GREMLIN Database
YEEC - Uncharacterized protein YeeC
UniProt: O34352 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (360)
Sequences: 248 (196)
Seq/√Len: 10.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
303_E312_P4.6781.00
306_S310_Y4.1660.99
48_K88_E3.9130.99
308_Y320_Q3.2180.95
301_N305_Q3.2010.95
180_F243_G3.1670.95
14_E18_F3.0610.94
337_L370_V3.0480.94
16_Q19_Y2.7880.90
222_F230_M2.7620.90
42_E377_M2.6900.89
134_T137_L2.6860.89
14_E19_Y2.6840.89
114_G118_L2.6780.89
198_L246_V2.6520.88
73_I83_L2.6040.87
53_E74_R2.5530.86
204_V232_L2.5060.85
213_K223_E2.4830.84
44_I89_I2.4670.84
212_G241_K2.4670.84
167_H198_L2.4560.84
308_Y333_I2.4270.83
319_Y368_Q2.3610.81
333_I337_L2.3470.81
201_V237_A2.2730.78
111_L118_L2.2730.78
18_F21_I2.2420.77
209_K214_T2.1810.75
239_L243_G2.1800.75
198_L240_Y2.1410.74
344_V365_E2.1290.74
201_V218_L2.1220.73
295_V299_I2.0540.71
273_L322_F2.0200.69
192_Y245_R2.0030.69
16_Q20_Q1.9780.68
56_K71_I1.9770.68
167_H223_E1.9530.67
211_K223_E1.9300.66
182_N223_E1.9220.65
198_L223_E1.9060.65
237_A241_K1.8990.64
175_R247_T1.8950.64
209_K213_K1.8840.64
319_Y335_H1.8810.64
42_E375_V1.8600.63
177_I193_I1.8390.62
152_K190_S1.8390.62
337_L366_D1.8150.61
43_I141_T1.8070.60
169_E175_R1.8000.60
14_E21_I1.7850.59
14_E20_Q1.7730.59
305_Q308_Y1.7730.59
341_N347_L1.7200.56
185_D223_E1.7080.56
211_K222_F1.7000.55
73_I130_S1.6830.55
235_L299_I1.6770.54
272_S279_I1.6710.54
120_G323_N1.6600.54
336_A370_V1.6530.53
18_F120_G1.6490.53
115_L118_L1.6440.53
185_D211_K1.6330.52
193_I244_R1.6310.52
310_Y354_L1.6300.52
167_H246_V1.6010.51
306_S341_N1.5920.50
160_E164_K1.5810.50
130_S135_S1.5800.50
304_N352_K1.5750.50
50_N71_I1.5680.49
40_F69_R1.5510.49
212_G216_A1.5470.48
111_L114_G1.5420.48
10_N14_E1.5400.48
200_Y216_A1.5250.47
26_K42_E1.5180.47
50_N161_E1.5060.46
247_T267_I1.4920.46
162_L221_I1.4810.45
141_T215_N1.4540.44
182_N243_G1.4470.44
303_E338_A1.4390.43
167_H333_I1.4270.43
190_S198_L1.4210.43
232_L240_Y1.4190.42
133_D312_P1.4020.42
19_Y120_G1.4010.42
192_Y201_V1.3890.41
155_D158_K1.3830.41
155_D219_R1.3820.41
162_L191_F1.3740.40
210_A213_K1.3640.40
299_I308_Y1.3640.40
19_Y22_T1.3410.39
157_G169_E1.3350.39
205_G216_A1.3310.38
279_I284_N1.3260.38
179_T267_I1.3180.38
114_G117_A1.2990.37
243_G299_I1.2990.37
52_R288_I1.2760.36
48_K346_I1.2720.36
48_K89_I1.2640.36
204_V218_L1.2580.35
46_F234_S1.2480.35
26_K121_D1.2450.35
270_L308_Y1.2380.34
35_P39_K1.2370.34
186_I218_L1.2310.34
152_K336_A1.2300.34
238_E241_K1.2280.34
304_N308_Y1.2190.34
175_R248_D1.2070.33
306_S340_N1.2010.33
310_Y348_G1.2000.33
96_S255_D1.1940.33
192_Y345_S1.1860.32
269_V315_I1.1820.32
18_F22_T1.1800.32
152_K248_D1.1790.32
205_G218_L1.1780.32
52_R55_Q1.1740.32
248_D329_F1.1650.31
14_E22_T1.1650.31
255_D352_K1.1640.31
271_K314_E1.1580.31
141_T279_I1.1540.31
34_D61_L1.1510.31
308_Y355_V1.1490.31
