GREMLIN Database
MINJ - Cell division topological determinant MinJ
UniProt: O34375 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (380)
Sequences: 374 (324)
Seq/√Len: 16.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
308_V322_L9.3431.00
158_A249_V5.2181.00
152_I253_G4.4181.00
330_K356_E4.2381.00
155_G253_G4.2031.00
148_G257_A4.1301.00
155_G246_A3.9551.00
105_S281_R3.8901.00
148_G253_G3.4680.99
162_A188_W3.2010.99
166_T182_Q3.1460.99
105_S151_I3.0820.99
151_I281_R3.0630.99
111_S115_L2.8760.98
111_S274_V2.8010.98
330_K376_H2.5900.96
23_W326_E2.5340.96
151_I256_V2.4650.95
151_I252_L2.4360.95
154_E281_R2.4200.94
86_A112_V2.3880.94
256_V277_A2.3580.93
106_A226_F2.3230.93
148_G155_G2.2630.92
46_T279_L2.1630.90
338_N341_D2.0820.88
182_Q365_R2.0140.86
105_S252_L1.9910.86
47_R326_E1.9700.85
77_G208_W1.9620.85
320_L357_I1.9270.84
41_R175_R1.9250.84
129_L152_I1.9240.84
155_G250_C1.8930.83
277_A280_G1.8890.83
263_S382_L1.8740.82
87_I253_G1.8580.81
311_I317_A1.8550.81
180_G309_L1.8350.81
299_F359_G1.7990.79
64_I120_L1.7810.79
148_G210_V1.7750.78
354_K368_Q1.7710.78
102_N188_W1.7590.78
246_A339_V1.7540.78
23_W363_E1.7510.77
349_N353_V1.7480.77
112_V116_I1.7450.77
258_V287_K1.7450.77
206_S227_V1.7170.76
326_E330_K1.7140.76
311_I324_I1.6970.75
47_R336_V1.6890.75
108_Y256_V1.6620.73
102_N282_I1.6330.72
107_A273_A1.6260.72
166_T242_I1.6140.71
25_F226_F1.5990.70
76_L277_A1.5930.70
42_K72_I1.5760.69
276_T280_G1.5750.69
40_E167_S1.5700.69
9_L17_F1.5610.69
354_K366_F1.5290.67
110_V147_L1.5280.67
23_W351_A1.5230.67
195_L315_T1.5010.65
148_G299_F1.4980.65
283_F287_K1.4960.65
69_L189_L1.4860.65
285_S308_V1.4720.64
344_E373_E1.4690.64
10_L27_I1.4630.63
149_L190_L1.4600.63
32_F339_V1.4570.63
63_L338_N1.4440.62
64_I239_E1.4240.61
158_A188_W1.4170.61
6_G86_A1.4120.61
76_L235_G1.4060.60
370_A378_E1.3970.60
329_T358_I1.3920.59
311_I323_K1.3880.59
152_I279_L1.3780.59
105_S154_E1.3770.59
155_G249_V1.3740.58
197_P316_P1.3720.58
41_R345_A1.3700.58
102_N274_V1.3700.58
76_L322_L1.3600.58
320_L367_D1.3580.57
173_S382_L1.3560.57
326_E376_H1.3550.57
241_S288_Q1.3550.57
352_Y372_Y1.3380.56
356_E376_H1.3370.56
71_V341_D1.3210.55
179_I307_M1.3170.55
206_S211_F1.3120.55
108_Y282_I1.3090.55
68_L78_I1.3040.54
94_A128_F1.3030.54
70_S150_L1.3000.54
94_A279_L1.2950.54
310_G324_I1.2920.54
115_L119_G1.2900.53
48_I275_C1.2800.53
68_L258_V1.2780.53
262_A269_L1.2590.52
