GREMLIN Database
MNTA - Manganese-binding lipoprotein MntA
UniProt: O34385 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 306 (285)
Sequences: 5999 (4815)
Seq/√Len: 285.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_I174_Q4.1291.00
155_M162_F3.8771.00
52_H158_H3.7901.00
49_G53_V3.7511.00
52_H161_A3.6971.00
148_E166_A3.4671.00
179_W295_R3.3811.00
136_S207_E3.3631.00
177_D208_Y3.2081.00
145_D170_K3.1811.00
159_A163_R2.8761.00
155_M158_H2.6101.00
152_S163_R2.5981.00
47_N172_D2.5641.00
158_H162_F2.5531.00
141_I170_K2.5491.00
148_E152_S2.5321.00
33_Q54_K2.5221.00
45_A85_L2.5051.00
144_V166_A2.4001.00
252_E256_N2.3871.00
42_A57_S2.1501.00
183_E302_T2.1081.00
44_A140_W2.0911.00
152_S159_A2.0541.00
148_E163_R2.0371.00
158_H161_A1.9921.00
114_A146_E1.9681.00
193_V211_K1.9531.00
56_T77_K1.9371.00
166_A170_K1.9131.00
45_A151_F1.9041.00
45_A147_I1.9031.00
35_T81_A1.8991.00
177_D181_R1.8841.00
161_A165_N1.8791.00
42_A46_E1.8501.00
236_L265_K1.8381.00
180_S298_I1.8101.00
234_D238_E1.7551.00
31_Q54_K1.7541.00
288_G292_G1.7451.00
235_L239_K1.7351.00
110_A113_E1.7001.00
144_V169_Y1.6551.00
138_P207_E1.6511.00
179_W299_N1.6091.00
150_Q153_K1.5941.00
160_D164_K1.5881.00
195_V236_L1.5821.00
289_T292_G1.5641.00
150_Q154_A1.5621.00
168_E172_D1.5601.00
85_L111_V1.5571.00
44_A169_Y1.5541.00
83_V150_Q1.5391.00
230_Q234_D1.5221.00
74_D77_K1.5181.00
172_D291_E1.5111.00
49_G151_F1.5091.00
52_H155_M1.4801.00
164_K168_E1.4781.00
139_L142_Y1.4611.00
299_N303_K1.4571.00
179_W183_E1.4401.00
33_Q56_T1.4251.00
83_V154_A1.4171.00
33_Q82_D1.4141.00
43_D47_N1.4081.00
48_I166_A1.3931.00
193_V239_K1.3871.00
138_P177_D1.3761.00
204_F298_I1.3691.00
245_F304_A1.3631.00
183_E299_N1.3601.00
142_Y146_E1.3541.00
167_K171_E1.3461.00
256_N263_K1.3371.00
170_K174_Q1.3291.00
163_R167_K1.3251.00
52_H165_N1.3221.00
180_S204_F1.3181.00
111_V143_A1.3171.00
107_Q153_K1.3121.00
178_K182_K1.3091.00
34_V151_F1.3071.00
133_V143_A1.2971.00
73_G76_K1.2921.00
172_D295_R1.2891.00
32_L154_A1.2861.00
145_D148_E1.2741.00
36_A42_A1.2681.00
175_Y179_W1.2631.00
167_K170_K1.2571.00
181_R185_A1.2561.00
174_Q178_K1.2421.00
47_N169_Y1.2331.00
76_K80_S1.2281.00
85_L109_A1.2241.00
228_D231_E1.2101.00
171_E175_Y1.2091.00
86_Y95_M1.2071.00
48_I144_V1.2041.00
44_A144_V1.2041.00
180_S294_F1.2031.00
86_Y110_A1.1941.00
124_G127_K1.1861.00
149_A152_S1.1831.00
41_I111_V1.1701.00
296_H300_T1.1601.00
160_D163_R1.1511.00
236_L267_H1.1481.00
47_N291_E1.1451.00
171_E174_Q1.1241.00
107_Q154_A1.1221.00
34_V53_V1.1211.00
205_G210_F1.1191.00
70_A94_K1.1171.00
136_S139_L1.1161.00
50_G161_A1.1161.00
233_V258_V1.1151.00
161_A164_K1.1141.00
68_Y74_D1.1121.00
232_L258_V1.1021.00
295_R299_N1.1011.00
146_E150_Q1.0911.00
66_H132_H1.0881.00
145_D149_A1.0831.00
109_A150_Q1.0691.00
115_I139_L1.0601.00
34_V83_V1.0551.00
164_K167_K1.0531.00
142_Y145_D1.0471.00
165_N168_E1.0471.00
85_L147_I1.0461.00
224_Y254_S1.0431.00
15_A18_G1.0421.00
213_K235_L1.0411.00
36_A57_S1.0381.00
145_D166_A1.0351.00
138_P141_I1.0171.00
130_D202_A1.0171.00
172_D175_Y1.0111.00
