GREMLIN Database
YOCR - Uncharacterized sodium-dependent transporter YocR
UniProt: O34383 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 445 (427)
Sequences: 4585 (3080)
Seq/√Len: 149.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
198_K202_M4.4301.00
195_E198_K4.2371.00
204_D207_A3.9411.00
147_L348_F3.7951.00
154_I344_G3.6641.00
297_F300_I3.6381.00
68_T75_S3.1721.00
144_G148_L3.1301.00
114_I303_L3.0421.00
64_I75_S2.9471.00
70_K78_T2.9041.00
197_I264_I2.8811.00
114_I307_L2.8601.00
240_K410_S2.8391.00
284_L309_F2.8221.00
201_L264_I2.7331.00
153_T317_A2.7321.00
58_L231_M2.5851.00
186_R189_T2.5101.00
77_K86_H2.5061.00
188_V197_I2.4551.00
130_T134_S2.3981.00
335_K338_R2.3531.00
69_Q240_K2.3011.00
143_V352_V2.2541.00
186_R301_F2.1861.00
29_K219_Q2.1781.00
159_K167_K2.1261.00
177_F258_V2.1191.00
194_M197_I2.1071.00
200_F263_G2.0941.00
26_A255_N2.0931.00
18_A254_M2.0901.00
400_P403_D2.0861.00
163_S167_K2.0781.00
425_L429_L2.0611.00
4_A236_A2.0571.00
110_I310_L2.0521.00
181_I261_M2.0491.00
181_I185_V1.9921.00
112_I116_K1.9881.00
20_S225_S1.9531.00
194_M198_K1.9351.00
70_K74_Q1.9111.00
184_M265_A1.8891.00
191_D275_L1.8781.00
55_L252_T1.8751.00
143_V355_A1.8751.00
147_L151_V1.8741.00
112_I141_L1.8711.00
54_G224_L1.8481.00
11_L15_L1.8401.00
117_G302_L1.8221.00
393_I398_K1.8161.00
143_V356_L1.8111.00
115_I145_G1.7851.00
423_L427_R1.7701.00
376_D380_S1.7651.00
49_F217_M1.7611.00
71_D330_K1.7511.00
255_N259_A1.7501.00
322_E336_R1.7471.00
107_G313_A1.7451.00
118_F303_L1.7441.00
201_L260_V1.7381.00
114_I310_L1.7261.00
111_L310_L1.7151.00
145_G148_L1.6971.00
6_Q69_Q1.6861.00
155_L159_K1.6771.00
200_F264_I1.6731.00
107_G149_F1.6681.00
146_Q351_G1.6641.00
147_L352_V1.6461.00
112_I145_G1.6451.00
191_D272_S1.6291.00
12_G166_E1.6221.00
186_R190_L1.6061.00
233_T323_I1.5971.00
386_L438_F1.5941.00
307_L311_F1.5831.00
18_A22_I1.5801.00
35_G277_P1.5641.00
234_Y319_S1.5411.00
180_F265_A1.5381.00
59_L248_A1.5271.00
156_V314_L1.5211.00
334_N342_L1.5031.00
20_S319_S1.5001.00
85_W394_F1.4961.00
184_M261_M1.4911.00
74_Q331_G1.4811.00
67_R407_E1.4751.00
334_N339_F1.4701.00
43_L260_V1.4681.00
178_L182_I1.4651.00
402_Q423_L1.4571.00
104_S146_Q1.4551.00
37_S211_N1.4521.00
132_F136_I1.4521.00
45_I213_I1.4511.00
62_F235_S1.4441.00
424_L428_Y1.4421.00
138_N143_V1.4371.00
99_L379_V1.4271.00
409_K415_K1.4221.00
122_L125_T1.4221.00
352_V356_L1.4191.00
354_S357_S1.4181.00
174_P178_L1.4131.00
76_Y232_V1.4091.00
155_L158_A1.4081.00
152_V314_L1.3981.00
59_L244_L1.3971.00
369_L373_D1.3921.00
99_L228_V1.3911.00
102_F376_D1.3881.00
209_D212_T1.3851.00
352_V355_A1.3741.00
269_A291_V1.3671.00
100_L317_A1.3651.00
372_F376_D1.3551.00
187_S269_A1.3521.00
