GREMLIN Database
UXAB - Altronate oxidoreductase
UniProt: O34354 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 480 (453)
Sequences: 2365 (1665)
Seq/√Len: 78.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_D87_M4.0781.00
310_H466_Q4.0081.00
52_V105_Y3.6211.00
459_H468_A3.1201.00
36_I261_F3.1121.00
301_L310_H3.0581.00
17_E50_A3.0461.00
221_V224_I3.0421.00
318_R339_D2.9841.00
228_T234_Q2.9341.00
50_A108_L2.8551.00
103_E156_A2.7931.00
94_R108_L2.7881.00
38_Q87_M2.7681.00
181_R185_L2.6571.00
111_S114_L2.6481.00
19_I36_I2.5481.00
178_E209_N2.4821.00
107_E160_D2.4671.00
249_I266_L2.4361.00
189_H202_H2.4271.00
307_A313_V2.4121.00
15_Y48_S2.3181.00
319_E323_D2.3011.00
133_R136_D2.2541.00
73_F86_H2.2271.00
206_T254_W2.1951.00
20_L114_L2.1861.00
312_E470_E2.1801.00
101_D104_A2.1681.00
64_N68_G2.1601.00
294_P361_A2.1561.00
322_D338_A2.1041.00
206_T252_P2.1001.00
467_R470_E2.0951.00
165_C205_N2.0771.00
184_V207_F2.0741.00
374_K442_D2.0721.00
352_H356_S2.0401.00
391_F449_L2.0111.00
314_G346_K1.9971.00
94_R104_A1.9941.00
109_A153_R1.9921.00
376_Y382_Q1.9771.00
152_F156_A1.9711.00
459_H471_Q1.9681.00
133_R137_R1.9621.00
295_V393_A1.9591.00
110_S152_F1.9581.00
35_Q245_Y1.9551.00
291_A390_S1.9481.00
199_Q203_E1.9421.00
188_A201_I1.9331.00
28_L32_I1.9311.00
260_P263_A1.9301.00
225_D229_A1.9251.00
69_L88_I1.9171.00
128_C183_T1.9131.00
167_L180_L1.9121.00
288_A317_I1.8871.00
50_A94_R1.8461.00
48_S93_S1.8391.00
17_E94_R1.8251.00
17_E114_L1.7991.00
34_W72_L1.7891.00
74_L241_G1.7811.00
72_L89_I1.7801.00
61_K65_E1.7771.00
291_A320_L1.7771.00
284_I338_A1.7761.00
452_R456_Y1.7671.00
295_V389_F1.7621.00
103_E107_E1.7531.00
460_I468_A1.7461.00
175_N178_E1.7361.00
37_D41_Q1.7341.00
284_I321_I1.7251.00
155_Q159_G1.7221.00
326_L338_A1.7121.00
16_P113_R1.6981.00
189_H198_T1.6901.00
152_F155_Q1.6881.00
10_D13_T1.6791.00
296_A307_A1.6551.00
145_K148_A1.6541.00
261_F266_L1.6531.00
51_V92_I1.6521.00
314_G318_R1.6491.00
288_A321_I1.6421.00
96_I105_Y1.6371.00
305_R309_E1.6311.00
20_L52_V1.6271.00
373_L391_F1.6211.00
17_E93_S1.6111.00
168_I249_I1.6091.00
156_A160_D1.5951.00
373_L449_L1.5891.00
164_G205_N1.5841.00
413_F418_W1.5831.00
18_K115_R1.5801.00
395_L432_V1.5781.00
175_N275_T1.5610.99
315_R319_E1.5460.99
304_V357_I1.5370.99
50_A114_L1.5330.99
447_P451_D1.5300.99
10_D14_Q1.5290.99
150_L184_V1.5240.99
166_V254_W1.5060.99
