GREMLIN Database
YFLN - Probable metallo-hydrolase YflN
UniProt: O34409 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (212)
Sequences: 10795 (8422)
Seq/√Len: 578.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_T175_S4.6671.00
78_L89_I3.5731.00
162_M179_D3.5711.00
44_S74_K3.5431.00
75_A101_Y3.2071.00
77_I176_L2.9411.00
48_I79_T2.7421.00
104_S150_P2.6481.00
182_R235_E2.5741.00
99_P147_Q2.5191.00
178_R181_G2.4981.00
230_A255_T2.3891.00
154_S160_E2.3461.00
18_E21_K2.3341.00
156_P160_E2.3111.00
34_Y238_L2.1971.00
154_S162_M2.1491.00
173_H187_G2.0981.00
46_V75_A2.0721.00
151_E228_K2.0521.00
75_A99_P2.0411.00
218_D221_T2.0391.00
37_Q45_F2.0381.00
34_Y185_V1.9771.00
163_W174_I1.9751.00
163_W176_L1.9361.00
101_Y147_Q1.9211.00
106_E172_G1.9071.00
103_H174_I1.8801.00
150_P153_G1.8561.00
103_H165_A1.8181.00
48_I185_V1.7991.00
161_W178_R1.7221.00
60_V95_H1.7031.00
102_I106_E1.6821.00
45_F73_L1.6491.00
147_Q153_G1.5551.00
107_M111_T1.5171.00
228_K231_G1.5091.00
79_T176_L1.4791.00
177_F182_R1.4751.00
149_L174_I1.4271.00
62_E65_Q1.4231.00
93_L146_V1.4181.00
42_P159_D1.3951.00
46_V77_I1.3881.00
224_E227_L1.3671.00
69_E72_Q1.3571.00
104_S108_P1.3481.00
183_V238_L1.3451.00
76_I98_V1.3411.00
57_G61_N1.3311.00
177_F184_L1.3311.00
186_A237_L1.3271.00
60_V64_K1.3271.00
44_S75_A1.3041.00
166_T173_H1.2941.00
107_M148_A1.2931.00
156_P159_D1.2771.00
79_T187_G1.2771.00
45_F68_G1.2751.00
182_R233_E1.2721.00
48_I176_L1.2661.00
221_T224_E1.2591.00
251_R255_T1.2321.00
50_A76_I1.2271.00
152_D162_M1.2061.00
160_E180_D1.1991.00
227_L231_G1.1931.00
35_F45_F1.1841.00
162_M177_F1.1771.00
104_S148_A1.1761.00
252_S256_E1.1741.00
166_T225_S1.1671.00
253_D256_E1.1661.00
101_Y149_L1.1641.00
76_I89_I1.1621.00
64_K95_H1.1541.00
164_I177_F1.1491.00
162_M232_L1.1371.00
175_S184_L1.1341.00
236_A246_T1.1311.00
177_F234_P1.1251.00
168_G225_S1.1231.00
61_N64_K1.1231.00
45_F74_K1.1211.00
161_W176_L1.1211.00
36_I48_I1.1171.00
50_A89_I1.1161.00
91_E95_H1.1141.00
151_E165_A1.1101.00
247_G252_S1.1091.00
223_A227_L1.1071.00
24_H37_Q1.1061.00
18_E24_H1.0971.00
230_A251_R1.0821.00
58_V62_E1.0771.00
103_H106_E1.0771.00
220_E224_E1.0591.00
106_E170_T1.0531.00
253_D257_L1.0481.00
227_L230_A1.0441.00
22_G37_Q1.0421.00
93_L100_V1.0241.00
154_S179_D1.0221.00
239_T242_G1.0071.00
46_V157_F1.0021.00
46_V161_W0.9891.00
34_Y240_G0.9891.00
183_V236_A0.9861.00
175_S189_A0.9791.00
61_N65_Q0.9691.00
77_I174_I0.9611.00
23_V178_R0.9481.00
24_H66_R0.9471.00
90_E94_E0.9431.00
254_L257_L0.9421.00
44_S72_Q0.9241.00
23_V36_I0.9231.00
184_L232_L0.9201.00
129_A132_S0.9171.00
80_H188_D0.9171.00
143_S146_V0.9161.00
189_A229_L0.9151.00
179_D182_R0.9081.00
105_R108_P0.9081.00
41_E44_S0.9081.00
35_F47_L0.9071.00
233_E251_R0.9061.00
64_K70_G0.9061.00
56_A88_A0.9001.00
36_I161_W0.8971.00
47_L73_L0.8891.00
164_I175_S0.8891.00
85_H188_D0.8881.00
20_A23_V0.8881.00
18_E22_G0.8841.00
58_V61_N0.8801.00
132_S136_P0.8751.00
32_N242_G0.8671.00
76_I100_V0.8621.00
47_L50_A0.8561.00
70_G96_W0.8521.00
167_P225_S0.8481.00
37_Q68_G0.8431.00
251_R254_L0.8431.00
91_E94_E0.8421.00
102_I107_M0.8401.00
45_F72_Q0.8361.00
219_T223_A0.8251.00
175_S225_S0.8191.00
175_S229_L0.8141.00
49_D80_H0.8131.00
37_Q42_P0.8111.00
48_I77_I0.8061.00
149_L163_W0.8041.00
185_V238_L0.8021.00
20_A181_G0.7971.00
22_G181_G0.7951.00
168_G173_H0.7941.00
64_K69_E0.7931.00
32_N240_G0.7921.00
130_K133_P0.7881.00
186_A239_T0.7871.00
78_L86_I0.7831.00
37_Q71_F0.7801.00
