GREMLIN Database
GLTB - Glutamate synthase [NADPH] small chain
UniProt: O34399 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 493 (439)
Sequences: 5440 (3197)
Seq/√Len: 152.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
371_K384_H5.1361.00
260_S374_A4.7041.00
84_R87_E4.0501.00
179_T220_V3.8441.00
151_T176_H3.6921.00
210_K213_T3.2601.00
256_E371_K3.1361.00
456_F485_Y3.0931.00
294_D318_S3.0131.00
327_K351_Y3.0061.00
382_E409_V2.8841.00
187_A221_T2.8781.00
373_V384_H2.8541.00
296_I412_A2.7941.00
435_N443_A2.7881.00
294_D413_Q2.7811.00
242_I458_A2.7531.00
242_I482_V2.7521.00
384_H409_V2.7511.00
181_F238_F2.7511.00
177_S218_D2.7151.00
294_D411_P2.6831.00
192_T206_E2.6181.00
373_V382_E2.6161.00
385_T408_K2.6111.00
79_L91_R2.5141.00
294_D317_K2.5101.00
180_V219_F2.5091.00
269_Y311_A2.4531.00
206_E210_K2.4491.00
261_K379_K2.4451.00
224_E227_V2.4251.00
176_H483_D2.3871.00
167_S242_I2.3701.00
437_V441_I2.3681.00
235_K454_G2.3141.00
89_L136_G2.2611.00
389_E401_R2.2481.00
183_R224_E2.2421.00
153_K239_D2.2071.00
318_S362_P2.1991.00
293_K317_K2.1881.00
210_K214_Q2.1721.00
370_T402_E2.1301.00
135_K139_N2.1161.00
454_G485_Y2.1151.00
80_V128_I2.0921.00
483_D487_M2.0371.00
463_R474_E2.0301.00
373_V409_V2.0281.00
387_Q408_K1.9871.00
86_K90_E1.9311.00
263_V372_M1.9301.00
220_V223_T1.9251.00
372_M380_L1.9031.00
163_A242_I1.8981.00
235_K452_I1.8941.00
233_E237_Q1.8871.00
380_L415_V1.8851.00
296_I383_L1.8771.00
232_D236_E1.8581.00
384_H407_E1.8511.00
245_T461_A1.8481.00
367_I408_K1.8321.00
252_D258_R1.8271.00
172_N217_I1.8211.00
150_R172_N1.8031.00
160_S187_A1.7941.00
296_I410_W1.7891.00
403_L406_T1.7711.00
320_H362_P1.7301.00
186_R206_E1.7231.00
79_L84_R1.7161.00
174_A483_D1.7081.00
150_R177_S1.6881.00
223_T229_I1.6781.00
412_A415_V1.6461.00
160_S182_E1.6461.00
89_L93_L1.6341.00
85_W131_T1.6241.00
179_T218_D1.6131.00
382_E411_P1.6061.00
158_V243_L1.6061.00
374_A381_K1.6041.00
230_T233_E1.5981.00
254_L258_R1.5951.00
179_T238_F1.5821.00
223_T228_D1.5521.00
320_H364_E1.5421.00
24_L312_L1.5331.00
335_D339_P1.5321.00
449_Q454_G1.5311.00
117_A122_A1.5311.00
225_I229_I1.5301.00
156_A181_F1.5291.00
322_F410_W1.5191.00
187_A219_F1.5191.00
72_L75_E1.5191.00
376_K381_K1.5181.00
187_A209_I1.5011.00
336_N339_P1.4951.00
157_I178_V1.4841.00
251_R422_E1.4821.00
105_V468_I1.4761.00
35_S38_A1.4751.00
475_G479_A1.4751.00
445_Y449_Q1.4671.00
442_S461_A1.4631.00
387_Q403_L1.4391.00
154_K237_Q1.4331.00
273_A310_T1.4251.00
370_T384_H1.4231.00
78_D82_R1.4211.00
386_I406_T1.4101.00
79_L87_E1.3981.00
154_K177_S1.3951.00
373_V381_K1.3821.00
381_K409_V1.3711.00
98_F180_V1.3711.00
387_Q406_T1.3701.00
242_I478_V1.3701.00
372_M415_V1.3581.00
326_P366_S1.3461.00
97_N169_D1.3461.00
156_A238_F1.3431.00
404_P407_E1.3431.00
80_V132_I1.3401.00