135_E139_Q1.5060.99
375_E378_E1.5030.99
121_T146_L1.4930.99
377_A446_I1.4860.99
158_K196_G1.4760.99
295_V460_I1.4750.99
201_I207_F1.4620.99
109_A165_C1.4580.99
36_I49_V1.4440.99
19_I49_V1.4250.99
396_Y457_L1.4220.99
424_D427_R1.4200.99
297_L408_P1.4150.99
434_G444_N1.4040.99
430_S450_T1.3960.99
444_N450_T1.3790.99
389_F468_A1.3760.99
196_G199_Q1.3710.99
75_Q223_S1.3670.99
33_D49_V1.3650.99
388_V453_V1.3590.99
463_L471_Q1.3560.98
185_L202_H1.3540.98
336_Q340_D1.3490.98
302_K306_D1.3480.98
151_Y201_I1.3470.98
117_I165_C1.3450.98
106_K156_A1.3450.98
302_K353_Y1.3410.98
104_A107_E1.3340.98
293_T358_A1.3330.98
396_Y461_H1.3320.98
312_E466_Q1.3270.98
304_V307_A1.3260.98
318_R322_D1.3230.98
436_Q445_E1.3110.98
221_V225_D1.2860.98
71_T88_I1.2830.98
271_V276_P1.2750.98
219_F224_I1.2740.98
219_F238_I1.2730.98
226_E230_D1.2730.98
284_I326_L1.2640.98
68_G95_G1.2590.98
291_A316_F1.2590.98
155_Q194_E1.2520.97
189_H199_Q1.2470.97
119_S146_L1.2420.97
182_E186_H1.2380.97
355_E397_F1.2360.97
40_N45_F1.2350.97
68_G94_R1.2330.97
151_Y188_A1.2290.97
106_K152_F1.2290.97
38_Q42_H1.2290.97
402_E406_D1.2270.97
458_N462_E1.2260.97
297_L397_F1.2250.97
155_Q193_L1.2230.97
308_V314_G1.2200.97
304_V354_L1.2140.97
71_T86_H1.2070.97
284_I341_V1.2050.97
279_T330_K1.2000.97
283_R375_E1.1900.97
459_H463_L1.1740.96
24_E92_I1.1720.96
198_T201_I1.1720.96
319_E386_R1.1710.96
342_L346_K1.1710.96
124_A363_S1.1690.96
69_L90_N1.1640.96
299_Y313_V1.1630.96
107_E110_S1.1630.96
189_H195_E1.1620.96
257_K262_A1.1590.96
463_L467_R1.1510.96
415_K418_W1.1480.96
134_L138_P1.1470.96
134_L137_R1.1460.96
139_Q142_F1.1450.96
322_D339_D1.1440.96
405_Q412_Q1.1400.96
34_W89_I1.1290.95
292_M313_V1.1260.95
436_Q442_D1.1190.95
110_S156_A1.1090.95
66_Q235_D1.1060.95
414_F417_V1.1060.95
60_I64_N1.1050.95
374_K440_G1.0980.95
74_L85_E1.0930.94
24_E51_V1.0900.94
290_T364_K1.0880.94
321_I338_A1.0830.94
297_L355_E1.0830.94
195_E199_Q1.0800.94
152_F193_L1.0780.94
464_G467_R1.0780.94
389_F460_I1.0780.94
154_Y157_F1.0720.94
273_D276_P1.0710.94
42_H263_A1.0670.94
303_T351_K1.0630.94
464_G468_A1.0610.93
22_F146_L1.0570.93
214_R241_G1.0530.93
22_F109_A1.0510.93
430_S454_A1.0500.93
355_E411_L1.0490.93
165_C254_W1.0470.93
167_L207_F1.0400.93
365_F390_S1.0390.93
450_T454_A1.0370.93
428_I434_G1.0350.93
308_V342_L1.0350.93
308_V317_I1.0300.92
27_F170_C1.0170.92
199_Q202_H1.0170.92
