GREMLIN Database
YVOD - Uncharacterized membrane protein YvoD
UniProt: O34382 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 312 (296)
Sequences: 297 (241)
Seq/√Len: 14.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_G95_L5.0661.00
106_T109_A4.9391.00
92_A270_F4.4601.00
89_F279_P4.4111.00
100_N230_A3.5940.99
277_V281_L3.1980.98
66_G74_G3.0150.97
162_M166_A2.8220.96
222_V226_T2.7760.96
209_Q247_K2.7500.95
132_V136_I2.5370.93
7_A193_D2.4780.92
204_L217_T2.4710.92
74_G95_L2.4360.91
124_G128_V2.4080.91
123_I127_A2.3210.89
94_M130_A2.2980.89
16_T178_A2.2830.88
175_L179_A2.2740.88
213_M253_A2.2600.88
188_I227_I2.2460.88
76_A222_V2.2170.87
94_M126_A2.2070.87
53_F127_A2.1840.86
68_M102_I2.1570.85
289_V297_H2.1400.85
75_I273_L2.1340.85
202_R205_S2.0470.82
191_L297_H2.0440.82
69_L73_A1.9810.80
217_T253_A1.9660.79
195_G198_Y1.9480.79
101_L123_I1.9460.79
208_T221_M1.9150.77
180_I231_Y1.9030.77
285_V293_M1.8710.76
191_L199_R1.8700.76
252_L296_A1.8690.76
53_F130_A1.8500.75
256_F260_C1.8210.74
197_L236_M1.7970.73
107_V240_V1.7650.71
12_G182_I1.7580.71
6_L61_I1.7310.70
297_H300_K1.7300.70
93_V133_I1.7270.69
60_A63_L1.7120.69
162_M165_E1.6920.68
57_G94_M1.6650.67
156_P161_G1.6530.66
23_I30_V1.6440.66
12_G231_Y1.6260.65
161_G166_A1.6110.64
115_I119_L1.5940.63
213_M217_T1.5800.62
8_G12_G1.5450.61
18_T108_A1.5290.60
9_L68_M1.5260.60
195_G227_I1.5170.59
161_G165_E1.5150.59
109_A114_R1.5000.58
263_V268_L1.4920.58
8_G185_M1.4910.58
61_I81_L1.4860.57
105_S115_I1.4850.57
248_R300_K1.4650.56
42_L45_L1.4230.54
103_I110_K1.4170.54
74_G222_V1.4040.53
56_S132_V1.3990.53
72_Y181_V1.3940.52
171_G175_L1.3760.52
252_L256_F1.3610.51
123_I167_L1.3570.50
188_I222_V1.3560.50
66_G180_I1.3550.50
57_G90_I1.3340.49
200_F203_W1.3300.49
23_I60_A1.3110.48
155_A294_A1.3000.47
128_V302_W1.3000.47
234_G260_C1.2920.47
166_A234_G1.2850.47
22_V44_R1.2770.46
97_F129_S1.2740.46
224_G257_L1.2590.45
46_I68_M1.2500.45
237_I247_K1.2440.44
289_V294_A1.2310.44
32_L102_I1.2290.44
80_T236_M1.2250.43
100_N107_V1.2230.43
60_A66_G1.2210.43
62_P91_L1.2140.43
201_S236_M1.2120.43
31_T166_A1.2000.42
163_L298_T1.1840.41
23_I77_G1.1820.41
138_H209_Q1.1770.41
106_T213_M1.1630.40
98_C130_A1.1610.40
177_L181_V1.1590.40
28_L136_I1.1590.40
43_V214_N1.1580.40
98_C253_A1.1560.40
221_M253_A1.1480.39
41_W45_L1.1460.39
118_I227_I1.1320.38
18_T257_L1.1320.38
93_V132_V1.1300.38
16_T20_G1.1300.38
49_V198_Y1.1250.38
101_L119_L1.1210.38
21_K207_F1.1170.38
136_I141_K1.1110.37
14_Q226_T1.1060.37
198_Y210_L1.1040.37
32_L145_Q1.0930.37
68_M114_R1.0920.36
85_V145_Q1.0800.36
260_C288_A1.0770.36
200_F204_L1.0730.36
20_G177_L1.0720.35
137_W278_W1.0670.35
120_A128_V1.0620.35
26_V30_V1.0610.35
222_V227_I1.0500.34
43_V219_M1.0500.34
236_M245_V1.0450.34
281_L296_A1.0420.34
204_L219_M1.0410.34
77_G250_M1.0380.34
73_A272_P1.0370.34
53_F94_M1.0280.33
126_A279_P1.0250.33
234_G256_F1.0230.33
202_R286_T1.0170.33
9_L186_I1.0160.33
278_W282_L1.0130.33
51_G128_V1.0040.32
285_V289_V1.0020.32
73_A92_A1.0000.32
22_V114_R0.9960.32
11_A223_T0.9950.32
102_I262_A0.9920.32
150_A243_D0.9910.32
130_A250_M0.9900.31
54_G134_N0.9900.31
80_T215_K0.9870.31