154_E188_W1.2580.52
107_A256_V1.2560.51
308_V336_V1.2420.51
175_R370_A1.2410.51
188_W292_D1.2410.51
40_E224_P1.2360.50
176_G197_P1.2340.50
359_G365_R1.2250.50
306_L352_Y1.2200.49
41_R224_P1.2130.49
13_A158_A1.2120.49
36_R343_Y1.2120.49
23_W47_R1.2070.49
304_Q358_I1.2060.49
27_I152_I1.2020.48
208_W222_W1.2010.48
352_Y368_Q1.1940.48
148_G260_G1.1930.48
220_F257_A1.1900.48
353_V371_S1.1870.47
317_A325_G1.1690.46
31_A196_V1.1660.46
211_F279_L1.1580.46
118_F282_I1.1570.46
352_Y370_A1.1560.46
177_L327_I1.1540.45
36_R54_D1.1510.45
109_I252_L1.1460.45
243_R293_N1.1420.45
175_R197_P1.1380.45
29_T322_L1.1340.44
147_L233_V1.1340.44
68_L94_A1.1290.44
151_I253_G1.1260.44
331_V354_K1.1160.43
66_G289_R1.1130.43
26_I93_A1.1110.43
154_E351_A1.1110.43
252_L281_R1.1100.43
86_A90_V1.1100.43
148_G256_V1.1060.43
125_A308_V1.0900.42
308_V320_L1.0870.42
10_L86_A1.0860.42
112_V254_L1.0840.41
226_F301_K1.0820.41
40_E175_R1.0800.41
111_S146_F1.0750.41
231_Q281_R1.0740.41
175_R224_P1.0740.41
131_R308_V1.0720.41
5_W201_L1.0710.41
80_I260_G1.0710.41
171_V186_R1.0680.40
23_W376_H1.0660.40
13_A153_T1.0650.40
275_C338_N1.0640.40
370_A373_E1.0490.39
368_Q375_E1.0460.39
310_G382_L1.0400.39
33_G365_R1.0370.39
175_R351_A1.0360.39
99_L255_A1.0360.39
186_R384_V1.0350.39
67_L240_T1.0310.38
75_G250_C1.0270.38
272_A293_N1.0270.38
108_Y297_F1.0150.38
182_Q383_F1.0130.37
320_L374_G1.0120.37
119_G123_Y1.0070.37
36_R316_P1.0070.37
147_L151_I1.0020.37
175_R343_Y1.0010.37
69_L149_L0.9980.37
249_V253_G0.9980.37
47_R366_F0.9960.36
111_S166_T0.9950.36
322_L355_L0.9950.36
154_E157_V0.9950.36
328_I363_E0.9910.36
49_A385_K0.9880.36
113_S292_D0.9880.36
269_L273_A0.9880.36
96_A147_L0.9830.36
328_I345_A0.9830.36
120_L143_V0.9780.35
147_L281_R0.9780.35
158_A284_L0.9750.35
24_F91_I0.9740.35
94_A99_L0.9720.35
190_L194_L0.9710.35
91_I336_V0.9690.35
94_A362_G0.9650.35
239_E255_A0.9640.35
176_G343_Y0.9620.35
112_V126_E0.9620.35
154_E282_I0.9610.35
68_L276_T0.9610.35
15_L67_L0.9600.35
18_L194_L0.9590.34
41_R349_N0.9540.34
263_S338_N0.9500.34
101_A284_L0.9480.34
193_F375_E0.9460.34
66_G309_L0.9430.34
69_L72_I0.9410.34
156_A273_A0.9400.33
211_F215_G0.9370.33
172_V249_V0.9320.33
163_H276_T0.9310.33
274_V282_I0.9280.33
115_L283_F0.9260.33
146_F382_L0.9230.33
211_F219_H0.9220.33
109_I144_A0.9150.32
180_G282_I0.9130.32
88_I147_L0.9120.32
345_A374_G0.9070.32
343_Y347_Q0.9050.32
79_S128_F0.9040.32
