GREMLIN Database
TCYJ - L-cystine-binding protein TcyJ
UniProt: O34406 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (244)
Sequences: 23013 (17019)
Seq/√Len: 1089.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_G94_I3.8451.00
146_I189_A3.7021.00
34_T76_E3.6471.00
69_E243_K2.9241.00
116_V242_K2.5051.00
154_A172_Y2.4411.00
173_A183_Q2.3671.00
88_S94_I2.3211.00
36_I76_E2.3171.00
103_K108_E2.2961.00
103_K223_Y2.2471.00
34_T74_T2.2331.00
176_G179_D2.2091.00
154_A158_T2.1481.00
36_I78_K2.1261.00
90_G110_R2.1081.00
249_T252_K2.1061.00
105_K108_E2.0901.00
251_K255_R2.0461.00
50_N56_T2.0431.00
65_A68_K2.0271.00
111_F225_M2.0201.00
144_T171_K2.0061.00
67_D75_F2.0051.00
226_F234_A2.0021.00
242_K246_K1.9961.00
69_E240_A1.9721.00
116_V238_D1.9581.00
234_A238_D1.9411.00
112_L234_A1.9411.00
194_A199_V1.9041.00
136_T139_D1.8881.00
65_A249_T1.8171.00
226_F237_T1.8091.00
180_T192_T1.8051.00
37_V63_M1.7721.00
126_T199_V1.7231.00
144_T169_H1.6981.00
135_H139_D1.6961.00
88_S93_K1.6801.00
98_A224_F1.6681.00
183_Q188_R1.6631.00
65_A244_L1.5961.00
149_A175_Q1.5851.00
50_N54_E1.5831.00
65_A69_E1.5621.00
128_K187_G1.5621.00
114_H238_D1.5311.00
80_M88_S1.5141.00
227_N230_S1.5021.00
235_D239_Q1.4981.00
49_L79_T1.4881.00
128_K131_N1.4831.00
120_Y221_E1.4631.00
61_E256_K1.4551.00
85_L97_I1.4471.00
69_E247_N1.4181.00
129_E209_R1.4081.00
64_K77_F1.4071.00
231_Q235_D1.4031.00
27_K31_Q1.3911.00
70_L73_Y1.3911.00
236_D239_Q1.3861.00
155_D159_K1.3731.00
48_F56_T1.3721.00
86_L111_F1.3641.00
144_T190_D1.3621.00
112_L229_G1.3591.00
66_I240_A1.3451.00
60_I64_K1.3421.00
101_M225_M1.3191.00
37_V96_V1.3111.00
130_D211_K1.2971.00
183_Q189_A1.2941.00
70_L240_A1.2901.00
185_E209_R1.2901.00
175_Q179_D1.2821.00
143_K190_D1.2641.00
196_P200_D1.2521.00
124_Y196_P1.2491.00
156_Y160_Y1.2491.00
59_D118_Y1.2481.00
158_T172_Y1.2471.00
141_H167_P1.2391.00
127_V191_A1.2381.00
123_M153_A1.2321.00
184_I210_Q1.2281.00
182_N186_T1.2271.00
125_I191_A1.2111.00
240_A243_K1.2081.00
146_I173_A1.2041.00
145_V191_A1.1961.00
63_M98_A1.1951.00
92_K227_N1.1881.00
147_V154_A1.1871.00
243_K247_N1.1821.00
41_T79_T1.1781.00
21_C26_N1.1721.00
87_T91_N1.1691.00
97_I101_M1.1591.00
106_E109_K1.1541.00
129_E211_K1.1541.00
27_K30_R1.1531.00
240_A244_L1.1441.00
28_T32_A1.1421.00
87_T90_G1.1421.00
33_Q73_Y1.1381.00
182_N185_E1.1271.00
80_M94_I1.1271.00
236_D240_A1.1221.00
58_Y253_L1.1201.00
245_E250_L1.1101.00
63_M77_F1.0931.00
173_A180_T1.0891.00
18_G21_C1.0701.00
58_Y258_L1.0701.00
64_K68_K1.0651.00
184_I192_T1.0631.00
81_D84_N1.0611.00
124_Y212_T1.0481.00
29_D33_Q1.0451.00
58_Y254_S1.0441.00
