TCYJ - BACSU - GREMLIN Contacts

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TCYJ - L-cystine-binding protein TcyJ

UniProt:	O34406	Sequences: MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFPNIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMAKNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKYNKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLLDTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	269 (244)
Sequences:	23013 (17019)
Seq/√Len:	1089.5

ECOLI - GLTI YHDW FLIY ARGT HISJ GLNH ARTJ ARTI MLTF EVGS
BACSU - TCYJ TCYK YCKB YXEM GLNH TCYA ARTP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
38_G	94_I	3.845	1.00
146_I	189_A	3.702	1.00
34_T	76_E	3.647	1.00
69_E	243_K	2.924	1.00
116_V	242_K	2.505	1.00
154_A	172_Y	2.441	1.00
173_A	183_Q	2.367	1.00
88_S	94_I	2.321	1.00
36_I	76_E	2.317	1.00
103_K	108_E	2.296	1.00
103_K	223_Y	2.247	1.00
34_T	74_T	2.233	1.00
176_G	179_D	2.209	1.00
154_A	158_T	2.148	1.00
36_I	78_K	2.126	1.00
90_G	110_R	2.108	1.00
249_T	252_K	2.106	1.00
105_K	108_E	2.090	1.00
251_K	255_R	2.046	1.00
50_N	56_T	2.043	1.00
65_A	68_K	2.027	1.00
111_F	225_M	2.020	1.00
144_T	171_K	2.006	1.00
67_D	75_F	2.005	1.00
226_F	234_A	2.002	1.00
242_K	246_K	1.996	1.00
69_E	240_A	1.972	1.00
116_V	238_D	1.958	1.00
234_A	238_D	1.941	1.00
112_L	234_A	1.941	1.00
194_A	199_V	1.904	1.00
136_T	139_D	1.888	1.00
65_A	249_T	1.817	1.00
226_F	237_T	1.809	1.00
180_T	192_T	1.805	1.00
37_V	63_M	1.772	1.00
126_T	199_V	1.723	1.00
144_T	169_H	1.698	1.00
135_H	139_D	1.696	1.00
88_S	93_K	1.680	1.00
98_A	224_F	1.668	1.00
183_Q	188_R	1.663	1.00
65_A	244_L	1.596	1.00
149_A	175_Q	1.585	1.00
50_N	54_E	1.583	1.00
65_A	69_E	1.562	1.00
128_K	187_G	1.562	1.00
114_H	238_D	1.531	1.00
80_M	88_S	1.514	1.00
227_N	230_S	1.502	1.00
235_D	239_Q	1.498	1.00
49_L	79_T	1.488	1.00
128_K	131_N	1.483	1.00
120_Y	221_E	1.463	1.00
61_E	256_K	1.455	1.00
85_L	97_I	1.447	1.00
69_E	247_N	1.418	1.00
129_E	209_R	1.408	1.00
64_K	77_F	1.407	1.00
231_Q	235_D	1.403	1.00
27_K	31_Q	1.391	1.00
70_L	73_Y	1.391	1.00
236_D	239_Q	1.386	1.00
155_D	159_K	1.373	1.00
48_F	56_T	1.372	1.00
86_L	111_F	1.364	1.00
144_T	190_D	1.362	1.00
112_L	229_G	1.359	1.00
66_I	240_A	1.345	1.00
60_I	64_K	1.342	1.00
101_M	225_M	1.319	1.00
37_V	96_V	1.311	1.00
130_D	211_K	1.297	1.00
183_Q	189_A	1.294	1.00
70_L	240_A	1.290	1.00
