YOBR - BACSU - GREMLIN Contacts

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YOBR - Uncharacterized N-acetyltransferase YobR

UniProt:	O34376	Sequences: MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTSADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCRSIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKMYDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQVMKENLAAVSLYGKIGFSPISEHHYRIKR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	247 (234)
Sequences:	945 (739)
Seq/√Len:	48.3

BACSU - YOBR

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
57_E	88_Y	4.917	1.00
172_V	179_G	4.597	1.00
179_G	207_A	3.888	1.00
197_T	232_K	3.784	1.00
36_K	92_D	3.016	1.00
170_G	184_I	3.004	1.00
237_P	240_E	2.913	1.00
80_D	244_R	2.908	1.00
19_F	63_L	2.830	1.00
180_G	216_F	2.730	1.00
168_A	186_V	2.723	1.00
84_A	244_R	2.690	1.00
95_F	237_P	2.635	1.00
97_M	231_G	2.600	1.00
168_A	195_A	2.504	1.00
167_T	190_H	2.486	1.00
97_M	227_V	2.484	1.00
53_Q	69_F	2.404	1.00
226_A	230_Y	2.362	1.00
217_L	230_Y	2.357	1.00
80_D	242_H	2.351	1.00
156_T	206_W	2.334	1.00
170_G	203_L	2.284	1.00
158_F	203_L	2.265	1.00
215_M	235_F	2.192	1.00
36_K	91_V	2.191	1.00
177_G	213_E	2.180	1.00
181_L	200_I	2.126	1.00
204_T	215_M	2.104	1.00
54_L	86_S	2.065	1.00
30_A	59_F	2.064	1.00
101_C	215_M	2.057	1.00
82_A	85_D	2.013	1.00
60_Y	65_L	1.936	0.99
57_E	86_S	1.895	0.99
23_I	28_L	1.879	0.99
31_N	38_A	1.822	0.99
30_A	65_L	1.812	0.99
95_F	221_K	1.806	0.99
36_K	220_M	1.747	0.99
181_L	184_I	1.722	0.98
124_S	128_D	1.695	0.98
58_L	62_S	1.631	0.98
204_T	235_F	1.609	0.98
41_V	56_A	1.604	0.97
37_R	223_N	1.600	0.97
200_I	233_I	1.577	0.97
179_G	204_T	1.563	0.97
35_T	38_A	1.550	0.97
144_Y	148_F	1.512	0.96
223_N	226_A	1.473	0.96
61_Q	67_V	1.467	0.96
94_C	221_K	1.460	0.96
98_T	238_I	1.444	0.95
93_E	221_K	1.414	0.95
80_D	84_A	1.404	0.94
167_T	195_A	1.359	0.93
100_L	208_K	1.356	0.93
160_M	199_V	1.342	0.93
13_A	175_I	1.335	0.93
190_H	193_K	1.324	0.93
57_E	67_V	1.317	0.92
118_W	156_T	1.314	0.92
11_A	216_F	1.314	0.92
182_S	186_V	1.307	0.92
184_I	200_I	1.288	0.91
192_G	228_S	1.282	0.91
51_D	54_L	1.282	0.91
93_E	240_E	1.272	0.91
206_W	212_A	1.269	0.91
107_R	193_K	1.261	0.91
97_M	237_P	1.260	0.91
95_F	227_V	1.236	0.90
24_G	45_A	1.230	0.89
100_L	214_R	1.223	0.89
42_W	70_H	1.213	0.89
41_V	69_F	1.211	0.89
178_Y	216_F	1.200	0.88
144_Y	150_R	1.184	0.88
113_R	118_W	1.181	0.87
197_T	229_L	1.168	0.87
170_G	230_Y	1.157	0.86
184_I	233_I	1.156	0.86
8_E	72_S	1.143	0.86
221_K	240_E	1.140	0.86
134_E	185_V	1.136	0.85
156_T	160_M	1.122	0.85
28_L	56_A	1.109	0.84
99_A	204_T	1.105	0.84
172_V	207_A	1.103	0.84
14_S	216_F	1.100	0.83
228_S	231_G	1.098	0.83
229_L	232_K	1.097	0.83
35_T	39_N	1.095	0.83
172_V	203_L	1.091	0.83
223_N	241_H	1.087	0.83
90_K	93_E	1.087	0.83
72_S	76_P	1.080	0.82
15_W	35_T	1.077	0.82
225_A	228_S	1.058	0.81
10_L	41_V	1.055	0.81
154_C	210_N	1.048	0.80
41_V	49_E	1.046	0.80
123_S	159_K	1.038	0.80
41_V	52_F	1.033	0.79
24_G	52_F	1.021	0.79
184_I	196_G	1.012	0.78
