GREMLIN Database
YOBN - Putative L-amino-acid oxidase YobN
UniProt: O34363 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 478 (426)
Sequences: 14972 (12326)
Seq/√Len: 597.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_H48_R4.2761.00
27_L280_A4.0391.00
25_H281_D3.8061.00
269_H276_T3.6291.00
255_K266_H3.6161.00
50_T248_L3.5721.00
54_A252_K3.5281.00
58_A249_Y3.3451.00
38_S284_I3.2401.00
285_V292_L3.0791.00
52_L278_F3.0321.00
27_L52_L2.8641.00
27_L278_F2.8041.00
31_A58_A2.7921.00
58_A240_L2.7641.00
266_H277_S2.7031.00
257_S266_H2.6721.00
467_G471_A2.6601.00
189_Y193_D2.5451.00
48_R246_N2.5411.00
56_G250_H2.5281.00
251_Q267_C2.4971.00
27_L265_I2.4921.00
233_D237_H2.3971.00
267_C278_F2.3961.00
254_M268_Q2.3741.00
252_K268_Q2.3601.00
382_S385_E2.3461.00
248_L276_T2.3341.00
29_I285_V2.3151.00
234_L237_H2.2431.00
286_T449_A2.1911.00
52_L248_L2.1421.00
26_I47_H2.0751.00
240_L247_I2.0681.00
34_S286_T2.0361.00
177_H185_T2.0111.00
66_R74_Y1.9981.00
29_I287_I1.9811.00
25_H50_T1.9591.00
248_L251_Q1.9581.00
426_A429_P1.9521.00
41_L468_I1.9501.00
413_S416_Q1.9371.00
282_L447_H1.9371.00
52_L280_A1.9291.00
425_T429_P1.9181.00
189_Y192_I1.9181.00
130_I133_Y1.9061.00
267_C275_F1.8951.00
33_L460_M1.8881.00
64_T74_Y1.8811.00
57_R63_C1.8261.00
388_Q392_L1.8151.00
24_K50_T1.7861.00
141_G144_S1.7741.00
267_C276_T1.7561.00
144_S147_L1.7541.00
256_M263_V1.7471.00
238_A241_P1.7141.00
264_T279_T1.7111.00
41_L44_N1.7101.00
254_M266_H1.6821.00
40_S242_Q1.6721.00
187_F191_A1.6621.00
180_S184_N1.6541.00
144_S148_M1.6261.00
187_F192_I1.6041.00
264_T277_S1.5941.00
188_S192_I1.5881.00
37_V464_I1.5771.00
284_I474_V1.5711.00
327_K405_E1.5641.00
425_T428_E1.5631.00
257_S277_S1.5601.00
26_I282_L1.5531.00
39_A51_I1.5531.00
395_S400_D1.5531.00
449_A470_V1.5511.00
251_Q269_H1.5471.00
178_S181_S1.5401.00
263_V283_A1.5351.00
395_S403_W1.5331.00
41_L472_Y1.5321.00
387_I409_G1.5231.00
248_L278_F1.5211.00
287_I292_L1.5091.00
192_I195_I1.4901.00
257_S264_T1.4841.00
384_G388_Q1.4721.00
422_G430_G1.4681.00
349_F353_P1.4671.00
203_A206_G1.4551.00
263_V445_R1.4521.00
99_P229_T1.4451.00
58_A236_P1.4331.00
427_F430_G1.4221.00
44_N95_K1.4151.00
61_R451_E1.3991.00
43_K245_T1.3911.00
259_G264_T1.3911.00
50_T246_N1.3751.00
140_Q144_S1.3741.00
251_Q276_T1.3661.00
253_M265_I1.3561.00
232_M460_M1.3541.00
52_L267_C1.3541.00
51_I247_I1.3501.00
52_L253_M1.3321.00
254_M275_F1.3301.00
62_V236_P1.3291.00
327_K407_V1.3241.00
25_H47_H1.3231.00
258_Q263_V1.3221.00
352_Y355_R1.3211.00
27_L50_T1.3201.00
151_L155_I1.3181.00
237_H241_P1.3181.00
298_E302_S1.3081.00
26_I42_L1.3071.00
73_L325_E1.3041.00
35_G286_T1.3001.00
31_A51_I1.2981.00
91_E95_K1.2921.00
127_A130_I1.2861.00