234_Q246_A0.9040.32
40_E332_N0.9030.32
162_A282_I0.8970.31
346_L352_Y0.8950.31
154_E180_G0.8940.31
13_A286_I0.8880.31
368_Q372_Y0.8830.31
363_E372_Y0.8810.30
252_L256_V0.8750.30
235_G292_D0.8720.30
62_G207_W0.8690.30
158_A246_A0.8680.30
180_G235_G0.8670.30
140_W322_L0.8620.29
276_T304_Q0.8610.29
33_G106_A0.8590.29
45_H318_E0.8580.29
150_L207_W0.8570.29
378_E383_F0.8560.29
368_Q376_H0.8530.29
138_V334_I0.8500.29
65_P78_I0.8500.29
244_I336_V0.8490.29
355_L381_I0.8490.29
221_L381_I0.8490.29
92_T373_E0.8460.29
302_R307_M0.8440.29
171_V181_Q0.8440.29
71_V94_A0.8430.29
91_I260_G0.8400.28
170_L292_D0.8380.28
330_K368_Q0.8350.28
199_N313_P0.8350.28
354_K369_R0.8350.28
330_K366_F0.8340.28
85_L271_G0.8340.28
6_G156_A0.8330.28
370_A377_H0.8320.28
195_L308_V0.8290.28
162_A181_Q0.8280.28
18_L113_S0.8230.28
233_V241_S0.8220.28
78_I239_E0.8190.27
346_L379_L0.8190.27
26_I302_R0.8190.27
52_Y55_L0.8180.27
232_R323_K0.8180.27
58_T235_G0.8160.27
252_L284_L0.8150.27
170_L241_S0.8090.27
29_T33_G0.8090.27
44_F224_P0.8080.27
211_F227_V0.8060.27
38_K361_N0.8020.27
173_S377_H0.8010.27
237_L299_F0.7960.26
6_G250_C0.7950.26
73_L149_L0.7940.26
144_A256_V0.7930.26
229_F277_A0.7930.26
93_A113_S0.7920.26
253_G256_V0.7910.26
173_S302_R0.7910.26
328_I365_R0.7890.26
354_K375_E0.7880.26
300_S322_L0.7850.26
148_G152_I0.7840.26
322_L375_E0.7820.26
125_A279_L0.7820.26
62_G205_L0.7810.26
94_A216_G0.7750.25
54_D113_S0.7750.25
18_L211_F0.7710.25
366_F376_H0.7700.25
261_A286_I0.7680.25
246_A281_R0.7670.25
107_A277_A0.7630.25
10_L14_G0.7630.25
315_T370_A0.7610.25
97_F328_I0.7610.25
6_G195_L0.7590.25
19_H146_F0.7590.25
22_F324_I0.7570.25
119_G362_G0.7550.25
65_P321_E0.7540.24
70_S155_G0.7540.24
144_A151_I0.7540.24
14_G67_L0.7530.24
144_A307_M0.7520.24
273_A280_G0.7510.24
56_K328_I0.7490.24
23_W331_V0.7480.24
63_L243_R0.7430.24
27_I341_D0.7410.24
302_R321_E0.7410.24
174_S330_K0.7390.24
356_E368_Q0.7390.24
194_L320_L0.7370.24
175_R377_H0.7370.24
275_C323_K0.7350.24
333_G376_H0.7330.24
26_I90_V0.7320.24
53_D234_Q0.7310.23
23_W330_K0.7280.23
71_V215_G0.7260.23
101_A135_G0.7250.23
174_S247_K0.7250.23
354_K371_S0.7240.23
173_S362_G0.7240.23
10_L242_I0.7240.23
75_G192_L0.7220.23
320_L361_N0.7220.23
55_L233_V0.7220.23
9_L272_A0.7210.23
119_G258_V0.7190.23
35_V254_L0.7190.23
40_E320_L0.7150.23
298_Y356_E0.7140.23
182_Q326_E0.7140.23
33_G36_R0.7130.23
196_V327_I0.7040.22
