GREMLIN Database
FPG - Formamidopyrimidine-DNA glycosylase
UniProt: O34403 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 276 (262)
Sequences: 5375 (3667)
Seq/√Len: 226.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_G65_H3.7291.00
190_T199_T3.6051.00
256_I267_H2.9881.00
196_S199_T2.8961.00
172_L177_V2.8691.00
162_A192_A2.8221.00
183_R213_E2.7541.00
159_V186_V2.7421.00
156_N193_N2.5921.00
63_L70_V2.5511.00
15_T19_K2.5371.00
50_E68_H2.5311.00
21_K102_D2.3001.00
240_F250_K2.2971.00
152_L162_A2.2601.00
145_S204_H2.2171.00
184_A206_E2.1961.00
25_S48_A2.0981.00
11_R62_L2.0611.00
244_K250_K2.0321.00
73_S81_Y2.0221.00
27_E99_T2.0211.00
149_K200_I1.9681.00
190_T194_Q1.9101.00
53_Q67_D1.9041.00
182_F251_N1.8991.00
199_T202_T1.8871.00
133_Q167_K1.8761.00
254_T270_A1.8721.00
257_S270_A1.8651.00
15_T54_S1.8641.00
11_R15_T1.8631.00
145_S201_K1.8361.00
259_I268_F1.8091.00
183_R206_E1.7951.00
147_Y151_R1.7921.00
21_K101_T1.7841.00
189_E259_I1.7781.00
157_R165_D1.7711.00
220_S239_H1.7531.00
149_K197_D1.7511.00
73_S117_M1.7441.00
25_S99_T1.7381.00
244_K247_E1.7011.00
162_A168_T1.6831.00
96_V117_M1.6521.00
54_S65_H1.6461.00
145_S205_A1.6441.00
206_E209_N1.6341.00
203_L207_I1.6341.00
241_V256_I1.6101.00
50_E67_D1.6001.00
46_K69_Y1.5941.00
161_T262_G1.5941.00
21_K104_T1.5911.00
24_K101_T1.5841.00
23_I66_L1.5831.00
258_K265_G1.5781.00
187_H274_T1.5521.00
30_W113_K1.5331.00
55_I64_F1.5251.00
158_A161_T1.5251.00
183_R240_F1.5191.00
183_R210_T1.5181.00
172_L207_I1.5161.00
180_A207_I1.5061.00
152_L200_I1.4671.00
254_T271_K1.4631.00
183_R209_N1.4521.00
197_D201_K1.4501.00
147_Y150_D1.4331.00
148_L204_H1.4301.00
208_K212_Q1.4291.00
195_L199_T1.4281.00
8_E57_R1.4211.00
213_E238_Q1.4151.00
94_V109_R1.3921.00
22_T51_T1.3811.00
149_K153_A1.3761.00
58_R137_E1.3731.00
145_S148_L1.3701.00
191_K194_Q1.3681.00
121_K124_E1.3641.00
65_H70_V1.3541.00
172_L180_A1.3481.00
157_R162_A1.3371.00
8_E12_R1.3251.00
152_L159_V1.3141.00
146_A197_D1.3121.00
185_G251_N1.3101.00
69_Y119_L1.3011.00
22_T101_T1.2951.00
178_D267_H1.2891.00
136_P140_A1.2661.00
212_Q216_D1.2581.00
70_V122_P1.2541.00
52_I66_L1.2481.00
187_H268_F1.2341.00
144_T147_Y1.2331.00
19_K54_S1.2181.00
245_K258_K1.2141.00
155_T162_A1.2011.00
29_R97_I1.1791.00
160_K177_V1.1541.00
52_I64_F1.1541.00
269_C272_C1.1411.00
213_E216_D1.1391.00
245_K267_H1.1371.00
8_E11_R1.1331.00
94_V97_I1.1261.00
44_A48_A1.1051.00
59_G166_Q1.1021.00
146_A150_D1.1011.00
18_V100_M1.1001.00
180_A203_L1.0931.00
157_R161_T1.0911.00
249_C269_C1.0821.00
72_V120_F1.0761.00
257_S268_F1.0761.00
205_A209_N1.0741.00
27_E97_I1.0691.00
42_E46_K1.0671.00
249_C252_C1.0611.00
204_H208_K1.0601.00
217_A238_Q1.0551.00
169_V172_L1.0531.00
143_F169_V1.0491.00
154_K193_N1.0481.00
163_L207_I1.0451.00
39_E42_E1.0341.00
52_I100_M1.0321.00