185_E	209_R	1.290	1.00
175_Q	179_D	1.282	1.00
143_K	190_D	1.264	1.00
196_P	200_D	1.252	1.00
124_Y	196_P	1.249	1.00
156_Y	160_Y	1.249	1.00
59_D	118_Y	1.248	1.00
158_T	172_Y	1.247	1.00
141_H	167_P	1.239	1.00
127_V	191_A	1.238	1.00
123_M	153_A	1.232	1.00
184_I	210_Q	1.228	1.00
182_N	186_T	1.227	1.00
125_I	191_A	1.211	1.00
240_A	243_K	1.208	1.00
146_I	173_A	1.204	1.00
145_V	191_A	1.196	1.00
63_M	98_A	1.195	1.00
92_K	227_N	1.188	1.00
147_V	154_A	1.187	1.00
243_K	247_N	1.182	1.00
41_T	79_T	1.178	1.00
21_C	26_N	1.172	1.00
87_T	91_N	1.169	1.00
97_I	101_M	1.159	1.00
106_E	109_K	1.154	1.00
129_E	211_K	1.154	1.00
27_K	30_R	1.153	1.00
240_A	244_L	1.144	1.00
28_T	32_A	1.142	1.00
87_T	90_G	1.142	1.00
33_Q	73_Y	1.138	1.00
182_N	185_E	1.127	1.00
80_M	94_I	1.127	1.00
236_D	240_A	1.122	1.00
58_Y	253_L	1.120	1.00
245_E	250_L	1.110	1.00
63_M	77_F	1.093	1.00
173_A	180_T	1.089	1.00
18_G	21_C	1.070	1.00
58_Y	258_L	1.070	1.00
64_K	68_K	1.065	1.00
184_I	192_T	1.063	1.00
81_D	84_N	1.061	1.00
124_Y	212_T	1.048	1.00
29_D	33_Q	1.045	1.00
58_Y	254_S	1.044	1.00
148_G	151_S	1.038	1.00
62_V	250_L	1.037	1.00
112_L	228_K	1.034	1.00
116_V	245_E	1.033	1.00
239_Q	243_K	1.025	1.00
63_M	75_F	1.022	1.00
49_L	53_G	1.014	1.00
69_E	249_T	1.004	1.00
184_I	189_A	1.004	1.00
61_E	257_W	1.003	1.00
37_V	75_F	0.998	1.00
232_T	236_D	0.994	1.00
56_T	61_E	0.990	1.00
61_E	64_K	0.986	1.00
62_V	244_L	0.983	1.00
127_V	213_V	0.982	1.00
112_L	231_Q	0.981	1.00
104_N	107_R	0.979	1.00
54_E	64_K	0.977	1.00
149_A	172_Y	0.974	1.00
249_T	253_L	0.971	1.00
103_K	117_P	0.971	1.00
96_V	237_T	0.966	1.00
32_A	36_I	0.962	1.00
155_D	158_T	0.957	1.00
29_D	32_A	0.948	1.00
255_R	259_G	0.948	1.00
179_D	182_N	0.945	1.00
73_Y	236_D	0.944	1.00
146_I	180_T	0.943	1.00
96_V	226_F	0.940	1.00
55_L	60_I	0.937	1.00
185_E	206_H	0.936	1.00
66_I	237_T	0.932	1.00
86_L	101_M	0.910	1.00
201_F	205_T	0.910	1.00
90_G	111_F	0.908	1.00
244_L	249_T	0.908	1.00
114_H	237_T	0.903	1.00
238_D	242_K	0.893	1.00
121_S	197_F	0.891	1.00
105_K	109_K	0.886	1.00
252_K	255_R	0.877	1.00
156_Y	159_K	0.876	1.00
113_Y	225_M	0.875	1.00
44_P	48_F	0.869	1.00
250_L	254_S	0.867	1.00
58_Y	250_L	0.865	1.00
46_I	119_N	0.863	1.00
238_D	241_I	0.850	1.00
171_K	183_Q	0.849	1.00
84_N	88_S	0.848	1.00
231_Q	234_A	0.848	1.00
41_T	55_L	0.847	1.00
17_L	20_G	0.842	1.00
29_D	73_Y	0.841	1.00
96_V	224_F	0.841	1.00
