GREMLIN Database
YTET - Putative oxidoreductase YteT
UniProt: O34371 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 428 (395)
Sequences: 790 (596)
Seq/√Len: 30.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_Q120_K4.6851.00
188_S304_Y4.1251.00
201_Q298_G3.6891.00
139_K142_E3.3961.00
141_K145_L3.2431.00
189_T400_S3.0921.00
153_T322_T3.0201.00
201_Q297_D2.9481.00
205_E295_K2.9011.00
39_P43_A2.8721.00
175_R178_Q2.8421.00
335_S339_F2.8171.00
214_Y280_F2.7461.00
152_V319_I2.7401.00
140_I326_I2.6551.00
335_S340_A2.6271.00
203_P294_V2.5901.00
3_N30_E2.5390.99
142_E146_D2.3850.99
85_V113_R2.3760.99
334_P339_F2.3750.99
238_K244_Y2.3680.99
85_V89_V2.3200.99
104_M394_A2.3100.99
277_A282_E2.3030.99
229_G234_T2.2810.99
183_L306_I2.2640.99
155_V195_V2.2620.99
65_E69_V2.2190.99
61_D65_E2.2150.98
143_M146_D2.2090.98
75_V91_S2.2030.98
235_C241_C2.1890.98
77_V88_I2.1310.98
202_N297_D2.1180.98
232_C235_C2.1110.98
229_G236_R2.1040.98
316_R329_N2.0880.98
339_F342_P2.0830.98
277_A283_E2.0800.98
335_S338_P2.0600.98
155_V199_L2.0560.98
235_C278_C2.0430.97
4_I29_Y2.0320.97
97_D123_G2.0260.97
307_I310_A1.9870.97
334_P338_P1.9870.97
93_Q121_S1.9820.97
410_S416_P1.9810.97
166_G183_L1.9680.97
220_E281_D1.9670.97
184_S411_V1.9480.97
104_M398_A1.9440.96
336_R339_F1.9260.96
149_I321_G1.9200.96
119_A395_E1.9130.96
144_I319_I1.8940.96
409_R413_E1.8180.95
232_C241_C1.8110.95
144_I152_V1.8000.95
241_C278_C1.8000.95
117_A120_K1.7980.95
143_M148_K1.7980.95
9_L34_L1.7760.94
64_D90_K1.7740.94
253_K256_I1.7630.94
204_E297_D1.7510.94
21_L29_Y1.7490.94
183_L287_E1.7420.94
38_D41_R1.7240.93
67_M91_S1.7080.93
65_E68_R1.7030.93
149_I326_I1.7020.93
62_A65_E1.6910.92
43_A47_K1.6910.92
225_P228_D1.6900.92
335_S342_P1.6840.92
290_Y411_V1.6770.92
88_I100_T1.6650.92
184_S404_G1.6650.92
106_T110_D1.6580.92
161_I306_I1.6440.91
337_I340_A1.6410.91
116_E120_K1.6400.91
208_A290_Y1.6370.91
229_G244_Y1.6190.91
100_T104_M1.6100.90
184_S292_A1.6090.90
79_G87_Y1.6090.90
85_V110_D1.6070.90
6_F18_I1.6020.90
334_P337_I1.6010.90
151_R323_K1.5970.90
232_C278_C1.5930.90
63_F87_Y1.5850.90
245_S248_H1.5470.89
93_Q117_A1.5470.89
152_V199_L1.5450.89
5_V75_V1.5360.88
194_L198_W1.5350.88
100_T125_V1.5320.88
181_G186_H1.5240.88
307_I320_N1.5170.88
5_V66_M1.5120.87
257_K262_E1.5020.87
253_K257_K1.4880.87
199_L300_A1.4590.85
6_F31_I1.4480.85
104_M125_V1.4440.85
161_I183_L1.4440.85
241_C244_Y1.4350.85
205_E209_Y1.4330.84
46_K49_F1.4260.84
370_G373_L1.3960.83
367_H371_D1.3960.83