200_F260_V1.3501.00
146_Q150_M1.3471.00
225_S230_V1.3431.00
389_L435_I1.3281.00
253_V257_L1.3231.00
185_V189_T1.3171.00
4_A330_K1.3101.00
326_A330_K1.3081.00
142_A355_A1.3061.00
186_R296_P1.3001.00
41_A205_L1.2931.00
399_I403_D1.2821.00
227_G388_A1.2781.00
45_I208_I1.2651.00
138_N141_L1.2641.00
8_S11_L1.2601.00
208_I212_T1.2581.00
71_D74_Q1.2571.00
91_L387_G1.2551.00
405_F423_L1.2471.00
396_P427_R1.2411.00
37_S212_T1.2391.00
60_G422_W1.2241.00
169_S315_T1.2201.00
366_I374_A1.2171.00
36_T211_N1.2151.00
72_A75_S1.2141.00
230_V320_M1.2131.00
271_F277_P1.2051.00
407_E410_S1.2021.00
129_D132_F1.1831.00
328_L343_G1.1831.00
19_G315_T1.1771.00
111_L149_F1.1731.00
364_V367_F1.1711.00
66_R407_E1.1511.00
284_L287_V1.1501.00
157_V325_V1.1471.00
52_L56_P1.1471.00
282_V286_N1.1441.00
188_V193_A1.1411.00
171_V175_A1.1320.99
315_T318_F1.1240.99
72_A229_S1.1220.99
93_M327_V1.1160.99
421_V425_L1.1140.99
124_Q127_G1.1130.99
172_L311_F1.1110.99
62_F251_V1.1100.99
374_A378_L1.1090.99
351_G354_S1.1070.99
183_L265_A1.1050.99
7_W16_A1.0960.99
129_D133_A1.0940.99
33_V215_Y1.0900.99
402_Q427_R1.0890.99
220_S255_N1.0890.99
403_D406_D1.0870.99
389_L438_F1.0780.99
340_A344_G1.0780.99
95_T383_L1.0770.99
364_V371_I1.0760.99
62_F231_M1.0750.99
63_I408_L1.0670.99
432_V436_I1.0650.99
112_I135_T1.0640.99
45_I212_T1.0590.99
303_L307_L1.0550.99
37_S215_Y1.0540.99
161_V164_G1.0490.99
13_F17_A1.0450.99
29_K33_V1.0440.99
182_I186_R1.0420.99
6_Q239_E1.0400.99
27_I312_A1.0370.99
137_S366_I1.0350.99
62_F248_A1.0320.99
242_E247_S1.0290.99
179_L304_A1.0230.99
220_S256_M1.0230.99
336_R340_A1.0220.99
256_M260_V1.0190.99
50_T220_S1.0190.99
424_L429_L1.0180.99
116_K131_I1.0170.99
5_N162_S1.0150.99
156_V168_A1.0120.99
402_Q406_D1.0110.99
14_I18_A1.0100.99
151_V155_L1.0080.99
338_R342_L1.0070.99
27_I309_F1.0050.99
59_L63_I1.0040.99
9_S12_G1.0030.99
195_E275_L1.0000.99
168_A172_L1.0000.99
124_Q128_F0.9980.99
154_I341_W0.9940.99
349_I353_P0.9930.99
245_V248_A0.9920.99
358_Y370_S0.9860.99
367_F374_A0.9830.99
191_D196_G0.9830.99
436_I440_H0.9810.99
335_K339_F0.9800.99
181_I184_M0.9800.99
100_L321_L0.9770.99
354_S371_I0.9750.98
57_L434_I0.9730.98
50_T256_M0.9720.98
111_L148_L0.9710.98
182_I301_F0.9700.98
193_A196_G0.9680.98
107_G317_A0.9680.98
33_V219_Q0.9680.98
150_M347_I0.9670.98
149_F317_A0.9660.98
52_L217_M0.9600.98
8_S12_G0.9500.98
119_T122_L0.9470.98
344_G348_F0.9400.98
111_L152_V0.9360.98
41_A208_I0.9340.98
228_V320_M0.9300.98
105_V355_A0.9300.98
396_P426_I0.9290.98
133_A136_I0.9250.98
106_V109_W0.9220.98
407_E411_G0.9190.98
278_D282_V0.9170.98
399_I407_E0.9130.98
129_D286_N0.9120.98
140_Y144_G0.9110.98
35_G271_F0.9100.98
377_Y382_I0.9080.98