63_M	224_F	0.840	1.00
108_E	228_K	0.836	1.00
178_N	182_N	0.826	1.00
252_K	256_K	0.825	1.00
102_A	220_T	0.825	1.00
49_L	55_L	0.822	1.00
138_K	141_H	0.819	1.00
122_P	196_P	0.819	1.00
82_F	85_L	0.815	1.00
127_V	131_N	0.813	1.00
14_F	17_L	0.812	1.00
30_R	33_Q	0.812	1.00
232_T	235_D	0.807	1.00
70_L	236_D	0.803	1.00
97_I	225_M	0.803	1.00
125_I	193_I	0.803	1.00
35_V	96_V	0.801	1.00
127_V	211_K	0.801	1.00
65_A	240_A	0.796	1.00
39_T	77_F	0.795	1.00
177_S	194_A	0.794	1.00
35_V	73_Y	0.793	1.00
243_K	246_K	0.786	1.00
39_T	60_I	0.785	1.00
13_V	16_L	0.784	1.00
165_G	168_I	0.783	1.00
63_M	96_V	0.778	1.00
64_K	75_F	0.777	1.00
244_L	247_N	0.775	1.00
126_T	210_Q	0.774	1.00
107_R	113_Y	0.758	1.00
39_T	99_H	0.747	1.00
251_K	254_S	0.746	1.00
66_I	70_L	0.746	1.00
244_L	250_L	0.746	1.00
89_L	97_I	0.736	1.00
78_K	93_K	0.735	1.00
34_T	73_Y	0.733	1.00
48_F	257_W	0.727	1.00
181_A	210_Q	0.723	1.00
80_M	85_L	0.722	1.00
200_D	204_K	0.719	1.00
36_I	95_D	0.718	1.00
35_V	67_D	0.716	1.00
69_E	244_L	0.714	1.00
244_L	248_G	0.714	1.00
254_S	258_L	0.711	1.00
124_Y	214_G	0.711	1.00
19_G	22_S	0.711	1.00
89_L	94_I	0.708	1.00
146_I	183_Q	0.707	1.00
224_F	237_T	0.707	1.00
140_L	191_A	0.707	1.00
86_L	90_G	0.706	1.00
84_N	87_T	0.706	1.00
239_Q	242_K	0.703	1.00
50_N	53_G	0.702	1.00
179_D	183_Q	0.698	1.00
171_K	189_A	0.698	1.00
181_A	185_E	0.693	1.00
40_G	47_A	0.688	1.00
126_T	181_A	0.686	1.00
121_S	196_P	0.681	1.00
62_V	241_I	0.678	1.00
38_G	85_L	0.678	1.00
114_H	224_F	0.677	1.00
66_I	98_A	0.677	1.00
147_V	172_Y	0.676	1.00
65_A	253_L	0.675	1.00
114_H	226_F	0.671	1.00
60_I	77_F	0.669	1.00
158_T	170_L	0.668	1.00
37_V	77_F	0.668	1.00
102_A	107_R	0.668	1.00
21_C	25_N	0.664	1.00
124_Y	199_V	0.658	1.00
128_K	209_R	0.657	1.00
230_S	233_L	0.655	1.00
14_F	18_G	0.651	1.00
92_K	229_G	0.649	1.00
112_L	230_S	0.648	1.00
43_F	82_F	0.644	1.00
17_L	21_C	0.643	1.00
113_Y	223_Y	0.641	1.00
201_F	204_K	0.639	1.00
210_Q	213_V	0.637	1.00
89_L	227_N	0.636	1.00
120_Y	219_D	0.636	1.00
144_T	189_A	0.636	1.00
11_L	14_F	0.635	1.00
122_P	219_D	0.632	1.00
11_L	15_A	0.632	1.00
78_K	94_I	0.628	1.00
134_I	139_D	0.628	1.00
157_I	170_L	0.627	1.00
235_D	238_D	0.625	1.00
89_L	111_F	0.625	1.00
122_P	218_L	0.623	1.00
82_F	101_M	0.623	1.00
10_L	13_V	0.622	1.00
242_K	245_E	0.619	1.00
43_F	100_N	0.619	1.00
116_V	241_I	0.617	1.00
40_G	82_F	0.614	1.00
22_S	25_N	0.612	1.00
