YTEU - BACSU - GREMLIN Contacts

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YTEU - Uncharacterized protein YteU

UniProt:	O34378	Sequences: MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPATAALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPSHFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTMLALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFYPETR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	222 (193)
Sequences:	1123 (1022)
Seq/√Len:	73.6

BACSU - YTEU YESL YESV

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
27_W	44_T	7.423	1.00
30_F	67_F	3.977	1.00
126_Y	156_T	3.837	1.00
42_P	79_N	3.755	1.00
30_F	68_W	3.569	1.00
47_L	186_S	3.275	1.00
36_G	39_G	2.765	1.00
89_G	120_F	2.634	1.00
49_A	70_E	2.427	1.00
27_W	47_L	2.375	1.00
27_W	182_V	2.338	1.00
93_Y	97_A	2.318	1.00
81_L	127_V	2.316	1.00
79_N	82_G	2.235	1.00
31_T	39_G	2.231	1.00
41_M	82_G	2.206	1.00
45_A	78_S	2.107	1.00
134_F	201_E	2.101	1.00
13_F	17_I	2.077	1.00
122_S	149_S	2.020	1.00
20_F	183_S	1.909	1.00
24_N	183_S	1.904	1.00
75_F	79_N	1.871	1.00
39_G	79_N	1.858	1.00
137_K	140_L	1.836	1.00
32_L	36_G	1.831	1.00
91_I	95_D	1.822	1.00
31_T	36_G	1.798	1.00
31_T	40_I	1.752	1.00
20_F	187_Y	1.732	1.00
64_L	68_W	1.721	1.00
85_L	127_V	1.718	1.00
85_L	123_M	1.704	1.00
39_G	42_P	1.679	1.00
123_M	146_L	1.659	1.00
70_E	74_E	1.647	1.00
8_G	11_L	1.631	1.00
22_Y	64_L	1.630	1.00
136_W	141_Y	1.591	0.99
23_T	47_L	1.553	0.99
52_R	133_H	1.505	0.99
9_R	12_R	1.477	0.99
30_F	71_Y	1.475	0.99
15_E	19_R	1.442	0.99
155_Y	195_A	1.420	0.99
85_L	124_L	1.402	0.99
152_Y	200_V	1.360	0.98
62_P	65_K	1.333	0.98
133_H	201_E	1.319	0.98
16_W	19_R	1.313	0.98
143_K	147_L	1.304	0.98
75_F	78_S	1.261	0.97
48_F	190_M	1.256	0.97
47_L	182_V	1.255	0.97
30_F	43_A	1.243	0.97
38_F	75_F	1.239	0.97
24_N	182_V	1.235	0.97
122_S	156_T	1.229	0.97
77_R	135_D	1.226	0.96
21_A	180_F	1.220	0.96
81_L	131_L	1.205	0.96
42_P	82_G	1.204	0.96
42_P	71_Y	1.190	0.96
163_T	189_H	1.188	0.96
69_Q	73_G	1.188	0.96
52_R	190_M	1.177	0.96
91_I	98_L	1.169	0.95
30_F	72_K	1.158	0.95
45_A	74_E	1.146	0.95
24_N	28_L	1.144	0.95
80_L	138_K	1.137	0.95
49_A	53_K	1.134	0.95
92_I	120_F	1.129	0.94
136_W	144_F	1.124	0.94
48_F	186_S	1.123	0.94
50_V	54_W	1.120	0.94
78_S	81_L	1.105	0.94
76_F	80_L	1.104	0.94
56_Q	194_Y	1.091	0.93
38_F	83_A	1.090	0.93
127_V	142_V	1.089	0.93
81_L	138_K	1.084	0.93
89_G	92_I	1.076	0.93
53_K	58_Q	1.074	0.93
22_Y	26_L	1.065	0.93
48_F	129_P	1.060	0.92
159_M	192_I	1.047	0.92
129_P	197_L	1.043	0.92