435_E438_L1.0110.92
34_W38_Q1.0020.91
304_V317_I0.9980.91
9_Y93_S0.9950.91
412_Q418_W0.9940.91
353_Y356_S0.9930.91
60_I95_G0.9920.91
408_P412_Q0.9920.91
396_Y403_T0.9920.91
118_I210_S0.9890.91
20_L153_R0.9880.91
135_E144_G0.9870.91
442_D445_E0.9860.91
321_I342_L0.9860.91
163_K255_I0.9800.90
178_E181_R0.9760.90
102_Y149_F0.9750.90
219_F239_V0.9730.90
467_R471_Q0.9730.90
297_L354_L0.9720.90
32_I118_I0.9700.90
35_Q264_A0.9670.90
34_W87_M0.9660.90
320_L387_L0.9640.90
372_T387_L0.9630.90
430_S434_G0.9600.90
318_R342_L0.9540.89
20_L117_I0.9530.89
38_Q245_Y0.9530.89
115_R256_G0.9530.89
417_V437_R0.9520.89
63_L68_G0.9520.89
167_L205_N0.9510.89
86_H231_L0.9500.89
326_L334_L0.9490.89
388_V449_L0.9450.89
305_R351_K0.9450.89
306_D309_E0.9440.89
316_F386_R0.9380.88
321_I341_V0.9380.88
363_S414_F0.9380.88
54_P149_F0.9370.88
334_L338_A0.9370.88
385_E452_R0.9310.88
383_L388_V0.9300.88
396_Y400_D0.9170.87
362_I394_L0.9170.87
194_E198_T0.9080.87
124_A368_R0.9070.87
168_I210_S0.9060.87
325_I372_T0.9060.87
303_T306_D0.9050.87
64_N94_R0.9040.87
18_K40_N0.9020.86
151_Y184_V0.9020.86
352_H368_R0.9000.86
452_R455_V0.8980.86
154_Y196_G0.8950.86
128_C179_K0.8950.86
18_K47_G0.8920.86
362_I438_L0.8910.86
58_E62_R0.8890.86
17_E108_L0.8820.85
108_L111_S0.8760.85
37_D91_S0.8750.85
65_E236_D0.8740.85
129_D132_D0.8730.85
19_I116_F0.8720.84
384_P448_K0.8700.84
53_Q59_K0.8690.84
127_V145_K0.8660.84
369_N390_S0.8530.83
253_D256_G0.8510.83
391_F453_V0.8500.83
227_I231_L0.8500.83
292_M354_L0.8460.83
226_E229_A0.8450.83
179_K182_E0.8440.82
336_Q339_D0.8440.82
325_I387_L0.8350.82
118_I247_W0.8340.82
32_I170_C0.8340.82
373_L388_V0.8310.82
78_K348_P0.8310.82
118_I168_I0.8290.81
405_Q408_P0.8280.81
284_I325_I0.8270.81
410_V415_K0.8240.81
395_L453_V0.8210.81
11_H15_Y0.8210.81
340_D343_N0.8200.81
185_L198_T0.8200.81
76_G243_Q0.8190.81
224_I238_I0.8170.80
320_L325_I0.8170.80
135_E140_K0.8130.80
71_T233_Y0.8120.80
352_H357_I0.8120.80
388_V452_R0.8080.80
53_Q95_G0.8080.80
299_Y310_H0.8050.79
253_D257_K0.8050.79
165_C188_A0.8030.79
185_L201_I0.8000.79
41_Q87_M0.8000.79
296_A354_L0.7980.79
425_M461_H0.7960.79
7_N90_N0.7960.79
370_L391_F0.7950.79
94_R107_E0.7940.78
53_Q97_D0.7920.78
98_L149_F0.7910.78
283_R328_V0.7910.78
222_D225_D0.7910.78
154_Y194_E0.7910.78
147_T184_V0.7860.78
385_E455_V0.7850.78
27_F32_I0.7830.78
339_D342_L0.7810.77
117_I167_L0.7800.77