66_R72_D1.2761.00
94_K99_P1.2681.00
180_S205_M1.2481.00
140_Q143_T1.2411.00
188_S191_A1.2301.00
427_F431_Q1.2261.00
28_V39_A1.2201.00
428_E431_Q1.2161.00
363_A407_V1.2121.00
187_F193_D1.2111.00
326_F391_L1.2111.00
403_W406_F1.2081.00
50_T280_A1.2061.00
187_F190_G1.2041.00
412_F416_Q1.1981.00
243_L247_I1.1941.00
447_H470_V1.1931.00
34_S466_S1.1921.00
58_A247_I1.1861.00
255_K298_E1.1851.00
203_A210_V1.1841.00
43_K49_V1.1791.00
91_E468_I1.1771.00
24_K281_D1.1691.00
422_G431_Q1.1671.00
101_N229_T1.1671.00
143_T147_L1.1551.00
387_I391_L1.1551.00
349_F352_Y1.1541.00
41_L467_G1.1531.00
287_I295_V1.1501.00
280_A283_A1.1471.00
200_D204_Y1.1461.00
268_Q275_F1.1341.00
50_T278_F1.1301.00
348_R352_Y1.1301.00
347_I352_Y1.1261.00
40_S239_F1.1261.00
383_E413_S1.1191.00
177_H181_S1.1181.00
470_V473_E1.1151.00
40_S44_N1.1121.00
90_L94_K1.1121.00
43_K243_L1.1091.00
349_F357_I1.1051.00
34_S449_A1.1021.00
340_K343_T1.0971.00
126_R129_G1.0951.00
154_P158_F1.0921.00
158_F162_N1.0901.00
422_G425_T1.0891.00
393_N396_E1.0871.00
410_T413_S1.0851.00
453_A469_R1.0841.00
288_P291_T1.0831.00
66_R233_D1.0801.00
194_M198_L1.0721.00
151_L154_P1.0671.00
259_G262_R1.0671.00
147_L151_L1.0661.00
327_K363_A1.0641.00
40_S243_L1.0631.00
410_T414_W1.0621.00
421_A424_F1.0551.00
424_F428_E1.0551.00
228_I235_L1.0511.00
269_H275_F1.0491.00
150_S154_P1.0481.00
200_D203_A1.0461.00
152_L158_F1.0411.00
23_P48_R1.0371.00
354_S357_I1.0321.00
422_G428_E1.0311.00
129_G132_R1.0301.00
52_L251_Q1.0301.00
352_Y356_N1.0291.00
191_A194_M1.0291.00
425_T430_G1.0281.00
469_R473_E1.0221.00
200_D207_M1.0201.00
127_A131_L1.0191.00
23_P279_T1.0131.00
424_F429_P1.0101.00
289_F452_H1.0091.00
108_P111_I1.0061.00
152_L156_L1.0041.00
347_I350_S1.0031.00
432_E439_I1.0011.00
282_L474_V1.0011.00
141_G145_E0.9981.00
251_Q278_F0.9971.00
130_I134_P0.9951.00
453_A466_S0.9891.00
31_A249_Y0.9851.00
332_E336_Q0.9841.00
348_R351_Y0.9821.00
262_R279_T0.9811.00
426_A431_Q0.9711.00
406_F409_G0.9711.00
426_A430_G0.9701.00
129_G133_Y0.9681.00
131_L134_P0.9661.00
340_K346_P0.9651.00
309_R312_R0.9621.00
424_F427_F0.9621.00
28_V49_V0.9611.00
388_Q403_W0.9561.00
187_F196_G0.9541.00
193_D196_G0.9531.00
450_G466_S0.9531.00
187_F194_M0.9511.00
256_M265_I0.9491.00
352_Y357_I0.9471.00
424_F430_G0.9441.00
256_M283_A0.9431.00
142_K145_E0.9371.00
389_Y392_L0.9351.00
157_N160_N0.9351.00
326_F406_F0.9341.00
23_P281_D0.9341.00
33_L62_V0.9331.00
42_L471_A0.9331.00
372_A375_A0.9301.00
333_K336_Q0.9301.00
24_K48_R0.9281.00
385_E388_Q0.9281.00
443_E446_V0.9281.00
322_I411_S0.9251.00
203_A208_S0.9241.00
151_L159_I0.9241.00
333_K337_H0.9231.00
190_G193_D0.9231.00
348_R357_I0.9221.00
155_I158_F0.9201.00
140_Q147_L0.9201.00