209_Y416_P1.3950.83
212_L219_S1.3950.83
161_I166_G1.3880.82
157_L317_L1.3710.82
290_Y407_M1.3700.82
333_E337_I1.3650.81
92_L123_G1.3530.81
333_E336_R1.3490.81
143_M149_I1.3470.81
155_V319_I1.3400.80
134_S370_G1.3330.80
401_I405_E1.3190.79
88_I114_V1.3170.79
196_N296_Y1.3130.79
64_D86_A1.3070.78
75_V98_V1.2990.78
105_V110_D1.2990.78
154_S320_N1.2910.78
334_P341_F1.2830.77
176_S283_E1.2770.77
104_M114_V1.2730.77
338_P341_F1.2640.76
139_K143_M1.2510.75
93_Q122_E1.2440.75
408_W411_V1.2420.75
58_F69_V1.2260.74
4_I21_L1.2210.73
137_H157_L1.2200.73
318_T327_E1.2100.73
120_K417_I1.1960.72
108_V409_R1.1880.71
92_L98_V1.1780.71
229_G233_G1.1770.71
111_A114_V1.1760.71
140_I149_I1.1730.70
170_F186_H1.1690.70
144_I149_I1.1670.70
90_K94_W1.1550.69
166_G306_I1.1410.68
173_W177_R1.1390.68
137_H315_Y1.1290.67
217_P282_E1.1210.67
41_R247_W1.1180.67
28_H380_L1.1170.67
72_P96_T1.1150.66
176_S285_D1.1120.66
24_R27_T1.1110.66
36_D42_F1.1020.65
74_I378_L1.0930.65
148_K356_Q1.0890.65
57_E60_E1.0880.64
230_R281_D1.0870.64
173_W182_G1.0800.64
88_I98_V1.0720.63
92_L118_E1.0720.63
409_R412_A1.0670.63
35_L66_M1.0620.63
117_A121_S1.0590.62
98_V123_G1.0490.62
228_D278_C1.0380.61
289_T305_S1.0350.61
260_H265_D1.0330.60
199_L296_Y1.0320.60
20_P25_F1.0270.60
393_G396_A1.0270.60
153_T213_N1.0260.60
415_K421_E1.0240.60
192_F404_G1.0230.60
392_A397_G1.0190.59
338_P342_P1.0160.59
209_Y295_K1.0150.59
360_V365_G1.0120.59
136_F328_S1.0060.58
6_F76_I1.0050.58
109_Q178_Q0.9980.58
167_A194_L0.9970.58
195_V302_L0.9950.57
342_P345_T0.9880.57
8_G12_R0.9870.57
293_A303_S0.9840.57
418_G421_E0.9820.56
261_L265_D0.9820.56
333_E338_P0.9810.56
247_W374_L0.9800.56
205_E418_G0.9770.56
334_P340_A0.9740.56
19_K23_E0.9730.56
136_F317_L0.9730.56
201_Q300_A0.9730.56
148_K151_R0.9650.55
37_A42_F0.9600.55
5_V72_P0.9600.55
176_S179_F0.9600.55
124_K382_K0.9590.55
407_M411_V0.9580.55
134_S137_H0.9570.54
61_D68_R0.9540.54
291_V301_L0.9500.54
79_G83_T0.9460.54
311_P327_E0.9440.53
274_R277_A0.9350.53
4_I74_I0.9330.53
82_D106_T0.9280.52
370_G374_L0.9250.52
242_H322_T0.9240.52
5_V33_G0.9240.52
97_D124_K0.9200.52
89_V113_R0.9160.51
238_K243_Y0.9150.51
341_F345_T0.9130.51
381_G386_R0.9100.51
225_P237_V0.9090.51
27_T151_R0.9030.50
256_I260_H0.8970.50
209_Y293_A0.8960.50
253_K258_D0.8950.50
211_A295_K0.8950.50
114_V303_S0.8940.49
286_I290_Y0.8940.49
246_R250_R0.8920.49
171_K215_Y0.8830.49
149_I152_V0.8770.48
151_R213_N0.8760.48
137_H197_W0.8710.48
378_L382_K0.8690.48