50_G	86_S	1.005	0.77
156_T	172_V	0.996	0.77
186_V	195_A	0.993	0.77
162_D	193_K	0.992	0.77
92_D	220_M	0.990	0.76
23_I	55_E	0.990	0.76
99_A	104_I	0.985	0.76
68_C	245_I	0.984	0.76
196_G	203_L	0.979	0.76
202_V	205_E	0.979	0.76
84_A	150_R	0.976	0.75
9_R	13_A	0.963	0.74
93_E	237_P	0.955	0.74
138_P	143_G	0.932	0.72
223_N	230_Y	0.925	0.71
13_A	173_S	0.920	0.71
5_R	9_R	0.920	0.71
227_V	231_G	0.919	0.71
145_K	150_R	0.917	0.71
192_G	198_Q	0.916	0.71
103_S	236_S	0.916	0.71
173_S	216_F	0.914	0.70
47_M	51_D	0.903	0.69
219_V	226_A	0.901	0.69
178_Y	214_R	0.899	0.69
11_A	218_Q	0.889	0.68
55_E	58_L	0.887	0.68
16_P	206_W	0.883	0.68
54_L	58_L	0.879	0.67
45_A	52_F	0.878	0.67
130_F	169_L	0.875	0.67
19_F	65_L	0.874	0.67
104_I	204_T	0.873	0.67
223_N	229_L	0.869	0.66
92_D	243_Y	0.867	0.66
12_A	20_Q	0.865	0.66
165_S	189_E	0.859	0.66
145_K	149_E	0.858	0.65
219_V	223_N	0.856	0.65
36_K	68_C	0.847	0.64
59_F	63_L	0.846	0.64
115_T	118_W	0.845	0.64
118_W	158_F	0.843	0.64
112_S	115_T	0.841	0.64
91_V	245_I	0.839	0.64
12_A	17_A	0.832	0.63
50_G	107_R	0.825	0.62
79_L	243_Y	0.823	0.62
49_E	52_F	0.818	0.62
10_L	178_Y	0.817	0.62
18_Y	32_F	0.808	0.61
94_C	199_V	0.806	0.61
11_A	180_G	0.792	0.59
170_G	199_V	0.784	0.58
82_A	86_S	0.782	0.58
49_E	86_S	0.781	0.58
48_P	82_A	0.780	0.58
159_K	165_S	0.776	0.58
168_A	175_I	0.774	0.57
101_C	208_K	0.768	0.57
186_V	199_V	0.764	0.56
195_A	202_V	0.762	0.56
142_K	146_H	0.761	0.56
158_F	199_V	0.757	0.56
118_W	192_G	0.754	0.56
190_H	195_A	0.752	0.55
30_A	63_L	0.751	0.55
25_K	45_A	0.751	0.55
38_A	151_M	0.751	0.55
21_K	62_S	0.750	0.55
15_W	37_R	0.749	0.55
18_Y	31_N	0.746	0.55
94_C	241_H	0.745	0.55
167_T	225_A	0.745	0.55
201_R	204_T	0.743	0.54
103_S	107_R	0.743	0.54
161_Y	165_S	0.742	0.54
57_E	124_S	0.734	0.54
51_D	58_L	0.733	0.53
12_A	70_H	0.732	0.53
102_R	213_E	0.719	0.52
56_A	67_V	0.717	0.52
5_R	17_A	0.717	0.52
143_G	151_M	0.715	0.52
138_P	186_V	0.713	0.51
49_E	236_S	0.711	0.51
156_T	210_N	0.710	0.51
118_W	135_G	0.709	0.51
168_A	171_T	0.708	0.51
199_V	202_V	0.708	0.51
102_R	142_K	0.704	0.50
7_I	38_A	0.703	0.50
89_E	245_I	0.702	0.50
26_W	29_R	0.700	0.50
42_W	56_A	0.700	0.50
61_Q	91_V	0.698	0.50
169_L	185_V	0.694	0.49
107_R	205_E	0.693	0.49
21_K	63_L	0.691	0.49
133_L	137_S	0.683	0.48
133_L	185_V	0.682	0.48
113_R	205_E	0.682	0.48
130_F	183_N	0.680	0.48
146_H	196_G	0.680	0.48
73_N	186_V	0.675	0.48
38_A	147_I	0.675	0.48
69_F	83_L	0.675	0.48
60_Y	216_F	0.673	0.47
192_G	225_A	0.673	0.47
32_F	54_L	0.670	0.47
171_T	175_I	0.665	0.47
40_S	94_C	0.665	0.47
14_S	29_R	0.663	0.46
186_V	200_I	0.663	0.46
218_Q	241_H	0.663	0.46
27_L	42_W	0.658	0.46
54_L	114_F	0.658	0.46
24_G	88_Y	0.657	0.46
108_T	205_E	0.653	0.45
129_E	166_L	0.651	0.45
13_A	22_S	0.649	0.45
60_Y	180_G	0.646	0.45
25_K	44_S	0.644	0.44
42_W	171_T	0.644	0.44
88_Y	238_I	0.642	0.44
175_I	216_F	0.641	0.44
160_M	168_A	0.640	0.44
37_R	226_A	0.640	0.44
144_Y	182_S	0.639	0.44
48_P	51_D	0.638	0.44
195_A	199_V	0.628	0.43
125_V	161_Y	0.627	0.43
12_A	42_W	0.627	0.43
19_F	30_A	0.626	0.43