425_T431_Q0.9191.00
463_A467_G0.9181.00
391_L395_S0.9171.00
93_I98_L0.9091.00
206_G210_V0.9071.00
324_I391_L0.9061.00
348_R353_P0.9031.00
93_I96_F0.9031.00
150_S153_Q0.9021.00
240_L249_Y0.9001.00
378_W381_L0.8991.00
422_G427_F0.8991.00
367_A371_W0.8981.00
350_S354_S0.8961.00
126_R130_I0.8941.00
92_Y96_F0.8921.00
154_P157_N0.8911.00
151_L156_L0.8871.00
339_G346_P0.8861.00
202_E205_M0.8851.00
349_F354_S0.8851.00
201_M206_G0.8831.00
351_Y356_N0.8821.00
308_R312_R0.8791.00
350_S357_I0.8781.00
353_P356_N0.8711.00
190_G194_M0.8711.00
76_N80_M0.8701.00
422_G426_A0.8701.00
65_L77_A0.8651.00
153_Q156_L0.8631.00
91_E94_K0.8621.00
436_Y439_I0.8621.00
38_S467_G0.8591.00
342_I345_L0.8581.00
141_G147_L0.8571.00
325_E408_S0.8551.00
438_Y441_V0.8551.00
256_M285_V0.8531.00
188_S193_D0.8481.00
184_N189_Y0.8471.00
41_L45_A0.8471.00
131_L135_V0.8471.00
47_H50_T0.8391.00
343_T346_P0.8381.00
140_Q145_E0.8361.00
237_H240_L0.8341.00
142_K146_E0.8331.00
392_L396_E0.8321.00
433_L436_Y0.8321.00
408_S413_S0.8321.00
392_L395_S0.8271.00
468_I472_Y0.8251.00
195_I198_L0.8251.00
149_L153_Q0.8231.00
55_S63_C0.8211.00
353_P357_I0.8211.00
236_P240_L0.8211.00
155_I159_I0.8211.00
370_T390_T0.8191.00
88_L468_I0.8191.00
385_E389_Y0.8161.00
432_E436_Y0.8161.00
200_D210_V0.8151.00
234_L238_A0.8141.00
182_F186_Y0.8111.00
339_G342_I0.8111.00
423_G429_P0.8081.00
379_D383_E0.8071.00
408_S414_W0.8061.00
332_E335_G0.8051.00
258_Q445_R0.8031.00
177_H182_F0.8011.00
189_Y194_M0.7981.00
447_H474_V0.7971.00
299_P302_S0.7961.00
25_H279_T0.7961.00
421_A425_T0.7951.00
334_A337_H0.7931.00
341_S346_P0.7901.00
422_G429_P0.7871.00
291_T294_F0.7831.00
259_G279_T0.7811.00
143_T146_E0.7801.00
201_M209_L0.7801.00
128_P132_R0.7781.00
434_E437_P0.7771.00
326_F330_F0.7761.00
230_G234_L0.7761.00
447_H473_E0.7741.00
405_E413_S0.7701.00
200_D211_E0.7681.00
407_V410_T0.7661.00
25_H278_F0.7661.00
350_S353_P0.7621.00
364_V368_S0.7611.00
436_Y441_V0.7601.00
141_G148_M0.7601.00
39_A243_L0.7591.00
200_D213_L0.7581.00
328_S405_E0.7581.00
89_T464_I0.7551.00
41_L95_K0.7531.00
265_I283_A0.7531.00
347_I353_P0.7521.00
435_L439_I0.7521.00
387_I390_T0.7511.00
156_L160_N0.7501.00
471_A474_V0.7471.00
228_I234_L0.7461.00
141_G162_N0.7421.00
152_L159_I0.7411.00
255_K296_K0.7411.00
359_A362_H0.7411.00
50_T281_D0.7411.00
191_A198_L0.7411.00
423_G428_E0.7401.00
140_Q148_M0.7391.00
424_F431_Q0.7391.00
61_R78_G0.7391.00
432_E435_L0.7341.00
339_G343_T0.7341.00
351_Y357_I0.7321.00
153_Q157_N0.7311.00
121_L124_F0.7281.00
305_Y309_R0.7231.00
340_K344_D0.7231.00
350_S355_R0.7211.00
258_Q443_E0.7211.00
156_L159_I0.7211.00
48_R281_D0.7211.00
285_V446_V0.7201.00
99_P102_V0.7171.00
146_E150_S0.7161.00
110_D113_Y0.7161.00
