GREMLIN Database
YFKA - Putative protein YfkA
UniProt: O34400 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (363)
Sequences: 189 (103)
Seq/√Len: 5.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_I178_T6.0860.99
302_D305_I5.6680.99
251_E281_A5.1160.98
207_I218_V5.0530.98
180_V214_Q4.9290.97
305_I327_A4.8760.97
146_E162_F3.9570.91
247_D277_R3.0750.76
96_K128_W3.0480.75
47_E147_D3.0420.75
305_I322_D3.0370.75
304_N315_P2.9250.72
233_L241_A2.6860.65
147_D151_I2.5910.62
243_H277_R2.4970.59
150_E162_F2.4760.58
251_E282_K2.3860.55
144_T151_I2.3270.53
243_H247_D2.2940.52
264_A279_R2.2770.51
33_N80_S2.2700.51
323_S326_S2.1410.47
244_R248_I2.1360.47
177_R181_D2.0530.44
208_T250_D1.9700.41
250_D253_T1.9470.40
66_D70_K1.9420.40
208_T253_T1.9180.39
44_M152_G1.8820.38
36_F68_L1.8670.38
328_Y332_R1.8550.37
151_I199_H1.8490.37
147_D199_H1.8190.36
302_D327_A1.8070.36
147_D218_V1.7920.35
89_M143_G1.7870.35
70_K73_E1.7810.35
236_K266_S1.7490.34
294_S328_Y1.7380.34
336_L354_V1.7020.33
277_R281_A1.6960.33
166_A170_E1.6740.32
142_W147_D1.6720.32
306_I311_G1.6710.32
161_T164_Q1.6630.32
316_L359_S1.6610.32
164_Q224_S1.6520.31
63_L129_I1.6490.31
225_D306_I1.6380.31
47_E195_R1.6310.31
238_M241_A1.6240.30
304_N318_N1.6040.30
69_L104_K1.6030.30
11_T319_I1.5910.30
98_Y263_Y1.5870.29
104_K108_E1.5870.29
252_N319_I1.5830.29
54_T83_I1.5790.29
14_F112_R1.5670.29
241_A302_D1.5630.29
169_F184_V1.5500.28
91_S296_L1.5320.28
193_N221_M1.5060.27
59_D76_P1.4960.27
33_N143_G1.4960.27
81_I111_V1.4820.27
364_T369_R1.4770.26
142_W192_L1.4680.26
98_Y296_L1.4550.26
63_L320_Q1.4520.26
26_Y32_T1.4410.26
233_L302_D1.4410.26
33_N53_Y1.4390.25
315_P321_T1.4370.25
332_R337_A1.4240.25
241_A305_I1.4140.25
218_V354_V1.4120.25
337_A341_S1.4120.25
136_L169_F1.4110.25
206_Q224_S1.3910.24
264_A332_R1.3890.24
161_T173_I1.3880.24
142_W151_I1.3800.24
225_D311_G1.3790.24
146_E149_A1.3750.24
53_Y160_P1.3740.24
136_L184_V1.3740.24
208_T238_M1.3690.24
241_A266_S1.3680.24
244_R281_A1.3630.24
282_K363_D1.3610.24
24_D348_R1.3440.23
67_L320_Q1.3420.23
181_D212_K1.3390.23
10_I53_Y1.3320.23
296_L322_D1.3060.22
181_D330_K1.2950.22
168_Y185_M1.2920.22
173_I206_Q1.2900.22
21_M146_E1.2860.22
19_A169_F1.2860.22
124_E273_K1.2820.22
100_V130_I1.2810.22
221_M255_M1.2760.22
11_T90_L1.2710.21
69_L81_I1.2610.21
334_T354_V1.2580.21
147_D341_S1.2570.21
337_A357_K1.2560.21
58_K96_K1.2490.21
142_W212_K1.2440.21
147_D207_I1.2410.21
33_N194_K1.2330.21
58_K285_T1.2290.20
210_D304_N1.2260.20
269_E279_R1.2230.20
30_Q102_L1.2180.20
36_F111_V1.2160.20
339_E357_K1.2090.20
33_N81_I1.2060.20
296_L313_T1.2010.20
205_R248_I1.1990.20
11_T338_K1.1970.20
236_K319_I1.1870.20
19_A340_L1.1850.20
237_E282_K1.1780.19
36_F324_L1.1760.19
207_I214_Q1.1670.19
69_L124_E1.1670.19
149_A162_F1.1660.19
233_L238_M1.1610.19
243_H271_D1.1440.19
11_T180_V1.1400.19
23_V29_M1.1370.19
