FPG - BACSU - GREMLIN Contacts

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FPG - Formamidopyrimidine-DNA glycosylase

UniProt:	O34403	Sequences: MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFARKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTDGTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVKTALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAGGSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	276 (262)
Sequences:	5375 (3667)
Seq/√Len:	226.5

ECOLI - FPG END8
BACSU - FPG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
56_G	65_H	3.729	1.00
190_T	199_T	3.605	1.00
256_I	267_H	2.988	1.00
196_S	199_T	2.896	1.00
172_L	177_V	2.869	1.00
162_A	192_A	2.822	1.00
183_R	213_E	2.754	1.00
159_V	186_V	2.742	1.00
156_N	193_N	2.592	1.00
63_L	70_V	2.551	1.00
15_T	19_K	2.537	1.00
50_E	68_H	2.531	1.00
21_K	102_D	2.300	1.00
240_F	250_K	2.297	1.00
152_L	162_A	2.260	1.00
145_S	204_H	2.217	1.00
184_A	206_E	2.196	1.00
25_S	48_A	2.098	1.00
11_R	62_L	2.061	1.00
244_K	250_K	2.032	1.00
73_S	81_Y	2.022	1.00
27_E	99_T	2.021	1.00
149_K	200_I	1.968	1.00
190_T	194_Q	1.910	1.00
53_Q	67_D	1.904	1.00
182_F	251_N	1.899	1.00
199_T	202_T	1.887	1.00
133_Q	167_K	1.876	1.00
254_T	270_A	1.872	1.00
257_S	270_A	1.865	1.00
15_T	54_S	1.864	1.00
11_R	15_T	1.863	1.00
145_S	201_K	1.836	1.00
259_I	268_F	1.809	1.00
183_R	206_E	1.795	1.00
147_Y	151_R	1.792	1.00
21_K	101_T	1.784	1.00
189_E	259_I	1.778	1.00
157_R	165_D	1.771	1.00
220_S	239_H	1.753	1.00
149_K	197_D	1.751	1.00
73_S	117_M	1.744	1.00
25_S	99_T	1.738	1.00
244_K	247_E	1.701	1.00
162_A	168_T	1.683	1.00
96_V	117_M	1.652	1.00
54_S	65_H	1.646	1.00
145_S	205_A	1.644	1.00
206_E	209_N	1.634	1.00
203_L	207_I	1.634	1.00
241_V	256_I	1.610	1.00
50_E	67_D	1.600	1.00
46_K	69_Y	1.594	1.00
161_T	262_G	1.594	1.00
21_K	104_T	1.591	1.00
24_K	101_T	1.584	1.00
23_I	66_L	1.583	1.00
258_K	265_G	1.578	1.00
187_H	274_T	1.552	1.00
30_W	113_K	1.533	1.00
55_I	64_F	1.525	1.00
158_A	161_T	1.525	1.00
183_R	240_F	1.519	1.00
183_R	210_T	1.518	1.00
172_L	207_I	1.516	1.00
180_A	207_I	1.506	1.00
152_L	200_I	1.467	1.00
254_T	271_K	1.463	1.00
183_R	209_N	1.452	1.00
197_D	201_K	1.450	1.00
147_Y	150_D	1.433	1.00
148_L	204_H	1.430	1.00
208_K	212_Q	1.429	1.00
195_L	199_T	1.428	1.00
8_E	57_R	1.421	1.00
213_E	238_Q	1.415	1.00
94_V	109_R	1.392	1.00
22_T	51_T	1.381	1.00
149_K	153_A	1.376	1.00
58_R	137_E	1.373	1.00
145_S	148_L	1.370	1.00
191_K	194_Q	1.368	1.00
121_K	124_E	1.364	1.00
65_H	70_V	1.354	1.00