98_I379_V0.9060.98
156_V318_F0.9060.98
421_V424_L0.9050.98
358_Y372_F0.9040.98
67_R406_D0.9030.98
154_I345_I0.8980.97
186_R295_M0.8980.97
100_L320_M0.8960.97
328_L334_N0.8950.97
153_T314_L0.8930.97
29_K376_D0.8890.97
341_W345_I0.8840.97
184_M188_V0.8800.97
60_G395_V0.8780.97
99_L320_M0.8780.97
182_I185_V0.8720.97
345_I349_I0.8700.97
28_W32_Y0.8690.97
101_S354_S0.8670.97
115_I118_F0.8660.97
87_W90_Y0.8660.97
125_T293_N0.8650.97
278_D287_V0.8650.97
130_T133_A0.8610.97
389_L393_I0.8610.97
125_T128_F0.8570.97
256_M259_A0.8570.97
281_P284_L0.8560.97
63_I404_L0.8540.97
16_A234_Y0.8530.96
190_L193_A0.8530.96
48_L51_V0.8520.96
35_G270_V0.8490.96
96_C324_L0.8470.96
88_I390_L0.8470.96
292_F302_L0.8430.96
17_A20_S0.8430.96
230_V319_S0.8410.96
182_I304_A0.8400.96
34_A200_F0.8370.96
86_H331_G0.8360.96
431_P434_I0.8360.96
138_N356_L0.8350.96
211_N215_Y0.8350.96
80_A394_F0.8340.96
295_M301_F0.8310.96
79_L395_V0.8310.96
12_G169_S0.8290.96
154_I340_A0.8280.96
280_G283_L0.8280.96
72_A232_V0.8250.96
329_S339_F0.8240.96
148_L152_V0.8220.96
369_L374_A0.8210.96
148_L151_V0.8170.96
208_I213_I0.8140.95
290_T294_Q0.8130.95
110_I309_F0.8090.95
197_I201_L0.8090.95
101_S358_Y0.8080.95
71_D326_A0.8060.95
405_F409_K0.8060.95
274_G277_P0.8040.95
72_A92_G0.8030.95
16_A20_S0.7990.95
97_F343_G0.7990.95
432_V435_I0.7940.95
7_W13_F0.7930.95
219_Q223_L0.7920.95
48_L52_L0.7920.95
353_P357_S0.7910.95
249_V253_V0.7890.95
34_A263_G0.7890.95
33_V37_S0.7880.95
104_S149_F0.7870.95
18_A315_T0.7860.94
172_L315_T0.7850.94
66_R411_G0.7850.94
35_G199_F0.7830.94
143_V147_L0.7790.94
357_S371_I0.7770.94
150_M348_F0.7770.94
25_G29_K0.7760.94
206_T209_D0.7750.94
187_S268_P0.7730.94
370_S373_D0.7720.94
100_L157_V0.7710.94
373_D376_D0.7700.94
123_S126_S0.7690.94
77_K331_G0.7680.94
82_G86_H0.7640.94
295_M298_G0.7630.94
237_Y322_E0.7620.94
390_L393_I0.7600.93
227_G384_M0.7590.93
131_I135_T0.7590.93
159_K163_S0.7570.93
228_V384_M0.7560.93
401_K423_L0.7560.93
348_F353_P0.7550.93
373_D377_Y0.7530.93
409_K412_S0.7520.93
26_A46_F0.7510.93
20_S230_V0.7500.93
239_E242_E0.7480.93
114_I118_F0.7450.93
77_K89_G0.7420.93
136_I139_P0.7390.92
74_Q77_K0.7380.92
272_S294_Q0.7360.92
86_H90_Y0.7350.92
406_D415_K0.7350.92
402_Q405_F0.7340.92
318_F322_E0.7330.92
229_S323_I0.7330.92
100_L351_G0.7320.92
414_L417_K0.7320.92
370_S374_A0.7320.92
158_A341_W0.7290.92
367_F371_I0.7290.92
341_W344_G0.7280.92
210_A213_I0.7280.92
93_M323_I0.7260.92
352_V357_S0.7250.92
273_F294_Q0.7250.92
392_S396_P0.7250.92
175_A179_L0.7220.92
226_V230_V0.7210.92
14_I251_V0.7190.91
49_F52_L0.7190.91
366_I369_L0.7190.91
73_V89_G0.7190.91
102_F380_S0.7190.91
22_I26_A0.7170.91
141_L145_G0.7170.91
28_W281_P0.7160.91