74_G119_L0.9780.31
31_T251_T0.9750.31
235_V254_F0.9720.31
200_F297_H0.9700.31
131_I295_I0.9660.30
52_L136_I0.9640.30
189_Q263_V0.9620.30
93_V102_I0.9600.30
256_F296_A0.9590.30
200_F230_A0.9520.30
49_V138_H0.9520.30
121_V291_L0.9450.29
28_L101_L0.9450.29
57_G236_M0.9440.29
254_F259_A0.9410.29
197_L231_Y0.9390.29
74_G192_R0.9340.29
202_R215_K0.9330.29
173_G288_A0.9300.29
67_N277_V0.9300.29
210_L213_M0.9280.29
141_K241_E0.9280.29
9_L131_I0.9240.28
167_L294_A0.9200.28
221_M251_T0.9170.28
116_G205_S0.9160.28
45_L271_I0.9160.28
234_G279_P0.9140.28
257_L292_T0.9090.28
184_L229_L0.9050.28
176_Q288_A0.9010.27
33_L233_A0.8990.27
188_I235_V0.8990.27
262_A292_T0.8970.27
79_L173_G0.8960.27
209_Q245_V0.8960.27
196_W289_V0.8890.27
121_V255_I0.8870.27
73_A220_T0.8830.27
26_V102_I0.8820.27
204_L222_V0.8820.27
213_M234_G0.8800.27
231_Y257_L0.8800.27
27_T33_L0.8800.27
78_I87_E0.8780.26
90_I94_M0.8770.26
27_T197_L0.8750.26
153_S160_L0.8730.26
129_S283_I0.8720.26
85_V88_V0.8680.26
195_G226_T0.8650.26
83_L188_I0.8610.26
76_A204_L0.8560.26
52_L290_L0.8550.26
94_M125_L0.8540.25
143_T184_L0.8530.25
192_R197_L0.8450.25
20_G107_V0.8440.25
273_L277_V0.8420.25
263_V281_L0.8400.25
110_K114_R0.8390.25
58_E191_L0.8320.25
98_C197_L0.8280.24
141_K209_Q0.8260.24
98_C199_R0.8260.24
97_F173_G0.8230.24
109_A115_I0.8150.24
204_L227_I0.8150.24
197_L257_L0.8120.24
154_A167_L0.8120.24
12_G218_S0.8110.24
223_T298_T0.8080.24
180_I246_S0.8080.24
188_I285_V0.8080.24
8_G101_L0.8060.24
199_R203_W0.8050.24
6_L10_A0.8030.23
93_V200_F0.8020.23
113_I250_M0.8010.23
233_A288_A0.8010.23
209_Q290_L0.7950.23
75_I100_N0.7890.23
92_A177_L0.7880.23
128_V290_L0.7870.23
160_L167_L0.7860.23
110_K262_A0.7850.23
40_D52_L0.7770.22
290_L294_A0.7760.22
132_V168_T0.7760.22
31_T70_N0.7700.22
68_M127_A0.7690.22
239_A243_D0.7690.22
100_N262_A0.7670.22
167_L174_V0.7670.22
289_V300_K0.7660.22
108_A249_D0.7660.22
20_G114_R0.7650.22
84_S289_V0.7630.22
180_I263_V0.7610.22
74_G227_I0.7590.22
121_V166_A0.7570.22
107_V209_Q0.7560.22
211_L249_D0.7550.22
113_I257_L0.7530.22
10_A101_L0.7530.22
254_F279_P0.7530.22
133_I262_A0.7520.22
20_G256_F0.7510.21
29_L200_F0.7500.21
127_A301_K0.7500.21
12_G197_L0.7470.21
145_Q207_F0.7410.21
165_E175_L0.7350.21
43_V213_M0.7290.21
26_V197_L0.7290.21
56_S213_M0.7240.21
289_V295_I0.7200.20
130_A278_W0.7160.20
192_R226_T0.7150.20
205_S276_P0.7110.20
298_T302_W0.7080.20
27_T75_I0.7070.20
60_A245_V0.7070.20
58_E149_I0.7070.20
12_G73_A0.7050.20
106_T115_I0.7020.20
131_I134_N0.7010.20
158_S161_G0.6990.20
210_L247_K0.6970.20
220_T272_P0.6970.20
143_T212_G0.6910.19
51_G155_A0.6880.19
156_P190_F0.6870.19
100_N245_V0.6870.19
63_L98_C0.6860.19
46_I61_I0.6850.19
200_F250_M0.6830.19
31_T35_H0.6830.19
56_S138_H0.6820.19
128_V199_R0.6820.19
73_A258_V0.6810.19
115_I134_N0.6810.19
157_D286_T0.6800.19
61_I294_A0.6780.19
240_V250_M0.6760.19
49_V133_I0.6750.19
40_D179_A0.6750.19
262_A299_W0.6720.19
15_T71_L0.6670.19
92_A147_G0.6610.18
56_S91_L0.6590.18
27_T170_A0.6580.18
24_F31_T0.6570.18
154_A157_D0.6560.18
236_M257_L0.6530.18
192_R236_M0.6520.18
119_L123_I0.6520.18
188_I296_A0.6510.18
127_A157_D0.6510.18
295_I302_W0.6510.18
