GREMLIN Database
HTRA - Serine protease Do-like HtrA
UniProt: O34358 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 449 (340)
Sequences: 2109 (1705)
Seq/√Len: 92.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
296_N300_K6.3141.00
398_G427_K5.1261.00
123_E233_R5.0881.00
428_I437_K4.6261.00
400_K418_A4.6011.00
228_D324_N4.4151.00
178_N204_S4.0731.00
225_N300_K3.9911.00
228_D231_D3.9311.00
224_A301_I3.8351.00
230_S324_N3.7741.00
199_A213_L3.7651.00
423_T438_K3.7211.00
187_L201_L3.7191.00
425_E436_T3.3621.00
376_I390_L3.1241.00
128_A223_V2.8081.00
398_G401_G2.6361.00
238_V258_V2.6171.00
425_E438_K2.5731.00
348_M407_G2.5641.00
197_V215_I2.4951.00
226_F323_S2.4821.00
285_I318_G2.4441.00
427_K434_E2.4201.00
376_I396_I2.4101.00
163_V293_P2.3831.00
232_L302_V2.2561.00
293_P301_I2.2421.00
175_I326_V2.2061.00
226_F327_K2.1681.00
186_S198_T2.1641.00
258_V279_I2.1531.00
394_D430_R2.1431.00
200_K216_S2.1191.00
423_T440_K2.1161.00
163_V301_I2.1141.00
398_G403_E2.1071.00
344_I439_I2.0851.00
347_S378_E2.0571.00
188_K196_E2.0251.00
119_S236_E1.9911.00
382_G386_E1.9111.00
122_V253_V1.9091.00
332_E336_K1.9011.00
428_I435_M1.8951.00
390_L426_V1.8411.00
175_I330_A1.8321.00
239_I297_T1.7191.00
217_D220_V1.7071.00
342_P420_I1.6881.00
232_L261_V1.6871.00
163_V224_A1.6291.00
375_Y393_E1.6281.00
327_K331_E1.6261.00
135_L186_S1.6211.00
125_L295_L1.5931.00
238_V297_T1.5891.00
402_K413_I1.5781.00
164_I191_L1.5621.00
212_V334_L1.5491.00
134_N187_L1.5411.00
215_I220_V1.5381.00
427_K436_T1.5321.00
227_G323_S1.5251.00
336_K340_E1.5141.00
119_S233_R1.4911.00
117_K236_E1.4731.00
237_T255_Q1.4691.00
118_I255_Q1.4501.00
343_Y384_P1.4390.99
343_Y445_E1.4380.99
405_D409_E1.4340.99
118_I239_I1.3940.99
397_I427_K1.3930.99
384_P442_D1.3760.99
224_A295_L1.3730.99
181_V187_L1.3690.99
234_T261_V1.3630.99
245_L314_V1.3630.99
117_K120_D1.3610.99
121_M295_L1.3560.99
255_Q282_D1.3560.99
323_S326_V1.3470.99
418_A422_D1.3250.99
200_K214_Q1.3230.99
406_T409_E1.3170.99
191_L197_V1.2980.99
125_L224_A1.2950.99
381_S386_E1.2890.99
399_L424_V1.2850.99
240_A305_N1.2810.99
281_T294_L1.2770.99
380_A383_S1.2690.99
285_I305_N1.2670.99
340_E443_Q1.2660.99
352_E355_P1.2650.99
390_L437_K1.2580.99
385_A388_A1.2570.99
133_T190_S1.2560.99
173_Y202_V1.2550.99
229_S324_N1.2450.98
308_K315_E1.2350.98
126_S251_R1.2250.98
166_K173_Y1.2180.98
174_I215_I1.2070.98
174_I213_L1.2000.98
173_Y214_Q1.1990.98
127_P222_K1.1950.98
400_K413_I1.1940.98
391_K430_R1.1880.98
191_L215_I1.1810.98
226_F301_I1.1700.98
424_V441_L1.1610.98
210_L304_I1.1590.98
188_K198_T1.1570.98
379_V392_A1.1530.98
350_D407_G1.1500.97
308_K314_V1.1500.97
398_G434_E1.1410.97
372_K405_D1.1360.97
426_V437_K1.1320.97
418_A441_L1.1270.97
237_T297_T1.1250.97
304_I326_V1.1250.97
