GREMLIN Database
YJIB - Putative cytochrome P450 YjiB
UniProt: O34374 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 396 (356)
Sequences: 44296 (32832)
Seq/√Len: 1740.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
326_R329_M3.7361.00
326_R331_D3.3451.00
274_Q336_P3.3261.00
264_E333_R3.1921.00
117_D365_S3.0651.00
298_E303_L3.0481.00
251_A279_A3.0341.00
251_A363_L2.9161.00
305_K308_D2.9131.00
247_L359_A2.8071.00
273_P360_N2.7401.00
203_R226_G2.6631.00
296_D306_E2.6321.00
254_S283_R2.6141.00
52_L55_D2.5611.00
296_D303_L2.5441.00
262_Y266_R2.5091.00
263_E267_S2.4991.00
319_R328_H2.3441.00
261_V271_L2.3441.00
265_L275_A2.3321.00
65_L295_R2.3231.00
202_K209_D2.1751.00
293_A304_I2.1741.00
196_A230_I2.1441.00
48_W308_D2.1391.00
200_E226_G2.1241.00
113_Q365_S2.1091.00
111_R146_E2.1081.00
66_F297_T2.1051.00
55_D300_G2.0871.00
264_E271_L2.0671.00
258_T261_V2.0541.00
201_E205_K2.0181.00
196_A226_G2.0041.00
348_F352_A1.9871.00
139_L362_A1.9871.00
254_S282_F1.9831.00
31_E34_R1.9411.00
298_E301_G1.9081.00
196_A200_E1.9031.00
253_Y257_E1.8601.00
266_R270_E1.7891.00
276_V359_A1.7841.00
277_E356_R1.7671.00
56_V317_A1.7551.00
266_R371_P1.7411.00
92_I232_F1.7291.00
261_V264_E1.7251.00
57_K61_G1.7171.00
39_V50_V1.7131.00
29_W32_S1.7121.00
248_I362_A1.7091.00
50_V59_V1.7021.00
186_K190_E1.7021.00
279_A330_F1.6921.00
115_I118_E1.6881.00
262_Y371_P1.6591.00
263_E371_P1.6451.00
115_I146_E1.6281.00
161_W190_E1.5931.00
64_E295_R1.5871.00
38_P52_L1.5821.00
296_D305_K1.5551.00
197_G201_E1.5521.00
200_E204_N1.5491.00
225_S228_E1.5451.00
160_A164_L1.5391.00
315_A319_R1.5371.00
262_Y367_I1.5181.00
111_R114_E1.5171.00
254_S258_T1.5141.00
251_A275_A1.5121.00
251_A255_I1.5031.00
157_Q161_W1.5021.00
280_L341_A1.4911.00
269_P368_S1.4871.00
126_R134_D1.4831.00
132_V249_S1.4791.00
114_E146_E1.4791.00
263_E266_R1.4731.00
124_Q370_F1.4641.00
29_W33_M1.4601.00
269_P364_T1.4471.00
365_S368_S1.4411.00
366_L372_H1.4341.00
265_L367_I1.4331.00
209_D212_S1.4081.00
212_S216_E1.3981.00
50_V55_D1.3931.00
54_D300_G1.3821.00
113_Q117_D1.3811.00
321_E328_H1.3781.00
104_V107_Q1.3601.00
274_Q333_R1.3491.00
282_F319_R1.3441.00
265_L272_M1.3241.00
109_E360_N1.3161.00
62_D65_L1.2991.00
247_L285_P1.2881.00
56_V312_A1.2861.00
200_E203_R1.2861.00
321_E327_P1.2821.00
58_K62_D1.2791.00
252_M366_L1.2771.00
318_N341_A1.2751.00
189_E193_A1.2681.00
271_L333_R1.2651.00
31_E328_H1.2641.00
323_K338_P1.2621.00
121_Q369_A1.2621.00
273_P277_E1.2611.00
87_P90_T1.2531.00
261_V275_A1.2521.00
164_L183_E1.2461.00
130_D133_H1.2461.00
193_A197_G1.2451.00
115_I142_I1.2441.00
272_M367_I1.2361.00
295_R306_E1.2351.00
32_S36_D1.2151.00
198_I201_E1.2141.00
86_P90_T1.2091.00
122_K134_D1.2001.00
256_L262_Y1.1991.00
268_H271_L1.1981.00
70_M73_Q1.1951.00
275_A279_A1.1951.00
87_P91_K1.1851.00
144_I240_G1.1811.00
84_M88_K1.1811.00