401_R404_P1.3391.00
386_I407_E1.3331.00
104_R134_D1.3291.00
181_F220_V1.3291.00
386_I403_L1.3171.00
158_V234_L1.3131.00
457_A462_R1.3101.00
36_E40_K1.3101.00
322_F367_I1.2981.00
130_R134_D1.2961.00
386_I402_E1.2901.00
370_T386_I1.2841.00
186_R193_Y1.2841.00
250_Q265_Y1.2811.00
449_Q453_D1.2771.00
157_I164_G1.2771.00
312_L355_E1.2741.00
297_V308_V1.2731.00
290_A414_L1.2651.00
364_E387_Q1.2601.00
152_G177_S1.2481.00
385_T410_W1.2451.00
75_E91_R1.2381.00
182_E221_T1.2341.00
213_T219_F1.2241.00
322_F385_T1.2231.00
77_N128_I1.2181.00
184_A271_T1.2111.00
269_Y416_F1.2051.00
269_Y314_Q1.2051.00
244_C458_A1.2031.00
295_V316_A1.2011.00
295_V311_A1.2001.00
296_I322_F1.1991.00
185_D222_N1.1971.00
26_D30_Y1.1971.00
367_I385_T1.1931.00
473_N477_E1.1791.00
481_E484_R1.1701.00
153_K176_H1.1631.00
97_N170_Q1.1591.00
172_N215_E1.1461.00
452_I455_V1.1411.00
135_K138_E1.1411.00
153_K486_L1.1401.00
393_N397_K1.1391.00
308_V321_Q1.1371.00
147_P150_R1.1150.99
257_G260_S1.1110.99
386_I404_P1.1110.99
96_N102_T1.1080.99
438_N443_A1.1080.99
133_I142_I1.0930.99
152_G176_H1.0910.99
272_L287_F1.0900.99
435_N451_N1.0870.99
281_N284_D1.0870.99
233_E236_E1.0870.99
171_L482_V1.0860.99
137_F207_R1.0840.99
226_G229_I1.0720.99
185_D275_K1.0690.99
335_D338_W1.0640.99
449_Q456_F1.0630.99
444_A462_R1.0610.99
205_V209_I1.0590.99
400_F404_P1.0590.99
86_K141_W1.0530.99
174_A480_R1.0470.99
192_T205_V1.0420.99
160_S221_T1.0420.99
176_H487_M1.0410.99
466_S470_W1.0400.99
383_L415_V1.0390.99
364_E367_I1.0380.99
247_A423_G1.0380.99
364_E408_K1.0360.99
86_K139_N1.0280.99
463_R470_W1.0230.99
392_K398_Y1.0170.99
450_T457_A1.0150.99
240_A482_V1.0150.99
71_N95_T1.0120.99
257_G374_A1.0090.99
184_A248_Q1.0070.99
231_A235_K1.0050.99
229_I233_E1.0010.99
326_P329_P1.0010.99
91_R94_K0.9970.99
308_V319_V0.9960.99
243_L461_A0.9950.99
294_D320_H0.9930.99
429_L436_S0.9930.99
38_A41_R0.9930.99
197_N203_G0.9910.99
148_K174_A0.9870.99
255_I369_T0.9860.99
165_L209_I0.9800.99
348_E352_E0.9790.99
124_S127_N0.9790.99
36_E135_K0.9790.99
185_D193_Y0.9760.99
128_I132_I0.9720.99
232_D452_I0.9710.99
291_K414_L0.9680.99
391_V398_Y0.9660.99
305_A350_A0.9650.99
444_A448_Y0.9640.98
329_P332_R0.9630.98
434_V442_S0.9620.98
160_S219_F0.9600.98
333_T336_N0.9600.98
449_Q485_Y0.9580.98
323_G326_P0.9430.98
332_R337_M0.9380.98
72_L91_R0.9360.98
154_K238_F0.9260.98
92_L96_N0.9170.98
191_L468_I0.9130.98
305_A321_Q0.9130.98
252_D265_Y0.9110.98
95_T476_R0.9090.98
181_F237_Q0.9080.98
72_L94_K0.9070.98
458_A478_V0.9070.98
442_S457_A0.9060.98
182_E219_F0.9020.98
169_D173_Q0.9010.98
327_K330_P0.8940.98
69_I473_N0.8940.98
36_E83_G0.8930.98
151_T487_M0.8880.97
226_G230_T0.8870.97
36_E85_W0.8850.97
76_W129_E0.8810.97
322_F364_E0.8790.97
144_P214_Q0.8760.97
393_N396_G0.8740.97
258_R417_I0.8720.97