249_L317_I1.1210.97
132_I213_L1.1120.97
168_E214_Q1.1110.97
161_S293_P1.1080.97
390_L428_I1.1040.97
370_L429_L1.1020.97
136_Q156_E1.0930.97
331_E335_S1.0870.96
172_A214_Q1.0860.96
419_K422_D1.0820.96
118_I122_V1.0810.96
163_V304_I1.0800.96
286_N289_N1.0800.96
426_V436_T1.0650.96
121_M239_I1.0610.96
240_A294_L1.0510.96
227_G232_L1.0500.96
187_L213_L1.0450.96
350_D408_S1.0450.96
232_L279_I1.0410.95
350_D406_T1.0240.95
346_V374_V1.0170.95
166_K172_A1.0160.95
121_M124_D1.0140.95
332_E339_I1.0110.95
164_I223_V1.0000.94
374_V411_R0.9970.94
379_V389_G0.9950.94
129_I293_P0.9950.94
379_V383_S0.9840.94
125_L301_I0.9830.94
401_G413_I0.9760.94
124_D225_N0.9700.93
283_A318_G0.9690.93
189_V199_A0.9610.93
217_D221_T0.9600.93
326_V330_A0.9570.93
413_I417_D0.9500.93
418_A424_V0.9500.93
168_E173_Y0.9500.93
387_K442_D0.9490.93
252_T317_I0.9460.92
397_I429_L0.9440.92
203_G333_L0.9430.92
430_R435_M0.9420.92
385_A389_G0.9390.92
352_E356_Q0.9330.92
98_S101_K0.9240.92
413_I418_A0.9190.91
245_L315_E0.9190.91
208_T341_R0.9180.91
347_S380_A0.9140.91
350_D374_V0.9120.91
178_N206_S0.9050.91
128_A222_K0.9030.91
351_L371_N0.8980.90
233_R236_E0.8960.90
165_F334_L0.8940.90
336_K339_I0.8890.90
190_S196_E0.8850.90
179_H209_D0.8830.90
234_T238_V0.8810.90
191_L195_T0.8740.89
122_V239_I0.8720.89
351_L368_S0.8720.89
121_M241_I0.8710.89
122_V126_S0.8710.89
379_V388_A0.8690.89
178_N182_E0.8690.89
429_L434_E0.8660.89
203_G212_V0.8620.89
177_N209_D0.8610.88
276_I325_D0.8580.88
172_A221_T0.8580.88
120_D233_R0.8480.88
370_L395_I0.8480.88
114_D237_T0.8480.88
190_S251_R0.8410.87
301_I323_S0.8400.87
259_S280_Q0.8400.87
343_Y444_K0.8400.87
236_E296_N0.8380.87
114_D117_K0.8380.87
205_D208_T0.8360.87
201_L204_S0.8330.87
353_Q357_N0.8300.87
179_H288_G0.8280.86
287_P311_E0.8270.86
232_L238_V0.8240.86
179_H290_S0.8170.86
404_I426_V0.8090.85
277_N325_D0.8090.85
131_G243_D0.8090.85
118_I253_V0.8040.85
202_V214_Q0.8030.85
401_G436_T0.8020.85
349_L377_R0.8020.85
426_V439_I0.8000.85
128_A224_A0.7980.84
332_E337_G0.7980.84
118_I237_T0.7960.84
197_V220_V0.7950.84
179_H280_Q0.7930.84
118_I121_M0.7920.84
243_D250_S0.7920.84
245_L309_I0.7910.84
158_G184_A0.7890.84
343_Y380_A0.7880.84
177_N280_Q0.7860.83
181_V204_S0.7860.83
397_I434_E0.7780.83
263_R280_Q0.7740.83
374_V396_I0.7690.82
122_V295_L0.7660.82
132_I189_V0.7650.82
164_I222_K0.7600.81
265_V274_T0.7580.81
379_V437_K0.7580.81
348_M374_V0.7580.81
266_S273_E0.7560.81
104_S107_S0.7560.81
174_I218_D0.7520.81
339_I342_P0.7480.80
134_N156_E0.7480.80
283_A288_G0.7460.80
356_Q371_N0.7440.80
310_S313_D0.7440.80
172_A217_D0.7430.80
251_R293_P0.7420.80
344_I384_P0.7400.80
285_I289_N0.7370.79
167_K217_D0.7340.79
135_L188_K0.7300.79
124_D222_K0.7280.79
160_G180_V0.7270.78
216_S219_H0.7270.78