66_D129_I1.1350.19
94_S99_V1.1290.18
212_K322_D1.1280.18
13_E304_N1.1230.18
178_T238_M1.1180.18
169_F206_Q1.1180.18
115_I326_S1.1170.18
322_D330_K1.1160.18
11_T275_L1.1100.18
210_D314_P1.1080.18
248_I282_K1.1030.18
329_E363_D1.0990.18
365_D368_K1.0890.18
30_Q364_T1.0890.18
270_D338_K1.0820.17
9_P167_R1.0800.17
145_V367_T1.0780.17
10_I272_Q1.0770.17
192_L233_L1.0710.17
61_N68_L1.0700.17
115_I212_K1.0690.17
22_D350_L1.0670.17
57_P111_V1.0590.17
358_N362_Q1.0530.17
164_Q206_Q1.0510.17
26_Y70_K1.0510.17
104_K341_S1.0510.17
200_I235_L1.0490.17
9_P304_N1.0470.17
53_Y56_Q1.0410.17
68_L155_M1.0360.17
14_F170_E1.0310.16
322_D327_A1.0300.16
363_D368_K1.0260.16
233_L335_K1.0260.16
207_I354_V1.0250.16
234_S237_E1.0180.16
68_L319_I1.0180.16
193_N255_M1.0140.16
202_H273_K1.0140.16
151_I207_I1.0130.16
36_F81_I1.0080.16
123_I243_H1.0060.16
127_E182_A1.0050.16
9_P270_D1.0020.16
9_P321_T1.0000.16
205_R367_T0.9970.16
30_Q77_R0.9960.16
302_D322_D0.9930.16
178_T316_L0.9900.16
151_I281_A0.9880.16
337_A340_L0.9740.15
97_E102_L0.9740.15
53_Y143_G0.9710.15
90_L354_V0.9690.15
332_R341_S0.9680.15
14_F21_M0.9680.15
47_E151_I0.9660.15
169_F327_A0.9650.15
8_R14_F0.9600.15
97_E282_K0.9600.15
158_R210_D0.9590.15
97_E151_I0.9590.15
97_E238_M0.9580.15
166_A319_I0.9540.15
58_K164_Q0.9510.15
180_V278_L0.9500.15
18_E350_L0.9490.15
83_I296_L0.9480.15
327_A359_S0.9410.15
143_G156_M0.9410.15
62_A98_Y0.9400.15
111_V180_V0.9370.15
9_P315_P0.9360.15
117_S133_L0.9360.15
170_E205_R0.9340.15
95_V278_L0.9270.15
224_S313_T0.9270.15
233_L305_I0.9250.15
228_S343_H0.9250.15
94_S136_L0.9250.15
96_K181_D0.9230.15
65_I144_T0.9170.14
159_K164_Q0.9160.14
171_K314_P0.9160.14
38_T334_T0.9160.14
95_V133_L0.9130.14
319_I338_K0.9120.14
151_I155_M0.9120.14
14_F68_L0.9110.14
263_Y312_D0.9090.14
12_P245_L0.9050.14
13_E329_E0.9050.14
97_E323_S0.9040.14
296_L345_P0.9030.14
14_F270_D0.9000.14
221_M230_L0.9000.14
207_I358_N0.8990.14
200_I266_S0.8970.14
252_N363_D0.8950.14
262_F274_L0.8930.14
63_L76_P0.8910.14
140_H152_G0.8910.14
178_T359_S0.8870.14
93_K119_L0.8820.14
200_I244_R0.8810.14
156_M201_E0.8800.14
182_A233_L0.8780.14
13_E323_S0.8750.14
122_D205_R0.8730.14
20_Y90_L0.8720.14
93_K180_V0.8690.14
262_F317_G0.8670.14
330_K359_S0.8620.14
80_S111_V0.8570.14
91_S311_G0.8540.13
113_T347_V0.8540.13
143_G200_I0.8490.13
11_T316_L0.8470.13
44_M133_L0.8430.13
359_S369_R0.8400.13
33_N334_T0.8360.13
54_T296_L0.8340.13
354_V358_N0.8330.13
44_M221_M0.8320.13
159_K340_L0.8300.13
130_I182_A0.8280.13
240_Q269_E0.8260.13
359_S371_A0.8260.13
96_K100_V0.8260.13
80_S122_D0.8230.13
21_M79_R0.8190.13
20_Y38_T0.8190.13
70_K364_T0.8180.13
180_V371_A0.8140.13
12_P195_R0.8130.13
200_I337_A0.8120.13
145_V166_A0.8120.13
205_R244_R0.8110.13
10_I157_D0.8110.13
167_R305_I0.8090.13
159_K294_S0.8080.13
144_T233_L0.8080.13
158_R167_R0.8070.13
155_M370_Q0.8040.13