307_I329_N0.8650.47
234_T238_K0.8630.47
318_T325_R0.8600.47
7_C35_L0.8570.47
5_V32_T0.8550.46
112_N418_G0.8530.46
16_M357_T0.8500.46
257_K260_H0.8480.46
77_V100_T0.8450.46
192_F304_Y0.8440.46
147_G322_T0.8400.45
165_H172_R0.8390.45
55_V60_E0.8390.45
227_E232_C0.8380.45
194_L330_E0.8370.45
311_P325_R0.8290.44
97_D385_L0.8290.44
171_K290_Y0.8260.44
168_S171_K0.8200.44
89_V127_V0.8120.43
287_E306_I0.8110.43
133_Y377_D0.8100.43
154_S314_G0.8090.43
158_N303_S0.8080.43
72_P305_S0.8070.43
244_Y247_W0.8070.43
162_D175_R0.8060.43
159_W169_Y0.8050.42
187_K193_D0.8040.42
382_K385_L0.8040.42
5_V29_Y0.8030.42
36_D45_C0.8020.42
401_I411_V0.8000.42
115_L119_A0.7970.42
128_A397_G0.7960.42
13_A18_I0.7950.42
175_R179_F0.7910.41
115_L398_A0.7900.41
11_S16_M0.7870.41
294_V302_L0.7870.41
262_E265_D0.7810.41
406_G417_I0.7790.40
144_I280_F0.7750.40
97_D122_E0.7740.40
47_K50_P0.7700.40
115_L394_A0.7700.40
9_L36_D0.7690.40
317_L328_S0.7680.40
151_R219_S0.7650.39
119_A144_I0.7630.39
159_W165_H0.7630.39
21_L31_I0.7610.39
184_S192_F0.7610.39
168_S279_I0.7580.39
148_K346_I0.7580.39
140_I410_S0.7560.39
182_G185_V0.7540.39
124_K152_V0.7540.39
229_G232_C0.7540.39
146_D149_I0.7530.39
259_D264_G0.7510.38
95_N122_E0.7500.38
68_R94_W0.7470.38
7_C10_S0.7450.38
336_R340_A0.7450.38
332_H336_R0.7430.38
17_F130_N0.7430.38
43_A383_D0.7400.38
168_S408_W0.7380.37
75_V417_I0.7380.37
340_A345_T0.7370.37
65_E120_K0.7360.37
67_M94_W0.7360.37
409_R415_K0.7360.37
85_V114_V0.7340.37
341_F344_Q0.7330.37
262_E266_Q0.7330.37
229_G235_C0.7300.37
55_V58_F0.7300.37
332_H335_S0.7290.37
316_R374_L0.7290.37
179_F417_I0.7280.37
178_Q285_D0.7250.36
9_L42_F0.7230.36
227_E237_V0.7210.36
22_M49_F0.7180.36
242_H323_K0.7170.36
325_R392_A0.7160.36
49_F64_D0.7150.36
248_H276_D0.7110.35
136_F401_I0.7110.35
19_K89_V0.7080.35
46_K59_S0.7080.35
113_R116_E0.7070.35
31_I123_G0.7050.35
32_T387_R0.7040.35
81_D165_H0.7040.35
229_G278_C0.7030.35
247_W250_R0.7010.35
339_F343_E0.7010.35
125_V394_A0.7010.35
92_L121_S0.7010.35
81_D172_R0.6980.34
24_R376_E0.6950.34
207_F303_S0.6950.34
166_G287_E0.6940.34
92_L125_V0.6940.34
4_I22_M0.6930.34
319_I323_K0.6920.34
208_A411_V0.6910.34
35_L63_F0.6900.34
90_K93_Q0.6880.34
261_L264_G0.6880.34
174_N275_P0.6880.34
366_G369_G0.6870.34
249_P263_A0.6870.34
78_A97_D0.6840.33
56_P61_D0.6840.33
313_E325_R0.6840.33
219_S410_S0.6840.33
140_I334_P0.6830.33
109_Q113_R0.6780.33
18_I44_V0.6760.33
413_E417_I0.6750.33
20_P375_L0.6720.33
136_F194_L0.6710.33
7_C66_M0.6710.33