148_G151_S1.0381.00
62_V250_L1.0371.00
112_L228_K1.0341.00
116_V245_E1.0331.00
239_Q243_K1.0251.00
63_M75_F1.0221.00
49_L53_G1.0141.00
69_E249_T1.0041.00
184_I189_A1.0041.00
61_E257_W1.0031.00
37_V75_F0.9981.00
232_T236_D0.9941.00
56_T61_E0.9901.00
61_E64_K0.9861.00
62_V244_L0.9831.00
127_V213_V0.9821.00
112_L231_Q0.9811.00
104_N107_R0.9791.00
54_E64_K0.9771.00
149_A172_Y0.9741.00
249_T253_L0.9711.00
103_K117_P0.9711.00
96_V237_T0.9661.00
32_A36_I0.9621.00
155_D158_T0.9571.00
29_D32_A0.9481.00
255_R259_G0.9481.00
179_D182_N0.9451.00
73_Y236_D0.9441.00
146_I180_T0.9431.00
96_V226_F0.9401.00
55_L60_I0.9371.00
185_E206_H0.9361.00
66_I237_T0.9321.00
86_L101_M0.9101.00
201_F205_T0.9101.00
90_G111_F0.9081.00
244_L249_T0.9081.00
114_H237_T0.9031.00
238_D242_K0.8931.00
121_S197_F0.8911.00
105_K109_K0.8861.00
252_K255_R0.8771.00
156_Y159_K0.8761.00
113_Y225_M0.8751.00
44_P48_F0.8691.00
250_L254_S0.8671.00
58_Y250_L0.8651.00
46_I119_N0.8631.00
238_D241_I0.8501.00
171_K183_Q0.8491.00
84_N88_S0.8481.00
231_Q234_A0.8481.00
41_T55_L0.8471.00
17_L20_G0.8421.00
29_D73_Y0.8411.00
96_V224_F0.8411.00
63_M224_F0.8401.00
108_E228_K0.8361.00
178_N182_N0.8261.00
252_K256_K0.8251.00
102_A220_T0.8251.00
49_L55_L0.8221.00
138_K141_H0.8191.00
122_P196_P0.8191.00
82_F85_L0.8151.00
127_V131_N0.8131.00
14_F17_L0.8121.00
30_R33_Q0.8121.00
232_T235_D0.8071.00
70_L236_D0.8031.00
97_I225_M0.8031.00
125_I193_I0.8031.00
35_V96_V0.8011.00
127_V211_K0.8011.00
65_A240_A0.7961.00
39_T77_F0.7951.00
177_S194_A0.7941.00
35_V73_Y0.7931.00
243_K246_K0.7861.00
39_T60_I0.7851.00
13_V16_L0.7841.00
165_G168_I0.7831.00
63_M96_V0.7781.00
64_K75_F0.7771.00
244_L247_N0.7751.00
126_T210_Q0.7741.00
107_R113_Y0.7581.00
39_T99_H0.7471.00
251_K254_S0.7461.00
66_I70_L0.7461.00
244_L250_L0.7461.00
89_L97_I0.7361.00
78_K93_K0.7351.00
34_T73_Y0.7331.00
48_F257_W0.7271.00
181_A210_Q0.7231.00
80_M85_L0.7221.00
200_D204_K0.7191.00
36_I95_D0.7181.00
35_V67_D0.7161.00
69_E244_L0.7141.00
244_L248_G0.7141.00
254_S258_L0.7111.00
124_Y214_G0.7111.00
19_G22_S0.7111.00
89_L94_I0.7081.00
146_I183_Q0.7071.00
224_F237_T0.7071.00
140_L191_A0.7071.00
86_L90_G0.7061.00
84_N87_T0.7061.00
239_Q242_K0.7031.00
50_N53_G0.7021.00
179_D183_Q0.6981.00
171_K189_A0.6981.00
181_A185_E0.6931.00
40_G47_A0.6881.00
126_T181_A0.6861.00
121_S196_P0.6811.00
62_V241_I0.6781.00
38_G85_L0.6781.00
114_H224_F0.6771.00
66_I98_A0.6771.00
147_V172_Y0.6761.00
65_A253_L0.6751.00
114_H226_F0.6711.00
60_I77_F0.6691.00
158_T170_L0.6681.00
37_V77_F0.6681.00
102_A107_R0.6681.00
21_C25_N0.6641.00
124_Y199_V0.6581.00
128_K209_R0.6571.00
230_S233_L0.6551.00
