GREMLIN Database
YOBR - Uncharacterized N-acetyltransferase YobR
UniProt: O34376 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 247 (234)
Sequences: 945 (739)
Seq/√Len: 48.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_E88_Y4.9171.00
172_V179_G4.5971.00
179_G207_A3.8881.00
197_T232_K3.7841.00
36_K92_D3.0161.00
170_G184_I3.0041.00
237_P240_E2.9131.00
80_D244_R2.9081.00
19_F63_L2.8301.00
180_G216_F2.7301.00
168_A186_V2.7231.00
84_A244_R2.6901.00
95_F237_P2.6351.00
97_M231_G2.6001.00
168_A195_A2.5041.00
167_T190_H2.4861.00
97_M227_V2.4841.00
53_Q69_F2.4041.00
226_A230_Y2.3621.00
217_L230_Y2.3571.00
80_D242_H2.3511.00
156_T206_W2.3341.00
170_G203_L2.2841.00
158_F203_L2.2651.00
215_M235_F2.1921.00
36_K91_V2.1911.00
177_G213_E2.1801.00
181_L200_I2.1261.00
204_T215_M2.1041.00
54_L86_S2.0651.00
30_A59_F2.0641.00
101_C215_M2.0571.00
82_A85_D2.0131.00
60_Y65_L1.9360.99
57_E86_S1.8950.99
23_I28_L1.8790.99
31_N38_A1.8220.99
30_A65_L1.8120.99
95_F221_K1.8060.99
36_K220_M1.7470.99
181_L184_I1.7220.98
124_S128_D1.6950.98
58_L62_S1.6310.98
204_T235_F1.6090.98
41_V56_A1.6040.97
37_R223_N1.6000.97
200_I233_I1.5770.97
179_G204_T1.5630.97
35_T38_A1.5500.97
144_Y148_F1.5120.96
223_N226_A1.4730.96
61_Q67_V1.4670.96
94_C221_K1.4600.96
98_T238_I1.4440.95
93_E221_K1.4140.95
80_D84_A1.4040.94
167_T195_A1.3590.93
100_L208_K1.3560.93
160_M199_V1.3420.93
13_A175_I1.3350.93
190_H193_K1.3240.93
57_E67_V1.3170.92
118_W156_T1.3140.92
11_A216_F1.3140.92
182_S186_V1.3070.92
184_I200_I1.2880.91
192_G228_S1.2820.91
51_D54_L1.2820.91
93_E240_E1.2720.91
206_W212_A1.2690.91
107_R193_K1.2610.91
97_M237_P1.2600.91
95_F227_V1.2360.90
24_G45_A1.2300.89
100_L214_R1.2230.89
42_W70_H1.2130.89
41_V69_F1.2110.89
178_Y216_F1.2000.88
144_Y150_R1.1840.88
113_R118_W1.1810.87
197_T229_L1.1680.87
170_G230_Y1.1570.86
184_I233_I1.1560.86
8_E72_S1.1430.86
221_K240_E1.1400.86
134_E185_V1.1360.85
156_T160_M1.1220.85
28_L56_A1.1090.84
99_A204_T1.1050.84
172_V207_A1.1030.84
14_S216_F1.1000.83
228_S231_G1.0980.83
229_L232_K1.0970.83
35_T39_N1.0950.83
172_V203_L1.0910.83
223_N241_H1.0870.83
90_K93_E1.0870.83
72_S76_P1.0800.82
15_W35_T1.0770.82
225_A228_S1.0580.81
10_L41_V1.0550.81
154_C210_N1.0480.80
41_V49_E1.0460.80
123_S159_K1.0380.80
41_V52_F1.0330.79
24_G52_F1.0210.79
184_I196_G1.0120.78
50_G86_S1.0050.77
156_T172_V0.9960.77
186_V195_A0.9930.77
162_D193_K0.9920.77
92_D220_M0.9900.76
23_I55_E0.9900.76
99_A104_I0.9850.76
68_C245_I0.9840.76
196_G203_L0.9790.76
202_V205_E0.9790.76
84_A150_R0.9760.75