273_A314_Q0.8710.97
293_K413_Q0.8700.97
176_H239_D0.8670.97
34_F38_A0.8640.97
370_T407_E0.8620.97
444_A449_Q0.8610.97
367_I387_Q0.8550.97
167_S478_V0.8510.97
93_L136_G0.8510.97
240_A485_Y0.8500.97
231_A432_F0.8490.97
437_V443_A0.8480.97
155_V482_V0.8460.97
80_V85_W0.8440.97
263_V380_L0.8420.96
403_L407_E0.8400.96
391_V401_R0.8400.96
276_S287_F0.8400.96
44_A81_Y0.8380.96
240_A486_L0.8380.96
366_S388_M0.8350.96
368_Q388_M0.8340.96
400_F403_L0.8330.96
39_S128_I0.8310.96
462_R474_E0.8310.96
482_V486_L0.8250.96
105_V200_L0.8250.96
116_L120_D0.8230.96
258_R372_M0.8210.96
320_H412_A0.8210.96
282_F285_K0.8180.96
156_A241_V0.8180.96
167_S244_C0.8160.96
232_D235_K0.8140.96
232_D431_Q0.8140.96
191_L200_L0.8130.96
167_S458_A0.8090.96
330_P333_T0.8090.96
206_E213_T0.8070.96
40_K83_G0.8050.95
71_N96_N0.8030.95
256_E384_H0.8010.95
305_A309_A0.7980.95
69_I472_I0.7970.95
109_P125_I0.7940.95
186_R192_T0.7940.95
129_E133_I0.7880.95
383_L412_A0.7850.95
364_E410_W0.7840.95
480_R484_R0.7820.95
165_L180_V0.7760.94
366_S390_K0.7750.94
284_D287_F0.7750.94
183_R248_Q0.7740.94
448_Y462_R0.7720.94
456_F481_E0.7710.94
292_G414_L0.7700.94
433_G452_I0.7640.94
392_K395_H0.7620.94
389_E406_T0.7600.94
209_I213_T0.7590.94
212_L217_I0.7570.94
444_A457_A0.7560.94
332_R336_N0.7530.94
298_I415_V0.7510.93
251_R439_N0.7500.93
276_S281_N0.7500.93
264_H288_I0.7470.93
29_E104_R0.7450.93
156_A234_L0.7420.93
264_H272_L0.7410.93
351_Y363_R0.7380.93
397_K400_F0.7370.93
427_P430_K0.7360.93
197_N274_T0.7360.93
371_K409_V0.7350.93
336_N346_T0.7340.93
170_Q476_R0.7340.93
184_A193_Y0.7340.93
313_R353_E0.7330.93
265_Y268_D0.7330.93
466_S469_V0.7330.93
402_E406_T0.7320.93
370_T373_V0.7310.93
78_D81_Y0.7290.92
51_T115_T0.7190.92
392_K399_E0.7190.92
213_T218_D0.7190.92
271_T275_K0.7180.92
447_D481_E0.7160.92
37_E41_R0.7160.92
87_E90_E0.7150.92
155_V171_L0.7150.92
69_I469_V0.7140.92
203_G206_E0.7130.92
325_H388_M0.7120.92
126_K129_E0.7110.91
31_S34_F0.7100.91
154_K179_T0.7100.91
276_S282_F0.7080.91
398_Y402_E0.7080.91
395_H398_Y0.7040.91
223_T230_T0.7020.91
386_I405_G0.7020.91
390_K398_Y0.7010.91
389_E403_L0.7000.91
71_N92_L0.6980.91
100_E133_I0.6970.91
163_A458_A0.6970.91
168_A180_V0.6960.91
184_A275_K0.6960.91
234_L241_V0.6940.90
249_K422_E0.6940.90
264_H414_L0.6930.90
70_Y473_N0.6920.90
258_R263_V0.6920.90
393_N399_E0.6920.90
324_K366_S0.6910.90
235_K453_D0.6910.90
197_N202_K0.6900.90
255_I263_V0.6890.90
103_G133_I0.6890.90
157_I242_I0.6890.90
96_N472_I0.6880.90
224_E228_D0.6850.90
155_V486_L0.6840.90
259_D374_A0.6840.90
134_D204_I0.6830.90
129_E132_I0.6780.89
448_Y477_E0.6760.89
369_T383_L0.6760.89
324_K369_T0.6750.89
170_Q173_Q0.6730.89
127_N130_R0.6730.89
297_V319_V0.6710.89
332_R335_D0.6710.89
389_E402_E0.6700.89
333_T337_M0.6700.89
321_Q324_K0.6690.89