172_L	180_A	1.348	1.00
157_R	162_A	1.337	1.00
8_E	12_R	1.325	1.00
152_L	159_V	1.314	1.00
146_A	197_D	1.312	1.00
185_G	251_N	1.310	1.00
69_Y	119_L	1.301	1.00
22_T	101_T	1.295	1.00
178_D	267_H	1.289	1.00
136_P	140_A	1.266	1.00
212_Q	216_D	1.258	1.00
70_V	122_P	1.254	1.00
52_I	66_L	1.248	1.00
187_H	268_F	1.234	1.00
144_T	147_Y	1.233	1.00
19_K	54_S	1.218	1.00
245_K	258_K	1.214	1.00
155_T	162_A	1.201	1.00
29_R	97_I	1.179	1.00
160_K	177_V	1.154	1.00
52_I	64_F	1.154	1.00
269_C	272_C	1.141	1.00
213_E	216_D	1.139	1.00
245_K	267_H	1.137	1.00
8_E	11_R	1.133	1.00
94_V	97_I	1.126	1.00
44_A	48_A	1.105	1.00
59_G	166_Q	1.102	1.00
146_A	150_D	1.101	1.00
18_V	100_M	1.100	1.00
180_A	203_L	1.093	1.00
157_R	161_T	1.091	1.00
249_C	269_C	1.082	1.00
72_V	120_F	1.076	1.00
257_S	268_F	1.076	1.00
205_A	209_N	1.074	1.00
27_E	97_I	1.069	1.00
42_E	46_K	1.067	1.00
249_C	252_C	1.061	1.00
204_H	208_K	1.060	1.00
217_A	238_Q	1.055	1.00
169_V	172_L	1.053	1.00
143_F	169_V	1.049	1.00
154_K	193_N	1.048	1.00
163_L	207_I	1.045	1.00
39_E	42_E	1.034	1.00
52_I	100_M	1.032	1.00
202_T	206_E	1.022	1.00
85_Q	88_E	1.021	1.00
81_Y	108_Y	1.019	1.00
26_V	47_L	1.012	1.00
145_S	149_K	1.010	1.00
184_A	202_T	1.009	1.00
51_T	67_D	1.005	1.00
186_V	203_L	1.001	1.00
43_F	117_M	1.000	1.00
249_C	272_C	0.998	1.00
182_F	240_F	0.988	1.00
53_Q	65_H	0.986	1.00
138_P	143_F	0.976	1.00
134_L	170_V	0.968	1.00
73_S	108_Y	0.968	1.00
155_T	192_A	0.963	1.00
234_M	237_L	0.962	1.00
261_V	266_T	0.961	1.00
61_F	72_V	0.959	1.00
252_C	269_C	0.956	1.00
50_E	69_Y	0.954	1.00
23_I	98_F	0.942	1.00
124_E	127_G	0.939	1.00
158_A	189_E	0.929	1.00
66_L	71_M	0.926	1.00
40_P	43_F	0.922	1.00
97_I	105_Q	0.916	1.00
94_V	107_R	0.913	0.99
219_G	233_G	0.911	0.99
195_L	200_I	0.909	0.99
41_E	44_A	0.902	0.99
95_H	113_K	0.900	0.99
153_A	200_I	0.896	0.99
177_V	266_T	0.892	0.99
201_K	205_A	0.875	0.99
151_R	168_T	0.875	0.99
149_K	201_K	0.871	0.99
13_T	218_G	0.869	0.99
248_P	255_M	0.869	0.99
15_T	55_I	0.868	0.99
47_L	66_L	0.849	0.99
149_K	152_L	0.849	0.99
12_R	15_T	0.848	0.99
198_K	202_T	0.847	0.99
13_T	228_S	0.845	0.99
189_E	261_V	0.843	0.99
11_R	55_I	0.842	0.99
90_D	97_I	0.842	0.99
80_K	111_V	0.842	0.99
40_P	44_A	0.842	0.99
248_P	254_T	0.841	0.99
232_I	237_L	0.830	0.99
120_F	130_P	0.830	0.99
146_A	201_K	0.818	0.99
71_M	98_F	0.811	0.99
69_Y	121_K	0.811	0.99
39_E	43_F	0.810	0.99
108_Y	117_M	0.808	0.99
209_N	213_E	0.804	0.99
28_I	96_V	0.803	0.99
98_F	117_M	0.803	0.99
64_F	71_M	0.802	0.99
155_T	168_T	0.802	0.99
172_L	211_L	0.797	0.99