219_R227_E1.1490.31
263_S320_Q1.1460.31
46_F119_L1.1440.31
282_I377_M1.1440.31
207_R213_K1.1440.31
93_E97_K1.1430.31
159_F201_V1.1410.31
216_A229_D1.1400.30
111_L115_L1.1380.30
209_K240_Y1.1300.30
76_D171_T1.1220.30
42_E192_Y1.1180.30
189_N192_Y1.1130.29
42_E69_R1.0990.29
322_F344_V1.0980.29
273_L312_P1.0950.29
135_S325_N1.0920.29
73_I248_D1.0920.29
261_D323_N1.0900.29
155_D295_V1.0880.28
13_M297_N1.0880.28
294_S306_S1.0850.28
198_L232_L1.0840.28
120_G267_I1.0830.28
119_L234_S1.0790.28
204_V240_Y1.0740.28
211_K232_L1.0740.28
211_K241_K1.0640.28
133_D336_A1.0520.27
44_I88_E1.0480.27
297_N300_R1.0370.27
261_D324_M1.0360.27
296_E315_I1.0270.26
131_I233_R1.0230.26
165_K221_I1.0220.26
213_K230_M1.0200.26
269_V349_A1.0200.26
20_Q120_G1.0190.26
81_E339_N1.0150.26
205_G237_A1.0100.26
222_F322_F1.0090.26
116_S120_G1.0060.25
204_V207_R1.0060.25
16_Q21_I1.0050.25
90_G269_V1.0050.25
211_K216_A1.0040.25
215_N231_L1.0030.25
272_S307_T1.0020.25
64_R69_R1.0000.25
209_K232_L0.9990.25
185_D246_V0.9960.25
42_E342_L0.9940.25
39_K138_Q0.9860.25
228_S348_G0.9790.24
293_G297_N0.9760.24
28_T53_E0.9750.24
36_E79_R0.9700.24
328_K336_A0.9680.24
228_S337_L0.9590.24
116_S119_L0.9540.24
130_S363_T0.9530.24
228_S370_V0.9480.23
169_E199_L0.9480.23
71_I86_Y0.9430.23
308_Y335_H0.9390.23
138_Q284_N0.9360.23
12_I21_I0.9360.23
301_N304_N0.9330.23
38_E68_S0.9320.23
122_N187_Q0.9310.23
201_V216_A0.9300.23
323_N338_A0.9270.23
323_N329_F0.9270.23
201_V215_N0.9210.23
14_E30_K0.9210.23
191_F230_M0.9160.22
308_Y352_K0.9140.22
198_L221_I0.9090.22
116_S121_D0.9080.22
18_F121_D0.9040.22
215_N346_I0.9020.22
270_L299_I0.9020.22
36_E322_F0.9010.22
184_Q247_T0.9010.22
251_D321_V0.8980.22
293_G305_Q0.8970.22
136_S153_I0.8970.22
344_V355_V0.8930.22
52_R176_K0.8930.22
310_Y346_I0.8920.22
243_G247_T0.8890.22
157_G203_D0.8880.21
153_I192_Y0.8880.21
185_D232_L0.8770.21
192_Y239_L0.8730.21
19_Y121_D0.8730.21
231_L242_H0.8720.21
21_I106_S0.8720.21
181_K222_F0.8680.21
221_I352_K0.8650.21
250_E333_I0.8640.21
211_K214_T0.8630.21
147_V201_V0.8620.21
258_R328_K0.8610.21
162_L200_Y0.8540.20
333_I336_A0.8530.20
51_G173_G0.8510.20
74_R283_K0.8490.20
304_N333_I0.8470.20
182_N209_K0.8420.20
165_K235_L0.8420.20
152_K280_S0.8410.20
13_M18_F0.8390.20
235_L243_G0.8370.20
96_S152_K0.8340.20
18_F30_K0.8340.20
85_E374_I0.8330.20
21_I120_G0.8300.20
308_Y341_N0.8290.20
191_F199_L0.8260.20
142_T215_N0.8250.20
11_E14_E0.8220.19
49_E122_N0.8200.19
139_K157_G0.8200.19
13_M21_I0.8190.19
212_G223_E0.8180.19
222_F262_V0.8180.19
243_G329_F0.8150.19
231_L325_N0.8130.19
61_L219_R0.8090.19
341_N355_V0.8060.19
42_E362_V0.8050.19
243_G321_V0.8050.19
45_E135_S0.8030.19
172_E371_I0.7970.19
179_T211_K0.7960.19
246_V320_Q0.7960.19
181_K190_S0.7940.19
285_L335_H0.7930.19
182_N190_S0.7900.19
164_K168_K0.7890.19
72_G247_T0.7880.19
185_D213_K0.7870.18
12_I304_N0.7870.18