202_T206_E1.0221.00
85_Q88_E1.0211.00
81_Y108_Y1.0191.00
26_V47_L1.0121.00
145_S149_K1.0101.00
184_A202_T1.0091.00
51_T67_D1.0051.00
186_V203_L1.0011.00
43_F117_M1.0001.00
249_C272_C0.9981.00
182_F240_F0.9881.00
53_Q65_H0.9861.00
138_P143_F0.9761.00
134_L170_V0.9681.00
73_S108_Y0.9681.00
155_T192_A0.9631.00
234_M237_L0.9621.00
261_V266_T0.9611.00
61_F72_V0.9591.00
252_C269_C0.9561.00
50_E69_Y0.9541.00
23_I98_F0.9421.00
124_E127_G0.9391.00
158_A189_E0.9291.00
66_L71_M0.9261.00
40_P43_F0.9221.00
97_I105_Q0.9161.00
94_V107_R0.9130.99
219_G233_G0.9110.99
195_L200_I0.9090.99
41_E44_A0.9020.99
95_H113_K0.9000.99
153_A200_I0.8960.99
177_V266_T0.8920.99
201_K205_A0.8750.99
151_R168_T0.8750.99
149_K201_K0.8710.99
13_T218_G0.8690.99
248_P255_M0.8690.99
15_T55_I0.8680.99
47_L66_L0.8490.99
149_K152_L0.8490.99
12_R15_T0.8480.99
198_K202_T0.8470.99
13_T228_S0.8450.99
189_E261_V0.8430.99
11_R55_I0.8420.99
90_D97_I0.8420.99
80_K111_V0.8420.99
40_P44_A0.8420.99
248_P254_T0.8410.99
232_I237_L0.8300.99
120_F130_P0.8300.99
146_A201_K0.8180.99
71_M98_F0.8110.99
69_Y121_K0.8110.99
39_E43_F0.8100.99
108_Y117_M0.8080.99
209_N213_E0.8040.99
28_I96_V0.8030.99
98_F117_M0.8030.99
64_F71_M0.8020.99
155_T168_T0.8020.99
172_L211_L0.7970.99
129_L132_S0.7970.99
89_P107_R0.7960.99
78_E111_V0.7880.99
64_F73_S0.7880.99
108_Y115_G0.7870.98
175_I220_S0.7870.98
182_F250_K0.7870.98
72_V131_L0.7820.98
33_I113_K0.7810.98
158_A191_K0.7810.98
164_L178_D0.7800.98
175_I242_Y0.7770.98
42_E45_R0.7760.98
18_V64_F0.7740.98
236_Q239_H0.7680.98
58_R63_L0.7660.98
78_E115_G0.7650.98
111_V114_F0.7640.98
164_L264_R0.7560.98
100_M104_T0.7510.98
159_V192_A0.7490.98
258_K267_H0.7450.98
161_T261_V0.7410.98
196_S200_I0.7400.98
12_R216_D0.7390.98
180_A184_A0.7390.98
140_A208_K0.7370.98
18_V52_I0.7360.98
148_L152_L0.7310.98
108_Y112_R0.7270.97
9_T215_I0.7260.97
92_K95_H0.7260.97
252_C272_C0.7240.97
93_H112_R0.7230.97
99_T105_Q0.7200.97
25_S44_A0.7170.97
101_T104_T0.7120.97
29_R95_H0.7120.97
221_T233_G0.7110.97
260_V265_G0.7110.97
230_G233_G0.7110.97
21_K100_M0.7100.97
254_T257_S0.7100.97
156_N191_K0.7070.97
65_H122_P0.7050.97
23_I100_M0.7050.97
140_A143_F0.7040.97
151_R154_K0.7040.97
159_V200_I0.7020.97
139_D208_K0.7020.97
112_R115_G0.7010.97
83_L104_T0.7000.97
246_D255_M0.6990.97
4_L8_E0.6960.97
45_R48_A0.6960.97
241_V244_K0.6910.97
139_D212_Q0.6890.97
110_D115_G0.6810.96
198_K274_T0.6810.96
194_Q199_T0.6810.96
178_D261_V0.6750.96
6_E219_G0.6730.96
141_E208_K0.6730.96
110_D114_F0.6720.96
76_R116_T0.6710.96
6_E175_I0.6690.96
8_E215_I0.6680.96
213_E217_A0.6680.96
163_L172_L0.6660.96
47_L71_M0.6660.96
197_D200_I0.6620.96
175_I180_A0.6620.96
19_K22_T0.6600.96
200_I204_H0.6570.95
60_K79_G0.6560.95
144_T204_H0.6510.95
17_L83_L0.6510.95
28_I98_F0.6490.95
213_E240_F0.6490.95
158_A262_G0.6480.95