9_R13_A0.9630.74
93_E237_P0.9550.74
138_P143_G0.9320.72
223_N230_Y0.9250.71
13_A173_S0.9200.71
5_R9_R0.9200.71
227_V231_G0.9190.71
145_K150_R0.9170.71
192_G198_Q0.9160.71
103_S236_S0.9160.71
173_S216_F0.9140.70
47_M51_D0.9030.69
219_V226_A0.9010.69
178_Y214_R0.8990.69
11_A218_Q0.8890.68
55_E58_L0.8870.68
16_P206_W0.8830.68
54_L58_L0.8790.67
45_A52_F0.8780.67
130_F169_L0.8750.67
19_F65_L0.8740.67
104_I204_T0.8730.67
223_N229_L0.8690.66
92_D243_Y0.8670.66
12_A20_Q0.8650.66
165_S189_E0.8590.66
145_K149_E0.8580.65
219_V223_N0.8560.65
36_K68_C0.8470.64
59_F63_L0.8460.64
115_T118_W0.8450.64
118_W158_F0.8430.64
112_S115_T0.8410.64
91_V245_I0.8390.64
12_A17_A0.8320.63
50_G107_R0.8250.62
79_L243_Y0.8230.62
49_E52_F0.8180.62
10_L178_Y0.8170.62
18_Y32_F0.8080.61
94_C199_V0.8060.61
11_A180_G0.7920.59
170_G199_V0.7840.58
82_A86_S0.7820.58
49_E86_S0.7810.58
48_P82_A0.7800.58
159_K165_S0.7760.58
168_A175_I0.7740.57
101_C208_K0.7680.57
186_V199_V0.7640.56
195_A202_V0.7620.56
142_K146_H0.7610.56
158_F199_V0.7570.56
118_W192_G0.7540.56
190_H195_A0.7520.55
30_A63_L0.7510.55
25_K45_A0.7510.55
38_A151_M0.7510.55
21_K62_S0.7500.55
15_W37_R0.7490.55
18_Y31_N0.7460.55
94_C241_H0.7450.55
167_T225_A0.7450.55
201_R204_T0.7430.54
103_S107_R0.7430.54
161_Y165_S0.7420.54
57_E124_S0.7340.54
51_D58_L0.7330.53
12_A70_H0.7320.53
102_R213_E0.7190.52
56_A67_V0.7170.52
5_R17_A0.7170.52
143_G151_M0.7150.52
138_P186_V0.7130.51
49_E236_S0.7110.51
156_T210_N0.7100.51
118_W135_G0.7090.51
168_A171_T0.7080.51
199_V202_V0.7080.51
102_R142_K0.7040.50
7_I38_A0.7030.50
89_E245_I0.7020.50
26_W29_R0.7000.50
42_W56_A0.7000.50
61_Q91_V0.6980.50
169_L185_V0.6940.49
107_R205_E0.6930.49
21_K63_L0.6910.49
133_L137_S0.6830.48
133_L185_V0.6820.48
113_R205_E0.6820.48
130_F183_N0.6800.48
146_H196_G0.6800.48
73_N186_V0.6750.48
38_A147_I0.6750.48
69_F83_L0.6750.48
60_Y216_F0.6730.47
192_G225_A0.6730.47
32_F54_L0.6700.47
171_T175_I0.6650.47
40_S94_C0.6650.47
14_S29_R0.6630.46
186_V200_I0.6630.46
218_Q241_H0.6630.46
27_L42_W0.6580.46
54_L114_F0.6580.46
24_G88_Y0.6570.46
108_T205_E0.6530.45
129_E166_L0.6510.45
13_A22_S0.6490.45
60_Y180_G0.6460.45
25_K44_S0.6440.44
42_W171_T0.6440.44
88_Y238_I0.6420.44
175_I216_F0.6410.44
160_M168_A0.6400.44
37_R226_A0.6400.44
144_Y182_S0.6390.44
48_P51_D0.6380.44
195_A199_V0.6280.43
125_V161_Y0.6270.43
12_A42_W0.6270.43
19_F30_A0.6260.43
192_G197_T0.6240.42
171_T178_Y0.6240.42
224_L227_V0.6230.42
179_G215_M0.6220.42
221_K227_V0.6200.42
117_K161_Y0.6200.42
78_G202_V0.6190.42
