GREMLIN Database
YODM - Putative lipid phosphate phosphatase YodM
UniProt: O34349 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 203 (168)
Sequences: 6388 (4993)
Seq/√Len: 385.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_G180_F4.0781.00
130_P187_F3.8371.00
92_N123_M3.3671.00
100_E115_F3.1891.00
101_R174_T2.8671.00
88_D127_C2.7931.00
134_Y191_K2.7221.00
87_T186_L2.6151.00
95_L99_I2.5961.00
117_F178_G2.5561.00
43_N167_Y2.4861.00
122_S162_G2.4141.00
88_D123_M2.4071.00
126_A158_A2.3411.00
130_P184_L2.2451.00
27_D101_R2.0311.00
126_A180_F2.0211.00
84_V127_C1.9801.00
179_G183_G1.9461.00
126_A162_G1.9311.00
50_T164_S1.9151.00
31_S166_V1.8731.00
122_S126_A1.8451.00
28_E32_K1.8201.00
46_M163_I1.7551.00
129_Y158_A1.7371.00
122_S180_F1.7371.00
35_V38_R1.7331.00
122_S179_G1.7111.00
125_A161_V1.6981.00
188_F192_G1.6691.00
166_V176_V1.6631.00
162_G176_V1.6611.00
31_S173_V1.6121.00
133_A151_Y1.6061.00
51_H54_A1.5471.00
183_G187_F1.5021.00
95_L118_P1.4941.00
49_I161_V1.4661.00
186_L190_V1.4641.00
52_L157_I1.4011.00
118_P182_L1.3961.00
101_R172_F1.3141.00
133_A154_A1.2601.00
33_A37_I1.2561.00
39_Q42_L1.2561.00
155_G158_A1.2441.00
96_K120_G1.2241.00
137_V151_Y1.1991.00
166_V173_V1.1961.00
46_M50_T1.1771.00
94_V98_W1.1731.00
116_S175_D1.1621.00
97_E115_F1.1581.00
24_Q28_E1.1551.00
49_I160_L1.1481.00
123_M182_L1.1311.00
38_R43_N1.1211.00
134_Y187_F1.1191.00
50_T168_L1.1141.00
116_S172_F1.1081.00
129_Y154_A1.1041.00
92_N120_G1.0951.00
93_K97_E1.0801.00
67_A71_F1.0651.00
129_Y157_I1.0531.00
80_L131_V1.0421.00
99_I117_F1.0381.00
130_P183_G1.0361.00
158_A180_F1.0321.00
54_A57_F1.0251.00
31_S35_V1.0191.00
184_L188_F1.0171.00
30_I34_A1.0131.00
118_P178_G1.0041.00
112_E170_V1.0001.00
87_T190_V0.9951.00
83_L86_G0.9951.00
55_S59_L0.9951.00
44_E48_G0.9941.00
125_A129_Y0.9931.00
126_A187_F0.9921.00
44_E47_T0.9881.00
42_L46_M0.9771.00
70_F73_R0.9741.00
37_I40_P0.9631.00
96_K103_R0.9571.00
117_F175_D0.9471.00
29_A33_A0.9451.00
151_Y154_A0.9421.00
133_A155_G0.9411.00
80_L190_V0.9391.00
133_A136_L0.9381.00
41_W45_V0.9331.00
58_L128_V0.9321.00
125_A158_A0.9271.00
26_A29_A0.9261.00
70_F74_K0.9181.00
126_A184_L0.9141.00
91_L186_L0.9091.00
68_G72_Y0.9071.00
185_L188_F0.9051.00
148_K152_I0.9021.00
180_F184_L0.9021.00
89_R93_K0.8971.00
81_M131_V0.8941.00
73_R76_W0.8871.00
98_W102_V0.8871.00
57_F60_P0.8851.00
160_L164_S0.8711.00
101_R116_S0.8631.00
46_M164_S0.8621.00
22_A25_S0.8551.00
25_S29_A0.8501.00
34_A166_V0.8481.00
43_N47_T0.8481.00
130_P155_G0.8441.00
84_V87_T0.8401.00
33_A36_L0.8401.00
84_V187_F0.8331.00
81_M85_F0.8281.00
131_V134_Y0.8281.00
130_P134_Y0.8211.00
57_F61_L0.8201.00
74_K77_D0.8181.00
121_H171_H0.8171.00
126_A159_V0.8151.00
30_I33_A0.8071.00
68_G71_F0.8021.00
182_L186_L0.7991.00
191_K195_E0.7841.00
56_S59_L0.7741.00
34_A37_I0.7731.00