192_G	197_T	0.624	0.42
171_T	178_Y	0.624	0.42
224_L	227_V	0.623	0.42
179_G	215_M	0.622	0.42
221_K	227_V	0.620	0.42
117_K	161_Y	0.620	0.42
78_G	202_V	0.619	0.42
169_L	183_N	0.616	0.42
26_W	178_Y	0.612	0.41
171_T	183_N	0.610	0.41
28_L	63_L	0.609	0.41
89_E	125_V	0.609	0.41
11_A	20_Q	0.607	0.41
100_L	103_S	0.605	0.41
183_N	220_M	0.604	0.41
217_L	226_A	0.603	0.40
99_A	108_T	0.602	0.40
93_E	243_Y	0.601	0.40
144_Y	171_T	0.599	0.40
218_Q	230_Y	0.599	0.40
12_A	26_W	0.595	0.40
10_L	184_I	0.591	0.39
196_G	204_T	0.590	0.39
8_E	27_L	0.589	0.39
16_P	150_R	0.587	0.39
99_A	235_F	0.587	0.39
28_L	192_G	0.585	0.39
37_R	241_H	0.582	0.38
53_Q	224_L	0.579	0.38
118_W	172_V	0.578	0.38
167_T	187_A	0.577	0.38
171_T	182_S	0.577	0.38
224_L	228_S	0.577	0.38
174_V	207_A	0.576	0.38
144_Y	183_N	0.575	0.38
97_M	208_K	0.574	0.38
181_L	215_M	0.572	0.37
27_L	48_P	0.570	0.37
96_Q	239_S	0.569	0.37
158_F	170_G	0.569	0.37
156_T	212_A	0.566	0.37
180_G	218_Q	0.566	0.37
105_M	108_T	0.566	0.37
16_P	151_M	0.565	0.37
33_G	65_L	0.563	0.37
173_S	215_M	0.558	0.36
36_K	94_C	0.556	0.36
74_A	77_K	0.556	0.36
161_Y	164_E	0.553	0.36
55_E	89_E	0.552	0.36
122_P	126_W	0.552	0.36
58_L	124_S	0.551	0.35
144_Y	151_M	0.550	0.35
230_Y	241_H	0.548	0.35
17_A	43_T	0.548	0.35
72_S	239_S	0.548	0.35
221_K	237_P	0.548	0.35
15_W	34_V	0.545	0.35
179_G	206_W	0.544	0.35
103_S	167_T	0.541	0.35
61_Q	66_P	0.540	0.34
155_K	174_V	0.539	0.34
77_K	224_L	0.538	0.34
148_F	241_H	0.538	0.34
173_S	180_G	0.536	0.34
69_F	88_Y	0.536	0.34
51_D	119_E	0.536	0.34
147_I	150_R	0.536	0.34
85_D	198_Q	0.535	0.34
108_T	113_R	0.534	0.34
172_V	215_M	0.534	0.34
86_S	188_E	0.532	0.34
17_A	95_F	0.529	0.33
170_G	181_L	0.529	0.33
13_A	20_Q	0.528	0.33
143_G	147_I	0.528	0.33
37_R	230_Y	0.525	0.33
143_G	146_H	0.524	0.33
162_D	167_T	0.524	0.33
163_K	196_G	0.524	0.33
53_Q	143_G	0.524	0.33
99_A	217_L	0.522	0.33
21_K	59_F	0.521	0.33
60_Y	178_Y	0.520	0.33
122_P	129_E	0.520	0.33
36_K	132_Q	0.519	0.33
83_L	86_S	0.519	0.33
81_D	213_E	0.517	0.32
37_R	40_S	0.517	0.32
186_V	229_L	0.517	0.32
83_L	88_Y	0.516	0.32
226_A	229_L	0.516	0.32
129_E	187_A	0.516	0.32
54_L	57_E	0.516	0.32
122_P	127_I	0.515	0.32
196_G	229_L	0.514	0.32
102_R	208_K	0.513	0.32
69_F	182_S	0.513	0.32
6_K	177_G	0.513	0.32
159_K	166_L	0.513	0.32
63_L	186_V	0.511	0.32
172_V	206_W	0.510	0.32
67_V	196_G	0.508	0.32
51_D	138_P	0.505	0.31
34_V	183_N	0.505	0.31
95_F	98_T	0.504	0.31
59_F	70_H	0.504	0.31
153_P	196_G	0.502	0.31
170_G	226_A	0.501	0.31
204_T	208_K	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4iusA	1	0.9555	100	0.532	Contact Map
3frmA	3	0.9109	100	0.596	Contact Map
3tt2A	1	0.9798	99.8	0.708	Contact Map
1p0hA	1	0.9555	99.8	0.716	Contact Map
2wpxA	1	0.9879	99.8	0.717	Contact Map
1sqhA	1	0.9109	99.7	0.73	Contact Map
1s3zA	2	0.5385	99.6	0.753	Contact Map
3ec4A	1	0.8745	99.6	0.759	Contact Map
3d3sA	2	0.5344	99.6	0.759	Contact Map
2ft0A	2	0.834	99.6	0.765	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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