38_P322_A1.1761.00
272_M364_T1.1761.00
164_L187_C1.1671.00
352_A356_R1.1661.00
41_F46_Q1.1651.00
264_E267_S1.1601.00
266_R367_I1.1561.00
117_D121_Q1.1531.00
325_D331_D1.1471.00
32_S35_K1.1451.00
292_I307_G1.1401.00
113_Q361_I1.1311.00
277_E339_H1.1271.00
157_Q190_E1.1241.00
52_L322_A1.1221.00
275_A330_F1.1191.00
124_Q369_A1.1191.00
120_I365_S1.1191.00
201_E204_N1.1181.00
51_F313_F1.1151.00
106_K109_E1.1101.00
116_T139_L1.1081.00
254_S279_A1.1001.00
116_T120_I1.0991.00
261_V332_I1.0941.00
261_V333_R1.0921.00
227_E231_P1.0921.00
192_A230_I1.0911.00
192_A196_A1.0861.00
182_E186_K1.0861.00
67_S294_K1.0851.00
146_E151_P1.0821.00
116_T365_S1.0821.00
79_N88_K1.0791.00
120_I370_F1.0761.00
37_A40_S1.0761.00
48_W304_I1.0751.00
109_E361_I1.0711.00
183_E187_C1.0591.00
318_N339_H1.0511.00
114_E118_E1.0471.00
91_K228_E1.0421.00
293_A308_D1.0411.00
66_F69_C1.0391.00
111_R115_I1.0341.00
157_Q160_A1.0331.00
118_E142_I1.0301.00
179_A183_E1.0291.00
55_D58_K1.0281.00
190_E193_A1.0241.00
112_I357_L1.0231.00
226_G230_I1.0221.00
188_E192_A1.0191.00
40_S49_S1.0181.00
116_T361_I1.0161.00
109_E113_Q1.0141.00
119_L139_L1.0111.00
269_P272_M1.0111.00
278_E281_R1.0041.00
271_L274_Q1.0031.00
34_R321_E1.0021.00
113_Q364_T1.0011.00
118_E122_K1.0001.00
112_I143_V0.9961.00
47_V311_L0.9941.00
258_T329_M0.9921.00
264_E268_H0.9901.00
270_E368_S0.9861.00
255_I265_L0.9841.00
213_I216_E0.9811.00
141_V241_N0.9811.00
292_I309_M0.9801.00
259_P263_E0.9781.00
102_P106_K0.9761.00
250_N283_R0.9701.00
293_A296_D0.9691.00
202_K212_S0.9601.00
80_S235_L0.9581.00
53_Y323_K0.9531.00
254_S257_E0.9521.00
265_L271_L0.9481.00
65_L297_T0.9441.00
198_I202_K0.9431.00
255_I262_Y0.9411.00
58_K300_G0.9401.00
255_I261_V0.9361.00
54_D58_K0.9341.00
105_M357_L0.9331.00
206_P216_E0.9311.00
118_E121_Q0.9311.00
365_S369_A0.9311.00
321_E325_D0.9291.00
297_T303_L0.9231.00
154_H157_Q0.9211.00
273_P356_R0.9111.00
150_V201_E0.9071.00
289_L314_V0.9031.00
88_K91_K0.9031.00
224_L228_E0.9031.00
164_L167_S0.8981.00
120_I369_A0.8931.00
271_L332_I0.8931.00
101_T104_V0.8901.00
50_V56_V0.8901.00
45_N309_M0.8891.00
190_E194_F0.8851.00
90_T94_S0.8841.00
54_D322_A0.8821.00
164_L168_T0.8811.00
109_E357_L0.8801.00
211_I233_C0.8781.00
275_A332_I0.8761.00
202_K205_K0.8691.00
160_A163_D0.8671.00
59_V312_A0.8651.00
355_A359_A0.8621.00
364_T368_S0.8591.00
122_K138_P0.8591.00
63_K297_T0.8551.00
372_H375_C0.8501.00
185_D189_E0.8491.00
28_P31_E0.8481.00
179_A182_E0.8471.00
260_G264_E0.8471.00
175_E178_K0.8461.00
145_S152_S0.8451.00
247_L279_A0.8451.00
156_E160_A0.8421.00
248_I359_A0.8411.00
356_R360_N0.8401.00
117_D369_A0.8391.00
88_K92_I0.8371.00
208_Q212_S0.8311.00
88_K228_E0.8311.00
131_L252_M0.8191.00
103_R107_Q0.8141.00
259_P262_Y0.8121.00
58_K297_T0.8121.00
189_E192_A0.8111.00
115_I151_P0.8101.00
159_K163_D0.8091.00
100_F350_L0.8091.00