43_A46_K0.6690.32
129_F397_G0.6690.32
31_I76_I0.6660.32
144_I198_W0.6660.32
207_F293_A0.6650.32
70_S94_W0.6650.32
114_V306_I0.6630.32
254_A257_K0.6630.32
105_V186_H0.6620.32
144_I295_K0.6600.32
238_K241_C0.6570.32
24_R120_K0.6570.32
97_D104_M0.6560.32
9_L319_I0.6550.31
20_P24_R0.6550.31
112_N141_K0.6540.31
176_S282_E0.6530.31
18_I45_C0.6530.31
102_K190_H0.6520.31
108_V112_N0.6500.31
417_I420_K0.6480.31
67_M405_E0.6470.31
137_H194_L0.6470.31
335_S343_E0.6460.31
86_A116_E0.6460.31
200_G305_S0.6440.31
154_S188_S0.6440.31
38_D271_T0.6440.31
169_Y185_V0.6430.31
401_I408_W0.6420.31
332_H337_I0.6420.31
241_C245_S0.6420.31
89_V93_Q0.6410.30
98_V211_A0.6410.30
194_L304_Y0.6390.30
166_G308_F0.6390.30
31_I37_A0.6380.30
152_V323_K0.6370.30
16_M374_L0.6340.30
183_L208_A0.6340.30
137_H317_L0.6330.30
188_S368_G0.6330.30
39_P61_D0.6290.30
374_L377_D0.6270.30
171_K275_P0.6270.30
229_G241_C0.6270.30
160_Y318_T0.6250.29
237_V280_F0.6220.29
162_D168_S0.6220.29
205_E317_L0.6210.29
56_P60_E0.6210.29
46_K50_P0.6200.29
276_D284_I0.6190.29
170_F356_Q0.6190.29
140_I319_I0.6180.29
112_N116_E0.6140.29
114_V392_A0.6130.29
394_A398_A0.6120.29
87_Y127_V0.6120.29
107_T148_K0.6120.29
141_K392_A0.6110.29
234_T237_V0.6100.28
158_N320_N0.6090.28
65_E125_V0.6080.28
108_V358_I0.6080.28
136_F330_E0.6070.28
113_R117_A0.6070.28
19_K48_K0.6060.28
80_R180_S0.6060.28
47_K200_G0.6040.28
21_L303_S0.6040.28
205_E297_D0.6030.28
195_V300_A0.6030.28
43_A62_A0.6030.28
187_K190_H0.6010.28
203_P399_Y0.5990.28
36_D55_V0.5980.28
7_C32_T0.5970.28
104_M292_A0.5970.28
263_A266_Q0.5970.28
195_V211_A0.5970.28
47_K119_A0.5960.28
205_E293_A0.5950.27
154_S305_S0.5940.27
301_L398_A0.5940.27
310_A316_R0.5930.27
210_G288_D0.5930.27
208_A286_I0.5920.27
339_F345_T0.5910.27
232_C283_E0.5900.27
11_S303_S0.5900.27
209_Y326_I0.5870.27
161_I171_K0.5860.27
258_D262_E0.5860.27
365_G391_L0.5840.27
44_V48_K0.5830.27
126_T136_F0.5820.27
118_E397_G0.5820.27
140_I144_I0.5820.27
144_I199_L0.5790.26
125_V419_M0.5790.26
226_E420_K0.5760.26
68_R122_E0.5760.26
195_V396_A0.5760.26
189_T401_I0.5750.26
118_E121_S0.5740.26
333_E339_F0.5740.26
238_K246_R0.5740.26
80_R164_Y0.5740.26
152_V289_T0.5730.26
104_M393_G0.5730.26
278_C401_I0.5730.26
381_G385_L0.5720.26
326_I360_V0.5720.26
72_P289_T0.5710.26
177_R285_D0.5700.26
227_E235_C0.5700.26
144_I357_T0.5700.26
91_S98_V0.5690.26
126_T390_I0.5690.26
165_H169_Y0.5690.26
291_V303_S0.5690.26
185_V189_T0.5690.26
248_H401_I0.5690.26
156_D318_T0.5680.26