368_S371_N0.7260.78
286_N290_S0.7260.78
263_R319_F0.7230.78
347_S377_R0.7230.78
254_T259_S0.7190.78
239_I255_Q0.7180.78
329_I333_L0.7160.77
180_V290_S0.7140.77
165_F212_V0.7110.77
261_V279_I0.7090.77
399_L410_L0.7090.77
209_D290_S0.7080.77
244_P319_F0.7080.77
254_T289_N0.7070.76
294_L320_A0.7070.76
180_V288_G0.7050.76
173_Y334_L0.7020.76
134_N184_A0.6990.76
293_P305_N0.6970.75
259_S286_N0.6960.75
86_Q90_S0.6930.75
231_D324_N0.6890.75
203_G329_I0.6870.74
119_S296_N0.6840.74
131_G250_S0.6840.74
137_A185_S0.6830.74
294_L305_N0.6830.74
280_Q288_G0.6800.74
238_V302_V0.6790.74
85_Q89_Q0.6780.73
131_G158_G0.6760.73
93_A98_S0.6720.73
121_M255_Q0.6720.73
178_N201_L0.6720.73
243_D307_M0.6650.72
372_K403_E0.6630.72
280_Q319_F0.6630.72
97_S100_S0.6630.72
178_N208_T0.6620.72
179_H319_F0.6600.71
163_V295_L0.6600.71
402_K417_D0.6580.71
399_L426_V0.6560.71
259_S263_R0.6550.71
396_I410_L0.6550.71
172_A220_V0.6550.71
210_L321_I0.6540.71
167_K223_V0.6540.71
278_V309_I0.6530.71
344_I424_V0.6510.70
348_M411_R0.6510.70
278_V342_P0.6510.70
166_K334_L0.6500.70
245_L308_K0.6480.70
177_N290_S0.6480.70
344_I410_L0.6470.70
409_E412_N0.6440.70
179_H283_A0.6430.69
209_D319_F0.6420.69
177_N288_G0.6420.69
227_G258_V0.6410.69
181_V213_L0.6400.69
376_I426_V0.6360.69
121_M310_S0.6350.69
220_V224_A0.6350.69
160_G179_H0.6350.69
241_I295_L0.6330.68
176_T211_A0.6320.68
194_G198_T0.6320.68
227_G300_K0.6310.68
88_T91_V0.6290.68
87_Q91_V0.6290.68
411_R414_L0.6280.68
243_D246_G0.6280.68
270_S273_E0.6260.67
116_S120_D0.6220.67
121_M194_G0.6200.67
243_D293_P0.6200.67
238_V281_T0.6190.67
98_S433_K0.6190.67
135_L157_S0.6180.66
414_L418_A0.6160.66
85_Q90_S0.6160.66
224_A323_S0.6150.66
128_A323_S0.6140.66
104_S152_S0.6140.66
95_S103_S0.6140.66
241_I252_T0.6140.66
338_Q443_Q0.6130.66
95_S98_S0.6130.66
142_S150_D0.6120.66
244_P249_L0.6120.66
133_T196_E0.6110.66
209_D280_Q0.6100.65
85_Q93_A0.6100.65
131_G245_L0.6100.65
439_I442_D0.6080.65
339_I422_D0.6060.65
385_A390_L0.6060.65
157_S201_L0.6050.65
243_D340_E0.6030.65
111_K114_D0.5980.64
259_S316_G0.5980.64
404_I410_L0.5970.64
254_T316_G0.5970.64
210_L330_A0.5960.64
226_F330_A0.5960.64
280_Q291_G0.5930.63
400_K426_V0.5920.63
127_P295_L0.5920.63
259_S289_N0.5910.63
175_I226_F0.5880.63
280_Q286_N0.5880.63
159_S250_S0.5870.62
230_S262_D0.5850.62
200_K218_D0.5850.62
391_K394_D0.5840.62
308_K317_I0.5840.62
309_I314_V0.5840.62
281_T284_A0.5840.62
86_Q101_K0.5840.62
161_S309_I0.5830.62
397_I406_T0.5820.62
351_L395_I0.5820.62
197_V218_D0.5800.62
84_S92_T0.5790.61
167_K423_T0.5790.61
114_D297_T0.5770.61
160_G322_P0.5760.61
215_I221_T0.5760.61
280_Q289_N0.5760.61
118_I257_I0.5750.61
86_Q91_V0.5750.61
86_Q89_Q0.5740.61
138_Q156_E0.5720.60
399_L404_I0.5720.60
317_I384_P0.5710.60