129_L	132_S	0.797	0.99
89_P	107_R	0.796	0.99
78_E	111_V	0.788	0.99
64_F	73_S	0.788	0.99
108_Y	115_G	0.787	0.98
175_I	220_S	0.787	0.98
182_F	250_K	0.787	0.98
72_V	131_L	0.782	0.98
33_I	113_K	0.781	0.98
158_A	191_K	0.781	0.98
164_L	178_D	0.780	0.98
175_I	242_Y	0.777	0.98
42_E	45_R	0.776	0.98
18_V	64_F	0.774	0.98
236_Q	239_H	0.768	0.98
58_R	63_L	0.766	0.98
78_E	115_G	0.765	0.98
111_V	114_F	0.764	0.98
164_L	264_R	0.756	0.98
100_M	104_T	0.751	0.98
159_V	192_A	0.749	0.98
258_K	267_H	0.745	0.98
161_T	261_V	0.741	0.98
196_S	200_I	0.740	0.98
12_R	216_D	0.739	0.98
180_A	184_A	0.739	0.98
140_A	208_K	0.737	0.98
18_V	52_I	0.736	0.98
148_L	152_L	0.731	0.98
108_Y	112_R	0.727	0.97
9_T	215_I	0.726	0.97
92_K	95_H	0.726	0.97
252_C	272_C	0.724	0.97
93_H	112_R	0.723	0.97
99_T	105_Q	0.720	0.97
25_S	44_A	0.717	0.97
101_T	104_T	0.712	0.97
29_R	95_H	0.712	0.97
221_T	233_G	0.711	0.97
260_V	265_G	0.711	0.97
230_G	233_G	0.711	0.97
21_K	100_M	0.710	0.97
254_T	257_S	0.710	0.97
156_N	191_K	0.707	0.97
65_H	122_P	0.705	0.97
23_I	100_M	0.705	0.97
140_A	143_F	0.704	0.97
151_R	154_K	0.704	0.97
159_V	200_I	0.702	0.97
139_D	208_K	0.702	0.97
112_R	115_G	0.701	0.97
83_L	104_T	0.700	0.97
246_D	255_M	0.699	0.97
4_L	8_E	0.696	0.97
45_R	48_A	0.696	0.97
241_V	244_K	0.691	0.97
139_D	212_Q	0.689	0.97
110_D	115_G	0.681	0.96
198_K	274_T	0.681	0.96
194_Q	199_T	0.681	0.96
178_D	261_V	0.675	0.96
6_E	219_G	0.673	0.96
141_E	208_K	0.673	0.96
110_D	114_F	0.672	0.96
76_R	116_T	0.671	0.96
6_E	175_I	0.669	0.96
8_E	215_I	0.668	0.96
213_E	217_A	0.668	0.96
163_L	172_L	0.666	0.96
47_L	71_M	0.666	0.96
197_D	200_I	0.662	0.96
175_I	180_A	0.662	0.96
19_K	22_T	0.660	0.96
200_I	204_H	0.657	0.95
60_K	79_G	0.656	0.95
144_T	204_H	0.651	0.95
17_L	83_L	0.651	0.95
28_I	98_F	0.649	0.95
213_E	240_F	0.649	0.95
158_A	262_G	0.648	0.95
220_S	236_Q	0.648	0.95
23_I	52_I	0.646	0.95
194_Q	257_S	0.642	0.95
136_P	169_V	0.642	0.95
91_D	109_R	0.640	0.95
14_L	55_I	0.639	0.95
14_L	81_Y	0.637	0.95
159_V	181_L	0.636	0.95
118_H	130_P	0.633	0.94
4_L	211_L	0.627	0.94
56_G	70_V	0.626	0.94
24_K	102_D	0.624	0.94
128_E	131_L	0.623	0.94
145_S	200_I	0.623	0.94
189_E	257_S	0.623	0.94
182_F	185_G	0.619	0.94
151_R	155_T	0.619	0.94
231_E	234_M	0.618	0.94
135_G	170_V	0.618	0.94
165_D	168_T	0.615	0.94
161_T	263_G	0.614	0.94
259_I	265_G	0.614	0.94
64_F	81_Y	0.611	0.93
30_W	33_I	0.610	0.93
84_H	90_D	0.608	0.93
120_F	124_E	0.605	0.93
76_R	112_R	0.603	0.93
43_F	71_M	0.603	0.93
202_T	205_A	0.602	0.93
143_F	204_H	0.600	0.93