92_L253_T0.8020.13
76_P192_L0.8010.13
18_E59_D0.8000.13
32_T127_E0.8000.13
159_K328_Y0.7950.13
39_T62_A0.7930.13
313_T322_D0.7920.13
170_E236_K0.7910.13
76_P218_V0.7900.12
77_R363_D0.7890.12
95_V286_V0.7870.12
323_S327_A0.7870.12
359_S362_Q0.7840.12
123_I316_L0.7790.12
235_L271_D0.7770.12
9_P28_D0.7750.12
266_S323_S0.7750.12
218_V279_R0.7750.12
315_P371_A0.7720.12
44_M255_M0.7720.12
21_M240_Q0.7720.12
71_R345_P0.7710.12
176_S238_M0.7700.12
60_P83_I0.7670.12
81_I90_L0.7670.12
53_Y156_M0.7660.12
207_I264_A0.7600.12
28_D332_R0.7570.12
26_Y112_R0.7560.12
296_L311_G0.7540.12
272_Q333_E0.7540.12
59_D190_T0.7520.12
235_L243_H0.7490.12
59_D63_L0.7480.12
133_L314_P0.7460.12
25_Q177_R0.7450.12
326_S330_K0.7430.12
90_L300_I0.7410.12
305_I324_L0.7400.12
240_Q319_I0.7390.12
9_P124_E0.7390.12
149_A185_M0.7380.12
40_T53_Y0.7370.12
180_V186_V0.7360.12
97_E244_R0.7350.12
71_R266_S0.7310.12
334_T357_K0.7280.12
10_I229_A0.7270.12
149_A202_H0.7250.12
250_D267_P0.7230.12
160_P350_L0.7220.12
314_P318_N0.7190.11
39_T113_T0.7180.11
25_Q273_K0.7180.11
26_Y122_D0.7160.11
54_T91_S0.7160.11
253_T280_A0.7150.11
38_T165_R0.7150.11
140_H165_R0.7140.11
16_P223_P0.7120.11
100_V158_R0.7120.11
80_S90_L0.7100.11
34_V202_H0.7100.11
305_I323_S0.7080.11
14_F327_A0.7080.11
128_W368_K0.7080.11
223_P296_L0.7070.11
90_L316_L0.7070.11
39_T235_L0.7060.11
60_P124_E0.7030.11
171_K223_P0.7030.11
212_K336_L0.7030.11
156_M160_P0.7020.11
100_V250_D0.7020.11
240_Q336_L0.6970.11
12_P171_K0.6960.11
54_T332_R0.6950.11
44_M153_F0.6940.11
66_D237_E0.6910.11
24_D340_L0.6900.11
22_D79_R0.6880.11
38_T140_H0.6830.11
199_H233_L0.6810.11
158_R178_T0.6810.11
77_R90_L0.6810.11
54_T275_L0.6800.11
128_W150_E0.6790.11
341_S367_T0.6790.11
34_V218_V0.6780.11
161_T268_D0.6770.11
44_M193_N0.6750.11
128_W186_V0.6730.11
157_D368_K0.6710.11
173_I275_L0.6700.11
269_E273_K0.6690.11
166_A358_N0.6690.11
18_E22_D0.6690.11
275_L282_K0.6680.11
11_T146_E0.6650.11
97_E234_S0.6650.11
197_L359_S0.6650.11
100_V214_Q0.6640.11
20_Y350_L0.6640.11
236_K320_Q0.6630.11
212_K248_I0.6620.11
270_D273_K0.6600.11
180_V207_I0.6600.11
238_M250_D0.6600.11
223_P338_K0.6590.11
90_L136_L0.6580.11
191_M221_M0.6560.11
21_M130_I0.6540.11
304_N321_T0.6530.11
200_I313_T0.6500.11
149_A160_P0.6480.11
362_Q367_T0.6480.11
80_S155_M0.6430.10
131_P317_G0.6430.10
76_P253_T0.6410.10
77_R100_V0.6400.10
58_K182_A0.6390.10
38_T198_P0.6360.10
38_T99_V0.6360.10
21_M305_I0.6350.10
181_D252_N0.6350.10
59_D206_Q0.6350.10
11_T62_A0.6340.10
38_T160_P0.6340.10
186_V345_P0.6330.10
144_T192_L0.6330.10
11_T326_S0.6330.10
197_L206_Q0.6330.10
212_K369_R0.6320.10
199_H253_T0.6320.10
181_D358_N0.6300.10
201_E357_K0.6260.10
10_I25_Q0.6260.10
40_T306_I0.6250.10
193_N230_L0.6240.10
201_E358_N0.6230.10
30_Q264_A0.6230.10
163_E166_A0.6220.10
281_A371_A0.6210.10
170_E329_E0.6210.10
151_I218_V0.6200.10