22_I177_F0.7160.91
221_F388_A0.7160.91
339_F342_L0.7130.91
428_Y432_V0.7110.91
47_I256_M0.7100.91
10_K246_Q0.7100.91
250_S254_M0.7090.91
386_L390_L0.7080.91
96_C229_S0.7060.91
140_Y152_V0.7050.91
32_Y277_P0.7050.91
328_L339_F0.7030.90
36_T215_Y0.6990.90
10_K247_S0.6960.90
58_L62_F0.6950.90
55_L231_M0.6930.90
80_A85_W0.6930.90
53_I433_A0.6930.90
423_L428_Y0.6930.90
348_F352_V0.6910.90
430_S433_A0.6900.90
334_N338_R0.6880.90
176_L312_A0.6850.89
281_P286_N0.6850.89
336_R339_F0.6840.89
115_I148_L0.6830.89
401_K405_F0.6810.89
59_L408_L0.6800.89
389_L392_S0.6800.89
13_F62_F0.6800.89
296_P368_H0.6790.89
299_I303_L0.6780.89
328_L332_D0.6760.89
20_S99_L0.6740.89
218_G381_N0.6730.88
369_L377_Y0.6730.88
73_V327_V0.6720.88
72_A93_M0.6720.88
58_L226_V0.6710.88
354_S375_A0.6710.88
422_W426_I0.6710.88
34_A40_G0.6700.88
425_L430_S0.6690.88
372_F375_A0.6690.88
123_S127_G0.6650.88
173_M315_T0.6640.88
225_S319_S0.6620.88
72_A327_V0.6600.88
111_L145_G0.6590.87
177_F181_I0.6560.87
324_L343_G0.6560.87
365_T369_L0.6560.87
397_L427_R0.6540.87
322_E329_S0.6540.87
34_A43_L0.6530.87
197_I203_P0.6520.87
91_L390_L0.6510.87
320_M324_L0.6510.87
17_A251_V0.6490.87
266_I289_P0.6470.86
131_I134_S0.6460.86
59_L245_V0.6440.86
380_S384_M0.6430.86
270_V275_L0.6410.86
266_I283_L0.6390.86
116_K141_L0.6360.86
192_G196_G0.6360.86
240_K407_E0.6360.86
79_L399_I0.6350.85
290_T293_N0.6340.85
74_Q78_T0.6330.85
112_I115_I0.6320.85
101_S317_A0.6320.85
33_V36_T0.6310.85
134_S194_M0.6310.85
357_S372_F0.6310.85
271_F274_G0.6300.85
365_T368_H0.6300.85
34_A208_I0.6280.85
141_L144_G0.6270.85
116_K121_G0.6250.85
11_L18_A0.6250.85
246_Q250_S0.6240.84
158_A337_K0.6240.84
235_S255_N0.6240.84
58_L252_T0.6220.84
353_P371_I0.6220.84
107_G310_L0.6200.84
227_G323_I0.6200.84
272_S276_K0.6170.84
154_I158_A0.6170.84
248_A252_T0.6150.84
129_D134_S0.6150.84
136_I142_A0.6130.83
157_V161_V0.6110.83
67_R403_D0.6070.83
41_A45_I0.6060.83
176_L308_L0.6050.83
103_Y106_V0.6050.83
435_I439_L0.6050.83
267_F272_S0.6040.83
95_T387_G0.6020.82
96_C323_I0.6020.82
57_L430_S0.6000.82
62_F244_L0.5990.82
104_S317_A0.5990.82
157_V321_L0.5990.82
138_N142_A0.5970.82
321_L347_I0.5960.82
135_T142_A0.5950.82
270_V277_P0.5940.81
133_A137_S0.5940.81
29_K106_V0.5940.81
75_S232_V0.5940.81
82_G85_W0.5930.81
33_V212_T0.5920.81
31_P38_G0.5910.81
123_S128_F0.5910.81
23_G30_F0.5910.81
167_K171_V0.5900.81
312_A315_T0.5870.81
192_G195_E0.5860.81
26_A256_M0.5840.80
192_G272_S0.5830.80
121_G126_S0.5820.80
187_S267_F0.5810.80
409_K416_R0.5800.80
140_Y145_G0.5790.80
394_F398_K0.5780.80
191_D194_M0.5770.80
49_F220_S0.5770.80
93_M324_L0.5760.79
102_F228_V0.5750.79
57_L220_S0.5740.79
89_G102_F0.5730.79
342_L346_A0.5710.79