337_L340_N0.7860.18
175_R307_T0.7850.18
185_D210_A0.7830.18
188_S223_E0.7830.18
166_C191_F0.7830.18
10_N21_I0.7830.18
88_E109_D0.7790.18
369_A373_E0.7780.18
35_P335_H0.7750.18
220_C300_R0.7750.18
21_I24_P0.7750.18
162_L344_V0.7750.18
201_V205_G0.7720.18
49_E96_S0.7670.18
208_K211_K0.7630.18
310_Y340_N0.7610.18
300_R315_I0.7610.18
307_T311_A0.7590.18
187_Q190_S0.7580.18
208_K222_F0.7570.18
209_K230_M0.7540.18
38_E67_A0.7530.18
269_V319_Y0.7510.17
243_G323_N0.7510.17
300_R378_V0.7500.17
157_G161_E0.7480.17
296_E364_L0.7440.17
18_F116_S0.7420.17
151_K172_E0.7390.17
38_E153_I0.7390.17
177_I246_V0.7380.17
255_D351_G0.7380.17
293_G303_E0.7370.17
155_D343_D0.7360.17
42_E263_S0.7360.17
183_E212_G0.7340.17
42_E48_K0.7340.17
90_G364_L0.7330.17
37_V233_R0.7330.17
35_P271_K0.7300.17
333_I377_M0.7300.17
278_Q282_I0.7300.17
223_E240_Y0.7280.17
147_V322_F0.7240.17
172_E206_E0.7220.17
81_E86_Y0.7210.17
80_M267_I0.7200.17
153_I350_N0.7190.17
79_R291_T0.7160.17
159_F246_V0.7140.17
42_E301_N0.7130.16
321_V326_A0.7120.16
90_G239_L0.7120.16
77_P81_E0.7120.16
88_E155_D0.7110.16
108_D364_L0.7090.16
131_I137_L0.7050.16
191_F204_V0.7050.16
182_N232_L0.7040.16
194_L199_L0.7010.16
15_S121_D0.6990.16
42_E257_V0.6970.16
168_K277_P0.6940.16
157_G267_I0.6930.16
138_Q366_D0.6910.16
167_H181_K0.6910.16
222_F232_L0.6890.16
74_R354_L0.6890.16
130_S329_F0.6880.16
47_V170_I0.6860.16
83_L208_K0.6850.16
18_F145_E0.6850.16
210_A223_E0.6830.16
41_L45_E0.6810.16
25_P235_L0.6790.16
141_T237_A0.6790.16
75_K255_D0.6780.16
32_Q36_E0.6780.16
273_L303_E0.6770.16
222_F370_V0.6760.16
14_E116_S0.6760.16
153_I242_H0.6730.15
75_K85_E0.6720.15
273_L338_A0.6720.15
84_K324_M0.6710.15
275_T280_S0.6700.15
182_N240_Y0.6700.15
44_I336_A0.6680.15
263_S308_Y0.6670.15
239_L245_R0.6650.15
194_L223_E0.6630.15
46_F189_N0.6590.15
20_Q141_T0.6590.15
363_T367_L0.6580.15
273_L324_M0.6580.15
11_E229_D0.6580.15
141_T333_I0.6570.15
333_I376_M0.6570.15
216_A237_A0.6560.15
14_E120_G0.6530.15
37_V264_T0.6510.15
150_R220_C0.6510.15
142_T146_Y0.6490.15
181_K208_K0.6480.15
193_I197_V0.6470.15
185_D209_K0.6460.15
110_I255_D0.6450.15
223_E246_V0.6450.15
20_Q23_T0.6450.15
282_I361_V0.6420.15
337_L363_T0.6410.15
118_L343_D0.6400.15
39_K79_R0.6390.15
41_L86_Y0.6390.15
73_I333_I0.6380.15
192_Y235_L0.6370.15
55_Q352_K0.6370.15
210_A222_F0.6350.15
169_E191_F0.6330.15
52_R63_E0.6330.15
81_E338_A0.6310.14
179_T305_Q0.6300.14
14_E112_K0.6290.14
218_L244_R0.6290.14
262_V310_Y0.6290.14
261_D301_N0.6280.14
175_R215_N0.6260.14
11_E55_Q0.6260.14
213_K216_A0.6230.14
205_G329_F0.6230.14
108_D157_G0.6230.14
214_T232_L0.6210.14
17_L317_T0.6200.14
186_I192_Y0.6180.14
113_S243_G0.6130.14
178_L186_I0.6130.14
340_N348_G0.6110.14
147_V271_K0.6110.14
73_I135_S0.6110.14
50_N113_S0.6110.14
35_P61_L0.6090.14
159_F202_E0.6080.14
65_S177_I0.6070.14
292_T333_I0.6050.14