113_T300_I0.6160.10
177_R332_R0.6150.10
155_M354_V0.6150.10
36_F300_I0.6140.10
77_R276_R0.6120.10
305_I335_K0.6090.10
56_Q75_I0.6080.10
154_A346_N0.6050.10
152_G221_M0.6030.10
95_V98_Y0.6020.10
57_P77_R0.6020.10
142_W218_V0.6010.10
47_E218_V0.6000.10
33_N156_M0.6000.10
272_Q279_R0.6000.10
127_E298_V0.5990.10
53_Y80_S0.5970.10
40_T158_R0.5950.10
178_T182_A0.5950.10
26_Y57_P0.5940.10
10_I208_T0.5910.10
197_L371_A0.5910.10
81_I200_I0.5890.10
92_L96_K0.5880.10
180_V367_T0.5870.10
129_I345_P0.5850.10
325_P347_V0.5850.10
191_M230_L0.5830.10
112_R207_I0.5810.10
25_Q248_I0.5800.10
158_R270_D0.5800.10
75_I364_T0.5800.10
9_P240_Q0.5790.10
121_L168_Y0.5790.10
162_F302_D0.5790.10
79_R154_A0.5780.10
124_E250_D0.5780.10
136_L359_S0.5770.10
13_E58_K0.5770.10
130_I322_D0.5760.10
142_W300_I0.5760.10
44_M140_H0.5740.10
14_F321_T0.5720.10
172_M278_L0.5720.10
122_D224_S0.5720.10
165_R190_T0.5720.10
38_T294_S0.5720.10
20_Y225_D0.5710.10
214_Q267_P0.5710.10
147_D214_Q0.5690.10
124_E371_A0.5670.10
76_P177_R0.5660.10
133_L317_G0.5660.10
89_M192_L0.5650.10
241_A339_E0.5630.10
16_P33_N0.5620.10
107_H184_V0.5620.10
63_L145_V0.5590.09
83_I100_V0.5580.09
269_E315_P0.5570.09
9_P13_E0.5570.09
98_Y244_R0.5550.09
104_K272_Q0.5500.09
8_R329_E0.5500.09
173_I208_T0.5490.09
9_P171_K0.5480.09
244_R333_E0.5450.09
192_L250_D0.5450.09
119_L186_V0.5440.09
38_T350_L0.5430.09
111_V324_L0.5420.09
177_R305_I0.5410.09
161_T359_S0.5410.09
32_T207_I0.5400.09
22_D38_T0.5380.09
270_D335_K0.5360.09
127_E130_I0.5360.09
214_Q333_E0.5350.09
113_T316_L0.5330.09
248_I271_D0.5320.09
47_E95_V0.5310.09
21_M154_A0.5310.09
186_V284_V0.5300.09
146_E240_Q0.5290.09
131_P195_R0.5280.09
39_T271_D0.5260.09
302_D347_V0.5260.09
133_L153_F0.5250.09
60_P143_G0.5250.09
9_P323_S0.5250.09
8_R321_T0.5250.09
41_L91_S0.5240.09
18_E294_S0.5230.09
159_K300_I0.5220.09
142_W231_E0.5210.09
44_M172_M0.5200.09
305_I341_S0.5190.09
106_A191_M0.5190.09
28_D370_Q0.5180.09
322_D326_S0.5180.09
145_V282_K0.5160.09
36_F237_E0.5150.09
172_M255_M0.5150.09
12_P314_P0.5140.09
161_T300_I0.5130.09
12_P32_T0.5130.09
145_V202_H0.5120.09
264_A273_K0.5110.09
155_M199_H0.5100.09
73_E328_Y0.5080.09
96_K313_T0.5070.09
108_E236_K0.5070.09
186_V316_L0.5060.09
40_T111_V0.5060.09
146_E185_M0.5020.09
151_I180_V0.5010.09
149_A168_Y0.5010.09
264_A354_V0.5000.09
208_T252_N0.5000.09
66_D77_R0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.8579 99.9 0.884 Contact Map
3c8fA 1 0.5979 99.9 0.886 Contact Map
4m7tA 1 0.6059 99.8 0.894 Contact Map
1tv8A 2 0.807 99.8 0.896 Contact Map
2z2uA 1 0.6193 99.8 0.906 Contact Map
3rfaA 1 0.6917 99.7 0.91 Contact Map
2yx0A 1 0.689 99.7 0.913 Contact Map
2a5hA 4 0.7721 99.6 0.915 Contact Map
3canA 2 0.4129 99.6 0.918 Contact Map
2qgqA 1 0.6702 99.6 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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