455_V459_H0.7780.77
355_E408_P0.7770.77
324_E386_R0.7770.77
107_E156_A0.7750.77
22_F153_R0.7740.77
36_I39_L0.7720.77
112_E162_T0.7720.77
137_R187_Y0.7710.76
147_T187_Y0.7710.76
44_D260_P0.7710.76
28_L33_D0.7700.76
36_I266_L0.7690.76
384_P388_V0.7690.76
50_A93_S0.7690.76
136_D140_K0.7650.76
322_D326_L0.7650.76
279_T375_E0.7640.76
119_S169_P0.7620.76
16_P46_N0.7620.76
262_A270_I0.7610.75
10_D15_Y0.7600.75
124_A360_N0.7570.75
288_A345_F0.7570.75
304_V364_K0.7560.75
135_E138_P0.7550.75
426_L454_A0.7540.75
200_W204_A0.7540.75
393_A465_M0.7540.75
335_S339_D0.7520.75
38_Q264_A0.7470.74
427_R430_S0.7450.74
188_A197_F0.7440.74
133_R138_P0.7410.74
360_N413_F0.7390.73
300_G310_H0.7390.73
17_E48_S0.7340.73
295_V313_V0.7340.73
323_D386_R0.7340.73
402_E405_Q0.7330.73
406_D412_Q0.7320.73
17_E113_R0.7320.73
153_R157_F0.7310.73
39_L264_A0.7300.72
166_V208_C0.7300.72
148_A187_Y0.7250.72
62_R236_D0.7250.72
52_V96_I0.7250.72
301_L397_F0.7250.72
283_R372_T0.7240.72
421_E424_D0.7230.72
170_C244_Y0.7200.71
292_M307_A0.7190.71
76_G79_D0.7180.71
297_L302_K0.7180.71
318_R338_A0.7170.71
370_L373_L0.7170.71
373_L387_L0.7160.71
53_Q60_I0.7160.71
156_A162_T0.7140.71
460_I465_M0.7140.71
312_E469_L0.7120.71
154_Y167_L0.7100.70
60_I100_S0.7090.70
153_R165_C0.7060.70
7_N10_D0.7040.70
312_E315_R0.7040.70
150_L180_L0.7020.69
49_V91_S0.7010.69
414_F418_W0.7000.69
290_T294_P0.6960.69
432_V438_L0.6950.69
141_T152_F0.6930.68
324_E376_Y0.6930.68
206_T255_I0.6920.68
284_I288_A0.6920.68
290_T361_A0.6920.68
188_A198_T0.6910.68
413_F417_V0.6910.68
38_Q41_Q0.6900.68
274_L278_R0.6890.68
151_Y154_Y0.6890.68
154_Y200_W0.6870.68
306_D354_L0.6830.67
246_L337_Y0.6760.67
434_G450_T0.6720.66
166_V253_D0.6710.66
97_D100_S0.6710.66
408_P411_L0.6710.66
88_I233_Y0.6700.66
72_L350_I0.6690.66
110_S153_R0.6670.66
389_F465_M0.6620.65
354_L357_I0.6610.65
109_A117_I0.6600.65
216_V231_L0.6590.65
363_S368_R0.6590.65
209_N250_E0.6570.64
328_V372_T0.6560.64
399_H461_H0.6560.64
403_T408_P0.6550.64
294_P397_F0.6550.64
66_Q69_L0.6540.64
214_R245_Y0.6540.64
301_L306_D0.6540.64
52_V98_L0.6520.64
290_T359_L0.6510.64
58_E61_K0.6500.64
363_S367_T0.6490.63
433_L449_L0.6480.63
24_E54_P0.6470.63
24_E53_Q0.6470.63
217_P337_Y0.6460.63
416_E419_C0.6450.63
44_D263_A0.6450.63
27_F31_F0.6440.63
391_F439_W0.6430.63
451_D455_V0.6430.63
7_N15_Y0.6420.63
299_Y312_E0.6400.62