43_D169_Y1.0101.00
215_L218_L1.0051.00
243_A270_T1.0031.00
187_I192_R0.9991.00
32_L49_G0.9991.00
299_N302_T0.9941.00
12_A15_A0.9831.00
168_E171_E0.9811.00
193_V213_K0.9811.00
32_L53_V0.9771.00
44_A147_I0.9711.00
246_V269_V0.9661.00
184_I298_I0.9661.00
296_H299_N0.9601.00
48_I162_F0.9491.00
35_T56_T0.9481.00
177_D207_E0.9471.00
288_G296_H0.9421.00
139_L206_N0.9401.00
169_Y173_L0.9341.00
107_Q150_Q0.9301.00
201_F272_G0.9281.00
233_V237_T0.9241.00
87_S143_A0.9211.00
35_T58_L0.9201.00
137_I173_L0.9191.00
199_D214_G0.9171.00
52_H162_F0.9141.00
139_L143_A0.9131.00
11_F14_F0.9061.00
140_W294_F0.9001.00
123_A126_G0.8971.00
36_A45_A0.8951.00
137_I207_E0.8871.00
181_R207_E0.8861.00
141_I145_D0.8831.00
35_T77_K0.8761.00
64_D67_L0.8741.00
194_L205_G0.8701.00
194_L212_V0.8681.00
144_V170_K0.8641.00
147_I151_F0.8631.00
149_A153_K0.8571.00
36_A41_I0.8461.00
192_R209_G0.8431.00
84_V95_M0.8431.00
231_E234_D0.8411.00
148_E170_K0.8381.00
97_D100_Q0.8351.00
86_Y108_S0.8311.00
49_G55_V0.8281.00
146_E149_A0.8261.00
182_K185_A0.8201.00
173_L176_L0.8201.00
36_A55_V0.8191.00
33_Q80_S0.8161.00
149_A163_R0.8151.00
10_L13_T0.8010.99
112_A133_V0.7960.99
245_F272_G0.7950.99
32_L82_D0.7930.99
43_D46_E0.7900.99
117_K120_L0.7900.99
85_L150_Q0.7850.99
211_K239_K0.7800.99
112_A115_I0.7800.99
34_V49_G0.7760.99
249_S277_S0.7710.99
83_V109_A0.7650.99
41_I143_A0.7640.99
298_I302_T0.7630.99
174_Q177_D0.7570.99
44_A143_A0.7560.99
233_V264_E0.7540.99
138_P181_R0.7510.99
234_D237_T0.7500.99
122_P125_E0.7480.99
196_T201_F0.7480.99
246_V271_I0.7470.99
48_I165_N0.7450.99
47_N289_T0.7450.99
19_C22_D0.7420.99
47_N165_N0.7390.99
179_W302_T0.7360.99
109_A146_E0.7360.99
191_S242_K0.7360.99
117_K126_G0.7340.99
16_L19_C0.7300.99
231_E235_L0.7280.99
270_T300_T0.7280.99
163_R166_A0.7260.99
64_D220_T0.7260.99
144_V148_E0.7240.99
137_I294_F0.7240.99
227_R230_Q0.7240.99
290_Y294_F0.7240.99
186_H302_T0.7230.99
194_L301_I0.7210.99
82_D154_A0.7200.99
111_V146_E0.7200.99
253_K256_N0.7180.99
50_G168_E0.7160.99
49_G52_H0.7160.99
179_W182_K0.7160.99
84_V99_L0.7150.99
225_G228_D0.7130.99
152_S166_A0.7120.99
120_L125_E0.7070.99
243_A304_A0.7050.99
121_I124_G0.7030.99
73_G77_K0.7030.99
60_G63_V0.7020.99
10_L14_F0.7010.99
145_D167_K0.7000.98
205_G212_V0.6990.98
179_W298_I0.6990.98
244_V267_H0.6940.98
117_K124_G0.6850.98
249_S273_G0.6850.98
35_T78_L0.6840.98
183_E186_H0.6790.98
75_T98_V0.6750.98
246_V255_I0.6750.98
196_T199_D0.6740.98
184_I210_F0.6730.98
93_G96_E0.6710.98
41_I87_S0.6690.98
34_V45_A0.6660.98
217_G220_T0.6660.98
42_A55_V0.6650.98
156_P159_A0.6640.98
197_A246_V0.6620.98
262_A269_V0.6620.98
45_A49_G0.6610.98
125_E128_T0.6610.98
183_E187_I0.6600.98
117_K122_P0.6590.98
121_I125_E0.6580.98
140_W143_A0.6570.98
117_K125_E0.6570.98
99_L108_S0.6560.98
115_I142_Y0.6550.98
12_A16_L0.6540.98
95_M99_L0.6530.98
294_F298_I0.6520.98
34_V55_V0.6490.98
195_V232_L0.6470.98
144_V173_L0.6460.97
182_K186_H0.6460.97
32_L155_M0.6450.97
172_D289_T0.6440.97
37_T92_E0.6420.97
65_P249_S0.6400.97
137_I177_D0.6400.97
103_G106_K0.6380.97