179_H289_N0.5700.60
87_Q90_S0.5700.60
165_F330_A0.5690.60
122_V241_I0.5690.60
209_D283_A0.5670.60
132_I199_A0.5670.60
135_L154_D0.5670.60
305_N316_G0.5660.60
212_V330_A0.5650.60
274_T411_R0.5640.59
180_V263_R0.5640.59
180_V280_Q0.5640.59
122_V125_L0.5640.59
84_S87_Q0.5620.59
91_V99_E0.5610.59
414_L439_I0.5610.59
201_L222_K0.5600.59
160_G209_D0.5580.59
85_Q88_T0.5570.58
249_L319_F0.5540.58
177_N285_I0.5530.58
131_G159_S0.5530.58
139_S153_E0.5530.58
209_D288_G0.5530.58
209_D293_P0.5530.58
346_V390_L0.5520.58
374_V407_G0.5520.58
131_G308_K0.5510.58
281_T320_A0.5510.58
89_Q95_S0.5500.58
383_S442_D0.5490.57
374_V404_I0.5490.57
260_G316_G0.5490.57
177_N286_N0.5480.57
177_N259_S0.5470.57
307_M310_S0.5470.57
164_I215_I0.5470.57
165_F193_D0.5460.57
135_L155_T0.5450.57
280_Q290_S0.5450.57
177_N180_V0.5440.57
264_T275_S0.5440.57
95_S102_K0.5410.56
94_T98_S0.5410.56
177_N289_N0.5400.56
94_T100_S0.5400.56
136_Q157_S0.5400.56
378_E388_A0.5390.56
96_T99_E0.5390.56
294_L316_G0.5370.56
105_S109_A0.5370.56
167_K220_V0.5360.56
90_S96_T0.5360.56
166_K214_Q0.5360.56
280_Q316_G0.5340.55
312_D406_T0.5330.55
208_T276_I0.5330.55
160_G280_Q0.5320.55
116_S119_S0.5310.55
244_P250_S0.5290.55
179_H286_N0.5280.54
311_E315_E0.5280.54
259_S284_A0.5270.54
265_V272_G0.5270.54
378_E392_A0.5270.54
128_A295_L0.5240.54
108_S298_D0.5230.54
388_A439_I0.5210.54
265_V307_M0.5200.53
236_E300_K0.5200.53
117_K237_T0.5170.53
134_N158_G0.5170.53
177_N318_G0.5170.53
308_K316_G0.5160.53
260_G270_S0.5160.53
386_E389_G0.5160.53
180_V209_D0.5140.53
189_V215_I0.5130.52
97_S106_S0.5130.52
139_S151_S0.5130.52
244_P289_N0.5120.52
335_S402_K0.5120.52
371_N395_I0.5120.52
86_Q97_S0.5110.52
298_D302_V0.5110.52
376_I437_K0.5110.52
276_I307_M0.5090.52
177_N283_A0.5090.52
288_G318_G0.5090.52
189_V323_S0.5080.52
160_G289_N0.5080.52
100_S378_E0.5080.52
174_I220_V0.5080.52
399_L414_L0.5080.52
129_I221_T0.5070.52
101_K104_S0.5070.52
161_S280_Q0.5070.52
422_D441_L0.5060.51
166_K221_T0.5060.51
400_K425_E0.5050.51
179_H263_R0.5040.51
250_S317_I0.5030.51
274_T412_N0.5030.51
276_I306_S0.5020.51
208_T329_I0.5020.51
90_S433_K0.5020.51
181_V184_A0.5010.51
265_V275_S0.5010.51
155_T390_L0.5010.51
289_N316_G0.5000.51
134_N342_P0.5000.51
179_H291_G0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ky9A 5 0.6882 100 0.455 Contact Map
3pv2A 6 0.6503 100 0.466 Contact Map
3stjA 6 0.6659 100 0.482 Contact Map
4a8cA 5 0.6793 100 0.483 Contact Map
4ic6A 4 0.6971 100 0.511 Contact Map
1lcyA 3 0.6526 100 0.513 Contact Map
3qo6A 5 0.706 100 0.519 Contact Map
4ri0A 3 0.6815 100 0.526 Contact Map
4flnA 5 0.6704 100 0.53 Contact Map
3numA 3 0.4232 100 0.534 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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