169_L183_N0.6160.42
26_W178_Y0.6120.41
171_T183_N0.6100.41
28_L63_L0.6090.41
89_E125_V0.6090.41
11_A20_Q0.6070.41
100_L103_S0.6050.41
183_N220_M0.6040.41
217_L226_A0.6030.40
99_A108_T0.6020.40
93_E243_Y0.6010.40
144_Y171_T0.5990.40
218_Q230_Y0.5990.40
12_A26_W0.5950.40
10_L184_I0.5910.39
196_G204_T0.5900.39
8_E27_L0.5890.39
16_P150_R0.5870.39
99_A235_F0.5870.39
28_L192_G0.5850.39
37_R241_H0.5820.38
53_Q224_L0.5790.38
118_W172_V0.5780.38
167_T187_A0.5770.38
171_T182_S0.5770.38
224_L228_S0.5770.38
174_V207_A0.5760.38
144_Y183_N0.5750.38
97_M208_K0.5740.38
181_L215_M0.5720.37
27_L48_P0.5700.37
96_Q239_S0.5690.37
158_F170_G0.5690.37
156_T212_A0.5660.37
180_G218_Q0.5660.37
105_M108_T0.5660.37
16_P151_M0.5650.37
33_G65_L0.5630.37
173_S215_M0.5580.36
36_K94_C0.5560.36
74_A77_K0.5560.36
161_Y164_E0.5530.36
55_E89_E0.5520.36
122_P126_W0.5520.36
58_L124_S0.5510.35
144_Y151_M0.5500.35
230_Y241_H0.5480.35
17_A43_T0.5480.35
72_S239_S0.5480.35
221_K237_P0.5480.35
15_W34_V0.5450.35
179_G206_W0.5440.35
103_S167_T0.5410.35
61_Q66_P0.5400.34
155_K174_V0.5390.34
77_K224_L0.5380.34
148_F241_H0.5380.34
173_S180_G0.5360.34
69_F88_Y0.5360.34
51_D119_E0.5360.34
147_I150_R0.5360.34
85_D198_Q0.5350.34
108_T113_R0.5340.34
172_V215_M0.5340.34
86_S188_E0.5320.34
17_A95_F0.5290.33
170_G181_L0.5290.33
13_A20_Q0.5280.33
143_G147_I0.5280.33
37_R230_Y0.5250.33
143_G146_H0.5240.33
162_D167_T0.5240.33
163_K196_G0.5240.33
53_Q143_G0.5240.33
99_A217_L0.5220.33
21_K59_F0.5210.33
60_Y178_Y0.5200.33
122_P129_E0.5200.33
36_K132_Q0.5190.33
83_L86_S0.5190.33
81_D213_E0.5170.32
37_R40_S0.5170.32
186_V229_L0.5170.32
83_L88_Y0.5160.32
226_A229_L0.5160.32
129_E187_A0.5160.32
54_L57_E0.5160.32
122_P127_I0.5150.32
196_G229_L0.5140.32
102_R208_K0.5130.32
69_F182_S0.5130.32
6_K177_G0.5130.32
159_K166_L0.5130.32
63_L186_V0.5110.32
172_V206_W0.5100.32
67_V196_G0.5080.32
51_D138_P0.5050.31
34_V183_N0.5050.31
95_F98_T0.5040.31
59_F70_H0.5040.31
153_P196_G0.5020.31
170_G226_A0.5010.31
204_T208_K0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4iusA 1 0.9555 100 0.532 Contact Map
3frmA 3 0.9109 100 0.596 Contact Map
3tt2A 1 0.9798 99.8 0.708 Contact Map
1p0hA 1 0.9555 99.8 0.716 Contact Map
2wpxA 1 0.9879 99.8 0.717 Contact Map
1sqhA 1 0.9109 99.7 0.73 Contact Map
1s3zA 2 0.5385 99.6 0.753 Contact Map
3ec4A 1 0.8745 99.6 0.759 Contact Map
3d3sA 2 0.5344 99.6 0.759 Contact Map
2ft0A 2 0.834 99.6 0.765 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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