GREMLIN Database
YBCI - Uncharacterized protein YbcI
UniProt: O34380 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 124 (117)
Sequences: 140 (97)
Seq/√Len: 9.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_D118_K3.1560.93
33_T58_S2.9610.90
10_S38_D2.6590.84
16_I55_V2.4100.77
95_F108_M2.4090.77
73_V95_F2.3290.75
23_Y38_D2.3210.74
77_I81_K2.2650.73
10_S40_I2.1610.69
100_S103_T2.1350.68
34_D37_R2.1010.67
38_D43_N2.0990.66
55_V101_S1.8870.58
18_Q22_D1.8070.54
94_S100_S1.7540.52
17_T31_V1.7510.52
58_S70_S1.7390.51
57_G67_Q1.7340.51
19_W43_N1.5760.44
112_L120_L1.5670.44
73_V108_M1.4920.41
66_K104_G1.4860.41
107_V119_N1.4590.39
19_W34_D1.4340.38
97_T106_R1.4310.38
49_T96_H1.4280.38
4_S7_S1.4190.38
55_V77_I1.4150.38
8_I102_R1.3930.37
8_I16_I1.3690.36
18_Q65_I1.3670.36
39_M92_V1.3490.35
33_T70_S1.3400.35
79_G107_V1.3400.35
22_D45_K1.3250.34
116_L120_L1.3030.33
84_I87_I1.3020.33
16_I71_E1.2870.33
58_S86_K1.2730.32
81_K94_S1.2730.32
8_I85_L1.2580.31
14_K111_K1.2420.31
17_T24_L1.2250.30
45_K56_C1.2180.30
82_D86_K1.2140.30
12_I84_I1.2090.30
40_I87_I1.1900.29
13_S108_M1.1530.28
6_G44_L1.1480.28
96_H100_S1.1470.27
67_Q102_R1.1330.27
11_E83_I1.1280.27
64_S108_M1.1140.26
22_D79_G1.1130.26
96_H99_L1.0790.25
18_Q34_D1.0690.25
51_A73_V1.0670.25
11_E53_Y1.0640.25
74_E100_S1.0600.25
21_K110_F1.0530.24
23_Y97_T1.0520.24
22_D43_N1.0440.24
5_K50_P1.0290.24
15_S45_K1.0250.23
30_S56_C1.0210.23
20_E23_Y1.0190.23
22_D65_I1.0160.23
39_M87_I1.0100.23
20_E108_M1.0070.23
43_N62_M1.0000.23
47_I109_V0.9990.23
6_G20_E0.9910.22
33_T74_E0.9860.22
55_V71_E0.9830.22
116_L119_N0.9790.22
10_S101_S0.9770.22
8_I79_G0.9630.22
11_E14_K0.9470.21
51_A95_F0.9370.21
65_I68_T0.9320.21
94_S103_T0.9290.21
21_K32_K0.9120.20
51_A110_F0.9060.20
60_E96_H0.9010.20
17_T30_S0.8870.19
56_C77_I0.8660.19
88_T116_L0.8550.19
44_L50_P0.8540.19
35_I40_I0.8500.18
84_I119_N0.8310.18
24_L75_S0.8300.18
88_T110_F0.8260.18
81_K86_K0.8130.17
33_T71_E0.8090.17
79_G96_H0.8080.17
14_K19_W0.8060.17
40_I54_V0.8040.17
89_G106_R0.7960.17
6_G76_G0.7890.17
36_L53_Y0.7880.17
63_L88_T0.7500.16
41_I83_I0.7460.16
38_D91_K0.7450.16
91_K113_C0.7420.16
28_S53_Y0.7400.16
31_V64_S0.7340.16
11_E41_I0.7240.15
8_I87_I0.7220.15
18_Q71_E0.7210.15
93_K113_C0.7120.15
18_Q58_S0.7080.15
17_T106_R0.7080.15
16_I80_L0.7050.15
54_V96_H0.7050.15
65_I82_D0.7040.15
20_E51_A0.7030.15
24_L63_L0.6770.14
99_L115_D0.6680.14
19_W63_L0.6550.14
46_G107_V0.6470.14
69_R98_D0.6430.14
51_A112_L0.6430.14
59_K99_L0.6410.14
35_I116_L0.6330.13
79_G83_I0.6260.13
14_K22_D0.6230.13
18_Q70_S0.6220.13
98_D104_G0.6130.13
43_N67_Q0.6120.13
60_E67_Q0.6120.13
39_M111_K0.6120.13
21_K28_S0.6090.13
33_T46_G0.6090.13
29_V120_L0.6030.13
58_S85_L0.6000.13
28_S64_S0.5950.13
40_I84_I0.5950.13
44_L76_G0.5930.13
26_R98_D0.5920.13
51_A106_R0.5860.12
56_C85_L0.5840.12
92_V107_V0.5820.12
58_S118_K0.5820.12
60_E84_I0.5810.12
43_N79_G0.5810.12
14_K18_Q0.5800.12
27_G98_D0.5800.12
18_Q68_T0.5760.12
66_K74_E0.5730.12
40_I91_K0.5700.12
17_T75_S0.5700.12
6_G51_A0.5610.12
35_I65_I0.5540.12
46_G106_R0.5520.12
17_T51_A0.5520.12
74_E104_G0.5510.12
17_T73_V0.5500.12
64_S68_T0.5460.12
79_G111_K0.5400.12
12_I35_I0.5330.12
57_G60_E0.5330.12
36_L56_C0.5290.11
51_A80_L0.5250.11
17_T95_F0.5230.11
18_Q38_D0.5220.11
47_I110_F0.5210.11
83_I109_V0.5210.11
20_E80_L0.5200.11
90_E95_F0.5200.11
49_T110_F0.5170.11
90_E93_K0.5120.11
17_T110_F0.5120.11
32_K35_I0.5040.11
112_L119_N0.5040.11
78_E117_E0.5020.11
34_D106_R0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qq8A 1 0.7742 21 0.946 Contact Map
2j85A 2 0.75 9.7 0.953 Contact Map
1avyA 3 0.4113 8.9 0.954 Contact Map
2bsgA 3 0.3871 5.2 0.959 Contact Map
2nz7A 2 0.5161 4.8 0.959 Contact Map
1vlcA 2 0.3871 4 0.961 Contact Map
3t98A 4 0.121 3.9 0.961 Contact Map
3tejA 1 0.4516 3.6 0.962 Contact Map
4j3hA 4 0.1452 3.5 0.962 Contact Map
3crdA 1 0.621 3.4 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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