71_M	117_M	0.599	0.93
158_A	188_P	0.595	0.92
14_L	64_F	0.594	0.92
50_E	53_Q	0.594	0.92
199_T	274_T	0.591	0.92
187_H	190_T	0.591	0.92
32_N	113_K	0.591	0.92
260_V	263_G	0.591	0.92
136_P	170_V	0.590	0.92
214_A	235_F	0.590	0.92
176_Y	211_L	0.590	0.92
4_L	9_T	0.588	0.92
81_Y	98_F	0.588	0.92
221_T	236_Q	0.587	0.92
221_T	230_G	0.587	0.92
185_G	202_T	0.585	0.92
30_W	76_R	0.583	0.92
243_G	267_H	0.583	0.92
13_T	83_L	0.583	0.92
116_T	130_P	0.579	0.91
198_K	201_K	0.578	0.91
139_D	211_L	0.577	0.91
55_I	65_H	0.576	0.91
230_G	234_M	0.573	0.91
255_M	270_A	0.572	0.91
160_K	178_D	0.571	0.91
217_A	237_L	0.571	0.91
77_M	114_F	0.571	0.91
58_R	131_L	0.570	0.91
46_K	119_L	0.569	0.91
7_V	77_M	0.565	0.90
60_K	74_H	0.564	0.90
245_K	255_M	0.560	0.90
66_L	69_Y	0.557	0.90
176_Y	214_A	0.557	0.90
24_K	99_T	0.556	0.90
80_K	109_R	0.553	0.89
177_V	261_V	0.553	0.89
84_H	91_D	0.552	0.89
150_D	154_K	0.552	0.89
4_L	57_R	0.550	0.89
210_T	214_A	0.550	0.89
26_V	43_F	0.550	0.89
77_M	93_H	0.550	0.89
6_E	115_G	0.549	0.89
189_E	274_T	0.548	0.89
182_F	252_C	0.547	0.89
150_D	197_D	0.546	0.89
219_G	235_F	0.544	0.89
186_V	199_T	0.544	0.89
240_F	251_N	0.541	0.88
136_P	168_T	0.540	0.88
138_P	169_V	0.538	0.88
43_F	46_K	0.533	0.88
50_E	122_P	0.532	0.88
46_K	121_K	0.531	0.87
138_P	211_L	0.528	0.87
84_H	88_E	0.528	0.87
204_H	207_I	0.525	0.87
205_A	271_K	0.525	0.87
251_N	271_K	0.525	0.87
9_T	12_R	0.524	0.87
211_L	215_I	0.523	0.87
123_G	127_G	0.521	0.86
158_A	192_A	0.521	0.86
152_L	192_A	0.521	0.86
195_L	203_L	0.519	0.86
251_N	255_M	0.519	0.86
146_A	149_K	0.518	0.86
19_K	55_I	0.517	0.86
153_A	197_D	0.515	0.86
210_T	240_F	0.514	0.86
228_S	231_E	0.514	0.86
74_H	79_G	0.514	0.86
137_E	170_V	0.513	0.86
232_I	236_Q	0.513	0.86
57_R	137_E	0.511	0.85
5_P	8_E	0.511	0.85
214_A	217_A	0.511	0.85
190_T	196_S	0.510	0.85
52_I	55_I	0.508	0.85
43_F	119_L	0.508	0.85
181_L	192_A	0.506	0.85
26_V	44_A	0.505	0.85
76_R	114_F	0.504	0.85
245_K	257_S	0.504	0.85
251_N	254_T	0.501	0.84
14_L	83_L	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3u6pA	1	0.913	100	0.039	Contact Map
1k82A	1	0.942	100	0.051	Contact Map
4pd2A	1	0.9783	100	0.057	Contact Map
3twlA	1	0.913	100	0.087	Contact Map
1ee8A	2	0.9493	100	0.121	Contact Map
3vk8A	1	0.9384	100	0.122	Contact Map
1k3xA	1	0.8949	100	0.137	Contact Map
4mb7A	2	0.8841	100	0.18	Contact Map
3w0fA	1	0.8949	100	0.231	Contact Map
1tdhA	1	0.8514	100	0.238	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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