429_L442_S0.6680.89
34_F127_N0.6680.89
145_R173_Q0.6670.89
108_A126_K0.6650.89
101_F205_V0.6610.88
180_V217_I0.6610.88
147_P172_N0.6600.88
166_A472_I0.6600.88
220_V237_Q0.6590.88
98_F472_I0.6590.88
281_N285_K0.6580.88
72_L95_T0.6580.88
458_A474_E0.6570.88
283_K286_Q0.6550.88
325_H390_K0.6550.88
291_K315_K0.6540.88
386_I400_F0.6530.88
115_T129_E0.6530.88
320_H410_W0.6510.87
266_A307_C0.6500.87
85_W135_K0.6480.87
245_T423_G0.6470.87
183_R425_E0.6470.87
478_V482_V0.6460.87
458_A482_V0.6460.87
157_I244_C0.6440.87
391_V397_K0.6430.87
390_K400_F0.6420.87
66_G113_S0.6420.87
325_H366_S0.6410.87
165_L212_L0.6410.87
260_S372_M0.6400.87
292_G317_K0.6380.86
253_L417_I0.6380.86
467_L470_W0.6380.86
89_L142_I0.6370.86
484_R488_G0.6360.86
296_I320_H0.6350.86
202_K205_V0.6350.86
272_L286_Q0.6330.86
230_T235_K0.6320.86
123_V128_I0.6320.86
349_Y354_A0.6320.86
347_L365_Y0.6310.86
430_K436_S0.6310.86
226_G234_L0.6300.86
393_N398_Y0.6300.86
324_K388_M0.6300.86
99_P103_G0.6280.86
296_I385_T0.6250.85
127_N131_T0.6250.85
323_G390_K0.6240.85
86_K143_Q0.6240.85
380_L413_Q0.6230.85
118_I121_P0.6210.85
249_K426_Q0.6210.85
323_G346_T0.6210.85
458_A475_G0.6150.84
193_Y248_Q0.6150.84
400_F406_T0.6150.84
79_L82_R0.6150.84
107_P467_L0.6140.84
276_S285_K0.6130.84
391_V395_H0.6120.84
110_C114_C0.6110.84
166_A170_Q0.6100.84
125_I129_E0.6100.84
325_H400_F0.6100.84
322_F383_L0.6100.84
31_S127_N0.6080.84
154_K218_D0.6070.84
307_C416_F0.6070.84
293_K414_L0.6070.84
93_L142_I0.6050.83
131_T135_K0.6050.83
371_K407_E0.6000.83
97_N166_A0.6000.83
155_V176_H0.6000.83
382_E412_A0.6000.83
218_D238_F0.5990.83
448_Y474_E0.5990.83
48_D78_D0.5970.83
449_Q481_E0.5970.83
173_Q215_E0.5970.83
92_L129_E0.5960.82
426_Q436_S0.5950.82
109_P112_G0.5950.82
99_P102_T0.5940.82
93_L211_L0.5930.82
76_W92_L0.5930.82
34_F39_S0.5920.82
157_I180_V0.5920.82
391_V394_E0.5910.82
104_R130_R0.5900.82
28_K35_S0.5900.82
39_S127_N0.5890.82
376_K379_K0.5890.82
368_Q386_I0.5890.82
317_K413_Q0.5880.82
347_L363_R0.5870.81
329_P333_T0.5870.81
395_H399_E0.5870.81
247_A461_A0.5860.81
264_H268_D0.5860.81
153_K487_M0.5850.81
391_V399_E0.5850.81
73_I77_N0.5840.81
269_Y291_K0.5840.81
327_K365_Y0.5830.81
324_K390_K0.5830.81
30_Y43_G0.5820.81
319_V325_H0.5820.81
323_G330_P0.5820.81
93_L96_N0.5810.81
144_P148_K0.5810.81
350_A353_E0.5810.81
251_R419_I0.5810.81
137_F211_L0.5810.81
164_G244_C0.5790.81
116_L123_V0.5790.81
143_Q214_Q0.5780.80
187_A206_E0.5780.80
93_L133_I0.5770.80
39_S131_T0.5770.80
42_Q45_R0.5760.80
437_V440_K0.5760.80
28_K32_A0.5750.80
255_I372_M0.5740.80
40_K44_A0.5740.80
428_L432_F0.5720.80
388_M402_E0.5720.80
100_E208_R0.5720.80
90_E94_K0.5720.80
89_L132_I0.5710.80
381_K411_P0.5700.80
208_R212_L0.5690.79
323_G419_I0.5690.79
253_L419_I0.5690.79
33_P138_E0.5680.79
