GREMLIN Database
YCEE - Uncharacterized protein YceE
UniProt: O34384 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (175)
Sequences: 3064 (1665)
Seq/√Len: 125.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_A106_I4.9871.00
159_C170_F3.6991.00
56_V60_D3.4841.00
51_A104_E3.3221.00
95_D98_K3.3121.00
140_E143_R3.2821.00
179_G183_A3.1281.00
10_R171_N2.7121.00
162_Y169_K2.6851.00
68_E75_I2.6431.00
48_L74_V2.6431.00
48_L103_I2.6311.00
177_F187_N2.6021.00
182_A186_R2.5931.00
28_G129_F2.3851.00
105_K160_E2.3701.00
60_D70_P2.2171.00
30_D127_N2.1621.00
130_V159_C2.1041.00
77_T93_I2.0391.00
164_H169_K2.0291.00
22_K95_D1.9301.00
131_R140_E1.9261.00
24_V91_Q1.8331.00
21_T97_S1.8291.00
109_T184_L1.7191.00
71_S100_P1.7001.00
99_I106_I1.6981.00
134_D139_N1.6721.00
46_A92_I1.6481.00
10_R169_K1.6431.00
3_I11_I1.6271.00
77_T91_Q1.6051.00
21_T136_E1.5521.00
75_I93_I1.5471.00
64_Y113_H1.5261.00
144_F174_G1.5001.00
160_E171_N1.4731.00
49_V107_G1.4671.00
26_G88_D1.4561.00
62_V69_H1.4361.00
46_A108_I1.3751.00
48_L60_D1.3601.00
94_V161_L1.3441.00
88_D131_R1.3011.00
6_S9_Q1.2881.00
45_S109_T1.2871.00
130_V170_F1.2861.00
152_I178_S1.2851.00
56_V102_H1.2821.00
45_S111_T1.2781.00
94_V108_I1.2771.00
20_L23_A1.2631.00
108_I161_L1.2501.00
47_F55_C1.2401.00
14_T17_N1.2250.99
41_D90_E1.2200.99
107_G160_E1.1970.99
22_K97_S1.1880.99
48_L99_I1.1860.99
162_Y171_N1.1680.99
42_L125_V1.1660.99
41_D79_D1.1580.99
69_H73_G1.1500.99
57_N60_D1.1220.99
53_D105_K1.1200.99
155_A177_F1.1200.99
24_V135_E1.1110.99
53_D104_E1.0740.99
73_G99_I1.0580.98
129_F143_R1.0540.98
25_I108_I1.0520.98
183_A187_N1.0510.98
144_F172_A1.0510.98
79_D83_G1.0490.98
24_V93_I1.0460.98
43_D64_Y1.0380.98
76_H90_E1.0310.98
80_N89_D1.0270.98
104_E166_G1.0190.98
161_L170_F1.0150.98
135_E138_Q1.0080.98
153_E177_F1.0050.98
79_D90_E0.9970.98
65_N113_H0.9970.98
14_T167_E0.9950.98
93_I135_E0.9930.98
24_V133_V0.9840.97
157_V160_E0.9770.97
78_G90_E0.9680.97
26_G131_R0.9550.97
56_V103_I0.9530.97
183_A186_R0.9480.97
48_L69_H0.9440.97
60_D71_S0.9440.97
157_V184_L0.9420.97
164_H167_E0.9370.97
45_S64_Y0.9370.97
41_D76_H0.9330.97
22_K135_E0.9270.96
48_L56_V0.9040.96
48_L106_I0.9010.96
50_D104_E0.8800.95
60_D69_H0.8780.95
111_T177_F0.8730.95
133_V140_E0.8710.95
10_R162_Y0.8710.95
22_K93_I0.8690.95
25_I132_V0.8690.95
64_Y111_T0.8660.95
11_I142_L0.8580.94
25_I94_V0.8470.94
23_A161_L0.8180.93
50_D103_I0.8180.93
47_F111_T0.8170.93
12_D17_N0.8170.93
21_T95_D0.8110.93
99_I163_R0.8100.93
110_V158_V0.8100.93
49_V160_E0.8080.93
30_D126_S0.8040.92
81_R118_R0.8000.92
121_N124_Q0.7970.92
79_D89_D0.7950.92
29_W90_E0.7820.91
49_V105_K0.7790.91
165_G169_K0.7740.91
121_N152_I0.7710.91
32_N40_F0.7610.90
80_N85_G0.7570.90
180_G183_A0.7560.90
8_G169_K0.7550.90
3_I12_D0.7470.89
82_T85_G0.7470.89
181_L185_C0.7430.89
157_V177_F0.7400.89
27_L44_A0.7310.88
40_F125_V0.7260.88