56_T	257_W	0.612	1.00
10_L	14_F	0.611	1.00
131_N	134_I	0.609	1.00
21_C	24_T	0.608	1.00
20_G	23_Q	0.606	1.00
173_A	189_A	0.602	1.00
133_K	211_K	0.598	1.00
90_G	227_N	0.598	1.00
39_T	55_L	0.598	1.00
152_N	220_T	0.597	1.00
103_K	113_Y	0.594	1.00
67_D	70_L	0.594	1.00
119_N	222_V	0.590	1.00
41_T	47_A	0.588	1.00
200_D	212_T	0.584	1.00
67_D	73_Y	0.580	1.00
23_Q	26_N	0.578	1.00
63_M	67_D	0.578	1.00
45_N	48_F	0.575	1.00
145_V	157_I	0.574	1.00
206_H	209_R	0.574	1.00
101_M	111_F	0.573	1.00
47_A	99_H	0.573	1.00
51_E	56_T	0.572	1.00
67_D	71_P	0.572	1.00
114_H	241_I	0.570	1.00
133_K	143_K	0.568	1.00
9_L	12_S	0.567	1.00
123_M	193_I	0.566	1.00
30_R	236_D	0.563	1.00
28_T	31_Q	0.562	1.00
203_N	206_H	0.562	1.00
16_L	21_C	0.560	1.00
157_I	193_I	0.560	1.00
68_K	249_T	0.559	1.00
43_F	46_I	0.555	1.00
117_P	120_Y	0.553	1.00
126_T	203_N	0.552	1.00
194_A	198_A	0.551	1.00
38_G	97_I	0.550	1.00
93_K	188_R	0.548	1.00
38_G	80_M	0.547	1.00
204_K	259_G	0.546	1.00
36_I	92_K	0.545	1.00
122_P	216_V	0.543	1.00
66_I	224_F	0.543	1.00
59_D	100_N	0.542	1.00
248_G	251_K	0.541	1.00
125_I	140_L	0.540	1.00
40_G	99_H	0.539	1.00
185_E	210_Q	0.538	1.00
82_F	107_R	0.538	1.00
15_A	19_G	0.537	1.00
22_S	26_N	0.537	1.00
160_Y	165_G	0.536	1.00
244_L	253_L	0.536	1.00
149_A	154_A	0.535	1.00
69_E	236_D	0.527	1.00
199_V	203_N	0.525	1.00
148_G	177_S	0.524	1.00
44_P	205_T	0.523	1.00
226_F	230_S	0.522	1.00
108_E	112_L	0.521	1.00
33_Q	236_D	0.520	1.00
85_L	88_S	0.520	1.00
70_L	233_L	0.518	1.00
202_Q	205_T	0.517	1.00
55_L	79_T	0.517	1.00
203_N	210_Q	0.517	1.00
63_M	66_I	0.515	1.00
32_A	95_D	0.514	1.00
121_S	222_V	0.513	1.00
12_S	15_A	0.513	1.00
78_K	88_S	0.512	1.00
180_T	183_Q	0.508	1.00
85_L	101_M	0.508	1.00
102_A	152_N	0.508	1.00
9_L	13_V	0.506	1.00
41_T	49_L	0.505	1.00
35_V	233_L	0.505	1.00
189_A	192_T	0.504	1.00
183_Q	186_T	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ohnA	1	0.8959	100	0.259	Contact Map
1xt8A	1	0.8773	100	0.259	Contact Map
3hv1A	2	0.9294	100	0.271	Contact Map
1pb7A	1	0.9257	100	0.274	Contact Map
2ylnA	1	0.8625	100	0.277	Contact Map
3kbrA	4	0.8401	100	0.278	Contact Map
2yjpA	1	0.8773	100	0.28	Contact Map
2vhaA	2	0.9219	100	0.28	Contact Map
4ymxA	1	0.8104	100	0.284	Contact Map
4powA	1	0.8364	100	0.285	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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