134_F	197_L	1.037	0.91
134_F	200_V	1.034	0.91
62_P	66_T	1.032	0.91
51_M	190_M	1.018	0.91
27_W	31_T	1.009	0.90
152_Y	196_V	1.009	0.90
126_Y	129_P	1.008	0.90
182_V	186_S	1.003	0.90
27_W	67_F	0.994	0.90
95_D	113_I	0.993	0.90
152_Y	199_K	0.976	0.89
42_P	45_A	0.975	0.89
18_M	21_A	0.973	0.89
85_L	128_F	0.968	0.88
43_A	71_Y	0.965	0.88
45_A	131_L	0.945	0.87
10_M	14_C	0.942	0.87
48_F	193_V	0.942	0.87
46_A	70_E	0.941	0.87
82_G	128_F	0.935	0.87
40_I	182_V	0.931	0.86
78_S	82_G	0.929	0.86
11_L	15_E	0.929	0.86
27_W	30_F	0.926	0.86
130_L	144_F	0.923	0.86
36_G	79_N	0.912	0.85
31_T	37_V	0.909	0.85
47_L	51_M	0.898	0.84
163_T	167_F	0.896	0.84
8_G	15_E	0.885	0.83
39_G	71_Y	0.884	0.83
118_F	121_V	0.875	0.83
11_L	14_C	0.874	0.83
52_R	132_V	0.872	0.83
92_I	116_F	0.867	0.82
19_R	22_Y	0.865	0.82
7_L	15_E	0.863	0.82
79_N	131_L	0.857	0.81
49_A	132_V	0.854	0.81
159_M	193_V	0.846	0.81
71_Y	75_F	0.844	0.80
95_D	99_I	0.836	0.80
167_F	171_A	0.834	0.80
84_V	142_V	0.828	0.79
26_L	31_T	0.826	0.79
88_I	92_I	0.818	0.78
175_G	178_P	0.817	0.78
23_T	126_Y	0.814	0.78
51_M	186_S	0.810	0.78
39_G	83_A	0.808	0.77
31_T	79_N	0.807	0.77
51_M	54_W	0.803	0.77
53_K	70_E	0.800	0.77
20_F	24_N	0.799	0.77
89_G	124_L	0.792	0.76
124_L	128_F	0.789	0.76
41_M	78_S	0.779	0.75
97_A	101_P	0.775	0.74
36_G	71_Y	0.766	0.74
11_L	99_I	0.766	0.74
55_I	58_Q	0.764	0.73
140_L	143_K	0.757	0.73
164_V	167_F	0.754	0.72
186_S	190_M	0.750	0.72
23_T	51_M	0.748	0.72
48_F	189_H	0.747	0.72
71_Y	79_N	0.740	0.71
188_C	191_R	0.738	0.71
155_Y	192_I	0.736	0.71
7_L	19_R	0.736	0.71
88_I	120_F	0.733	0.70
24_N	82_G	0.729	0.70
37_V	86_A	0.721	0.69
136_W	140_L	0.716	0.69
51_M	187_Y	0.714	0.68
67_F	127_V	0.709	0.68
111_F	115_I	0.709	0.68
38_F	79_N	0.708	0.68
141_Y	145_S	0.698	0.67
24_N	181_S	0.694	0.66
162_L	188_C	0.694	0.66
16_W	54_W	0.690	0.66
44_T	52_R	0.686	0.65
56_Q	134_F	0.684	0.65
120_F	124_L	0.683	0.65
31_T	42_P	0.683	0.65
17_I	95_D	0.683	0.65
32_L	105_L	0.682	0.65
19_R	54_W	0.679	0.64
66_T	70_E	0.679	0.64
170_L	177_V	0.674	0.64
98_L	143_K	0.673	0.64
82_G	86_A	0.667	0.63
123_M	129_P	0.665	0.63
152_Y	155_Y	0.665	0.63
126_Y	197_L	0.662	0.62
20_F	182_V	0.659	0.62
100_Y	103_H	0.658	0.62
53_K	133_H	0.657	0.62
106_L	118_F	0.657	0.62
65_K	158_T	0.656	0.62
13_F	28_L	0.647	0.61
26_L	68_W	0.641	0.60
74_E	77_R	0.638	0.60
107_H	142_V	0.638	0.60
123_M	142_V	0.633	0.59
148_L	200_V	0.632	0.59
32_L	82_G	0.632	0.59
65_K	69_Q	0.628	0.58
79_N	141_Y	0.627	0.58
155_Y	187_Y	0.619	0.57
132_V	136_W	0.619	0.57
20_F	51_M	0.617	0.57
70_E	131_L	0.614	0.57
