GREMLIN Database
CWLK - Peptidoglycan L-alanyl-D-glutamate endopeptidase CwlK
UniProt: O34360 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 167 (135)
Sequences: 263 (194)
Seq/√Len: 16.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_E163_E6.4741.00
143_K152_D4.8941.00
69_E76_E4.1941.00
150_G158_D3.3830.99
63_I128_N3.3180.99
101_Y106_L2.7410.97
78_D97_G2.5780.96
91_I152_D2.3900.94
134_D137_E2.2360.92
58_A95_A2.1820.91
141_I144_T2.1220.89
34_L37_M1.9360.84
110_F162_L1.8420.81
78_D160_P1.7620.78
106_L159_Y1.7090.76
150_G160_P1.6950.75
50_N54_L1.6740.74
98_G103_N1.6670.74
82_K86_T1.6420.73
54_L138_V1.6320.72
58_A141_I1.5620.69
96_R103_N1.5340.67
90_N118_S1.4890.65
126_D137_E1.4860.65
113_Q163_E1.4830.65
81_Y85_R1.4790.64
136_L139_V1.4790.64
94_Y162_L1.4750.64
44_H106_L1.4390.62
37_M52_D1.3910.59
66_V119_I1.3860.59
142_A145_L1.3600.58
126_D134_D1.3310.56
139_V142_A1.3210.55
83_Q89_G1.2960.54
110_F139_V1.2820.53
123_M139_V1.2730.53
54_L65_V1.2510.51
61_K66_V1.2430.51
61_K141_I1.2360.50
101_Y163_E1.2270.50
41_S75_K1.2250.50
38_P60_N1.2020.48
80_L93_T1.1940.48
41_S48_K1.1890.48
54_L145_L1.1880.48
79_E114_K1.1600.46
54_L112_L1.1490.45
61_K88_K1.1250.44
79_E83_Q1.0990.42
42_D51_A1.0700.41
133_S136_L1.0540.40
76_E94_Y1.0270.38
36_D130_N1.0180.38
96_R99_E1.0080.37
121_W135_W0.9990.37
43_L134_D0.9920.36
111_A142_A0.9880.36
63_I138_V0.9810.36
39_V59_A0.9800.36
63_I141_I0.9790.36
120_I127_G0.9780.36
77_Q80_L0.9710.35
55_K69_E0.9680.35
121_W142_A0.9570.34
139_V165_I0.9490.34
51_A108_I0.9470.34
111_A121_W0.9440.34
123_M159_Y0.9430.34
81_Y146_G0.9410.34
64_D113_Q0.9350.33
91_I138_V0.9310.33
87_K104_Y0.9290.33
149_W152_D0.9280.33
58_A71_F0.9170.32
67_I117_G0.9150.32
82_K97_G0.9130.32
54_L134_D0.9080.32
154_K157_K0.8990.31
77_Q100_S0.8940.31
128_N137_E0.8930.31
110_F136_L0.8840.31
108_I115_K0.8830.31
35_Q39_V0.8640.30
95_A99_E0.8620.30
63_I130_N0.8600.29
36_D39_V0.8590.29
34_L38_P0.8550.29
55_K70_G0.8550.29
133_S140_E0.8540.29
81_Y84_G0.8530.29
40_P58_A0.8380.28
127_G163_E0.8360.28
112_L135_W0.8340.28
101_Y159_Y0.8320.28
37_M94_Y0.8300.28
36_D70_G0.8200.28
128_N147_F0.8130.27
35_Q75_K0.8090.27
78_D86_T0.7980.27
40_P71_F0.7970.26
75_K79_E0.7880.26
108_I163_E0.7820.26
67_I73_S0.7820.26
30_S34_L0.7740.25
73_S106_L0.7730.25
71_F157_K0.7720.25
36_D154_K0.7670.25
44_H104_Y0.7670.25
85_R93_T0.7600.25
112_L121_W0.7600.25
131_G137_E0.7560.25
110_F145_L0.7530.24
135_W138_V0.7420.24
97_G104_Y0.7410.24
90_N114_K0.7380.24
73_S82_K0.7270.23
88_K94_Y0.7130.23
42_D60_N0.7130.23
42_D118_S0.7080.23
55_K132_K0.7050.22
66_V113_Q0.7010.22
84_G149_W0.6990.22
93_T100_S0.6910.22
98_G135_W0.6880.22
35_Q148_E0.6860.22
108_I147_F0.6810.21
156_F162_L0.6790.21
138_V143_K0.6780.21
96_R144_T0.6780.21
43_L78_D0.6760.21
106_L163_E0.6720.21
38_P133_S0.6710.21
47_V147_F0.6690.21
68_T134_D0.6690.21
41_S155_R0.6630.21
127_G164_M0.6600.21
61_K144_T0.6590.21
114_K118_S0.6590.21
33_A155_R0.6580.21
32_N70_G0.6570.21
126_D130_N0.6520.20
63_I103_N0.6510.20
121_W156_F0.6500.20
86_T162_L0.6420.20
59_A155_R0.6400.20
32_N36_D0.6370.20
131_G134_D0.6360.20
112_L120_I0.6340.20
118_S148_E0.6330.20
94_Y99_E0.6300.19
59_A64_D0.6280.19
32_N39_V0.6270.19
55_K58_A0.6260.19
44_H108_I0.6240.19
75_K96_R0.6240.19
69_E73_S0.6130.19
61_K118_S0.6110.19
121_W157_K0.6070.19
52_D164_M0.6070.19
30_S37_M0.6060.19
110_F135_W0.6050.19
81_Y96_R0.6010.18
112_L139_V0.6000.18
39_V82_K0.5950.18
101_Y111_A0.5920.18
39_V71_F0.5900.18
80_L133_S0.5880.18
37_M46_I0.5880.18
56_A64_D0.5860.18
33_A40_P0.5850.18
98_G156_F0.5820.18
51_A88_K0.5820.18
48_K148_E0.5810.18
34_L144_T0.5760.18
56_A124_E0.5750.18
35_Q164_M0.5740.17
74_F148_E0.5730.17
65_V114_K0.5710.17
97_G103_N0.5700.17
68_T119_I0.5690.17
57_A144_T0.5650.17
103_N135_W0.5500.17
132_K154_K0.5490.17
83_Q90_N0.5430.16
71_F106_L0.5400.16
30_S64_D0.5380.16
49_Q57_A0.5380.16
112_L134_D0.5370.16
50_N145_L0.5330.16
88_K144_T0.5280.16
40_P148_E0.5220.16
124_E154_K0.5210.16
31_Q34_L0.5200.16
48_K52_D0.5160.16
79_E108_I0.5030.15
123_M136_L0.5030.15
72_R102_H0.5000.15
72_R107_A0.5000.15
102_H107_A0.5000.15
102_H109_D0.5000.15
72_R109_D0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mxzA 1 0.7485 100 0.488 Contact Map
2vo9A 1 0.8024 100 0.517 Contact Map
4ox3A 1 0.9641 99.4 0.773 Contact Map
4mphA 2 0.8982 99.4 0.774 Contact Map
4muqA 1 0.9281 99.3 0.777 Contact Map
4nt9B 3 0.8623 99.3 0.777 Contact Map
4murA 2 0.8982 99.3 0.78 Contact Map
1r44A 1 0.9341 98.1 0.856 Contact Map
2ibgE 1 0.6707 97.7 0.869 Contact Map
3k7iB 1 0.7844 97.4 0.876 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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