35_F63_A0.7791.00
216_T222_A0.7791.00
250_F254_L0.7751.00
102_I110_V0.7711.00
160_E179_D0.7711.00
234_P237_L0.7661.00
224_E228_K0.7631.00
129_A133_P0.7611.00
178_R185_V0.7591.00
67_F70_G0.7571.00
252_S255_T0.7541.00
133_P136_P0.7541.00
177_F232_L0.7511.00
212_P215_F0.7511.00
19_A238_L0.7501.00
33_V47_L0.7461.00
33_V51_G0.7431.00
164_I228_K0.7381.00
178_R183_V0.7371.00
37_Q66_R0.7351.00
74_K99_P0.7321.00
187_G240_G0.7301.00
84_D241_H0.7281.00
108_P112_G0.7251.00
93_L97_D0.7241.00
33_V59_I0.7211.00
238_L244_P0.7201.00
217_P220_E0.7201.00
82_H85_H0.7191.00
60_V70_G0.7181.00
250_F253_D0.7161.00
108_P111_T0.7151.00
142_I145_H0.7151.00
170_T173_H0.7071.00
62_E66_R0.7051.00
25_G238_L0.7031.00
75_A147_Q0.7021.00
99_P146_V0.7021.00
132_S135_F0.7021.00
248_K252_S0.6961.00
247_G250_F0.6941.00
213_A216_T0.6901.00
237_L245_M0.6851.00
81_G106_E0.6851.00
109_Y171_P0.6801.00
76_I92_I0.6771.00
184_L237_L0.6761.00
115_D118_P0.6711.00
80_H85_H0.6701.00
222_A226_I0.6691.00
56_A91_E0.6661.00
88_A91_E0.6641.00
41_E46_V0.6611.00
23_V185_V0.6551.00
218_D222_A0.6551.00
50_A88_A0.6551.00
149_L153_G0.6541.00
20_A235_E0.6541.00
106_E109_Y0.6541.00
165_A174_I0.6531.00
208_L211_P0.6501.00
86_I110_V0.6471.00
82_H170_T0.6461.00
23_V183_V0.6451.00
166_T189_A0.6421.00
41_E159_D0.6391.00
105_R165_A0.6381.00
89_I100_V0.6361.00
245_M253_D0.6341.00
53_P87_G0.6281.00
186_A190_V0.6271.00
215_F218_D0.6271.00
192_T245_M0.6271.00
184_L234_P0.6221.00
68_G72_Q0.6201.00
19_A23_V0.6171.00
92_I96_W0.6161.00
73_L96_W0.6161.00
225_S228_K0.6161.00
25_G34_Y0.6121.00
63_A68_G0.6121.00
35_F73_L0.6111.00
47_L92_I0.6111.00
114_E117_P0.6101.00
57_G60_V0.6091.00
164_I232_L0.6071.00
43_H158_L0.6061.00
20_A29_Q0.6031.00
189_A225_S0.6031.00
20_A236_A0.6031.00
169_H188_D0.6031.00
173_H240_G0.6021.00
46_V158_L0.6021.00
189_A222_A0.6001.00
43_H74_K0.5981.00
33_V50_A0.5951.00
90_E93_L0.5941.00
49_D188_D0.5941.00
81_G102_I0.5921.00
109_Y114_E0.5911.00
81_G86_I0.5901.00
104_S107_M0.5881.00
81_G172_G0.5871.00
25_G28_V0.5861.00
192_T243_I0.5851.00
45_F69_E0.5851.00
37_Q41_E0.5811.00
227_L255_T0.5791.00
191_I242_G0.5791.00
36_I178_R0.5761.00
248_K251_R0.5741.00
106_E165_A0.5701.00
79_T82_H0.5670.99
63_A66_R0.5650.99
60_V96_W0.5650.99
80_H84_D0.5640.99
49_D85_H0.5630.99
211_P222_A0.5610.99
161_W185_V0.5590.99
67_F72_Q0.5560.99
23_V27_T0.5520.99
47_L63_A0.5500.99
233_E236_A0.5470.99
86_I89_I0.5420.99
109_Y113_K0.5420.99
53_P88_A0.5400.99
101_Y153_G0.5390.99
111_T144_S0.5360.99
153_G163_W0.5330.99
239_T245_M0.5300.99
112_G115_D0.5280.99
105_R171_P0.5270.99
107_M146_V0.5270.99
50_A78_L0.5270.99
20_A24_H0.5250.99
19_A25_G0.5240.99
82_H168_G0.5240.99
220_E223_A0.5230.99
150_P165_A0.5210.99
85_H241_H0.5190.99
106_E110_V0.5170.99
20_A27_T0.5130.99
149_L176_L0.5120.99
45_F63_A0.5100.99
107_M110_V0.5100.99
166_T187_G0.5080.99
212_P217_P0.5080.99
25_G29_Q0.5060.99
57_G91_E0.5050.99
73_L98_V0.5010.99
22_G25_G0.5010.99
18_E66_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zo4A 1 0.8598 100 0.333 Contact Map
2fhxA 2 0.8826 100 0.374 Contact Map
2yheA 3 0.9432 100 0.378 Contact Map
3vpeA 1 0.8902 100 0.379 Contact Map
2cfuA 2 0.9318 100 0.381 Contact Map
2vw8A 2 0.9129 100 0.382 Contact Map
4nurA 2 0.9432 100 0.384 Contact Map
4pdxA 2 0.9242 100 0.387 Contact Map
1k07A 1 0.8712 100 0.395 Contact Map
3q6vA 1 0.8182 100 0.398 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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