111_A393_G0.5670.26
337_I343_E0.5670.26
18_I197_W0.5640.26
90_K403_V0.5640.26
50_P104_M0.5630.26
360_V363_N0.5620.25
294_V317_L0.5610.25
204_E295_K0.5590.25
218_D421_E0.5580.25
252_S266_Q0.5570.25
173_W176_S0.5560.25
76_I106_T0.5550.25
147_G299_G0.5540.25
316_R327_E0.5530.25
99_I128_A0.5530.25
323_K420_K0.5520.25
66_M75_V0.5520.25
17_F172_R0.5520.25
160_Y316_R0.5500.25
7_C85_V0.5500.25
9_L63_F0.5500.25
39_P297_D0.5470.25
192_F403_V0.5470.25
111_A265_D0.5470.25
194_L197_W0.5460.24
143_M321_G0.5450.24
68_R120_K0.5440.24
151_R409_R0.5430.24
305_S308_F0.5430.24
290_Y306_I0.5420.24
91_S378_L0.5410.24
146_D386_R0.5410.24
77_V251_S0.5400.24
87_Y203_P0.5380.24
326_I359_Q0.5380.24
22_M377_D0.5370.24
64_D153_T0.5360.24
149_I324_G0.5360.24
16_M216_G0.5350.24
129_F159_W0.5340.24
319_I326_I0.5340.24
210_G411_V0.5310.24
32_T142_E0.5310.24
102_K187_K0.5310.24
390_I393_G0.5290.24
186_H192_F0.5290.24
154_S310_A0.5280.23
228_D232_C0.5270.23
316_R396_A0.5270.23
80_R303_S0.5270.23
99_I382_K0.5260.23
71_K96_T0.5250.23
380_L384_P0.5240.23
181_G185_V0.5240.23
412_A415_K0.5240.23
255_S297_D0.5230.23
326_I414_K0.5230.23
6_F45_C0.5220.23
187_K367_H0.5220.23
206_V294_V0.5220.23
175_R283_E0.5220.23
91_S137_H0.5210.23
291_V305_S0.5210.23
137_H160_Y0.5210.23
55_V65_E0.5210.23
164_Y167_A0.5190.23
72_P88_I0.5190.23
159_W171_K0.5190.23
154_S370_G0.5190.23
17_F220_E0.5180.23
45_C49_F0.5180.23
122_E155_V0.5180.23
126_T180_S0.5180.23
58_F68_R0.5160.23
312_Y327_E0.5150.23
154_S304_Y0.5140.23
260_H263_A0.5140.23
130_N191_H0.5140.23
168_S276_D0.5140.23
98_V125_V0.5130.23
146_D421_E0.5130.23
152_V357_T0.5110.22
154_S289_T0.5110.22
283_E413_E0.5090.22
143_M147_G0.5090.22
160_Y404_G0.5080.22
27_T68_R0.5080.22
65_E70_S0.5060.22
234_T242_H0.5050.22
130_N159_W0.5040.22
315_Y397_G0.5030.22
246_R249_P0.5020.22
40_K263_A0.5020.22
41_R197_W0.5020.22
50_P57_E0.5010.22
47_K116_E0.5010.22
276_D286_I0.5010.22
77_V98_V0.5010.22
116_E119_A0.5010.22
44_V47_K0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ixaA 2 0.8575 100 0.642 Contact Map
2nvwA 3 0.8131 100 0.644 Contact Map
3btvA 2 0.8411 100 0.65 Contact Map
1h6dA 8 0.7991 100 0.656 Contact Map
3dtyA 4 0.7967 100 0.66 Contact Map
3v5nA 4 0.764 100 0.661 Contact Map
3db2A 2 0.7827 100 0.666 Contact Map
1zh8A 2 0.75 100 0.667 Contact Map
3ezyA 4 0.778 100 0.668 Contact Map
3ceaA 4 0.785 100 0.668 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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