50_D102_H0.7210.88
47_F58_D0.7190.87
41_D89_D0.7160.87
47_F187_N0.7150.87
163_R168_W0.7130.87
61_F66_N0.7120.87
111_T183_A0.7060.86
153_E175_S0.7030.86
12_D167_E0.7030.86
160_E173_I0.6990.86
132_V159_C0.6930.85
181_L188_Y0.6910.85
10_R164_H0.6880.85
58_D61_F0.6870.85
104_E163_R0.6830.85
31_T84_E0.6830.85
55_C60_D0.6830.85
48_L73_G0.6790.84
8_G176_G0.6760.84
99_I103_I0.6700.83
90_E110_V0.6700.83
29_W41_D0.6620.83
25_I170_F0.6620.83
90_E112_I0.6610.83
150_F156_V0.6610.83
153_E176_G0.6580.82
55_C185_C0.6550.82
44_A76_H0.6520.82
83_G90_E0.6480.81
39_D81_R0.6450.81
84_E87_G0.6450.81
48_L71_S0.6410.81
66_N70_P0.6400.81
22_K136_E0.6390.81
9_Q152_I0.6380.80
67_L76_H0.6380.80
134_D141_L0.6380.80
55_C61_F0.6330.80
96_F163_R0.6330.80
30_D82_T0.6290.79
9_Q171_N0.6250.79
186_R189_G0.6220.79
66_N69_H0.6210.79
103_I136_E0.6190.78
23_A96_F0.6180.78
107_G157_V0.6180.78
109_T185_C0.6150.78
31_T126_S0.6140.78
80_N83_G0.6140.78
62_V74_V0.6130.78
4_Q12_D0.6110.77
3_I6_S0.6100.77
50_D56_V0.6070.77
78_G85_G0.6070.77
47_F63_F0.6050.77
37_G64_Y0.6010.76
155_A180_G0.6000.76
112_I120_Q0.6000.76
28_G131_R0.5990.76
30_D84_E0.5960.76
82_T86_D0.5950.76
44_A110_V0.5940.76
29_W122_F0.5940.76
83_G89_D0.5930.75
20_L134_D0.5930.75
32_N126_S0.5910.75
105_K157_V0.5910.75
48_L70_P0.5910.75
150_F153_E0.5890.75
129_F133_V0.5880.75
122_F125_V0.5850.74
153_E180_G0.5840.74
55_C58_D0.5820.74
146_L158_V0.5770.73
66_N113_H0.5770.73
112_I121_N0.5720.73
58_D70_P0.5710.73
10_R175_S0.5700.72
7_K144_F0.5700.72
40_F120_Q0.5690.72
5_L79_D0.5690.72
8_G162_Y0.5680.72
105_K162_Y0.5670.72
5_L9_Q0.5660.72
110_V130_V0.5630.72
132_V158_V0.5620.71
50_D54_N0.5610.71
80_N84_E0.5580.71
128_A146_L0.5540.70
20_L141_L0.5520.70
45_S76_H0.5520.70
179_G184_L0.5510.70
56_V70_P0.5500.70
4_Q11_I0.5480.70
132_V179_G0.5450.69
108_I130_V0.5440.69
14_T178_S0.5430.69
171_N175_S0.5400.68
177_F184_L0.5400.68
146_L149_D0.5370.68
157_V187_N0.5370.68
175_S178_S0.5360.68
38_H124_Q0.5340.68
25_I158_V0.5270.67
144_F149_D0.5270.67
128_A151_S0.5270.67
155_A179_G0.5270.67
5_L90_E0.5230.66
31_T40_F0.5230.66
65_N111_T0.5220.66
20_L28_G0.5210.66
99_I168_W0.5200.66
14_T19_G0.5180.65
82_T87_G0.5150.65
76_H92_I0.5120.64
22_K139_N0.5120.64
79_D112_I0.5110.64
88_D129_F0.5070.64
120_Q124_Q0.5060.63
32_N150_F0.5060.63
177_F183_A0.5050.63
19_G164_H0.5040.63
150_F185_C0.5000.63
122_F172_A0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ibzA 1 0.9219 100 -0.014 Contact Map
2kxtA 1 0.901 100 -0.013 Contact Map
2qngA 1 0.8698 100 0.072 Contact Map
2qz7A 1 0.8594 100 0.078 Contact Map
4um9B 2 0.8021 5.6 0.955 Contact Map
2i0fA 3 0.4583 4.6 0.957 Contact Map
4mcjA 3 0.651 4.3 0.957 Contact Map
1edyA 2 0.6615 4.2 0.958 Contact Map
3od5A 1 0.2812 4.1 0.958 Contact Map
3fcsB 1 0.8021 4.1 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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