30_I166_V0.7671.00
129_Y133_A0.7661.00
47_T51_H0.7651.00
159_V180_F0.7641.00
122_S176_V0.7621.00
88_D186_L0.7581.00
105_D110_V0.7561.00
66_G70_F0.7541.00
59_L63_V0.7501.00
45_V160_L0.7491.00
84_V131_V0.7481.00
50_T54_A0.7361.00
136_L154_A0.7321.00
190_V194_D0.7301.00
84_V88_D0.7271.00
46_M49_I0.7271.00
80_L83_L0.7241.00
173_V177_L0.7231.00
46_M167_Y0.7211.00
45_V48_G0.7181.00
152_I156_V0.7181.00
126_A155_G0.7131.00
28_E34_A0.7111.00
53_G161_V0.7051.00
131_V135_F0.6981.00
150_V154_A0.6960.99
29_A32_K0.6950.99
88_D92_N0.6940.99
192_G196_K0.6940.99
34_A169_G0.6930.99
95_L182_L0.6910.99
111_H114_S0.6900.99
80_L134_Y0.6860.99
70_F75_T0.6850.99
83_L194_D0.6800.99
48_G51_H0.6800.99
157_I161_V0.6800.99
85_F88_D0.6770.99
56_S60_P0.6770.99
80_L84_V0.6770.99
122_S125_A0.6720.99
88_D124_N0.6720.99
181_S184_L0.6700.99
50_T165_R0.6680.99
69_M74_K0.6680.99
106_F109_L0.6670.99
21_N24_Q0.6610.99
91_L182_L0.6610.99
120_G171_H0.6590.99
163_I167_Y0.6590.99
174_T178_G0.6510.99
100_E114_S0.6490.99
132_I154_A0.6470.99
84_V190_V0.6470.99
105_D111_H0.6470.99
90_L94_V0.6410.99
123_M179_G0.6350.99
131_V187_F0.6280.99
25_S28_E0.6280.99
127_C131_V0.6270.99
37_I163_I0.6260.99
77_D80_L0.6260.99
125_A157_I0.6260.99
27_D174_T0.6230.99
31_S34_A0.6160.99
92_N182_L0.6160.99
90_L93_K0.6160.99
30_I173_V0.6130.99
77_D81_M0.6100.99
85_F128_V0.5960.98
40_P43_N0.5950.98
67_A70_F0.5920.98
21_N25_S0.5910.98
105_D109_L0.5880.98
66_G82_L0.5870.98
42_L167_Y0.5850.98
84_V91_L0.5830.98
101_R175_D0.5790.98
102_V114_S0.5780.98
162_G166_V0.5730.98
80_L194_D0.5680.98
55_S60_P0.5670.98
69_M73_R0.5580.98
89_R92_N0.5560.98
193_F196_K0.5510.97
43_N46_M0.5510.97
23_V26_A0.5510.97
149_M153_I0.5470.97
39_Q44_E0.5440.97
123_M127_C0.5420.97
112_E115_F0.5400.97
101_R117_F0.5390.97
174_T177_L0.5390.97
108_P112_E0.5380.97
112_E124_N0.5370.97
190_V193_F0.5350.97
76_W80_L0.5240.96
71_F74_K0.5210.96
134_Y195_E0.5200.96
137_V147_K0.5200.96
122_S170_V0.5190.96
131_V191_K0.5170.96
63_V82_L0.5150.96
69_M72_Y0.5150.96
35_V169_G0.5140.96
170_V173_V0.5130.96
178_G181_S0.5120.96
31_S168_L0.5120.96
87_T90_L0.5120.96
187_F191_K0.5080.96
130_P188_F0.5070.96
22_A28_E0.5060.96
164_S168_L0.5050.96
47_T168_L0.5020.96
161_V164_S0.5020.96
32_K36_L0.5010.95
134_Y188_F0.5010.95
123_M158_A0.5010.95
70_F78_G0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4px7A 1 0.9015 100 0.355 Contact Map
1qi9A 2 0.9163 99.9 0.455 Contact Map
1up8A 9 0.9261 99.9 0.457 Contact Map
1d2tA 5 0.9458 99.9 0.464 Contact Map
4citA 1 0.9557 99.9 0.478 Contact Map
2ipbA 2 0.9458 99.9 0.48 Contact Map
3w36A 2 0.9507 99.8 0.513 Contact Map
3bb0A 1 0.9557 99.7 0.555 Contact Map
2kluA 1 0.1724 25.1 0.925 Contact Map
2m20A 2 0.1527 8 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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