110_P114_E0.8081.00
274_Q335_H0.8081.00
242_E246_N0.8061.00
41_F44_E0.8021.00
33_M40_S0.8011.00
56_V340_I0.8011.00
96_V350_L0.7991.00
274_Q337_N0.7991.00
46_Q308_D0.7961.00
252_M367_I0.7951.00
192_A234_T0.7941.00
293_A305_K0.7931.00
371_P374_E0.7921.00
181_L185_D0.7921.00
53_Y57_K0.7901.00
128_E375_C0.7891.00
122_K126_R0.7861.00
64_E67_S0.7851.00
133_H138_P0.7841.00
39_V55_D0.7831.00
187_C190_E0.7831.00
61_G344_H0.7821.00
54_D57_K0.7821.00
49_S313_F0.7811.00
197_G200_E0.7801.00
37_A302_H0.7751.00
135_F362_A0.7711.00
304_I310_V0.7701.00
135_F252_M0.7701.00
192_A227_E0.7681.00
139_L143_V0.7681.00
360_N364_T0.7671.00
256_L372_H0.7651.00
52_L300_G0.7581.00
260_G263_E0.7561.00
193_A196_A0.7521.00
118_E151_P0.7521.00
218_E223_K0.7521.00
89_H93_R0.7521.00
272_M360_N0.7491.00
138_P142_I0.7431.00
114_E151_P0.7421.00
31_E316_S0.7401.00
38_P320_D0.7391.00
99_A213_I0.7381.00
143_V358_E0.7341.00
261_V331_D0.7331.00
361_I365_S0.7291.00
74_T77_I0.7291.00
303_L306_E0.7291.00
59_V299_I0.7291.00
96_V236_L0.7271.00
199_I203_R0.7261.00
244_T358_E0.7261.00
195_F233_C0.7221.00
103_R106_K0.7191.00
112_I354_L0.7191.00
162_S166_V0.7171.00
163_D167_S0.7161.00
107_Q208_Q0.7141.00
300_G303_L0.7121.00
271_L275_A0.7111.00
161_W164_L0.7101.00
375_C378_I0.7091.00
140_P244_T0.7071.00
255_I275_A0.7051.00
259_P371_P0.7051.00
183_E186_K0.7031.00
68_S294_K0.7031.00
247_L280_L0.7001.00
102_P353_P0.6981.00
84_M92_I0.6971.00
299_I304_I0.6971.00
328_H331_D0.6961.00
123_F129_F0.6951.00
60_V312_A0.6951.00
196_A227_E0.6941.00
129_F134_D0.6921.00
67_S85_D0.6921.00
255_I367_I0.6901.00
156_E159_K0.6891.00
194_F197_G0.6881.00
123_F134_D0.6861.00
39_V302_H0.6851.00
93_R97_N0.6851.00
251_A330_F0.6841.00
71_P74_T0.6841.00
284_A318_N0.6831.00
96_V232_F0.6831.00
219_E222_E0.6821.00
207_E212_S0.6821.00
354_L358_E0.6801.00
240_G243_T0.6761.00
47_V309_M0.6751.00
314_V340_I0.6721.00
272_M363_L0.6721.00
208_Q213_I0.6681.00
331_D334_R0.6681.00
293_A307_G0.6681.00
313_F316_S0.6671.00
172_K175_E0.6651.00
185_D188_E0.6651.00
274_Q332_I0.6631.00
239_A243_T0.6631.00
164_L190_E0.6631.00
344_H348_F0.6631.00
110_P113_Q0.6621.00
294_K306_E0.6611.00
320_D323_K0.6561.00
218_E221_G0.6531.00
180_F184_R0.6521.00
58_K63_K0.6511.00
38_P300_G0.6481.00
181_L184_R0.6461.00
116_T119_L0.6461.00
116_T362_A0.6441.00
280_L339_H0.6441.00
60_V314_V0.6421.00
149_G209_D0.6411.00
31_E35_K0.6401.00
290_R311_L0.6391.00
251_A276_V0.6391.00
326_R334_R0.6361.00
121_Q124_Q0.6331.00
65_L68_S0.6281.00
42_D47_V0.6271.00
256_L374_E0.6261.00
282_F328_H0.6251.00
27_F315_A0.6241.00
182_E185_D0.6211.00
203_R218_E0.6191.00
194_F198_I0.6181.00
167_S170_K0.6151.00
150_V198_I0.6151.00
128_E376_V0.6111.00
53_Y320_D0.6101.00
119_L123_F0.6051.00
100_F236_L0.6031.00
252_M363_L0.6021.00
133_H137_Y0.6021.00
333_R336_P0.6011.00
68_S85_D0.5991.00
192_A231_P0.5981.00
