124	0.99
153_Q	157_S	1.117	0.99
78_Y	81_Q	1.116	0.99
101_T	168_V	1.109	0.99
6_G	85_R	1.108	0.99
98_D	102_L	1.107	0.99
167_G	211_M	1.106	0.99
73_G	77_E	1.100	0.99
63_S	66_R	1.098	0.99
88_L	111_L	1.090	0.99
151_Y	184_I	1.083	0.99
167_G	209_N	1.077	0.99
159_Y	163_V	1.077	0.99
102_L	105_D	1.060	0.99
25_A	29_L	1.056	0.99
158_I	202_C	1.055	0.99
66_R	69_H	1.030	0.99
203_L	243_I	1.020	0.99
92_Y	116_L	1.016	0.99
235_L	245_L	1.015	0.99
151_Y	180_V	1.015	0.99
78_Y	82_L	1.011	0.99
218_S	229_Y	1.011	0.99
162_I	205_A	1.011	0.99
118_V	158_I	1.008	0.99
71_I	84_I	1.008	0.99
181_Q	227_G	1.006	0.98
206_I	213_L	1.002	0.98
19_D	24_Y	1.001	0.98
25_A	74_L	0.998	0.98
153_Q	156_R	0.993	0.98
31_K	257_V	0.990	0.98
15_H	43_P	0.988	0.98
219_G	229_Y	0.984	0.98
221_R	259_Y	0.977	0.98
215_F	235_L	0.976	0.98
173_R	248_G	0.974	0.98
152_E	156_R	0.969	0.98
25_A	78_Y	0.969	0.98
26_E	78_Y	0.959	0.98
162_I	209_N	0.946	0.98
43_P	91_D	0.941	0.98
10_T	24_Y	0.939	0.98
21_L	70_E	0.934	0.98
151_Y	155_Y	0.934	0.98
69_H	73_G	0.924	0.97
66_R	70_E	0.923	0.97
158_I	177_I	0.922	0.97
198_L	201_L	0.922	0.97
74_L	78_Y	0.912	0.97
33_F	36_I	0.907	0.97
116_L	169_Y	0.907	0.97
102_L	106_T	0.905	0.97
26_E	81_Q	0.901	0.97
116_L	161_S	0.895	0.97
85_R	112_D	0.890	0.97
207_E	242_K	0.880	0.96
177_I	213_L	0.873	0.96
65_E	107_Y	0.870	0.96
28_A	36_I	0.863	0.96
68_I	72_S	0.863	0.96
115_I	173_R	0.860	0.96
75_K	86_T	0.859	0.96
24_Y	27_E	0.855	0.96
161_S	174_V	0.849	0.96
169_Y	211_M	0.846	0.96
42_A	90_V	0.843	0.95
99_E	103_F	0.842	0.95
39_T	87_G	0.834	0.95
24_Y	254_A	0.826	0.95
156_R	201_L	0.825	0.95
98_D	105_D	0.817	0.95
70_E	74_L	0.817	0.95
25_A	84_I	0.812	0.94
99_E	105_D	0.808	0.94
162_I	202_C	0.806	0.94
204_N	208_E	0.803	0.94
11_P	70_E	0.802	0.94
13_C	40_E	0.801	0.94
26_E	77_E	0.796	0.94
74_L	84_I	0.796	0.94
173_R	246_V	0.793	0.94
5_D	258_G	0.793	0.94
157_S	160_S	0.790	0.94
218_S	222_K	0.787	0.94
10_T	21_L	0.786	0.93
227_G	231_E	0.776	0.93
218_S	221_R	0.775	0.93
42_A	91_D	0.775	0.93
6_G	39_T	0.774	0.93
219_G	230_I	0.773	0.93
100_I	103_F	0.771	0.93
24_Y	38_F	0.763	0.92
27_E	254_A	0.762	0.92
149_A	153_Q	0.758	0.92
159_Y	198_L	0.758	0.92
206_I	211_M	0.756	0.92
68_I	71_I	0.754	0.92
5_D	8_I	0.750	0.92
156_R	160_S	0.749	0.92
169_Y	206_I	0.748	0.92
13_C	16_G	0.747	0.92
201_L	204_N	0.747	0.92
115_I	248_G	0.746	0.92
100_I	104_L	0.744	0.91
158_I	174_V	0.743	0.91
8_I	39_T	0.743	0.91
37_T	173_R	0.742	0.91
199_V	203_L	0.736	0.91
220_L	228_I	0.735	0.91
118_V	174_V	0.733	0.91
6_G	246_V	0.733	0.91
65_E	69_H	0.729	0.91
25_A	36_I	0.725	0.90
212_E	246_V	0.723	0.90
13_C	43_P	0.722	0.90
29_L	79_R	0.719	0.90
154_Y	158_I	0.713	0.90
201_L	205_A	0.691	0.88
236_N	240_Q	0.688	0.88
118_V	161_S	0.683	0.88
38_F	71_I	0.682	0.88
206_I	243_I	0.676	0.87
177_I	203_L	0.675	0.87
64_L	103_F	0.672	0.87
24_Y	251_A	0.666	0.86
43_P	238_A	0.660	0.86
233_W	236_N	0.658	0.86
16_G	20_T	0.656	0.85
107_Y	111_L	0.656	0.85
113_D	170_K	0.654	0.85
181_Q	231_E	0.646	0.85
78_Y	84_I	0.639	0.84
251_A	257_V	0.639	0.84
