GREMLIN Database
YTMI - Uncharacterized N-acetyltransferase YtmI
UniProt: O34350 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 178 (144)
Sequences: 3240 (2485)
Seq/√Len: 207.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_R58_E4.1591.00
108_E142_Y4.0391.00
23_S91_L2.9611.00
57_L99_A2.8261.00
64_I94_Y2.6001.00
55_I106_Y2.2391.00
110_K115_M2.2231.00
138_R144_V2.1991.00
104_L140_R2.1881.00
15_S42_I2.0771.00
59_R97_Q2.0731.00
67_I107_V2.0721.00
123_L137_Y2.0641.00
144_V147_E2.0331.00
106_Y109_E1.9881.00
23_S92_P1.9401.00
58_E61_G1.8871.00
85_V104_L1.8551.00
59_R64_I1.8071.00
110_K116_L1.7991.00
7_R13_D1.7951.00
57_L65_S1.7921.00
9_A17_L1.7811.00
101_S140_R1.7721.00
62_K93_E1.7321.00
134_A138_R1.7291.00
56_V63_L1.7261.00
19_K23_S1.6961.00
108_E121_L1.6501.00
47_E51_H1.6061.00
83_P113_R1.6011.00
65_S90_T1.5031.00
101_S105_T1.4841.00
9_A56_V1.4321.00
11_V50_E1.4181.00
134_A158_M1.4171.00
59_R94_Y1.3991.00
67_I103_L1.3881.00
41_D44_M1.3731.00
14_A49_I1.3541.00
67_I88_F1.3511.00
101_S139_R1.3361.00
125_T133_L1.3341.00
85_V123_L1.3271.00
6_F106_Y1.3261.00
71_F118_A1.3211.00
69_I107_V1.3191.00
36_P39_R1.3171.00
109_E115_M1.3071.00
106_Y110_K1.2941.00
9_A54_A1.2681.00
82_Y120_A1.2421.00
27_P95_K1.2371.00
16_E63_L1.2241.00
92_P95_K1.2101.00
10_T13_D1.1901.00
135_D138_R1.1681.00
11_V46_S1.1591.00
94_Y97_Q1.1271.00
21_V66_T1.1231.00
62_K91_L1.1201.00
16_E19_K1.1181.00
125_T130_H1.1051.00
65_S103_L1.1001.00
23_S93_E1.0981.00
130_H133_L1.0891.00
128_R154_I1.0841.00
144_V158_M1.0751.00
42_I46_S1.0691.00
83_P118_A1.0361.00
58_E63_L1.0331.00
134_A144_V0.9881.00
102_K105_T0.9741.00
105_T140_R0.9721.00
90_T99_A0.9711.00
16_E62_K0.9671.00
26_Q29_R0.9550.99
98_G101_S0.9500.99
147_E154_I0.9490.99
109_E114_D0.9430.99
152_G155_G0.9430.99
16_E91_L0.9410.99
71_F83_P0.9390.99
100_G137_Y0.9290.99
144_V156_V0.9220.99
46_S50_E0.9220.99
35_W39_R0.9210.99
19_K22_N0.9180.99
53_S110_K0.9170.99
48_N87_W0.9160.99
67_I85_V0.8810.99
5_I58_E0.8780.99
57_L64_I0.8680.99
24_A89_A0.8650.99
17_L66_T0.8600.99
113_R121_L0.8600.99
85_V121_L0.8560.99
105_T109_E0.8550.99
34_D37_S0.8550.99
121_L142_Y0.8400.99
25_F28_I0.8250.99
43_Q46_S0.8180.98
84_F133_L0.8170.98
70_R86_W0.8160.98
33_I36_P0.8110.98
66_T89_A0.8020.98
86_W124_G0.7890.98
133_L136_M0.7890.98
9_A13_D0.7830.98
26_Q30_Q0.7810.98
31_L132_W0.7810.98
71_F116_L0.7800.98
149_E154_I0.7690.98
20_L63_L0.7660.98
18_L22_N0.7560.97