157_V340_A0.5700.79
156_V164_G0.5690.79
47_I51_V0.5680.79
240_K411_G0.5670.78
57_L392_S0.5660.78
212_T219_Q0.5660.78
104_S150_M0.5660.78
32_Y281_P0.5660.78
186_R191_D0.5660.78
76_Y391_I0.5660.78
28_W280_G0.5650.78
59_L314_L0.5650.78
121_G125_T0.5650.78
108_G146_Q0.5640.78
225_S320_M0.5640.78
64_I79_L0.5640.78
96_C230_V0.5640.78
406_D410_S0.5620.78
351_G357_S0.5610.78
105_V364_V0.5600.78
38_G42_F0.5580.77
60_G426_I0.5550.77
175_A311_F0.5550.77
61_E65_G0.5540.77
8_S162_S0.5540.77
120_G299_I0.5510.76
67_R399_I0.5510.76
46_F223_L0.5500.76
198_K201_L0.5490.76
55_L248_A0.5490.76
78_T432_V0.5490.76
87_W91_L0.5480.76
266_I288_L0.5480.76
237_Y326_A0.5480.76
99_L380_S0.5470.76
120_G123_S0.5470.76
26_A50_T0.5470.76
122_L128_F0.5460.76
7_W422_W0.5460.76
395_V399_I0.5420.75
234_Y316_S0.5420.75
151_V435_I0.5410.75
232_V391_I0.5410.75
302_L306_L0.5400.75
405_F408_L0.5400.75
135_T141_L0.5390.75
25_G28_W0.5360.74
14_I250_S0.5360.74
101_S375_A0.5350.74
122_L293_N0.5350.74
11_L14_I0.5350.74
184_M197_I0.5350.74
417_K421_V0.5340.74
305_F322_E0.5340.74
132_F135_T0.5340.74
150_M153_T0.5320.74
160_G289_P0.5320.74
173_M176_L0.5310.74
64_I395_V0.5310.74
63_I129_D0.5300.74
243_N412_S0.5300.74
28_W38_G0.5280.73
92_G387_G0.5270.73
188_V191_D0.5260.73
233_T319_S0.5260.73
244_L248_A0.5260.73
15_L19_G0.5250.73
85_W390_L0.5240.73
329_S334_N0.5240.73
29_K380_S0.5220.73
28_W31_P0.5190.72
129_D136_I0.5180.72
351_G355_A0.5180.72
13_F238_L0.5180.72
168_A171_V0.5170.72
348_F351_G0.5160.72
106_V281_P0.5160.72
285_F305_F0.5160.72
230_V392_S0.5150.72
436_I439_L0.5140.71
278_D281_P0.5140.71
189_T192_G0.5130.71
51_V424_L0.5120.71
266_I319_S0.5120.71
296_P299_I0.5110.71
32_Y279_Q0.5100.71
180_F262_A0.5100.71
268_P272_S0.5080.71
404_L407_E0.5070.70
72_A230_V0.5060.70
50_T252_T0.5060.70
97_F324_L0.5060.70
426_I430_S0.5060.70
235_S434_I0.5060.70
60_G63_I0.5060.70
405_F421_V0.5060.70
81_P124_Q0.5050.70
17_A231_M0.5050.70
26_A259_A0.5040.70
85_W88_I0.5040.70
301_F304_A0.5030.70
346_A350_V0.5030.70
243_N246_Q0.5020.70
88_I394_F0.5020.70
238_L242_E0.5010.69
172_L318_F0.5010.69
94_V98_I0.5010.69
12_G170_Q0.5010.69
393_I397_L0.5000.69
199_F271_F0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xp4A 1 0.973 100 0.012 Contact Map
4us3A 1 0.982 100 0.033 Contact Map
2a65A 2 0.9506 100 0.071 Contact Map
3giaA 1 0.8697 98.6 0.901 Contact Map
4djkA 2 0.8674 98.1 0.914 Contact Map
3l1lA 2 0.8382 98 0.918 Contact Map
2jlnA 1 0.8652 96.6 0.934 Contact Map
4wgvA 2 0.8337 96.6 0.934 Contact Map
3dh4A 3 0.8494 90.2 0.951 Contact Map
2xq2A 2 0.8607 89.4 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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