411_L418_W0.6390.62
299_Y466_Q0.6390.62
377_A449_L0.6390.62
362_I412_Q0.6380.62
20_L109_A0.6360.62
9_Y37_D0.6350.62
181_R202_H0.6340.62
54_P57_S0.6340.62
174_E287_G0.6310.61
161_Q199_Q0.6290.61
303_T350_I0.6290.61
296_A301_L0.6280.61
227_I230_D0.6250.61
406_D418_W0.6250.61
211_L274_L0.6240.60
160_D163_K0.6210.60
11_H90_N0.6210.60
413_F416_E0.6210.60
32_I247_W0.6180.60
162_T204_A0.6160.59
8_V41_Q0.6160.59
295_V465_M0.6160.59
216_V350_I0.6140.59
118_I170_C0.6120.59
185_L350_I0.6120.59
146_L167_L0.6120.59
389_F456_Y0.6110.59
411_L415_K0.6110.59
407_D412_Q0.6110.59
217_P247_W0.6100.59
34_W245_Y0.6100.59
106_K149_F0.6100.59
313_V469_L0.6090.59
311_P315_R0.6090.59
117_I150_L0.6090.59
369_N387_L0.6080.58
50_A96_I0.6070.58
183_T186_H0.6070.58
465_M469_L0.6060.58
22_F105_Y0.6060.58
138_P143_P0.6050.58
280_K334_L0.6050.58
99_F102_Y0.6040.58
186_H190_L0.6040.58
123_E360_N0.6040.58
128_C132_D0.6030.58
256_G262_A0.6030.58
377_A448_K0.6020.58
371_P374_K0.6020.58
56_G59_K0.6010.58
123_E359_L0.6010.58
57_S60_I0.6010.58
359_L411_L0.5980.57
217_P239_V0.5980.57
377_A384_P0.5980.57
244_Y247_W0.5970.57
302_K351_K0.5960.57
276_P329_L0.5950.57
170_C337_Y0.5950.57
28_L31_F0.5950.57
119_S150_L0.5940.57
405_Q411_L0.5940.57
106_K110_S0.5930.57
370_L374_K0.5930.57
371_P375_E0.5930.57
224_I237_L0.5930.57
220_P223_S0.5920.56
396_Y460_I0.5910.56
219_F237_L0.5910.56
114_L149_F0.5900.56
139_Q144_G0.5900.56
45_F48_S0.5890.56
157_F163_K0.5890.56
339_D343_N0.5860.56
112_E163_K0.5840.55
76_G348_P0.5840.55
116_F261_F0.5830.55
74_L245_Y0.5830.55
162_T165_C0.5810.55
168_I261_F0.5810.55
223_S240_V0.5800.55
151_Y187_Y0.5790.55
290_T356_S0.5770.55
111_S162_T0.5760.54
120_N171_E0.5740.54
40_N91_S0.5740.54
282_V368_R0.5740.54
96_I104_A0.5720.54
320_L386_R0.5720.54
102_Y105_Y0.5720.54
62_R237_L0.5700.54
398_Y408_P0.5690.53
368_R453_V0.5680.53
225_D234_Q0.5680.53
328_V376_Y0.5680.53
37_D90_N0.5670.53
146_L184_V0.5670.53
70_Y214_R0.5660.53
203_E225_D0.5660.53
323_D381_G0.5650.53
98_L102_Y0.5650.53
350_I369_N0.5630.53
372_T375_E0.5610.52
417_V435_E0.5610.52
181_R252_P0.5590.52
343_N348_P0.5590.52
262_A266_L0.5590.52
211_L248_V0.5590.52
403_T465_M0.5580.52
55_R58_E0.5580.52
261_F270_I0.5570.52
365_F369_N0.5570.52
208_C251_G0.5560.52
147_T153_R0.5550.52
404_L407_D0.5540.52
287_G369_N0.5540.52
20_L108_L0.5530.51
223_S226_E0.5520.51
404_L408_P0.5510.51