6_S	63_V	0.614	0.57
138_K	141_Y	0.610	0.56
77_R	80_L	0.609	0.56
66_T	147_L	0.609	0.56
29_F	199_K	0.609	0.56
146_L	158_T	0.606	0.56
27_W	48_F	0.599	0.55
194_Y	198_L	0.599	0.55
20_F	166_L	0.599	0.55
52_R	56_Q	0.598	0.55
121_V	160_L	0.597	0.55
68_W	72_K	0.592	0.54
55_I	187_Y	0.589	0.54
14_C	23_T	0.589	0.54
40_I	82_G	0.588	0.54
80_L	84_V	0.588	0.54
130_L	136_W	0.588	0.54
38_F	161_A	0.582	0.53
121_V	199_K	0.579	0.52
135_D	164_V	0.579	0.52
50_V	70_E	0.577	0.52
65_K	68_W	0.575	0.52
105_L	108_I	0.574	0.52
53_K	61_V	0.574	0.52
43_A	46_A	0.573	0.52
131_L	196_V	0.573	0.52
70_E	73_G	0.572	0.52
51_M	55_I	0.570	0.51
153_L	157_L	0.569	0.51
196_V	200_V	0.568	0.51
26_L	63_V	0.566	0.51
158_T	161_A	0.565	0.51
129_P	190_M	0.565	0.51
140_L	145_S	0.561	0.50
99_I	103_H	0.559	0.50
165_A	174_P	0.557	0.50
19_R	39_G	0.556	0.50
78_S	131_L	0.556	0.50
144_F	148_L	0.556	0.50
115_I	134_F	0.555	0.49
30_F	39_G	0.553	0.49
164_V	171_A	0.552	0.49
22_Y	126_Y	0.552	0.49
166_L	181_S	0.551	0.49
144_F	147_L	0.550	0.49
135_D	138_K	0.550	0.49
162_L	177_V	0.550	0.49
165_A	178_P	0.549	0.49
12_R	124_L	0.549	0.49
101_P	119_L	0.546	0.48
50_V	66_T	0.544	0.48
117_G	121_V	0.540	0.48
114_M	118_F	0.539	0.47
109_L	169_L	0.539	0.47
63_V	81_L	0.537	0.47
27_W	186_S	0.536	0.47
159_M	189_H	0.536	0.47
157_L	161_A	0.536	0.47
74_E	134_F	0.534	0.47
127_V	141_Y	0.533	0.47
182_V	187_Y	0.533	0.47
95_D	201_E	0.532	0.47
97_A	100_Y	0.532	0.47
158_T	192_I	0.530	0.46
110_R	148_L	0.530	0.46
111_F	114_M	0.529	0.46
53_K	66_T	0.529	0.46
42_P	61_V	0.528	0.46
137_K	141_Y	0.528	0.46
41_M	133_H	0.528	0.46
29_F	185_I	0.527	0.46
62_P	129_P	0.526	0.46
145_S	183_S	0.526	0.46
30_F	42_P	0.521	0.45
89_G	128_F	0.519	0.45
18_M	98_L	0.517	0.45
45_A	70_E	0.516	0.45
163_T	185_I	0.516	0.45
147_L	172_Y	0.516	0.45
122_S	160_L	0.511	0.44
125_F	169_L	0.511	0.44
166_L	185_I	0.510	0.44
58_Q	67_F	0.508	0.44
198_L	201_E	0.508	0.44
48_F	52_R	0.506	0.43
22_Y	25_L	0.503	0.43
96_L	150_V	0.503	0.43
96_L	110_R	0.500	0.43

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3giaA	1	0.8198	69	0.919	Contact Map
3wdoA	1	0.9414	36.1	0.934	Contact Map
2cfqA	1	0.9054	35.2	0.934	Contact Map
4pypA	1	0.8333	35	0.934	Contact Map
2zy9A	2	0.7117	32.6	0.935	Contact Map
4djkA	2	0.8468	32.2	0.935	Contact Map
4tphA	2	0.7523	32.2	0.935	Contact Map
3effK	4	0.5315	27.8	0.937	Contact Map
4h33A	3	0.3649	25.1	0.939	Contact Map
4j05A	3	0.8559	21.3	0.941	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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