175_G	214_D	0.639	0.84
6_G	113_D	0.639	0.84
8_I	38_F	0.637	0.84
200_S	204_N	0.633	0.83
31_K	255_G	0.632	0.83
217_T	249_S	0.631	0.83
98_D	104_L	0.630	0.83
145_G	153_Q	0.629	0.83
10_T	13_C	0.627	0.83
39_T	115_I	0.626	0.83
116_L	166_L	0.624	0.83
166_L	169_Y	0.624	0.83
247_F	264_F	0.623	0.82
6_G	173_R	0.622	0.82
40_E	214_D	0.618	0.82
202_C	205_A	0.617	0.82
227_G	232_D	0.617	0.82
197_G	200_S	0.616	0.82
75_K	82_L	0.614	0.82
199_V	202_C	0.614	0.82
145_G	150_V	0.614	0.82
68_I	111_L	0.613	0.81
118_V	157_S	0.613	0.81
42_A	175_G	0.611	0.81
90_V	100_I	0.610	0.81
221_R	224_Y	0.603	0.80
195_I	198_L	0.603	0.80
11_P	17_S	0.602	0.80
145_G	149_A	0.598	0.80
42_A	103_F	0.597	0.80
174_V	206_I	0.596	0.80
97_E	100_I	0.592	0.79
15_H	91_D	0.590	0.79
178_T	235_L	0.590	0.79
22_R	73_G	0.588	0.79
122_R	157_S	0.588	0.79
148_E	188_P	0.588	0.79
155_Y	195_I	0.588	0.79
92_Y	161_S	0.585	0.78
187_F	190_S	0.584	0.78
91_D	118_V	0.583	0.78
26_E	79_R	0.582	0.78
207_E	210_G	0.581	0.78
22_R	82_L	0.581	0.78
11_P	21_L	0.579	0.78
217_T	221_R	0.577	0.77
156_R	159_Y	0.577	0.77
33_F	257_V	0.575	0.77
98_D	101_T	0.571	0.77
5_D	13_C	0.570	0.77
13_C	24_Y	0.570	0.77
28_A	33_F	0.569	0.76
105_D	168_V	0.567	0.76
235_L	239_K	0.567	0.76
217_T	247_F	0.564	0.76
236_N	239_K	0.562	0.76
99_E	102_L	0.562	0.76
239_K	245_L	0.560	0.75
196_R	200_S	0.560	0.75
152_E	202_C	0.558	0.75
23_Q	251_A	0.554	0.74
100_I	105_D	0.553	0.74
119_H	252_H	0.551	0.74
39_T	173_R	0.551	0.74
174_V	213_L	0.550	0.74
5_D	36_I	0.549	0.74
222_K	229_Y	0.549	0.74
30_K	262_E	0.547	0.74
121_L	150_V	0.544	0.73
38_F	84_I	0.544	0.73
41_H	176_H	0.543	0.73
233_W	237_E	0.543	0.73
204_N	207_E	0.540	0.73
149_A	156_R	0.539	0.72
77_E	208_E	0.536	0.72
14_P	47_S	0.535	0.72
214_D	247_F	0.535	0.72
212_E	244_P	0.533	0.72
90_V	114_S	0.532	0.72
148_E	152_E	0.532	0.72
184_I	188_P	0.531	0.71
12_F	21_L	0.530	0.71
215_F	264_F	0.524	0.70
62_A	66_R	0.523	0.70
94_A	97_E	0.523	0.70
196_R	237_E	0.523	0.70
154_Y	179_L	0.522	0.70
43_P	62_A	0.520	0.70
177_I	206_I	0.517	0.69
94_A	157_S	0.517	0.69
148_E	201_L	0.515	0.69
151_Y	181_Q	0.511	0.68
221_R	260_A	0.511	0.68
21_L	40_E	0.509	0.68
76_K	102_L	0.509	0.68
77_E	105_D	0.508	0.68
60_A	63_S	0.507	0.68
14_P	60_A	0.506	0.68
44_L	248_G	0.506	0.68
113_D	178_T	0.506	0.68
4_R	248_G	0.505	0.68
74_L	77_E	0.505	0.68
259_Y	262_E	0.505	0.68
173_R	213_L	0.504	0.67
10_T	16_G	0.502	0.67
61_Q	65_E	0.501	0.67
43_P	59_M	0.501	0.67
182_K	248_G	0.500	0.67
187_F	260_A	0.500	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3dcpA	1	0.9888	100	0.351	Contact Map
4gc3A	1	0.8955	100	0.377	Contact Map
2yxoA	3	0.903	100	0.416	Contact Map
3b0xA	1	0.7836	100	0.497	Contact Map
2w9mA	1	0.7724	100	0.504	Contact Map
1m65A	3	0.7313	100	0.516	Contact Map
2wjeA	1	0.7873	100	0.534	Contact Map
3qy7A	1	0.7761	100	0.551	Contact Map
2anuA	5	0.7201	100	0.607	Contact Map
2yb1A	1	0.8134	100	0.608	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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