28_T94_V0.6050.14
212_G244_R0.6040.14
96_S165_K0.6030.14
26_K114_G0.6030.14
324_M344_V0.6030.14
14_E121_D0.6020.14
186_I236_S0.6020.14
140_V155_D0.6000.14
188_S191_F0.6000.14
113_S118_L0.5980.14
118_L121_D0.5980.14
36_E39_K0.5950.14
181_K211_K0.5940.14
107_I112_K0.5920.14
327_S332_A0.5900.14
52_R352_K0.5900.14
27_K246_V0.5890.14
16_Q89_I0.5870.14
47_V50_N0.5860.13
12_I305_Q0.5790.13
246_V301_N0.5780.13
296_E319_Y0.5780.13
178_L371_I0.5750.13
67_A90_G0.5740.13
35_P219_R0.5720.13
221_I260_D0.5710.13
338_A362_V0.5710.13
340_N350_N0.5710.13
24_P75_K0.5700.13
39_K64_R0.5700.13
131_I319_Y0.5690.13
229_D241_K0.5680.13
345_S352_K0.5680.13
21_I121_D0.5670.13
26_K301_N0.5670.13
135_S297_N0.5670.13
373_E376_M0.5670.13
93_E135_S0.5640.13
304_N365_E0.5600.13
50_N255_D0.5590.13
159_F288_I0.5570.13
160_E315_I0.5570.13
90_G186_I0.5560.13
273_L323_N0.5550.13
46_F63_E0.5550.13
193_I221_I0.5550.13
202_E317_T0.5530.13
76_D367_L0.5520.13
159_F219_R0.5520.13
310_Y350_N0.5520.13
331_T335_H0.5510.13
286_Y349_A0.5500.13
53_E371_I0.5500.13
208_K240_Y0.5490.13
62_T66_L0.5490.13
76_D107_I0.5480.13
152_K229_D0.5480.13
262_V308_Y0.5470.13
184_Q243_G0.5470.13
269_V377_M0.5470.13
191_F198_L0.5450.13
304_N338_A0.5440.13
188_S230_M0.5440.13
176_K247_T0.5440.13
190_S240_Y0.5430.13
221_I333_I0.5420.13
166_C238_E0.5420.13
185_D273_L0.5390.12
141_T199_L0.5370.12
198_L304_N0.5360.12
366_D370_V0.5360.12
64_R68_S0.5360.12
332_A341_N0.5330.12
296_E333_I0.5320.12
46_F222_F0.5300.12
304_N323_N0.5290.12
157_G367_L0.5290.12
282_I305_Q0.5290.12
42_E55_Q0.5280.12
32_Q78_D0.5280.12
33_Y57_V0.5280.12
181_K294_S0.5280.12
113_S299_I0.5270.12
17_L321_V0.5260.12
181_K240_Y0.5220.12
231_L234_S0.5220.12
278_Q370_V0.5210.12
146_Y237_A0.5210.12
171_T294_S0.5210.12
215_N237_A0.5200.12
15_S193_I0.5190.12
310_Y363_T0.5190.12
278_Q333_I0.5180.12
216_A244_R0.5180.12
148_A228_S0.5170.12
73_I344_V0.5170.12
307_T329_F0.5170.12
153_I348_G0.5170.12
47_V89_I0.5160.12
71_I345_S0.5150.12
251_D290_F0.5150.12
108_D163_F0.5150.12
296_E318_T0.5150.12
200_Y341_N0.5140.12
165_K169_E0.5140.12
166_C357_K0.5130.12
15_S111_L0.5120.12
137_L242_H0.5090.12
266_F283_K0.5090.12
139_K321_V0.5080.12
153_I349_A0.5050.12
81_E214_T0.5050.12
346_I354_L0.5050.12
19_Y116_S0.5030.12
50_N354_L0.5030.12
41_L246_V0.5030.12
75_K154_K0.5020.12
23_T315_I0.5020.12
148_A159_F0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5c8hA 1 0.2539 50.7 0.976 Contact Map
1ywlA 1 0.233 40.9 0.977 Contact Map
4yk8B 1 0.1518 29.3 0.979 Contact Map
2ktaA 1 0.1754 18 0.981 Contact Map
1zg2A 1 0.233 15.4 0.981 Contact Map
4xlgA 1 0.267 11 0.983 Contact Map
2kmuA 1 0.1309 10.4 0.983 Contact Map
4j2gA 2 0.1047 7.8 0.984 Contact Map
2d6fA 2 0.3979 6.4 0.984 Contact Map
2o36A 1 0.1597 6.4 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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