28_I130_H0.7500.97
17_L56_V0.7480.97
14_A45_V0.7470.97
45_V48_N0.7470.97
64_I99_A0.7460.97
47_E50_E0.7450.97
138_R158_M0.7450.97
35_W124_G0.7450.97
54_A68_T0.7380.97
133_L137_Y0.7320.97
59_R62_K0.7270.97
69_I83_P0.7240.97
48_N68_T0.7200.96
34_D39_R0.7200.96
22_N26_Q0.7160.96
62_K94_Y0.7160.96
84_F124_G0.7160.96
8_L53_S0.7140.96
14_A18_L0.7130.96
25_F87_W0.7120.96
18_L42_I0.7100.96
7_R56_V0.7060.96
132_W135_D0.6990.96
27_P30_Q0.6960.96
95_K132_W0.6950.96
150_K153_D0.6910.96
100_G136_M0.6880.95
13_D58_E0.6860.95
82_Y122_T0.6850.95
6_F103_L0.6820.95
74_E82_Y0.6600.94
28_I124_G0.6530.94
88_F100_G0.6490.94
95_K136_M0.6480.94
125_T134_A0.6350.93
53_S69_I0.6350.93
93_E97_Q0.6320.93
104_L108_E0.6290.93
127_A133_L0.6270.93
16_E20_L0.6260.93
124_G130_H0.6250.93
96_G136_M0.6220.92
15_S19_K0.6200.92
150_K155_G0.6200.92
20_L89_A0.6190.92
20_L24_A0.6130.92
28_I31_L0.6080.91
9_A49_I0.6060.91
66_T87_W0.6040.91
14_A54_A0.6030.91
87_W130_H0.6020.91
155_G158_M0.6000.91
57_L103_L0.5950.91
8_L52_H0.5930.90
36_P40_A0.5900.90
14_A42_I0.5880.90
21_V89_A0.5850.90
20_L70_R0.5810.90
131_P135_D0.5800.89
21_V87_W0.5770.89
96_G132_W0.5720.89
149_E152_G0.5680.89
25_F124_G0.5650.88
125_T156_V0.5650.88
55_I69_I0.5610.88
88_F140_R0.5590.88
57_L102_K0.5560.87
74_E122_T0.5560.87
94_Y99_A0.5540.87
17_L21_V0.5540.87
147_E156_V0.5500.87
91_L94_Y0.5500.87
89_A133_L0.5500.87
69_I110_K0.5490.87
18_L87_W0.5480.87
132_W139_R0.5440.86
6_F65_S0.5400.86
45_V66_T0.5400.86
28_I155_G0.5380.86
87_W124_G0.5320.85
10_T61_G0.5240.84
27_P31_L0.5230.84
66_T127_A0.5230.84
99_A102_K0.5210.84
95_K100_G0.5190.84
8_L55_I0.5160.83
83_P121_L0.5140.83
55_I110_K0.5130.83
120_A145_Y0.5110.83
125_T132_W0.5110.83
40_A48_N0.5100.83
84_F122_T0.5090.82
54_A66_T0.5090.82
11_V14_A0.5080.82
10_T15_S0.5070.82
15_S62_K0.5070.82
31_L143_E0.5070.82
11_V49_I0.5060.82
37_S40_A0.5050.82
107_V158_M0.5000.81
51_H60_D0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oh1A 1 0.882 99.9 0.385 Contact Map
2fiaA 1 0.8652 99.9 0.422 Contact Map
2j8mA 2 0.8933 99.9 0.43 Contact Map
2pc1A 1 0.882 99.9 0.44 Contact Map
3zj0A 1 0.8708 99.9 0.445 Contact Map
3h4qA 1 0.7753 99.9 0.445 Contact Map
1gheA 1 0.8652 99.9 0.446 Contact Map
3kkwA 1 0.8539 99.9 0.448 Contact Map
3dr6A 2 0.9045 99.9 0.448 Contact Map
4l8aA 1 0.8539 99.9 0.452 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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