195_L218_F0.7010.22
351_A354_K0.7000.22
17_F312_I0.7000.22
152_I254_L0.6990.22
313_P377_H0.6970.22
22_F69_L0.6970.22
86_A234_Q0.6960.22
66_G180_G0.6940.22
68_L131_R0.6930.22
205_L245_T0.6870.22
112_V338_N0.6870.22
351_A368_Q0.6860.22
8_E372_Y0.6860.22
59_Y74_G0.6860.22
45_H167_S0.6850.22
42_K54_D0.6840.22
192_L203_S0.6840.22
336_V350_R0.6830.21
113_S323_K0.6820.21
90_V278_L0.6810.21
27_I32_F0.6790.21
21_L190_L0.6780.21
230_G297_F0.6760.21
345_A355_L0.6740.21
97_F196_V0.6720.21
47_R375_E0.6720.21
207_W210_V0.6690.21
195_L306_L0.6690.21
94_A158_A0.6680.21
366_F370_A0.6670.21
227_V363_E0.6670.21
68_L240_T0.6660.21
123_Y285_S0.6640.21
320_L372_Y0.6630.21
12_S226_F0.6630.21
36_R197_P0.6610.21
27_I86_A0.6590.21
186_R309_L0.6590.21
109_I213_V0.6590.21
26_I74_G0.6590.21
254_L279_L0.6550.20
124_Q341_D0.6550.20
17_F153_T0.6530.20
157_V260_G0.6520.20
190_L321_E0.6510.20
208_W343_Y0.6500.20
33_G187_V0.6490.20
317_A326_E0.6460.20
249_V281_R0.6450.20
116_I262_A0.6410.20
119_G304_Q0.6390.20
311_I347_Q0.6380.20
94_A261_A0.6380.20
36_R365_R0.6380.20
206_S273_A0.6370.20
24_F65_P0.6360.20
86_A381_I0.6360.20
10_L303_D0.6340.20
33_G249_V0.6340.20
311_I315_T0.6330.20
6_G269_L0.6330.20
71_V318_E0.6320.20
9_L283_F0.6320.20
193_F222_W0.6310.19
199_N203_S0.6300.19
12_S326_E0.6300.19
137_A145_V0.6300.19
64_I382_L0.6290.19
25_F368_Q0.6270.19
12_S147_L0.6270.19
201_L311_I0.6270.19
79_S382_L0.6250.19
312_I376_H0.6250.19
23_W354_K0.6240.19
8_E12_S0.6230.19
23_W175_R0.6220.19
243_R260_G0.6210.19
129_L262_A0.6140.19
143_V211_F0.6130.19
78_I145_V0.6130.19
320_L350_R0.6120.19
255_A276_T0.6120.19
72_I250_C0.6120.19
47_R368_Q0.6110.19
193_F196_V0.6110.19
13_A131_R0.6110.19
331_V375_E0.6110.19
351_A376_H0.6110.19
256_V276_T0.6090.19
232_R263_S0.6070.19
111_S154_E0.6070.19
288_Q297_F0.6060.19
35_V80_I0.6050.19
24_F274_V0.6050.19
37_I311_I0.6050.19
188_W281_R0.6050.19
45_H274_V0.6040.19
169_A181_Q0.6040.19
349_N363_E0.6030.18
306_L328_I0.6010.18
71_V142_A0.5990.18
260_G336_V0.5950.18
72_I149_L0.5940.18
84_L88_I0.5940.18
172_V179_I0.5940.18
306_L373_E0.5930.18
83_G174_S0.5930.18
147_L226_F0.5920.18
350_R373_E0.5920.18
137_A193_F0.5920.18
162_A358_I0.5910.18
93_A278_L0.5900.18
182_Q347_Q0.5900.18
20_P44_F0.5880.18
24_F265_L0.5860.18
175_R270_A0.5850.18
47_R354_K0.5850.18
326_E365_R0.5840.18
229_F333_G0.5830.18
10_L18_L0.5830.18
102_N207_W0.5820.18
252_L280_G0.5820.18
