GREMLIN Database
YTEU - Uncharacterized protein YteU
UniProt: O34378 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 222 (193)
Sequences: 1123 (1022)
Seq/√Len: 73.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_W44_T7.4231.00
30_F67_F3.9771.00
126_Y156_T3.8371.00
42_P79_N3.7551.00
30_F68_W3.5691.00
47_L186_S3.2751.00
36_G39_G2.7651.00
89_G120_F2.6341.00
49_A70_E2.4271.00
27_W47_L2.3751.00
27_W182_V2.3381.00
93_Y97_A2.3181.00
81_L127_V2.3161.00
79_N82_G2.2351.00
31_T39_G2.2311.00
41_M82_G2.2061.00
45_A78_S2.1071.00
134_F201_E2.1011.00
13_F17_I2.0771.00
122_S149_S2.0201.00
20_F183_S1.9091.00
24_N183_S1.9041.00
75_F79_N1.8711.00
39_G79_N1.8581.00
137_K140_L1.8361.00
32_L36_G1.8311.00
91_I95_D1.8221.00
31_T36_G1.7981.00
31_T40_I1.7521.00
20_F187_Y1.7321.00
64_L68_W1.7211.00
85_L127_V1.7181.00
85_L123_M1.7041.00
39_G42_P1.6791.00
123_M146_L1.6591.00
70_E74_E1.6471.00
8_G11_L1.6311.00
22_Y64_L1.6301.00
136_W141_Y1.5910.99
23_T47_L1.5530.99
52_R133_H1.5050.99
9_R12_R1.4770.99
30_F71_Y1.4750.99
15_E19_R1.4420.99
155_Y195_A1.4200.99
85_L124_L1.4020.99
152_Y200_V1.3600.98
62_P65_K1.3330.98
133_H201_E1.3190.98
16_W19_R1.3130.98
143_K147_L1.3040.98
75_F78_S1.2610.97
48_F190_M1.2560.97
47_L182_V1.2550.97
30_F43_A1.2430.97
38_F75_F1.2390.97
24_N182_V1.2350.97
122_S156_T1.2290.97
77_R135_D1.2260.96
21_A180_F1.2200.96
81_L131_L1.2050.96
42_P82_G1.2040.96
42_P71_Y1.1900.96
163_T189_H1.1880.96
69_Q73_G1.1880.96
52_R190_M1.1770.96
91_I98_L1.1690.95
30_F72_K1.1580.95
45_A74_E1.1460.95
24_N28_L1.1440.95
80_L138_K1.1370.95
49_A53_K1.1340.95
92_I120_F1.1290.94
136_W144_F1.1240.94
48_F186_S1.1230.94
50_V54_W1.1200.94
78_S81_L1.1050.94
76_F80_L1.1040.94
56_Q194_Y1.0910.93
38_F83_A1.0900.93
127_V142_V1.0890.93
81_L138_K1.0840.93
89_G92_I1.0760.93
53_K58_Q1.0740.93
22_Y26_L1.0650.93
48_F129_P1.0600.92
159_M192_I1.0470.92
129_P197_L1.0430.92
134_F197_L1.0370.91
134_F200_V1.0340.91
62_P66_T1.0320.91
51_M190_M1.0180.91
27_W31_T1.0090.90
152_Y196_V1.0090.90
126_Y129_P1.0080.90
182_V186_S1.0030.90
27_W67_F0.9940.90
95_D113_I0.9930.90
152_Y199_K0.9760.89
42_P45_A0.9750.89
18_M21_A0.9730.89
85_L128_F0.9680.88
43_A71_Y0.9650.88
45_A131_L0.9450.87
10_M14_C0.9420.87
48_F193_V0.9420.87
46_A70_E0.9410.87
82_G128_F0.9350.87
40_I182_V0.9310.86
78_S82_G0.9290.86
11_L15_E0.9290.86
27_W30_F0.9260.86
130_L144_F0.9230.86
36_G79_N0.9120.85
31_T37_V0.9090.85
47_L51_M0.8980.84
163_T167_F0.8960.84
8_G15_E0.8850.83
39_G71_Y0.8840.83
118_F121_V0.8750.83
11_L14_C0.8740.83
52_R132_V0.8720.83
92_I116_F0.8670.82
19_R22_Y0.8650.82
7_L15_E0.8630.82
79_N131_L0.8570.81
49_A132_V0.8540.81
159_M193_V0.8460.81
71_Y75_F0.8440.80
95_D99_I0.8360.80
167_F171_A0.8340.80
84_V142_V0.8280.79
26_L31_T0.8260.79
88_I92_I0.8180.78
175_G178_P0.8170.78
23_T126_Y0.8140.78
51_M186_S0.8100.78
39_G83_A0.8080.77
31_T79_N0.8070.77
51_M54_W0.8030.77
53_K70_E0.8000.77
20_F24_N0.7990.77
89_G124_L0.7920.76
124_L128_F0.7890.76
41_M78_S0.7790.75
97_A101_P0.7750.74
36_G71_Y0.7660.74
11_L99_I0.7660.74
55_I58_Q0.7640.73
140_L143_K0.7570.73
164_V167_F0.7540.72
186_S190_M0.7500.72
23_T51_M0.7480.72
48_F189_H0.7470.72