140_P358_E0.5981.00
254_S330_F0.5971.00
276_V356_R0.5971.00
159_K162_S0.5951.00
293_A297_T0.5931.00
184_R188_E0.5911.00
86_P346_I0.5901.00
293_A310_V0.5891.00
104_V108_W0.5891.00
137_Y163_D0.5861.00
342_F356_R0.5861.00
276_V360_N0.5841.00
272_M275_A0.5831.00
68_S84_M0.5831.00
206_P212_S0.5821.00
58_K299_I0.5801.00
144_I147_L0.5791.00
166_V170_K0.5791.00
208_Q216_E0.5791.00
232_F235_L0.5781.00
171_D175_E0.5781.00
158_F162_S0.5761.00
377_S380_P0.5751.00
267_S270_E0.5751.00
57_K344_H0.5751.00
58_K298_E0.5751.00
284_A287_P0.5741.00
81_I232_F0.5721.00
252_M372_H0.5721.00
140_P245_T0.5711.00
268_H272_M0.5711.00
28_P32_S0.5711.00
184_R187_C0.5701.00
105_M354_L0.5691.00
79_N227_E0.5681.00
112_I361_I0.5651.00
112_I358_E0.5641.00
48_W302_H0.5631.00
104_V213_I0.5631.00
361_I364_T0.5611.00
122_K142_I0.5601.00
157_Q197_G0.5591.00
247_L276_V0.5581.00
51_F320_D0.5581.00
293_A306_E0.5571.00
122_K125_G0.5571.00
66_F293_A0.5561.00
78_G82_I0.5551.00
81_I235_L0.5541.00
256_L375_C0.5531.00
325_D329_M0.5531.00
209_D213_I0.5521.00
49_S311_L0.5511.00
272_M276_V0.5511.00
26_P30_Y0.5491.00
203_R215_V0.5481.00
173_S178_K0.5471.00
264_E332_I0.5471.00
251_A359_A0.5471.00
114_E117_D0.5471.00
166_V169_P0.5461.00
227_E230_I0.5461.00
160_A190_E0.5431.00
214_L229_L0.5421.00
324_F335_H0.5411.00
34_R51_F0.5411.00
265_L269_P0.5411.00
255_I258_T0.5401.00
257_E374_E0.5401.00
59_V66_F0.5391.00
141_V237_L0.5381.00
294_K297_T0.5371.00
280_L285_P0.5371.00
168_T171_D0.5361.00
199_I215_V0.5331.00
92_I228_E0.5311.00
343_G348_F0.5311.00
55_D299_I0.5311.00
195_F198_I0.5301.00
54_D323_K0.5291.00
27_F31_E0.5281.00
137_Y245_T0.5261.00
304_I308_D0.5251.00
119_L122_K0.5251.00
218_E222_E0.5251.00
161_W187_C0.5241.00
376_V379_T0.5241.00
128_E132_V0.5231.00
290_R309_M0.5221.00
40_S51_F0.5211.00
331_D337_N0.5201.00
30_Y33_M0.5191.00
95_V217_A0.5191.00
35_K322_A0.5181.00
108_W112_I0.5171.00
274_Q331_D0.5171.00
53_Y338_P0.5161.00
210_I214_L0.5161.00
52_L56_V0.5161.00
131_L135_F0.5151.00
81_I96_V0.5151.00
244_T355_A0.5151.00
92_I95_V0.5141.00
64_E69_C0.5131.00
187_C191_L0.5111.00
374_E377_S0.5101.00
115_I143_V0.5091.00
319_R327_P0.5091.00
186_K189_E0.5071.00
38_P51_F0.5061.00
134_D138_P0.5051.00
167_S171_D0.5041.00
145_S237_L0.5031.00
56_V60_V0.5021.00
228_E232_F0.5011.00
213_I217_A0.5001.00
269_P367_I0.5001.00
250_N381_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rm4A 1 0.9167 100 0.215 Contact Map
2z3tA 1 0.9444 100 0.23 Contact Map
4tpnA 1 0.9394 100 0.234 Contact Map
2xkrA 1 0.9621 100 0.236 Contact Map
3bujA 1 0.9545 100 0.238 Contact Map
3ejbB 1 0.9419 100 0.24 Contact Map
4ggvA 1 0.9646 100 0.241 Contact Map
2uuqA 2 0.9444 100 0.243 Contact Map
1q5dA 1 0.9646 100 0.246 Contact Map
4e2pA 1 0.899 100 0.247 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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