14_F18_G0.6511.00
92_K229_G0.6491.00
112_L230_S0.6481.00
43_F82_F0.6441.00
17_L21_C0.6431.00
113_Y223_Y0.6411.00
201_F204_K0.6391.00
210_Q213_V0.6371.00
89_L227_N0.6361.00
120_Y219_D0.6361.00
144_T189_A0.6361.00
11_L14_F0.6351.00
122_P219_D0.6321.00
11_L15_A0.6321.00
78_K94_I0.6281.00
134_I139_D0.6281.00
157_I170_L0.6271.00
235_D238_D0.6251.00
89_L111_F0.6251.00
122_P218_L0.6231.00
82_F101_M0.6231.00
10_L13_V0.6221.00
242_K245_E0.6191.00
43_F100_N0.6191.00
116_V241_I0.6171.00
40_G82_F0.6141.00
22_S25_N0.6121.00
56_T257_W0.6121.00
10_L14_F0.6111.00
131_N134_I0.6091.00
21_C24_T0.6081.00
20_G23_Q0.6061.00
173_A189_A0.6021.00
133_K211_K0.5981.00
90_G227_N0.5981.00
39_T55_L0.5981.00
152_N220_T0.5971.00
103_K113_Y0.5941.00
67_D70_L0.5941.00
119_N222_V0.5901.00
41_T47_A0.5881.00
200_D212_T0.5841.00
67_D73_Y0.5801.00
23_Q26_N0.5781.00
63_M67_D0.5781.00
45_N48_F0.5751.00
145_V157_I0.5741.00
206_H209_R0.5741.00
101_M111_F0.5731.00
47_A99_H0.5731.00
51_E56_T0.5721.00
67_D71_P0.5721.00
114_H241_I0.5701.00
133_K143_K0.5681.00
9_L12_S0.5671.00
123_M193_I0.5661.00
30_R236_D0.5631.00
28_T31_Q0.5621.00
203_N206_H0.5621.00
16_L21_C0.5601.00
157_I193_I0.5601.00
68_K249_T0.5591.00
43_F46_I0.5551.00
117_P120_Y0.5531.00
126_T203_N0.5521.00
194_A198_A0.5511.00
38_G97_I0.5501.00
93_K188_R0.5481.00
38_G80_M0.5471.00
204_K259_G0.5461.00
36_I92_K0.5451.00
122_P216_V0.5431.00
66_I224_F0.5431.00
59_D100_N0.5421.00
248_G251_K0.5411.00
125_I140_L0.5401.00
40_G99_H0.5391.00
185_E210_Q0.5381.00
82_F107_R0.5381.00
15_A19_G0.5371.00
22_S26_N0.5371.00
160_Y165_G0.5361.00
244_L253_L0.5361.00
149_A154_A0.5351.00
69_E236_D0.5271.00
199_V203_N0.5251.00
148_G177_S0.5241.00
44_P205_T0.5231.00
226_F230_S0.5221.00
108_E112_L0.5211.00
33_Q236_D0.5201.00
85_L88_S0.5201.00
70_L233_L0.5181.00
202_Q205_T0.5171.00
55_L79_T0.5171.00
203_N210_Q0.5171.00
63_M66_I0.5151.00
32_A95_D0.5141.00
121_S222_V0.5131.00
12_S15_A0.5131.00
78_K88_S0.5121.00
180_T183_Q0.5081.00
85_L101_M0.5081.00
102_A152_N0.5081.00
9_L13_V0.5061.00
41_T49_L0.5051.00
35_V233_L0.5051.00
189_A192_T0.5041.00
183_Q186_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ohnA 1 0.8959 100 0.259 Contact Map
1xt8A 1 0.8773 100 0.259 Contact Map
3hv1A 2 0.9294 100 0.271 Contact Map
1pb7A 1 0.9257 100 0.274 Contact Map
2ylnA 1 0.8625 100 0.277 Contact Map
3kbrA 4 0.8401 100 0.278 Contact Map
2yjpA 1 0.8773 100 0.28 Contact Map
2vhaA 2 0.9219 100 0.28 Contact Map
4ymxA 1 0.8104 100 0.284 Contact Map
4powA 1 0.8364 100 0.285 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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