323_G331_A0.5660.79
103_G130_R0.5660.79
264_H416_F0.5650.79
33_P39_S0.5640.79
388_M400_F0.5630.79
312_L354_A0.5620.79
325_H398_Y0.5600.78
186_R282_F0.5590.78
272_L276_S0.5570.78
152_G239_D0.5570.78
115_T118_I0.5570.78
282_F286_Q0.5570.78
142_I214_Q0.5560.78
212_L215_E0.5560.78
235_K241_V0.5550.78
75_E78_D0.5550.78
123_V129_E0.5540.78
380_L416_F0.5530.78
438_N441_I0.5530.78
429_L434_V0.5510.77
116_L121_P0.5500.77
296_I415_V0.5490.77
289_D416_F0.5490.77
319_V323_G0.5480.77
443_A446_G0.5470.77
398_Y401_R0.5470.77
269_Y273_A0.5470.77
205_V212_L0.5460.77
65_S113_S0.5460.77
76_W125_I0.5450.77
231_A234_L0.5440.76
265_Y417_I0.5430.76
425_E428_L0.5430.76
470_W474_E0.5430.76
390_K399_E0.5420.76
257_G371_K0.5400.76
323_G366_S0.5390.76
198_M349_Y0.5390.76
267_M271_T0.5390.76
423_G426_Q0.5390.76
181_F229_I0.5380.76
355_E362_P0.5380.76
446_G449_Q0.5380.76
434_V452_I0.5360.75
74_P78_D0.5350.75
86_K135_K0.5340.75
197_N201_E0.5330.75
303_T474_E0.5320.75
191_L202_K0.5320.75
76_W469_V0.5320.75
297_V415_V0.5310.75
323_G388_M0.5310.75
152_G155_V0.5300.75
248_Q267_M0.5300.75
386_I408_K0.5300.75
26_D31_S0.5300.75
115_T119_S0.5290.74
324_K368_Q0.5280.74
46_C49_C0.5280.74
261_K374_A0.5270.74
427_P431_Q0.5270.74
391_V400_F0.5270.74
109_P467_L0.5260.74
426_Q440_K0.5260.74
388_M403_L0.5260.74
52_P116_L0.5250.74
36_E131_T0.5240.74
71_N76_W0.5240.74
98_F215_E0.5240.74
232_D433_G0.5230.74
50_G53_F0.5220.73
339_P349_Y0.5220.73
240_A456_F0.5210.73
425_E429_L0.5210.73
173_Q211_L0.5200.73
398_Y403_L0.5200.73
249_K425_E0.5190.73
372_M383_L0.5170.73
197_N305_A0.5160.73
276_S284_D0.5150.72
200_L313_R0.5150.72
37_E40_K0.5140.72
323_G332_R0.5140.72
449_Q452_I0.5130.72
73_I78_D0.5120.72
133_I137_F0.5120.72
457_A461_A0.5110.72
321_Q351_Y0.5110.72
225_I233_E0.5110.72
194_G267_M0.5100.72
116_L119_S0.5090.72
354_A362_P0.5090.72
248_Q425_E0.5080.71
260_S378_G0.5080.71
153_K177_S0.5080.71
39_S130_R0.5070.71
76_W126_K0.5060.71
381_K384_H0.5060.71
247_A465_Q0.5050.71
88_A132_I0.5050.71
307_C311_A0.5040.71
145_R148_K0.5040.71
102_T126_K0.5040.71
198_M305_A0.5030.71
211_L214_Q0.5030.71
234_L238_F0.5030.71
436_S443_A0.5030.71
431_Q436_S0.5020.71
262_G374_A0.5020.71
156_A237_Q0.5020.71
394_E397_K0.5010.70
41_R44_A0.5010.70
153_K488_G0.5000.70
295_V414_L0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ylfB 1 0.929 100 0.295 Contact Map
1gteA 4 0.9391 100 0.305 Contact Map
2vdcG 1 0.8966 100 0.311 Contact Map
1cjcA 1 0.6613 100 0.627 Contact Map
1lqtA 1 0.6592 100 0.64 Contact Map
1mo9A 2 0.6815 100 0.651 Contact Map
3ctyA 2 0.5801 100 0.679 Contact Map
1hyuA 2 0.8783 100 0.679 Contact Map
2q0lA 2 0.5781 100 0.681 Contact Map
1vdcA 2 0.6045 100 0.681 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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