GREMLIN Database
YTPP - Thioredoxin-like protein YtpP
UniProt: O34357 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 107 (96)
Sequences: 8749 (5613)
Seq/√Len: 572.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_R62_C2.8241.00
40_E93_K2.3461.00
11_E64_E2.3401.00
74_V84_R2.1761.00
92_T95_E2.0771.00
19_S49_T2.0591.00
7_T60_D2.0521.00
44_N93_K2.0031.00
5_E51_Y1.8711.00
7_T61_T1.8351.00
54_D57_K1.8161.00
44_N97_E1.7931.00
22_M52_Y1.7871.00
81_E84_R1.7701.00
28_C31_C1.7351.00
37_F40_E1.6741.00
74_V81_E1.6651.00
65_W76_F1.6401.00
38_L50_Y1.6371.00
18_W75_V1.6091.00
45_F97_E1.5941.00
20_V38_L1.5551.00
7_T58_F1.5331.00
37_F93_K1.5281.00
20_V73_F1.5191.00
13_A49_T1.5021.00
90_R95_E1.4881.00
55_R70_I1.4771.00
41_L50_Y1.4761.00
26_D54_D1.4251.00
9_E13_A1.4051.00
85_F91_K1.3741.00
95_E98_Q1.3681.00
45_F101_T1.3521.00
41_L97_E1.3381.00
19_S51_Y1.3361.00
97_E101_T1.2981.00
6_S9_E1.2691.00
34_V73_F1.2631.00
85_F99_F1.2121.00
5_E13_A1.1551.00
34_V37_F1.1541.00
53_V61_T1.1351.00
83_N99_F1.1301.00
22_M35_E1.1271.00
21_F76_F1.1171.00
41_L93_K1.1111.00
13_A19_S1.1041.00
35_E39_P1.0901.00
75_V99_F1.0791.00
6_S58_F1.0511.00
35_E52_Y1.0291.00
11_E15_K1.0201.00
34_V96_I1.0121.00
59_I63_A1.0041.00
53_V62_C0.9871.00
18_W77_N0.9851.00
93_K97_E0.9661.00
38_L73_F0.9461.00
39_P52_Y0.9461.00
91_K95_E0.9371.00
41_L45_F0.9071.00
43_A46_P0.8951.00
33_F90_R0.8531.00
48_F100_L0.8491.00
20_V50_Y0.8431.00
75_V100_L0.8391.00
5_E9_E0.8351.00
13_A17_D0.8221.00
77_N82_V0.8101.00
41_L96_I0.8091.00
29_P32_R0.8061.00
23_F65_W0.8051.00
94_E98_Q0.7941.00
12_K16_D0.7941.00
10_L65_W0.7931.00
73_F96_I0.7861.00
5_E21_F0.7791.00
45_F48_F0.7781.00
14_V19_S0.7721.00
24_S52_Y0.7691.00
9_E51_Y0.7671.00
37_F92_T0.7521.00
10_L23_F0.7521.00
60_D64_E0.7481.00
98_Q101_T0.7461.00
17_D78_E0.7351.00
34_V91_K0.7311.00
91_K99_F0.7271.00
58_F61_T0.7181.00
26_D56_D0.7141.00
22_M34_V0.7081.00
22_M30_D0.7031.00
42_E50_Y0.6871.00
24_S70_I0.6731.00
18_W78_E0.6671.00
20_V96_I0.6651.00
67_I72_S0.6631.00
34_V38_L0.6611.00
27_W32_R0.6581.00
37_F41_L0.6531.00
26_D32_R0.6511.00
17_D49_T0.6441.00
40_E43_A0.6331.00
68_Y84_R0.6301.00
11_E16_D0.6151.00
23_F55_R0.6141.00
10_L61_T0.6111.00
59_I62_C0.6111.00
24_S54_D0.6071.00
20_V100_L0.6061.00
30_D33_F0.6051.00
23_F74_V0.6001.00
25_A56_D0.5991.00
21_F53_V0.5961.00
61_T64_E0.5961.00
21_F51_Y0.5951.00
38_L100_L0.5931.00
30_D69_G0.5911.00
77_N80_K0.5881.00
55_R67_I0.5801.00
29_P33_F0.5801.00
14_V17_D0.5791.00
20_V75_V0.5781.00
62_C65_W0.5761.00
9_E12_K0.5640.99
44_N101_T0.5550.99
94_E97_E0.5450.99
48_F52_Y0.5430.99
10_L21_F0.5400.99
76_F81_E0.5340.99
60_D63_A0.5340.99
83_N102_D0.5260.99
99_F102_D0.5260.99
66_E84_R0.5170.99
85_F95_E0.5160.99
53_V58_F0.5130.99
23_F67_I0.5110.99
25_A36_P0.5070.99
38_L96_I0.5060.99
30_D91_K0.5050.99
40_E44_N0.5050.99
27_W56_D0.5030.99
69_G86_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f8uA 2 0.9813 99.8 0.194 Contact Map
2r2jA 2 0.9626 99.8 0.197 Contact Map
3apoA 1 0.9065 99.8 0.2 Contact Map
2b5eA 1 0.9813 99.8 0.206 Contact Map
3wgdA 3 0.972 99.8 0.237 Contact Map
4i6xA 1 0.972 99.8 0.238 Contact Map
4tveA 1 0.9813 99.8 0.239 Contact Map
4ekzA 1 0.9813 99.8 0.24 Contact Map
3ed3A 1 0.9813 99.8 0.24 Contact Map
4tw5A 3 0.9813 99.8 0.244 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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