71_Y79_N0.7400.71
188_C191_R0.7380.71
155_Y192_I0.7360.71
7_L19_R0.7360.71
88_I120_F0.7330.70
24_N82_G0.7290.70
37_V86_A0.7210.69
136_W140_L0.7160.69
51_M187_Y0.7140.68
67_F127_V0.7090.68
111_F115_I0.7090.68
38_F79_N0.7080.68
141_Y145_S0.6980.67
24_N181_S0.6940.66
162_L188_C0.6940.66
16_W54_W0.6900.66
44_T52_R0.6860.65
56_Q134_F0.6840.65
120_F124_L0.6830.65
31_T42_P0.6830.65
17_I95_D0.6830.65
32_L105_L0.6820.65
19_R54_W0.6790.64
66_T70_E0.6790.64
170_L177_V0.6740.64
98_L143_K0.6730.64
82_G86_A0.6670.63
123_M129_P0.6650.63
152_Y155_Y0.6650.63
126_Y197_L0.6620.62
20_F182_V0.6590.62
100_Y103_H0.6580.62
53_K133_H0.6570.62
106_L118_F0.6570.62
65_K158_T0.6560.62
13_F28_L0.6470.61
26_L68_W0.6410.60
74_E77_R0.6380.60
107_H142_V0.6380.60
123_M142_V0.6330.59
148_L200_V0.6320.59
32_L82_G0.6320.59
65_K69_Q0.6280.58
79_N141_Y0.6270.58
155_Y187_Y0.6190.57
132_V136_W0.6190.57
20_F51_M0.6170.57
70_E131_L0.6140.57
6_S63_V0.6140.57
138_K141_Y0.6100.56
77_R80_L0.6090.56
66_T147_L0.6090.56
29_F199_K0.6090.56
146_L158_T0.6060.56
27_W48_F0.5990.55
194_Y198_L0.5990.55
20_F166_L0.5990.55
52_R56_Q0.5980.55
121_V160_L0.5970.55
68_W72_K0.5920.54
55_I187_Y0.5890.54
14_C23_T0.5890.54
40_I82_G0.5880.54
80_L84_V0.5880.54
130_L136_W0.5880.54
38_F161_A0.5820.53
121_V199_K0.5790.52
135_D164_V0.5790.52
50_V70_E0.5770.52
65_K68_W0.5750.52
105_L108_I0.5740.52
53_K61_V0.5740.52
43_A46_A0.5730.52
131_L196_V0.5730.52
70_E73_G0.5720.52
51_M55_I0.5700.51
153_L157_L0.5690.51
196_V200_V0.5680.51
26_L63_V0.5660.51
158_T161_A0.5650.51
129_P190_M0.5650.51
140_L145_S0.5610.50
99_I103_H0.5590.50
165_A174_P0.5570.50
19_R39_G0.5560.50
78_S131_L0.5560.50
144_F148_L0.5560.50
115_I134_F0.5550.49
30_F39_G0.5530.49
164_V171_A0.5520.49
22_Y126_Y0.5520.49
166_L181_S0.5510.49
144_F147_L0.5500.49
135_D138_K0.5500.49
162_L177_V0.5500.49
165_A178_P0.5490.49
12_R124_L0.5490.49
101_P119_L0.5460.48
50_V66_T0.5440.48
117_G121_V0.5400.48
114_M118_F0.5390.47
109_L169_L0.5390.47
63_V81_L0.5370.47
27_W186_S0.5360.47
159_M189_H0.5360.47
157_L161_A0.5360.47
74_E134_F0.5340.47
127_V141_Y0.5330.47
182_V187_Y0.5330.47
95_D201_E0.5320.47
97_A100_Y0.5320.47
158_T192_I0.5300.46
110_R148_L0.5300.46
111_F114_M0.5290.46
53_K66_T0.5290.46
42_P61_V0.5280.46
137_K141_Y0.5280.46
41_M133_H0.5280.46
29_F185_I0.5270.46
62_P129_P0.5260.46
145_S183_S0.5260.46
30_F42_P0.5210.45
89_G128_F0.5190.45
18_M98_L0.5170.45
45_A70_E0.5160.45
163_T185_I0.5160.45
147_L172_Y0.5160.45
122_S160_L0.5110.44
125_F169_L0.5110.44
166_L185_I0.5100.44
58_Q67_F0.5080.44
198_L201_E0.5080.44
48_F52_R0.5060.43
22_Y25_L0.5030.43
96_L150_V0.5030.43
96_L110_R0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3giaA 1 0.8198 69 0.919 Contact Map
3wdoA 1 0.9414 36.1 0.934 Contact Map
2cfqA 1 0.9054 35.2 0.934 Contact Map
4pypA 1 0.8333 35 0.934 Contact Map
2zy9A 2 0.7117 32.6 0.935 Contact Map
4djkA 2 0.8468 32.2 0.935 Contact Map
4tphA 2 0.7523 32.2 0.935 Contact Map
3effK 4 0.5315 27.8 0.937 Contact Map
4h33A 3 0.3649 25.1 0.939 Contact Map
4j05A 3 0.8559 21.3 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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