220_S236_Q0.6480.95
23_I52_I0.6460.95
194_Q257_S0.6420.95
136_P169_V0.6420.95
91_D109_R0.6400.95
14_L55_I0.6390.95
14_L81_Y0.6370.95
159_V181_L0.6360.95
118_H130_P0.6330.94
4_L211_L0.6270.94
56_G70_V0.6260.94
24_K102_D0.6240.94
128_E131_L0.6230.94
145_S200_I0.6230.94
189_E257_S0.6230.94
182_F185_G0.6190.94
151_R155_T0.6190.94
231_E234_M0.6180.94
135_G170_V0.6180.94
165_D168_T0.6150.94
161_T263_G0.6140.94
259_I265_G0.6140.94
64_F81_Y0.6110.93
30_W33_I0.6100.93
84_H90_D0.6080.93
120_F124_E0.6050.93
76_R112_R0.6030.93
43_F71_M0.6030.93
202_T205_A0.6020.93
143_F204_H0.6000.93
71_M117_M0.5990.93
158_A188_P0.5950.92
14_L64_F0.5940.92
50_E53_Q0.5940.92
199_T274_T0.5910.92
187_H190_T0.5910.92
32_N113_K0.5910.92
260_V263_G0.5910.92
136_P170_V0.5900.92
214_A235_F0.5900.92
176_Y211_L0.5900.92
4_L9_T0.5880.92
81_Y98_F0.5880.92
221_T236_Q0.5870.92
221_T230_G0.5870.92
185_G202_T0.5850.92
30_W76_R0.5830.92
243_G267_H0.5830.92
13_T83_L0.5830.92
116_T130_P0.5790.91
198_K201_K0.5780.91
139_D211_L0.5770.91
55_I65_H0.5760.91
230_G234_M0.5730.91
255_M270_A0.5720.91
160_K178_D0.5710.91
217_A237_L0.5710.91
77_M114_F0.5710.91
58_R131_L0.5700.91
46_K119_L0.5690.91
7_V77_M0.5650.90
60_K74_H0.5640.90
245_K255_M0.5600.90
66_L69_Y0.5570.90
176_Y214_A0.5570.90
24_K99_T0.5560.90
80_K109_R0.5530.89
177_V261_V0.5530.89
84_H91_D0.5520.89
150_D154_K0.5520.89
4_L57_R0.5500.89
210_T214_A0.5500.89
26_V43_F0.5500.89
77_M93_H0.5500.89
6_E115_G0.5490.89
189_E274_T0.5480.89
182_F252_C0.5470.89
150_D197_D0.5460.89
219_G235_F0.5440.89
186_V199_T0.5440.89
240_F251_N0.5410.88
136_P168_T0.5400.88
138_P169_V0.5380.88
43_F46_K0.5330.88
50_E122_P0.5320.88
46_K121_K0.5310.87
138_P211_L0.5280.87
84_H88_E0.5280.87
204_H207_I0.5250.87
205_A271_K0.5250.87
251_N271_K0.5250.87
9_T12_R0.5240.87
211_L215_I0.5230.87
123_G127_G0.5210.86
158_A192_A0.5210.86
152_L192_A0.5210.86
195_L203_L0.5190.86
251_N255_M0.5190.86
146_A149_K0.5180.86
19_K55_I0.5170.86
153_A197_D0.5150.86
210_T240_F0.5140.86
228_S231_E0.5140.86
74_H79_G0.5140.86
137_E170_V0.5130.86
232_I236_Q0.5130.86
57_R137_E0.5110.85
5_P8_E0.5110.85
214_A217_A0.5110.85
190_T196_S0.5100.85
52_I55_I0.5080.85
43_F119_L0.5080.85
181_L192_A0.5060.85
26_V44_A0.5050.85
76_R114_F0.5040.85
245_K257_S0.5040.85
251_N254_T0.5010.84
14_L83_L0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u6pA 1 0.913 100 0.039 Contact Map
1k82A 1 0.942 100 0.051 Contact Map
4pd2A 1 0.9783 100 0.057 Contact Map
3twlA 1 0.913 100 0.087 Contact Map
1ee8A 2 0.9493 100 0.121 Contact Map
3vk8A 1 0.9384 100 0.122 Contact Map
1k3xA 1 0.8949 100 0.137 Contact Map
4mb7A 2 0.8841 100 0.18 Contact Map
3w0fA 1 0.8949 100 0.231 Contact Map
1tdhA 1 0.8514 100 0.238 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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