282_L445_R0.7151.00
350_S356_N0.7151.00
254_M267_C0.7141.00
37_V467_G0.7131.00
90_L100_T0.7111.00
40_S95_K0.7111.00
203_A207_M0.7101.00
125_E128_P0.7091.00
199_L210_V0.7091.00
209_L213_L0.7091.00
434_E439_I0.7081.00
360_N363_A0.7061.00
140_Q152_L0.7061.00
73_L360_N0.7041.00
152_L155_I0.7031.00
24_K27_L0.7031.00
437_P441_V0.7021.00
339_G345_L0.7021.00
144_S152_L0.7001.00
376_L379_D0.7001.00
204_Y207_M0.6971.00
155_I162_N0.6941.00
349_F356_N0.6941.00
151_L158_F0.6921.00
200_D212_V0.6911.00
37_V41_L0.6901.00
159_I162_N0.6891.00
76_N81_R0.6891.00
194_M197_V0.6881.00
64_T233_D0.6881.00
33_L463_A0.6871.00
28_V35_G0.6851.00
192_I197_V0.6831.00
150_S158_F0.6801.00
295_V299_P0.6801.00
148_M152_L0.6801.00
309_R313_E0.6781.00
201_M205_M0.6781.00
107_T110_D0.6771.00
53_E249_Y0.6751.00
33_L37_V0.6751.00
201_M207_M0.6751.00
188_S194_M0.6731.00
421_A430_G0.6731.00
394_L398_Y0.6711.00
51_I243_L0.6701.00
213_L216_S0.6671.00
189_Y196_G0.6671.00
283_A445_R0.6671.00
148_M151_L0.6641.00
199_L207_M0.6611.00
43_K244_K0.6601.00
25_H280_A0.6591.00
436_Y440_P0.6591.00
114_A119_T0.6581.00
210_V213_L0.6551.00
349_F355_R0.6551.00
253_M267_C0.6511.00
200_D206_G0.6511.00
179_L183_L0.6511.00
73_L363_A0.6471.00
47_H281_D0.6471.00
379_D382_S0.6461.00
150_S162_N0.6461.00
440_P473_E0.6451.00
44_N242_Q0.6451.00
449_A467_G0.6431.00
238_A242_Q0.6431.00
151_L162_N0.6421.00
156_L162_N0.6421.00
202_E206_G0.6411.00
412_F415_S0.6411.00
421_A427_F0.6411.00
339_G344_D0.6411.00
394_L401_I0.6411.00
201_M210_V0.6401.00
340_K345_L0.6401.00
128_P131_L0.6381.00
157_N161_Q0.6381.00
33_L236_P0.6381.00
408_S416_Q0.6381.00
114_A117_I0.6381.00
201_M208_S0.6381.00
154_P162_N0.6371.00
152_L162_N0.6361.00
211_E214_R0.6361.00
346_P349_F0.6361.00
208_S211_E0.6351.00
34_S463_A0.6331.00
435_L438_Y0.6321.00
140_Q155_I0.6321.00
188_S195_I0.6291.00
432_E438_Y0.6271.00
142_K147_L0.6241.00
408_S412_F0.6241.00
145_E149_L0.6231.00
386_R411_S0.6231.00
351_Y354_S0.6221.00
202_E207_M0.6211.00
199_L202_E0.6171.00
193_D197_V0.6171.00
190_G195_I0.6161.00
28_V284_I0.6141.00
381_L385_E0.6141.00
200_D208_S0.6141.00
421_A428_E0.6131.00
199_L208_S0.6121.00
410_T416_Q0.6101.00
432_E437_P0.6091.00
52_L265_I0.6081.00
142_K148_M0.6061.00
324_I368_S0.6061.00
465_E469_R0.6051.00
201_M204_Y0.6051.00
24_K47_H0.6051.00
160_N163_P0.6041.00
141_G154_P0.6011.00
210_V215_E0.6011.00
411_S415_S0.6001.00
43_K246_N0.5991.00
347_I351_Y0.5991.00
204_Y213_L0.5981.00
147_L155_I0.5981.00
347_I355_R0.5981.00
404_S407_V0.5961.00
199_L213_L0.5951.00
199_L215_E0.5941.00
200_D215_E0.5941.00
33_L464_I0.5931.00
393_N397_I0.5931.00
199_L206_G0.5921.00
341_S345_L0.5911.00
91_E96_F0.5901.00
289_F293_R0.5901.00