363_S372_T0.5510.51
375_E380_K0.5510.51
24_E55_R0.5500.51
337_Y341_V0.5500.51
124_A356_S0.5500.51
290_T357_I0.5500.51
157_F204_A0.5480.51
462_E471_Q0.5480.51
134_L144_G0.5480.51
63_L170_C0.5470.51
26_N240_V0.5460.51
429_A454_A0.5450.50
158_K194_E0.5440.50
63_L237_L0.5440.50
270_I273_D0.5430.50
465_M468_A0.5420.50
186_H189_H0.5410.50
42_H264_A0.5410.50
301_L313_V0.5410.50
373_L377_A0.5390.50
133_R140_K0.5390.50
369_N372_T0.5390.50
400_D403_T0.5390.50
294_P307_A0.5380.50
98_L105_Y0.5380.50
324_E370_L0.5380.50
165_C255_I0.5360.49
432_V439_W0.5360.49
415_K419_C0.5350.49
357_I364_K0.5340.49
107_E111_S0.5340.49
300_G402_E0.5320.49
225_D228_T0.5300.48
60_I219_F0.5300.48
374_K378_E0.5290.48
246_L269_K0.5280.48
199_Q445_E0.5280.48
174_E278_R0.5260.48
73_F227_I0.5250.48
70_Y89_I0.5250.48
95_G368_R0.5250.48
34_W373_L0.5250.48
72_L216_V0.5250.48
86_H227_I0.5240.48
189_H201_I0.5240.48
42_H445_E0.5230.48
36_I270_I0.5220.47
244_Y280_K0.5220.47
120_N278_R0.5210.47
39_L45_F0.5210.47
366_K440_G0.5200.47
297_L358_A0.5200.47
167_L354_L0.5200.47
28_L118_I0.5190.47
426_L458_N0.5190.47
222_D351_K0.5190.47
136_D139_Q0.5180.47
159_G162_T0.5170.47
73_F231_L0.5170.47
455_V471_Q0.5170.47
356_S363_S0.5150.47
440_G444_N0.5150.47
358_A397_F0.5150.47
357_I368_R0.5140.46
395_L439_W0.5140.46
158_K197_F0.5130.46
128_C186_H0.5120.46
146_L151_Y0.5110.46
31_F170_C0.5110.46
179_K183_T0.5100.46
358_A363_S0.5090.46
203_E462_E0.5090.46
24_E95_G0.5090.46
16_P45_F0.5080.46
128_C190_L0.5080.46
71_T235_D0.5070.46
157_F161_Q0.5070.46
162_T205_N0.5070.46
451_D463_L0.5060.45
364_K368_R0.5060.45
211_L278_R0.5050.45
147_T368_R0.5050.45
76_G349_Y0.5040.45
39_L44_D0.5040.45
216_V352_H0.5040.45
151_Y155_Q0.5040.45
26_N360_N0.5030.45
120_N172_L0.5020.45
66_Q237_L0.5020.45
21_Q31_F0.5020.45
151_Y157_F0.5010.45
116_F256_G0.5000.45
195_E230_D0.5000.45
96_I108_L0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4im7A 1 0.9667 100 0.124 Contact Map
1lj8A 1 0.9708 100 0.125 Contact Map
3h2zA 2 0.7667 100 0.371 Contact Map
3hn2A 2 0.6188 92.3 0.964 Contact Map
3wfiA 2 0.6417 89.3 0.966 Contact Map
2ew2A 2 0.65 86.9 0.968 Contact Map
3egoA 2 0.6042 86.1 0.968 Contact Map
2qytA 1 0.5896 79.7 0.97 Contact Map
3i83A 2 0.6375 75.5 0.971 Contact Map
3hwrA 2 0.6188 65.6 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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