71_L285_V0.6500.18
42_L82_D0.6460.18
276_P279_P0.6440.18
67_N242_D0.6440.18
15_T81_L0.6430.18
68_M269_V0.6420.18
92_A262_A0.6390.18
28_L93_V0.6360.18
59_A170_A0.6360.18
155_A290_L0.6350.18
50_M264_V0.6340.18
47_T282_L0.6330.17
112_G206_P0.6310.17
38_V47_T0.6300.17
128_V167_L0.6280.17
134_N138_H0.6270.17
227_I262_A0.6260.17
93_V129_S0.6240.17
33_L78_I0.6240.17
43_V46_I0.6200.17
223_T231_Y0.6180.17
192_R198_Y0.6160.17
214_N253_A0.6150.17
66_G69_L0.6140.17
126_A254_F0.6120.17
246_S289_V0.6120.17
20_G234_G0.6120.17
129_S137_W0.6080.17
83_L91_L0.6030.17
191_L259_A0.6020.17
169_K251_T0.6010.17
118_I262_A0.6000.16
125_L287_T0.5990.16
33_L83_L0.5940.16
161_G164_A0.5930.16
137_W282_L0.5900.16
209_Q215_K0.5890.16
121_V252_L0.5890.16
6_L148_F0.5890.16
219_M250_M0.5890.16
47_T149_I0.5880.16
31_T170_A0.5870.16
171_G301_K0.5860.16
6_L247_K0.5850.16
141_K174_V0.5830.16
53_F56_S0.5830.16
160_L164_A0.5800.16
82_D154_A0.5780.16
184_L237_I0.5770.16
218_S286_T0.5760.16
76_A219_M0.5750.16
17_W79_L0.5750.16
106_T253_A0.5740.16
11_A195_G0.5730.16
82_D190_F0.5730.16
132_V164_A0.5720.16
186_I203_W0.5720.16
16_T26_V0.5720.16
85_V140_G0.5690.16
225_L271_I0.5690.16
161_G190_F0.5680.16
166_A300_K0.5680.16
10_A56_S0.5670.16
43_V164_A0.5670.16
73_A201_S0.5670.16
68_M231_Y0.5660.15
15_T18_T0.5660.15
120_A160_L0.5650.15
22_V138_H0.5630.15
81_L250_M0.5620.15
57_G276_P0.5620.15
22_V93_V0.5620.15
116_G124_G0.5620.15
73_A105_S0.5610.15
56_S204_L0.5610.15
123_I207_F0.5600.15
250_M254_F0.5590.15
20_G24_F0.5590.15
103_I204_L0.5590.15
171_G300_K0.5590.15
170_A211_L0.5560.15
275_I280_L0.5550.15
62_P78_I0.5540.15
77_G223_T0.5530.15
59_A62_P0.5530.15
19_L267_T0.5520.15
204_L226_T0.5520.15
131_I300_K0.5520.15
21_K238_K0.5510.15
254_F281_L0.5490.15
21_K150_A0.5480.15
46_I200_F0.5480.15
233_A256_F0.5460.15
210_L217_T0.5450.15
129_S262_A0.5440.15
9_L290_L0.5440.15
173_G256_F0.5440.15
98_C233_A0.5430.15
170_A257_L0.5430.15
217_T243_D0.5430.15
144_A280_L0.5420.15
157_D298_T0.5410.15
6_L134_N0.5410.15
124_G295_I0.5380.15
138_H264_V0.5370.15
205_S214_N0.5350.15
19_L180_I0.5350.15
78_I88_V0.5340.15
75_I88_V0.5340.15
235_V250_M0.5320.15
180_I287_T0.5290.14
68_M229_L0.5270.14
37_P262_A0.5250.14
30_V226_T0.5240.14
68_M120_A0.5240.14
71_L95_L0.5240.14
165_E294_A0.5220.14
32_L289_V0.5210.14
68_M187_I0.5210.14
67_N181_V0.5190.14
46_I56_S0.5180.14
167_L175_L0.5160.14
141_K150_A0.5160.14
128_V286_T0.5160.14
93_V100_N0.5140.14
123_I264_V0.5110.14
111_V227_I0.5100.14
279_P283_I0.5100.14
150_A155_A0.5090.14
57_G197_L0.5090.14
130_A292_T0.5070.14
7_A52_L0.5050.14
29_L102_I0.5050.14
34_Q191_L0.5040.14
201_S218_S0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd6A 3 0.8558 96.6 0.936 Contact Map
4r1iA 2 0.6506 15.9 0.974 Contact Map
4r0cA 3 0.6122 14.6 0.974 Contact Map
3w9iA 3 0.4551 4.9 0.979 Contact Map
2gfpA 2 0.391 4.8 0.979 Contact Map
2nwlA 3 0.5288 3.4 0.981 Contact Map
1jb0K 1 0.1314 3.4 0.981 Contact Map
2m20A 2 0.1218 3.2 0.981 Contact Map
4kt0K 1 0.1538 2.8 0.982 Contact Map
4gxbB 1 0.0032 2.6 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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