143_T148_M0.5901.00
254_M257_S0.5881.00
423_G426_A0.5871.00
188_S198_L0.5861.00
342_I346_P0.5851.00
62_V79_P0.5831.00
437_P440_P0.5811.00
388_Q391_L0.5791.00
206_G209_L0.5791.00
304_S443_E0.5771.00
345_L396_E0.5751.00
146_E149_L0.5751.00
304_S308_R0.5751.00
36_L243_L0.5721.00
284_I447_H0.5711.00
110_D120_R0.5701.00
364_V367_A0.5691.00
200_D216_S0.5691.00
268_Q276_T0.5681.00
359_A363_A0.5671.00
201_M213_L0.5671.00
142_K151_L0.5671.00
71_D408_S0.5661.00
262_R444_G0.5661.00
204_Y211_E0.5661.00
76_N232_M0.5661.00
45_A472_Y0.5661.00
96_F239_F0.5651.00
351_Y355_R0.5651.00
158_F161_Q0.5621.00
290_S294_F0.5611.00
338_G341_S0.5601.00
433_L437_P0.5591.00
152_L161_Q0.5591.00
144_S151_L0.5581.00
154_P161_Q0.5570.99
124_F127_A0.5560.99
257_S298_E0.5550.99
240_L245_T0.5550.99
341_S344_D0.5530.99
155_I161_Q0.5520.99
79_P232_M0.5520.99
423_G427_F0.5520.99
433_L438_Y0.5500.99
368_S394_L0.5500.99
37_V239_F0.5490.99
288_P452_H0.5490.99
192_I198_L0.5480.99
199_L203_A0.5470.99
395_S399_G0.5460.99
307_K310_A0.5450.99
117_I120_R0.5440.99
206_G213_L0.5440.99
94_K97_K0.5440.99
157_N162_N0.5440.99
400_D404_S0.5430.99
433_L439_I0.5410.99
154_P159_I0.5410.99
325_E407_V0.5410.99
38_S470_V0.5390.99
191_A197_V0.5390.99
39_A245_T0.5370.99
109_M113_Y0.5360.99
203_A213_L0.5350.99
147_L152_L0.5350.99
116_G121_L0.5340.99
204_Y210_V0.5340.99
386_R390_T0.5330.99
36_L51_I0.5330.99
406_F413_S0.5320.99
209_L212_V0.5310.99
140_Q162_N0.5310.99
151_L157_N0.5300.99
199_L214_R0.5300.99
106_R111_I0.5290.99
117_I121_L0.5260.99
332_E337_H0.5260.99
33_L239_F0.5240.99
207_M210_V0.5240.99
145_E151_L0.5220.99
62_V460_M0.5220.99
29_I253_M0.5210.99
297_V302_S0.5200.99
307_K442_P0.5190.99
411_S414_W0.5190.99
342_I347_I0.5180.99
347_I354_S0.5160.99
83_P225_F0.5160.99
116_G120_R0.5150.99
90_L93_I0.5140.99
460_M464_I0.5130.99
156_L161_Q0.5120.99
119_T122_Q0.5120.99
135_V140_Q0.5120.99
51_I58_A0.5120.99
289_F311_I0.5100.99
132_R136_A0.5100.99
92_Y95_K0.5100.99
145_E148_M0.5090.99
98_L103_F0.5090.99
211_E215_E0.5090.99
47_H282_L0.5070.99
207_M213_L0.5060.99
191_A196_G0.5030.99
150_S156_L0.5020.99
208_S213_L0.5010.99
470_V474_V0.5010.99
113_Y118_K0.5010.99
92_Y464_I0.5000.99
149_L152_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i59A 1 0.9017 100 0.332 Contact Map
2yg5A 2 0.91 100 0.335 Contact Map
2iidA 2 0.9812 100 0.352 Contact Map
1s3eA 2 0.9059 100 0.355 Contact Map
3x0vA 2 0.9414 100 0.378 Contact Map
1b37A 4 0.8766 100 0.383 Contact Map
3we0A 3 0.9289 100 0.391 Contact Map
4iv9A 2 0.977 100 0.394 Contact Map
2vvmA 2 0.9226 100 0.4 Contact Map
2ivdA 1 0.8682 100 0.404 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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