9_L235_G0.5790.18
129_L322_L0.5770.18
237_L316_P0.5770.18
59_Y156_A0.5760.18
6_G255_A0.5750.17
153_T253_G0.5740.17
78_I85_L0.5730.17
83_G86_A0.5730.17
16_F189_L0.5730.17
158_A162_A0.5720.17
5_W79_S0.5720.17
5_W8_E0.5720.17
202_E339_V0.5710.17
42_K80_I0.5700.17
340_S355_L0.5690.17
182_Q342_F0.5680.17
32_F149_L0.5680.17
251_I278_L0.5680.17
258_V290_V0.5680.17
52_Y166_T0.5660.17
263_S267_T0.5630.17
47_R331_V0.5630.17
59_Y164_V0.5620.17
180_G299_F0.5570.17
57_F177_L0.5570.17
68_L90_V0.5560.17
355_L383_F0.5550.17
11_K48_I0.5550.17
250_C257_A0.5540.17
299_F330_K0.5540.17
178_P381_I0.5530.17
136_F334_I0.5530.17
64_I311_I0.5530.17
24_F336_V0.5520.17
56_K59_Y0.5500.17
106_A151_I0.5490.17
24_F96_A0.5490.17
320_L352_Y0.5480.17
297_F352_Y0.5470.17
70_S228_G0.5470.17
226_F329_T0.5460.17
41_R370_A0.5450.16
29_T76_L0.5450.16
74_G258_V0.5440.16
248_R291_N0.5440.16
137_A254_L0.5430.16
27_I300_S0.5430.16
366_F378_E0.5400.16
198_G357_I0.5400.16
374_G377_H0.5390.16
27_I76_L0.5380.16
69_L368_Q0.5360.16
69_L73_L0.5360.16
132_F152_I0.5350.16
36_R175_R0.5330.16
69_L153_T0.5320.16
146_F309_L0.5310.16
275_C279_L0.5310.16
26_I373_E0.5300.16
75_G79_S0.5280.16
333_G356_E0.5270.16
17_F196_V0.5240.16
100_R180_G0.5210.16
182_Q372_Y0.5210.16
173_S278_L0.5210.16
105_S147_L0.5200.16
218_F276_T0.5180.16
127_P131_R0.5180.16
187_V190_L0.5170.16
210_V277_A0.5170.16
308_V319_D0.5170.16
79_S108_Y0.5160.16
172_V382_L0.5160.16
178_P327_I0.5150.16
27_I84_L0.5150.16
166_T331_V0.5140.16
5_W17_F0.5140.16
99_L182_Q0.5140.16
309_L379_L0.5130.15
22_F263_S0.5130.15
317_A320_L0.5130.15
172_V303_D0.5130.15
18_L193_F0.5110.15
182_Q225_Y0.5110.15
6_G372_Y0.5100.15
268_P292_D0.5100.15
326_E354_K0.5100.15
269_L276_T0.5090.15
212_T217_S0.5090.15
90_V255_A0.5090.15
365_R383_F0.5060.15
139_V263_S0.5060.15
262_A340_S0.5060.15
25_F86_A0.5020.15
8_E15_L0.5020.15
14_G322_L0.5000.15
23_W173_S0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i18A 1 0.2267 99.1 0.896 Contact Map
2pzdA 2 0.267 99.1 0.897 Contact Map
2hgaA 1 0.2368 99.1 0.897 Contact Map
2krgA 1 0.3098 99 0.9 Contact Map
2kl1A 1 0.2116 99 0.902 Contact Map
2i6vA 1 0.2116 99 0.902 Contact Map
2i4sA 1 0.2594 98.9 0.904 Contact Map
4n6xA 1 0.2191 98.9 0.905 Contact Map
4xh7A 1 0.262 98.9 0.905 Contact Map
2p3wA 2 0.2821 98.9 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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