194_L210_F0.6380.97
152_S162_F0.6370.97
292_G295_R0.6360.97
78_L98_V0.6350.97
133_V139_L0.6350.97
173_L290_Y0.6340.97
13_T16_L0.6330.97
255_I262_A0.6330.97
119_K122_P0.6310.97
117_K123_A0.6230.97
278_D281_G0.6230.97
281_G292_G0.6220.97
53_V151_F0.6200.97
120_L124_G0.6200.97
184_I187_I0.6160.97
94_K98_V0.6150.97
46_E55_V0.6140.97
89_L112_A0.6130.97
32_L151_F0.6110.96
148_E162_F0.6100.96
37_T86_Y0.6090.96
196_T212_V0.6090.96
291_E295_R0.6070.96
132_H198_H0.6030.96
175_Y178_K0.6030.96
141_I148_E0.6020.96
8_A14_F0.6000.96
48_I148_E0.5990.96
41_I85_L0.5980.96
181_R209_G0.5960.96
198_H247_E0.5960.96
108_S112_A0.5930.96
109_A147_I0.5930.96
58_L78_L0.5910.96
38_T91_L0.5880.96
89_L131_P0.5860.96
183_E298_I0.5860.96
186_H191_S0.5860.96
71_S74_D0.5840.95
72_Q226_L0.5830.95
247_E250_V0.5820.95
244_V255_I0.5810.95
108_S111_V0.5800.95
300_T303_K0.5800.95
136_S206_N0.5790.95
268_T303_K0.5790.95
96_E100_Q0.5780.95
140_W147_I0.5770.95
119_K124_G0.5770.95
202_A206_N0.5750.95
48_I152_S0.5740.95
87_S91_L0.5730.95
29_D54_K0.5730.95
120_L123_A0.5720.95
180_S184_I0.5720.95
115_I146_E0.5710.95
169_Y291_E0.5700.95
246_V250_V0.5700.95
111_V115_I0.5690.95
273_G276_Y0.5680.95
204_F208_Y0.5670.95
137_I291_E0.5650.95
87_S133_V0.5650.95
39_S43_D0.5640.95
38_T64_D0.5630.94
227_R231_E0.5630.94
229_V258_V0.5620.94
27_S30_Q0.5610.94
9_V13_T0.5610.94
213_K232_L0.5610.94
262_A268_T0.5590.94
197_A250_V0.5590.94
178_K181_R0.5560.94
47_N144_V0.5540.94
141_I173_L0.5480.94
187_I302_T0.5470.94
176_L294_F0.5460.94
130_D198_H0.5460.94
243_A267_H0.5450.93
291_E294_F0.5430.93
28_A31_Q0.5420.93
137_I180_S0.5410.93
195_V241_I0.5400.93
34_V85_L0.5360.93
17_T20_G0.5350.93
213_K231_E0.5330.93
226_L230_Q0.5320.93
211_K281_G0.5310.93
217_G228_D0.5300.93
204_F301_I0.5300.93
186_H190_K0.5300.93
199_D212_V0.5290.92
204_F210_F0.5280.92
106_K240_Q0.5280.92
40_Q43_D0.5280.92
176_L291_E0.5270.92
58_L226_L0.5270.92
51_K161_A0.5260.92
25_G28_A0.5260.92
43_D289_T0.5260.92
48_I169_Y0.5240.92
281_G287_E0.5230.92
140_W290_Y0.5220.92
169_Y172_D0.5190.92
137_I208_Y0.5180.92
62_G250_V0.5180.92
66_H198_H0.5170.92
199_D202_A0.5170.92
195_V235_L0.5170.92
255_I269_V0.5150.91
233_V257_A0.5150.91
200_A247_E0.5150.91
78_L102_I0.5130.91
252_E255_I0.5130.91
99_L104_E0.5130.91
13_T17_T0.5110.91
143_A147_I0.5090.91
63_V67_L0.5090.91
59_M65_P0.5080.91
86_Y96_E0.5060.91
262_A267_H0.5060.91
281_G286_K0.5050.91
91_L131_P0.5040.91
236_L244_V0.5040.91
26_K29_D0.5030.91
48_I147_I0.5030.91
8_A12_A0.5030.91
70_A98_V0.5010.90
29_D33_Q0.5010.90
212_V215_L0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xrvA 1 0.8464 100 0.081 Contact Map
4utoA 1 0.8791 100 0.087 Contact Map
1toaA 1 0.8922 100 0.112 Contact Map
2o1eA 1 0.8595 100 0.124 Contact Map
3ujpA 4 0.8824 100 0.129 Contact Map
4nnoA 1 0.8824 100 0.133 Contact Map
3cx3A 1 0.8497 100 0.134 Contact Map
4cl2A 1 0.8497 100 0.139 Contact Map
2prsA 1 0.8301 100 0.142 Contact Map
3mfqA 1 0.8889 100 0.148 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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